Homo sapiens (human): 135 Entry 135               CDS       T01001                                  Gene name ADORA2A, A2aR, ADORA2, RDC8 Definition (RefSeq) adenosine A2a receptor   KO K04266   adenosine receptor A2a Organism hsa  Homo sapiens (human) Pathway hsa04015   Rap1 signaling pathway hsa04020   Calcium signaling pathway hsa04024   cAMP signaling pathway hsa04080   Neuroactive ligand-receptor interaction hsa04270   Vascular smooth muscle contraction hsa05012   Parkinson's disease hsa05034   Alcoholism Drug target Adenosine (DG00243):  D00045 D02300 D02769 Aminophylline (DG01062):  D00227 D05429 Apadenoson:  D03212 Binodenoson:  D03120 Caffeine (DG00974):  D00528 D01453 D07603 Choline theophyllinate:  D02017 Enprofylline:  D04006 Evodenoson:  D10362 Istradefylline:  D04641 Proxyphylline:  D01771 Regadenoson:  D05711 Sonedenoson:  D09003 Theophylline (DG01061):  D00371 D01712 D06103 D06104 Tozadenant:  D10174 Vipadenant:  D09991 Brite KEGG Orthology (KO) [BR:hsa00001]  Environmental Information Processing   Signal transduction    04015 Rap1 signaling pathway     135 (ADORA2A)    04020 Calcium signaling pathway     135 (ADORA2A)    04024 cAMP signaling pathway     135 (ADORA2A)   Signaling molecules and interaction    04080 Neuroactive ligand-receptor interaction     135 (ADORA2A)  Organismal Systems   Circulatory system    04270 Vascular smooth muscle contraction     135 (ADORA2A)  Human Diseases   Neurodegenerative diseases    05012 Parkinson's disease     135 (ADORA2A)   Substance dependence    05034 Alcoholism     135 (ADORA2A) G protein-coupled receptors [BR:hsa04030]  Class A. Rhodopsin family   Base and nucleoside    Adenosine     135 (ADORA2A) SSDB Motif Pfam:  7tm_1 7TM_GPCR_Srsx 7tm_4 GPR_Gpa2_C Ni_hydr_CYTB Other DBs NCBI-GeneID:  135 NCBI-ProteinID:  NP_000666 OMIM:  102776 HGNC:  263 Ensembl:  ENSG00000128271 Vega:  OTTHUMG00000150761 Pharos:  P29274(Tclin) UniProt:  P29274 B3KVQ4 X5DNB4 LinkDB Structure PDB:  4UHR 4UG2 2YDV 3VG9 2YDO 3VGA 3UZA 3PWH 3REY 3UZC 5G53 3RFM Position 22q11.23 AA seq 412 aa MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAI PFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTR AKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYF NFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVG LFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFR KIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNG YALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS NT seq 1239 nt   +upstreamnt  +downstreamnt atgcccatcatgggctcctcggtgtacatcacggtggagctggccattgctgtgctggcc atcctgggcaatgtgctggtgtgctgggccgtgtggctcaacagcaacctgcagaacgtc accaactactttgtggtgtcactggcggcggccgacatcgcagtgggtgtgctcgccatc ccctttgccatcaccatcagcaccgggttctgcgctgcctgccacggctgcctcttcatt gcctgcttcgtcctggtcctcacgcagagctccatcttcagtctcctggccatcgccatt gaccgctacattgccatccgcatcccgctccggtacaatggcttggtgaccggcacgagg gctaagggcatcattgccatctgctgggtgctgtcgtttgccatcggcctgactcccatg ctaggttggaacaactgcggtcagccaaaggagggcaagaaccactcccagggctgcggg gagggccaagtggcctgtctctttgaggatgtggtccccatgaactacatggtgtacttc aacttctttgcctgtgtgctggtgcccctgctgctcatgctgggtgtctatttgcggatc ttcctggcggcgcgacgacagctgaagcagatggagagccagcctctgccgggggagcgg gcacggtccacactgcagaaggaggtccatgctgccaagtcactggccatcattgtgggg ctctttgccctctgctggctgcccctacacatcatcaactgcttcactttcttctgcccc gactgcagccacgcccctctctggctcatgtacctggccatcgtcctctcccacaccaat tcggttgtgaatcccttcatctacgcctaccgtatccgcgagttccgccagaccttccgc aagatcattcgcagccacgtcctgaggcagcaagaacctttcaaggcagctggcaccagt gcccgggtcttggcagctcatggcagtgacggagagcaggtcagcctccgtctcaacggc cacccgccaggagtgtgggccaacggcagtgctccccaccctgagcggaggcccaatggc tatgccctggggctggtgagtggagggagtgcccaagagtcccaggggaacacgggcctc ccagacgtggagctccttagccatgagctcaagggagtgtgcccagagccccctggccta gatgaccccctggcccaggatggagcaggagtgtcctga

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