| Entry |
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| Gene name |
FYN, SLK, SYN, p59-FYN
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| Definition |
(RefSeq) FYN proto-oncogene, Src family tyrosine kinase
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| KO |
| tyrosine-protein kinase Fyn [EC: 2.7.10.2] |
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| Organism |
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| Pathway |
| Sphingolipid signaling pathway | | Phospholipase D signaling pathway | | Axon guidance | | Osteoclast differentiation | | Focal adhesion | | Adherens junction | | Platelet activation | | Natural killer cell mediated cytotoxicity | | T cell receptor signaling pathway | | Fc epsilon RI signaling pathway | | Cholinergic synapse | | Prion diseases | | Pathogenic Escherichia coli infection | | Measles | | Viral myocarditis |
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| Drug target |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
Environmental Information Processing
Signal transduction
04072 Phospholipase D signaling pathway
2534 (FYN)
04071 Sphingolipid signaling pathway
2534 (FYN)
Cellular Processes
Cellular community - eukaryotes
04510 Focal adhesion
2534 (FYN)
04520 Adherens junction
2534 (FYN)
Organismal Systems
Immune system
04611 Platelet activation
2534 (FYN)
04650 Natural killer cell mediated cytotoxicity
2534 (FYN)
04660 T cell receptor signaling pathway
2534 (FYN)
04664 Fc epsilon RI signaling pathway
2534 (FYN)
Nervous system
04725 Cholinergic synapse
2534 (FYN)
Development
04360 Axon guidance
2534 (FYN)
04380 Osteoclast differentiation
2534 (FYN)
Human Diseases
Neurodegenerative diseases
05020 Prion diseases
2534 (FYN)
Cardiovascular diseases
05416 Viral myocarditis
2534 (FYN)
Infectious diseases
05130 Pathogenic Escherichia coli infection
2534 (FYN)
05162 Measles
2534 (FYN)
Enzymes [BR:hsa01000]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.2 non-specific protein-tyrosine kinase
2534 (FYN)
Protein kinases [BR:hsa01001]
Non-receptor tyrosine kinases
SRC family
2534 (FYN)
Membrane trafficking [BR:hsa04131]
Exocytosis
Calcium ion-dependent exocytosis
Kinases and associated proteins
2534 (FYN)
Endocytosis
Lipid raft mediated endocytosis
Flotillin-dependent endocytosis
2534 (FYN)
Cell adhesion molecules and their ligands [BR:hsa04516]
1. Immunoglobulin Superfamily
Immune system
CD2 family
CD48, BCM1; CD48 antigen [KO:K06479]
2534 (FYN)
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| SSDB |
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| Motif |
 |
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| Other DBs |
NCBI-GeneID: NCBI-ProteinID: OMIM: HGNC: Ensembl: Vega: Pharos: UniProt: |
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| LinkDB |
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| Structure |
PDB: |
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| Position |
6q21
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| AA seq |
537 aa  
MGCVQCKDKEATKLTEERDGSLNQSSGYRYGTDPTPQHYPSFGVTSIPNYNNFHAAGGQG
LTVFGGVNSSSHTGTLRTRGGTGVTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWW
EARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTFLIRESET
TKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYSERAAGLCC
RLVVPCHKGMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWNGNTKVAIKT
LKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEEPIYIVTEYMNKGSLLDFLKDGEGR
ALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEY
TARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVE
RGYRMPCPQDCPISLHELMIHCWKKDPEERPTFEYLQSFLEDYFTATEPQYQPGENL |
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| NT seq |
1614 nt  +upstreamnt +downstreamnt
atgggctgtgtgcaatgtaaggataaagaagcaacaaaactgacggaggagagggacggc
agcctgaaccagagctctgggtaccgctatggcacagaccccacccctcagcactacccc
agcttcggtgtgacctccatccccaactacaacaacttccacgcagccgggggccaagga
ctcaccgtctttggaggtgtgaactcttcgtctcatacggggaccttgcgtacgagagga
ggaacaggagtgacactctttgtggccctttatgactatgaagcacggacagaagatgac
ctgagttttcacaaaggagaaaaatttcaaatattgaacagctcggaaggagattggtgg
gaagcccgctccttgacaactggagagacaggttacattcccagcaattatgtggctcca
gttgactctatccaggcagaagagtggtactttggaaaacttggccgaaaagatgctgag
cgacagctattgtcctttggaaacccaagaggtacctttcttatccgcgagagtgaaacc
accaaaggtgcctattcactttctatccgtgattgggatgatatgaaaggagaccatgtc
aaacattataaaattcgcaaacttgacaatggtggatactacattaccacccgggcccag
tttgaaacacttcagcagcttgtacaacattactcagagagagctgcaggtctctgctgc
cgcctagtagttccctgtcacaaagggatgccaaggcttaccgatctgtctgtcaaaacc
aaagatgtctgggaaatccctcgagaatccctgcagttgatcaagagactgggaaatggg
cagtttggggaagtatggatgggtacctggaatggaaacacaaaagtagccataaagact
cttaaaccaggcacaatgtcccccgaatcattccttgaggaagcgcagatcatgaagaag
ctgaagcacgacaagctggtccagctctatgcagtggtgtctgaggagcccatctacatc
gtcaccgagtatatgaacaaaggaagtttactggatttcttaaaagatggagaaggaaga
gctctgaaattaccaaatcttgtggacatggcagcacaggtggctgcaggaatggcttac
atcgagcgcatgaattatatccatagagatctgcgatcagcaaacattctagtggggaat
ggactcatatgcaagattgctgacttcggattggcccgattgatagaagacaatgagtac
acagcaagacaaggtgcaaagttccccatcaagtggacggcccccgaggcagccctgtac
gggaggttcacaatcaagtctgacgtgtggtcttttggaatcttactcacagagctggtc
accaaaggaagagtgccatacccaggcatgaacaaccgggaggtgctggagcaggtggag
cgaggctacaggatgccctgcccgcaggactgccccatctctctgcatgagctcatgatc
cactgctggaaaaaggaccctgaagaacgccccacttttgagtacttgcagagcttcctg
gaagactactttaccgcgacagagccccagtaccaacctggtgaaaacctgtaa |
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