KEGG   Homo sapiens (human): 2554Help
Entry
2554              CDS       T01001                                 

Gene name
GABRA1, ECA4, EIEE19, EJM, EJM5
Definition
gamma-aminobutyric acid (GABA) A receptor, alpha 1
Orthology
K05175  
gamma-aminobutyric acid receptor subunit alpha
Organism
hsa  Homo sapiens (human)
Pathway
Neuroactive ligand-receptor interaction
Retrograde endocannabinoid signaling
GABAergic synapse
Morphine addiction
Nicotine addiction
Disease
H00808  
Idiopathic generalized epilepsies (IGEs)
Drug target
Furosemide: 
Hexobarbital: 
Thiopental: 
Propofol: 
Methylphenobarbital: 
Phenobarbital: 
Clonazepam: 
Aminobutyric acid: 
Diazepam: 
Chlordiazepoxide: 
Medazepam: 
Oxazepam: 
Potassium clorazepate: 
Lorazepam: 
Adinazolam: 
Bromazepam: 
Clobazam: 
Prazepam: 
Alprazolam: 
Nordazepam: 
Fludiazepam: 
Ethyl loflazepate: 
Etizolam: 
Clotiazepam: 
Cloxazolam: 
Tofisopam: 
Meprobamate: 
Pentobarbital: 
Amobarbital: 
Barbital: 
Secobarbital: 
Flurazepam: 
Nitrazepam: 
Flunitrazepam: 
Estazolam: 
Triazolam: 
Lormetazepam: 
Temazepam: 
Midazolam: 
Brotizolam: 
Quazepam: 
Loprazolam: 
Glutethimide: 
Zopiclone: 
Zolpidem: 
Eszopiclone: 
Methaqualone: 
Pentetrazol: 
Flumazenil: 
Other: 
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    2554 (GABRA1)
 Organismal Systems
  Nervous system
   04727 GABAergic synapse
    2554 (GABRA1)
   04723 Retrograde endocannabinoid signaling
    2554 (GABRA1)
 Human Diseases
  Substance dependence
   05032 Morphine addiction
    2554 (GABRA1)
   05033 Nicotine addiction
    2554 (GABRA1)
Ion channels [BR:hsa04040]
 Cys-loop superfamily
  GABA-A
   2554 (GABRA1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
Ensembl: 
Vega: 
UniProt: 
LinkDB All DBs
Position
5q34
AA seq 456 aa AA seqDB search
MRKSPGLSDCLWAWILLLSTLTGRSYGQPSLQDELKDNTTVFTRILDRLLDGYDNRLRPG
LGERVTEVKTDIFVTSFGPVSDHDMEYTIDVFFRQSWKDERLKFKGPMTVLRLNNLMASK
IWTPDTFFHNGKKSVAHNMTMPNKLLRITEDGTLLYTMRLTVRAECPMHLEDFPMDAHAC
PLKFGSYAYTRAEVVYEWTREPARSVVVAEDGSRLNQYDLLGQTVDSGIVQSSTGEYVVM
TTHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISA
RNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGYAWDGKSVVPEKPKKVKDP
LIKKNNTYAPTATSYTPNLARGDPGLATIAKSATIEPKEVKPETKPPEPKKTFNSVSKID
RLSRIAFPLLFGIFNLVYWATYLNREPQLKAPTPHQ
NT seq 1371 nt NT seq  +upstreamnt  +downstreamnt
atgaggaaaagtccaggtctgtctgactgtctttgggcctggatcctccttctgagcaca
ctgactggaagaagctatggacagccgtcattacaagatgaacttaaagacaataccact
gtcttcaccaggattttggacagactcctagatggttatgacaatcgcctgagaccagga
ttgggagagcgtgtaaccgaagtgaagactgatatcttcgtcaccagtttcggacccgtt
tcagaccatgatatggaatatacaatagatgtatttttccgtcaaagctggaaggatgaa
aggttaaaatttaaaggacctatgacagtcctccggttaaataacctaatggcaagtaaa
atctggactccggacacatttttccacaatggaaagaagtcagtggcccacaacatgacc
atgcccaacaaactcctgcggatcacagaggatggcaccttgctgtacaccatgaggctg
acagtgagagctgaatgtccgatgcatttggaggacttccctatggatgcccatgcttgc
ccactaaaatttggaagttatgcttatacaagagcagaagttgtttatgaatggaccaga
gagccagcacgctcagtggttgtagcagaagatggatcacgtctaaaccagtatgacctt
cttggacaaacagtagactctggaattgtccagtcaagtacaggagaatatgttgttatg
accactcatttccacttgaagagaaagattggctactttgttattcaaacatacctgcca
tgcataatgacagtgattctctcacaagtctccttctggctcaacagagagtctgtacca
gcaagaactgtctttggagtaacaactgtgctcaccatgacaacattgagcatcagtgcc
agaaactccctccctaaggtggcttatgcaacagctatggattggtttattgccgtgtgc
tatgcctttgtgttctcagctctgattgagtttgccacagtaaactatttcactaagaga
ggttatgcatgggatggcaaaagtgtggttccagaaaagccaaagaaagtaaaggatcct
cttattaagaaaaacaacacttacgctccaacagcaaccagctacacccctaatttggcc
aggggcgacccgggcttagccaccattgctaaaagtgcaaccatagaacctaaagaggtc
aagcccgaaacaaaaccaccagaacccaagaaaacctttaacagtgtcagcaaaattgac
cgactgtcaagaatagccttcccgctgctatttggaatctttaacttagtctactgggct
acgtatttaaacagagagcctcagctaaaagcccccacaccacatcaatag

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