KEGG   Homo sapiens (human): 1786Help
Entry
1786              CDS       T01001                                 

Gene name
DNMT1, ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT
Definition
DNA (cytosine-5-)-methyltransferase 1 (EC:2.1.1.37)
Orthology
K00558  
DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
Organism
hsa  Homo sapiens (human)
Pathway
Cysteine and methionine metabolism
Metabolic pathways
MicroRNAs in cancer
Module
Methionine degradation
Drug target
Azacitidine: 
Decitabine: 
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Metabolism
  Amino acid metabolism
   00270 Cysteine and methionine metabolism
    1786 (DNMT1)
 Human Diseases
  Cancers
   05206 MicroRNAs in cancer
    1786 (DNMT1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.37  DNA (cytosine-5-)-methyltransferase
     1786 (DNMT1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
Ensembl: 
Vega: 
UniProt: 
LinkDB All DBs
Structure
PDB: 

Jmol
Position
19p13.2
AA seq 1632 aa AA seqDB search
MPARTAPARVPTLAVPAISLPDDVRRRLKDLERDSLTEKECVKEKLNLLHEFLQTEIKNQ
LCDLETKLRKEELSEEGYLAKVKSLLNKDLSLENGAHAYNREVNGRLENGNQARSEARRV
GMADANSPPKPLSKPRTPRRSKSDGEAKRSRDPPASASQVTGIRAEPSPSPRITRKSTRQ
TTITSHFAKGPAKRKPQEESERAKSDESIKEEDKDQDEKRRRVTSRERVARPLPAEEPER
AKSGTRTEKEEERDEKEEKRLRSQTKEPTPKQKLKEEPDREARAGVQADEDEDGDEKDEK
KHRSQPKDLAAKRRPEEKEPEKVNPQISDEKDEDEKEEKRRKTTPKEPTEKKMARAKTVM
NSKTHPPKCIQCGQYLDDPDLKYGQHPPDAVDEPQMLTNEKLSIFDANESGFESYEALPQ
HKLTCFSVYCKHGHLCPIDTGLIEKNIELFFSGSAKPIYDDDPSLEGGVNGKNLGPINEW
WITGFDGGEKALIGFSTSFAEYILMDPSPEYAPIFGLMQEKIYISKIVVEFLQSNSDSTY
EDLINKIETTVPPSGLNLNRFTEDSLLRHAQFVVEQVESYDEAGDSDEQPIFLTPCMRDL
IKLAGVTLGQRRAQARRQTIRHSTREKDRGPTKATTTKLVYQIFDTFFAEQIEKDDREDK
ENAFKRRRCGVCEVCQQPECGKCKACKDMVKFGGSGRSKQACQERRCPNMAMKEADDDEE
VDDNIPEMPSPKKMHQGKKKKQNKNRISWVGEAVKTDGKKSYYKKVCIDAETLEVGDCVS
VIPDDSSKPLYLARVTALWEDSSNGQMFHAHWFCAGTDTVLGATSDPLELFLVDECEDMQ
LSYIHSKVKVIYKAPSENWAMEGGMDPESLLEGDDGKTYFYQLWYDQDYARFESPPKTQP
TEDNKFKFCVSCARLAEMRQKEIPRVLEQLEDLDSRVLYYSATKNGILYRVGDGVYLPPE
AFTFNIKLSSPVKRPRKEPVDEDLYPEHYRKYSDYIKGSNLDAPEPYRIGRIKEIFCPKK
SNGRPNETDIKIRVNKFYRPENTHKSTPASYHADINLLYWSDEEAVVDFKAVQGRCTVEY
GEDLPECVQVYSMGGPNRFYFLEAYNAKSKSFEDPPNHARSPGNKGKGKGKGKGKPKSQA
CEPSEPEIEIKLPKLRTLDVFSGCGGLSEGFHQAGISDTLWAIEMWDPAAQAFRLNNPGS
TVFTEDCNILLKLVMAGETTNSRGQRLPQKGDVEMLCGGPPCQGFSGMNRFNSRTYSKFK
NSLVVSFLSYCDYYRPRFFLLENVRNFVSFKRSMVLKLTLRCLVRMGYQCTFGVLQAGQY
GVAQTRRRAIILAAAPGEKLPLFPEPLHVFAPRACQLSVVVDDKKFVSNITRLSSGPFRT
ITVRDTMSDLPEVRNGASALEISYNGEPQSWFQRQLRGAQYQPILRDHICKDMSALVAAR
MRHIPLAPGSDWRDLPNIEVRLSDGTMARKLRYTHHDRKNGRSSSGALRGVCSCVEAGKA
CDPAARQFNTLIPWCLPHTGNRHNHWAGLYGRLEWDGFFSTTVTNPEPMGKQGRVLHPEQ
HRVVSVRECARSQGFPDTYRLFGNILDKHRQVGNAVPPPLAKAIGLEIKLCMLAKARESA
SAKIKEEEAAKD
NT seq 4899 nt NT seq  +upstreamnt  +downstreamnt
atgccggcgcgtaccgccccagcccgggtgcccacactggccgtcccggccatctcgctg
cccgacgatgtccgcaggcggctcaaagatttggaaagagacagcttaacagaaaaggaa
tgtgtgaaggagaaattgaatctcttgcacgaatttctgcaaacagaaataaagaatcag
ttatgtgacttggaaaccaaattacgtaaagaagaattatccgaggagggctacctggct
aaagtcaaatcccttttaaataaagatttgtccttggagaacggtgctcatgcttacaac
cgggaagtgaatggacgtctagaaaacgggaaccaagcaagaagtgaagcccgtagagtg
ggaatggcagatgccaacagcccccccaaacccctttccaaacctcgcacgcccaggagg
agcaagtccgatggagaggctaagcgttcaagagaccctcctgcctcagcctcccaagta
actgggattagagctgaaccttcacctagccccaggattacaaggaaaagcaccaggcaa
accaccatcacatctcattttgcaaagggccctgccaaacggaaacctcaggaagagtct
gaaagagccaaatcggatgagtccatcaaggaagaagacaaagaccaggatgagaagaga
cgtagagttacatccagagaacgagttgctagaccgcttcctgcagaagaacctgaaaga
gcaaaatcaggaacgcgcactgaaaaggaagaagaaagagatgaaaaagaagaaaagaga
ctccgaagtcaaaccaaagaaccaacacccaaacagaaactgaaggaggagccggacaga
gaagccagggcaggcgtgcaggctgacgaggacgaagatggagacgagaaagatgagaag
aagcacagaagtcaacccaaagatctagctgccaaacggaggcccgaagaaaaagaacct
gaaaaagtaaatccacagatttctgatgaaaaagacgaggatgaaaaggaggagaagaga
cgcaaaacgacccccaaagaaccaacggagaaaaaaatggctcgcgccaaaacagtcatg
aactccaagacccaccctcccaagtgcattcagtgcgggcagtacctggacgaccctgac
ctcaaatatgggcagcacccaccagacgcggtggatgagccacagatgctgacaaatgag
aagctgtccatctttgatgccaacgagtctggctttgagagttatgaggcgcttccccag
cacaaactgacctgcttcagtgtgtactgtaagcacggtcacctgtgtcccatcgacacc
ggcctcatcgagaagaatatcgaactcttcttttctggttcagcaaaaccaatctatgat
gatgacccatctcttgaaggtggtgttaatggcaaaaatcttggccccataaatgaatgg
tggatcactggctttgatggaggtgaaaaggccctcatcggcttcagcacctcatttgcc
gaatacattctgatggatcccagtcccgagtatgcgcccatatttgggctgatgcaggag
aagatctacatcagcaagattgtggtggagttcctgcagagcaattccgactcgacctat
gaggacctgatcaacaagatcgagaccacggttcctccttctggcctcaacttgaaccgc
ttcacagaggactccctcctgcgacacgcgcagtttgtggtggagcaggtggagagttat
gacgaggccggggacagtgatgagcagcccatcttcctgacaccctgcatgcgggacctg
atcaagctggctggggtcacgctgggacagaggcgagcccaggcgaggcggcagaccatc
aggcattctaccagggagaaggacaggggacccacgaaagccaccaccaccaagctggtc
taccagatcttcgatactttcttcgcagagcaaattgaaaaggatgacagagaagacaag
gagaacgcctttaagcgccggcgatgtggcgtctgtgaggtgtgtcagcagcctgagtgt
gggaaatgtaaagcctgcaaggacatggttaaatttggtggcagtggacggagcaagcag
gcttgccaagagcggaggtgtcccaatatggccatgaaggaggcagatgacgatgaggaa
gtcgatgataacatcccagagatgccgtcacccaaaaaaatgcaccaggggaagaagaag
aaacagaacaagaatcgcatctcttgggtcggagaagccgtcaagactgatgggaagaag
agttactataagaaggtgtgcattgatgcggaaaccctggaagtgggggactgtgtctct
gttattccagatgattcctcaaaaccgctgtatctagcaagggtcacggcgctgtgggag
gacagcagcaacgggcagatgtttcacgcccactggttctgcgctgggacagacacagtc
ctcggggccacgtcggaccctctggagctgttcttggtggatgaatgtgaggacatgcag
ctttcatatatccacagcaaagtgaaagtcatctacaaagccccctccgaaaactgggcc
atggagggaggcatggatcccgagtccctgctggagggggacgacgggaagacctacttc
taccagctgtggtatgatcaagactacgcgagattcgagtcccctccaaaaacccagcca
acagaggacaacaagttcaaattctgtgtgagctgtgcccgtctggctgagatgaggcaa
aaagaaatccccagggtcctggagcagctcgaggacctggatagccgggtcctctactac
tcagccaccaagaacggcatcctgtaccgagttggtgatggtgtgtacctgccccctgag
gccttcacgttcaacatcaagctgtccagtcccgtgaaacgcccacggaaggagcccgtg
gatgaggacctgtacccagagcactaccggaaatactccgactacatcaaaggcagcaac
ctggatgcccctgagccctaccgaattggccggatcaaagagatcttctgtcccaagaag
agcaacggcaggcccaatgagactgacatcaaaatccgggtcaacaagttctacaggcct
gagaacacccacaagtccactccagcgagctaccacgcagacatcaacctgctctactgg
agcgacgaggaggccgtggtggacttcaaggctgtgcagggccgctgcaccgtggagtat
ggggaggacctgcccgagtgcgtccaggtgtactccatgggcggccccaaccgcttctac
ttcctcgaggcctataatgcaaagagcaaaagctttgaagatcctcccaaccatgcccgt
agccctggaaacaaagggaagggcaagggaaaagggaagggcaagcccaagtcccaagcc
tgtgagccgagcgagccagagatagagatcaagctgcccaagctgcggaccctggatgtg
ttttctggctgcggggggttgtcggagggattccaccaagcaggcatctctgacacgctg
tgggccatcgagatgtgggaccctgcggcccaggcgttccggctgaacaaccccggctcc
acagtgttcacagaggactgcaacatcctgctgaagctggtcatggctggggagaccacc
aactcccgcggccagcggctgccccagaagggagacgtggagatgctgtgcggcgggccg
ccctgccagggcttcagcggcatgaaccgcttcaattcgcgcacctactccaagttcaaa
aactctctggtggtttccttcctcagctactgcgactactaccggccccggttcttcctc
ctggagaatgtcaggaactttgtctccttcaagcgctccatggtcctgaagctcaccctc
cgctgcctggtccgcatgggctatcagtgcaccttcggcgtgctgcaggccggtcagtac
ggcgtggcccagactaggaggcgggccatcatcctggccgcggcccctggagagaagctc
cctctgttcccggagccactgcacgtgtttgctccccgggcctgccagctgagcgtggtg
gtggatgacaagaagtttgtgagcaacataaccaggttgagctcgggtcctttccggacc
atcacggtgcgagacacgatgtccgacctgccggaggtgcggaatggagcctcggcactg
gagatctcctacaacggggagcctcagtcctggttccagaggcagctccggggcgcacag
taccagcccatcctcagggaccacatctgtaaggacatgagtgcattggtggctgcccgc
atgcggcacatccccttggccccagggtcagactggcgcgatctgcccaacatcgaggtg
cggctctcagacggcaccatggccaggaagctgcggtatacccaccatgacaggaagaac
ggccgcagcagctctggggccctccgtggggtctgctcctgcgtggaagccggcaaagcc
tgcgaccccgcagccaggcagttcaacaccctcatcccctggtgcctgccccacaccggg
aaccggcacaaccactgggctggcctctatggaaggctcgagtgggacggcttcttcagc
acaaccgtcaccaaccccgagcccatgggcaagcagggccgcgtgctccacccagagcag
caccgtgtggtgagcgtgcgggagtgtgcccgctcccagggcttccctgacacctaccgg
ctcttcggcaacatcctggacaagcaccggcaggtgggcaatgccgtgccaccgcccctg
gccaaagccattggcttggagatcaagctttgtatgttggccaaagcccgagagagtgcc
tcagctaaaataaaggaggaggaagctgctaaggactag

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