KEGG T01001: 2534

Homo sapiens (human): 2534

Entry

2534 CDS T01001

Gene name

FYN, SLK, SYN, p59-FYN

Definition

(RefSeq) FYN proto-oncogene, Src family tyrosine kinase

K05703

tyrosine-protein kinase Fyn [EC:2.7.10.2]

Organism

hsa Homo sapiens (human)

Pathway

hsa04071	Sphingolipid signaling pathway
hsa04072	Phospholipase D signaling pathway
hsa04360	Axon guidance
hsa04380	Osteoclast differentiation
hsa04510	Focal adhesion
hsa04520	Adherens junction
hsa04611	Platelet activation
hsa04650	Natural killer cell mediated cytotoxicity
hsa04660	T cell receptor signaling pathway
hsa04664	Fc epsilon RI signaling pathway
hsa04725	Cholinergic synapse
hsa05020	Prion diseases
hsa05130	Pathogenic Escherichia coli infection
hsa05162	Measles
hsa05416	Viral myocarditis

Drug target

Dasatinib (DG00714):

D03658 D06414

Brite

KEGG Orthology (KO) [BR:hsa00001]
Environmental Information Processing
  Signal transduction
   04072 Phospholipase D signaling pathway
    2534 (FYN)
   04071 Sphingolipid signaling pathway
    2534 (FYN)
Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    2534 (FYN)
   04520 Adherens junction
    2534 (FYN)
Organismal Systems
  Immune system
   04611 Platelet activation
    2534 (FYN)
   04650 Natural killer cell mediated cytotoxicity
    2534 (FYN)
   04660 T cell receptor signaling pathway
    2534 (FYN)
   04664 Fc epsilon RI signaling pathway
    2534 (FYN)
  Nervous system
   04725 Cholinergic synapse
    2534 (FYN)
  Development
   04360 Axon guidance
    2534 (FYN)
   04380 Osteoclast differentiation
    2534 (FYN)
Human Diseases
  Neurodegenerative diseases
   05020 Prion diseases
    2534 (FYN)
  Cardiovascular diseases
   05416 Viral myocarditis
    2534 (FYN)
  Infectious diseases
   05130 Pathogenic Escherichia coli infection
    2534 (FYN)
   05162 Measles
    2534 (FYN)
Enzymes [BR:hsa01000]
2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     2534 (FYN)
Protein kinases [BR:hsa01001]
Tyrosine protein kinases
  Src family
   2534 (FYN)
Membrane trafficking [BR:hsa04131]
Exocytosis
  Calcium ion-dependent exocytosis
   Kinases and associated proteins
    2534 (FYN)
Endocytosis
  Lipid raft mediated endocytosis
   Flotillin-dependent endocytosis
    2534 (FYN)
Cell adhesion molecules and their ligands [BR:hsa04516]
1. Immunoglobulin Superfamily
  Immune system
   CD2 family
    CD48, BCM1; CD48 antigen [KO:K06479]
     2534 (FYN)

SSDB

Motif

Pfam:

Pkinase_Tyr Pkinase SH2 SH3_1 SH3_9 SH3_2 Haspin_kinase SH3_3

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

P06241(Tclin)

UniProt:

P06241

LinkDB

Structure

PDB:

4U1P 3UA7 4EIK 3H0H 3UA6 1SHF 4U17 4ZNX 3H0I 1FYN 1M27 1EFN 4D8D 1G83 3H0F 2DQ7 1AVZ 2MRJ 2MRK 2MQI 1ZBJ 1A0N 1AZG 1AOT 1AOU 1NYF 1NYG

Position

6q21

AA seq 537 aa
MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQG
LTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWW
EARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESET
TKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCC
RLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKT
LKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGR
ALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEY
TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVE
RGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL

NT seq 1614 nt +upstreamnt +downstreamnt
atgggctgtgtgcaatgtaaggataaagaagcaacaaaactgacggaggagagggacggc
agcctgaaccagagctctgggtaccgctatggcacagaccccacccctcagcactacccc
agcttcggtgtgacctccatccccaactacaacaacttccacgcagccgggggccaagga
ctcaccgtctttggaggtgtgaactcttcgtctcatacggggaccttgcgtacgagagga
ggaacaggagtgacactctttgtggccctttatgactatgaagcacggacagaagatgac
ctgagttttcacaaaggagaaaaatttcaaatattgaacagctcggaaggagattggtgg
gaagcccgctccttgacaactggagagacaggttacattcccagcaattatgtggctcca
gttgactctatccaggcagaagagtggtactttggaaaacttggccgaaaagatgctgag
cgacagctattgtcctttggaaacccaagaggtacctttcttatccgcgagagtgaaacc
accaaaggtgcctattcactttctatccgtgattgggatgatatgaaaggagaccatgtc
aaacattataaaattcgcaaacttgacaatggtggatactacattaccacccgggcccag
tttgaaacacttcagcagcttgtacaacattactcagagagagctgcaggtctctgctgc
cgcctagtagttccctgtcacaaagggatgccaaggcttaccgatctgtctgtcaaaacc
aaagatgtctgggaaatccctcgagaatccctgcagttgatcaagagactgggaaatggg
cagtttggggaagtatggatgggtacctggaatggaaacacaaaagtagccataaagact
cttaaaccaggcacaatgtcccccgaatcattccttgaggaagcgcagatcatgaagaag
ctgaagcacgacaagctggtccagctctatgcagtggtgtctgaggagcccatctacatc
gtcaccgagtatatgaacaaaggaagtttactggatttcttaaaagatggagaaggaaga
gctctgaaattaccaaatcttgtggacatggcagcacaggtggctgcaggaatggcttac
atcgagcgcatgaattatatccatagagatctgcgatcagcaaacattctagtggggaat
ggactcatatgcaagattgctgacttcggattggcccgattgatagaagacaatgagtac
acagcaagacaaggtgcaaagttccccatcaagtggacggcccccgaggcagccctgtac
gggaggttcacaatcaagtctgacgtgtggtcttttggaatcttactcacagagctggtc
accaaaggaagagtgccatacccaggcatgaacaaccgggaggtgctggagcaggtggag
cgaggctacaggatgccctgcccgcaggactgccccatctctctgcatgagctcatgatc
cactgctggaaaaaggaccctgaagaacgccccacttttgagtacttgcagagcttcctg
gaagactactttaccgcgacagagccccagtaccaacctggtgaaaacctgtaa

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