Homo sapiens (human): 2065
Entry
2065 CDS
T01001
Gene name
ERBB3, ErbB-3, HER3, LCCS2, MDA-BF-1, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3, p85-sErbB3
Definition
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3 (EC:2.7.10.1)
Orthology
K05084
receptor tyrosine-protein kinase erbB-3 [EC:
2.7.10.1
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04012
ErbB signaling pathway
hsa04020
Calcium signaling pathway
hsa04144
Endocytosis
hsa05205
Proteoglycans in cancer
hsa05206
MicroRNAs in cancer
Disease
H00408
Type I diabetes mellitus
H00865
Lethal congenital contractural syndrome (LCCS)
Drug target
Other:
D03350
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
Environmental Information Processing
Signal transduction
04012 ErbB signaling pathway
2065 (ERBB3)
04020 Calcium signaling pathway
2065 (ERBB3)
Cellular Processes
Transport and catabolism
04144 Endocytosis
2065 (ERBB3)
Human Diseases
Cancers
05206 MicroRNAs in cancer
2065 (ERBB3)
05205 Proteoglycans in cancer
2065 (ERBB3)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.1 receptor protein-tyrosine kinase
2065 (ERBB3)
Protein kinases [BR:
hsa01001
]
Tyrosine protein kinases
EGFR family [OT]
2065 (ERBB3)
Enzyme-linked receptors [BR:
hsa01020
]
Receptor tyrosine kinases
RTK class I (EGF receptor family)
2065 (ERBB3)
Cytokine receptors [BR:
hsa04050
]
Receptor tyrosine kinase
RTK class I (EGF receptor family)
2065 (ERBB3)
SSDB
Motif
Pfam:
Recep_L_domain
Other DBs
NCBI-GI:
54792102
NCBI-GeneID:
2065
OMIM:
190151
HGNC:
3431
HPRD:
01820
Ensembl:
ENSG00000065361
Vega:
OTTHUMG00000170140
UniProt:
P21860
LinkDB
Structure
PDB:
1M6B
4LEO
3P11
Position
12q13
AA seq
183 aa
MRANDALQVLGLLFSLARGSEVGNSQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVM
GNLEIVLTGHNADLSFLQWIREVTGYVLVAMNEFSTLPLPNLRVVRGTQVYDGKFAIFVM
LNYNTNSSHALRQLRLTQLTGQFPMVPSGLTPQPAQDWYLLDDDPRLLTLSASSKVPVTL
AAV
NT seq
552 nt
+upstream
nt +downstream
nt
atgagggcgaacgacgctctgcaggtgctgggcttgcttttcagcctggcccggggctcc
gaggtgggcaactctcaggcagtgtgtcctgggactctgaatggcctgagtgtgaccggc
gatgctgagaaccaataccagacactgtacaagctctacgagaggtgtgaggtggtgatg
gggaaccttgagattgtgctcacgggacacaatgccgacctctccttcctgcagtggatt
cgagaagtgacaggctatgtcctcgtggccatgaatgaattctctactctaccattgccc
aacctccgcgtggtgcgagggacccaggtctacgatgggaagtttgccatcttcgtcatg
ttgaactataacaccaactccagccacgctctgcgccagctccgcttgactcagctcacc
ggtcagttcccgatggttccttctggcctcacccctcagccagcccaagactggtacctc
cttgatgatgacccaagactgctcactctaagtgcctcttccaaggtgcctgtcaccttg
gccgctgtctaa
DBGET
integrated database retrieval system
