Homo sapiens (human): 2065
Entry
2065 CDS
T01001
Gene name
ERBB3, ErbB-3, HER3, LCCS2, MDA-BF-1, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3, p85-sErbB3
Definition
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3 (EC:2.7.10.1)
Orthology
K05084
receptor tyrosine-protein kinase erbB-3 [EC:
2.7.10.1
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04012
ErbB signaling pathway
hsa04020
Calcium signaling pathway
hsa04144
Endocytosis
hsa05205
Proteoglycans in cancer
hsa05206
MicroRNAs in cancer
Disease
H00408
Type I diabetes mellitus
H00865
Lethal congenital contractural syndrome (LCCS)
Drug target
Other:
D03350
Class
Environmental Information Processing; Signal transduction; ErbB signaling pathway [PATH:
hsa04012
]
Environmental Information Processing; Signal transduction; Calcium signaling pathway [PATH:
hsa04020
]
Cellular Processes; Transport and catabolism; Endocytosis [PATH:
hsa04144
]
Human Diseases; Cancers; MicroRNAs in cancer [PATH:
hsa05206
]
Human Diseases; Cancers; Proteoglycans in cancer [PATH:
hsa05205
]
SSDB
Motif
Pfam:
Recep_L_domain
Other DBs
NCBI-GI:
54792102
NCBI-GeneID:
2065
OMIM:
190151
HGNC:
3431
HPRD:
01820
Ensembl:
ENSG00000065361
Vega:
OTTHUMG00000170140
UniProt:
P21860
LinkDB
Structure
PDB:
1M6B
4LEO
3P11
Position
12q13
AA seq
183 aa
MRANDALQVLGLLFSLARGSEVGNSQAVCPGTLNGLSVTGDAENQYQTLYKLYERCEVVM
GNLEIVLTGHNADLSFLQWIREVTGYVLVAMNEFSTLPLPNLRVVRGTQVYDGKFAIFVM
LNYNTNSSHALRQLRLTQLTGQFPMVPSGLTPQPAQDWYLLDDDPRLLTLSASSKVPVTL
AAV
NT seq
552 nt
+upstream
nt +downstream
nt
atgagggcgaacgacgctctgcaggtgctgggcttgcttttcagcctggcccggggctcc
gaggtgggcaactctcaggcagtgtgtcctgggactctgaatggcctgagtgtgaccggc
gatgctgagaaccaataccagacactgtacaagctctacgagaggtgtgaggtggtgatg
gggaaccttgagattgtgctcacgggacacaatgccgacctctccttcctgcagtggatt
cgagaagtgacaggctatgtcctcgtggccatgaatgaattctctactctaccattgccc
aacctccgcgtggtgcgagggacccaggtctacgatgggaagtttgccatcttcgtcatg
ttgaactataacaccaactccagccacgctctgcgccagctccgcttgactcagctcacc
ggtcagttcccgatggttccttctggcctcacccctcagccagcccaagactggtacctc
cttgatgatgacccaagactgctcactctaagtgcctcttccaaggtgcctgtcaccttg
gccgctgtctaa
DBGET
integrated database retrieval system
