KEGG H.sapiens: 1581

Homo sapiens (human): 1581

Entry

1581 CDS H.sapiens

Gene name CYP7A1, CP7A, CYP7, CYPVII, MGC126826, MGC138389

Definition cytochrome P450, family 7, subfamily A, polypeptide 1
(EC:1.14.13.17)

Orthology K00489 cytochrome P450, family 7, subfamily A (cholesterol
7alpha-monooxygenase) [EC:1.14.13.17]

Pathway hsa00120 Primary bile acid biosynthesis
hsa00140 Steroid hormone biosynthesis
hsa01100 Metabolic pathways
hsa03320 PPAR signaling pathway

Class Metabolism; Lipid Metabolism; Primary bile acid biosynthesis
[PATH:hsa00120]
Metabolism; Lipid Metabolism; Steroid hormone biosynthesis
[PATH:hsa00140]
Organismal Systems; Endocrine System; PPAR signaling pathway
[PATH:hsa03320]

SSDB

Motif Pfam: p450
PROSITE: CYTOCHROME_P450 PROKAR_LIPOPROTEIN

Other DBs NCBI-GI: 166295200
NCBI-GeneID: 1581
OMIM: 118455
HGNC: 2651
HPRD: 00324
Ensembl: ENSG00000167910
UniProt: P22680

Structure

PDB: 3DAX

Position 8q11-q12

AA seq 504 aa
MMTTSLIWGIAIAACCCLWLILGIRRRQTGEPPLENGLIPYLGCALQFGANPLEFLRANQ
RKHGHVFTCKLMGKYVHFITNPLSYHKVLCHGKYFDWKKFHFATSAKAFGHRSIDPMDGN
TTENINDTFIKTLQGHALNSLTESMMENLQRIMRPPVSSNSKTAAWVTEGMYSFCYRVMF
EAGYLTIFGRDLTRRDTQKAHILNNLDNFKQFDKVFPALVAGLPIHMFRTAHNAREKLAE
SLRHENLQKRESISELISLRMFLNDTLSTFDDLEKAKTHLVVLWASQANTIPATFWSLFQ
MIRNPEAMKAATEEVKRTLENAGQKVSLEGNPICLSQAELNDLPVLDSIIKESLRLSSAS
LNIRTAKEDFTLHLEDGSYNIRKDDIIALYPQLMHLDPEIYPDPLTFKYDRYLDENGKTK
TTFYCNGLKLKYYYMPFGSGATICPGRLFAIHEIKQFLILMLSYFELELIEGQAKCPPLD
QSRAGLGILPPLNDIEFKYKFKHL

NT seq 1515 nt +upstreamnt +downstreamnt
atgatgaccacatctttgatttgggggattgctatagcagcatgctgttgtctatggctt
attcttggaattaggagaaggcaaacgggtgaaccacctctagagaatggattaattcca
tacctgggctgtgctctgcaatttggtgccaatcctcttgagttcctcagagcaaatcaa
aggaaacatggtcatgtttttacctgcaaactaatgggaaaatatgtccatttcatcaca
aatcccttgtcataccataaggtgttgtgccacggaaaatattttgattggaaaaaattt
cactttgctacttctgcgaaggcatttgggcacagaagcattgacccgatggatggaaat
accactgaaaacataaacgacactttcatcaaaaccctgcagggccatgccttgaattcc
ctcacggaaagcatgatggaaaacctccaacgtatcatgagacctccagtctcctctaac
tcaaagaccgctgcctgggtgacagaagggatgtattctttctgctaccgagtgatgttt
gaagctgggtatttaactatctttggcagagatcttacaaggcgggacacacagaaagca
catattctaaacaatcttgacaacttcaagcaattcgacaaagtctttccagccctggta
gcaggcctccccattcacatgttcaggactgcgcacaatgcccgggagaaactggcagag
agcttgaggcacgagaacctccaaaagagggaaagcatctcagaactgatcagcctgcgc
atgtttctcaatgacactttgtccacctttgatgatctggagaaggccaagacacacctc
gtggtcctctgggcatcgcaagcaaacaccattccagcgactttctggagtttatttcaa
atgattaggaacccagaagcaatgaaagcagctactgaagaagtgaaaagaacattagag
aatgctggtcaaaaagtcagcttggaaggcaatcctatttgtttgagtcaagcagaactg
aatgacctgccagtattagatagtataatcaaggaatcgctgaggctttccagtgcctcc
ctcaacatccggacagctaaggaggatttcactttgcaccttgaggacggttcctacaac
atccgaaaagatgacatcatagctctttacccacagttaatgcacttagatccagaaatc
tacccagaccctttgacttttaaatatgataggtatcttgatgaaaacgggaagacaaag
actaccttctattgtaatggactcaagttaaagtattactacatgccctttggatcggga
gctacaatatgtcctggaagattgttcgctatccacgaaatcaagcaatttttgattctg
atgctttcttattttgaattggagcttatagagggccaagctaaatgtccacctttggac
cagtcccgggcaggcttgggcattttgccgccattgaatgatattgaatttaaatataaa
ttcaagcatttgtga

All links

Pathway (4)   
   KEGG PATHWAY (4)   
Disease (1)   
   OMIM (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (10)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (4)   
   UniGene (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
Protein sequence (3)   
   UniProt (1)   
   RefSeq(pep) (1)   
   IPI (1)   
DNA sequence (13)   
   RefSeq(nuc) (1)   
   GenBank (6)   
   EMBL (6)   
3D Structure (1)   
   PDB (1)   
Protein domain (3)   
   Pfam (1)   
   PROSITE (2)   
All databases (37)

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