KEGG   Homo sapiens (human): 1540Help
Entry
1540              CDS       T01001                                 

Gene name
CYLD, BRSS, CDMT, CYLD1, CYLDI, EAC, MFT, MFT1, SBS, TEM, USPL2
Definition
cylindromatosis (turban tumor syndrome) (EC:3.4.19.12)
Orthology
K08601  
ubiquitin thioesterase CYLD [EC:3.4.19.12]
Organism
hsa  Homo sapiens (human)
Pathway
Osteoclast differentiation
RIG-I-like receptor signaling pathway
Disease
H00827  
Brooke-Spiegler syndrome
H00828  
Familial cylindromatosis
H00829  
Multiple familial trichoepithelioma
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Organismal Systems
  Immune system
   04622 RIG-I-like receptor signaling pathway
    1540 (CYLD)
  Development
   04380 Osteoclast differentiation
    1540 (CYLD)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.19  Omega peptidases
    3.4.19.12  ubiquitinyl hydrolase 1
     1540 (CYLD)
Peptidases [BR:hsa01002]
 Cysteine Peptidases
  Family C67
   1540 (CYLD)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
Ensembl: 
Vega: 
UniProt: 
LinkDB All DBs
Structure
PDB: 

Jmol
Position
16q12.1
AA seq 953 aa AA seqDB search
MSSGLWSQEKVTSPYWEERIFYLLLQECSVTDKQTQKLLKVPKGSIGQYIQDRSVGHSRI
PSAKGKKNQIGLKILEQPHAVLFVDEKDVVEINEKFTELLLAITNCEERFSLFKNRNRLS
KGLQIDVGCPVKVQLRSGEEKFPGVVRFRGPLLAERTVSGIFFGVELLEEGRGQGFTDGV
YQGKQLFQCDEDCGVFVALDKLELIEDDDTALESDYAGPGDTMQVELPPLEINSRVSLKV
GETIESGTVIFCDVLPGKESLGYFVGVDMDNPIGNWDGRFDGVQLCSFACVESTILLHIN
DIIPESVTQERRPPKLAFMSRGVGDKGSSSHNKPKATGSTSDPGNRNRSELFYTLNGSSV
DSQPQSKSKNTWYIDEVAEDPAKSLTEISTDFDRSSPPLQPPPVNSLTTENRFHSLPFSL
TKMPNTNGSIGHSPLSLSAQSVMEELNTAPVQESPPLAMPPGNSHGLEVGSLAEVKENPP
FYGVIRWIGQPPGLNEVLAGLELEDECAGCTDGTFRGTRYFTCALKKALFVKLKSCRPDS
RFASLQPVSNQIERCNSLAFGGYLSEVVEENTPPKMEKEGLEIMIGKKKGIQGHYNSCYL
DSTLFCLFAFSSVLDTVLLRPKEKNDVEYYSETQELLRTEIVNPLRIYGYVCATKIMKLR
KILEKVEAASGFTSEEKDPEEFLNILFHHILRVEPLLKIRSAGQKVQDCYFYQIFMEKNE
KVGVPTIQQLLEWSFINSNLKFAEAPSCLIIQMPRFGKDFKLFKKIFPSLELNITDLLED
TPRQCRICGGLAMYECRECYDDPDISAGKIKQFCKTCNTQVHLHPKRLNHKYNPVSLPKD
LPDWDWRHGCIPCQNMELFAVLCIETSHYVAFVKYGKDDSAWLFFDSMADRDGGQNGFNI
PQVTPCPEVGEYLKMSLEDLHSLDSRRIQGCARRLLCDAYMCMYQSPTMSLYK
NT seq 2862 nt NT seq  +upstreamnt  +downstreamnt
atgagttcaggcttatggagccaagaaaaagtcacttcaccctactgggaagagcggatt
ttttacttgcttcttcaagaatgcagcgttacagacaaacaaacacaaaagctccttaaa
gtaccgaagggaagtataggacagtatattcaagatcgttctgtggggcattcaaggatt
ccttctgcaaaaggcaagaaaaatcagattggattaaaaattctagagcaacctcatgca
gttctctttgttgatgaaaaggatgttgtagagataaatgaaaagttcacagagttactt
ttggcaattaccaattgtgaggagaggttcagcctgtttaaaaacagaaacagactaagt
aaaggcctccaaatagacgtgggctgtcctgtgaaagtacagctgagatctggggaagaa
aaatttcctggagttgtacgcttcagaggacccctgttagcagagaggacagtctccgga
atattctttggagttgaattgctggaagaaggtcgtggtcaaggtttcactgacggggtg
taccaagggaaacagctttttcagtgtgatgaagattgtggcgtgtttgttgcattggac
aagctagaactcatagaagatgatgacactgcattggaaagtgattacgcaggtcctggg
gacacaatgcaggtcgaacttcctcctttggaaataaactccagagtttctttgaaggtt
ggagaaacaatagaatctggaacagttatattctgtgatgttttgccaggaaaagaaagc
ttaggatattttgttggtgtggacatggataaccctattggcaactgggatggaagattt
gatggagtgcagctttgtagttttgcgtgtgttgaaagtacaattctattgcacatcaat
gatatcatcccagagagtgtgacgcaggaaaggaggcctcccaaacttgcctttatgtca
agaggtgttggggacaaaggttcatccagtcataataaaccaaaggctacaggatctacc
tcagaccctggaaatagaaacagatctgaattattttataccttaaatgggtcttctgtt
gactcacaaccacaatccaaatcaaaaaatacatggtacattgatgaagttgcagaagac
cctgcaaaatctcttacagagatatctacagactttgaccgttcttcaccaccactccag
cctcctcctgtgaactcactgaccaccgagaacagattccactctttaccattcagtctc
accaagatgcccaataccaatggaagtattggccacagtccactttctctgtcagcccag
tctgtaatggaagagctaaacactgcacccgtccaagagagtccacccttggccatgcct
cctgggaactcacatggtctagaagtgggctcattggctgaagttaaggagaaccctcct
ttctatggggtaatccgttggatcggtcagccaccaggactgaatgaagtgctcgctgga
ctggaactggaagatgagtgtgcaggctgtacggatggaaccttcagaggcactcggtat
ttcacctgtgccctgaagaaggcgctgtttgtgaaactgaagagctgcaggcctgactct
aggtttgcatcattgcagccggtttccaatcagattgagcgctgtaactctttagcattt
ggaggctacttaagtgaagtagtagaagaaaatactccaccaaaaatggaaaaagaaggc
ttggagataatgattgggaagaagaaaggcatccagggtcattacaattcttgttactta
gactcaaccttattctgcttatttgcttttagttctgttctggacactgtgttacttaga
cccaaagaaaagaacgatgtagaatattatagtgaaacccaagagctactgaggacagaa
attgttaatcctctgagaatatatggatatgtgtgtgccacaaaaattatgaaactgagg
aaaatacttgaaaaggtggaggctgcatcaggatttacctctgaagaaaaagatcctgag
gaattcttgaatattctgtttcatcatattttaagggtagaacctttgctaaaaataaga
tcagcaggtcaaaaggtacaagattgttacttctatcaaatttttatggaaaaaaatgag
aaagttggcgttcccacaattcagcagttgttagaatggtcttttatcaacagtaacctg
aaatttgcagaggcaccatcatgtctgattattcagatgcctcgatttggaaaagacttt
aaactatttaaaaaaatttttccttctctggaattaaatataacagatttacttgaagac
actcccagacagtgccggatatgtggagggcttgcaatgtatgagtgtagagaatgctac
gacgatccggacatctcagctggaaaaatcaagcagttttgtaaaacctgcaacactcaa
gtccaccttcatccgaagaggctgaatcataaatataacccagtgtcacttcccaaagac
ttacccgactgggactggagacacggctgcatcccttgccagaatatggagttatttgct
gttctctgcatagaaacaagccactatgttgcttttgtgaagtatgggaaggacgattct
gcctggctcttctttgacagcatggccgatcgggatggtggtcagaatggcttcaacatt
cctcaagtcaccccatgcccagaagtaggagagtacttgaagatgtctctggaagacctg
cattccttggactccaggagaatccaaggctgtgcacgaagactgctttgtgatgcatat
atgtgcatgtaccagagtccaacaatgagtttgtacaaataa

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