KEGG   Homo sapiens (human): 3708Help
Entry
3708              CDS       T01001                                 

Gene name
ITPR1, INSP3R1, IP3R, IP3R1, SCA15, SCA16, SCA29
Definition
inositol 1,4,5-trisphosphate receptor, type 1
Orthology
K04958  
inositol 1,4,5-triphosphate receptor type 1
Organism
hsa  Homo sapiens (human)
Pathway
Calcium signaling pathway
Phosphatidylinositol signaling system
Oocyte meiosis
Vascular smooth muscle contraction
Gap junction
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Cholinergic synapse
Serotonergic synapse
Dopaminergic synapse
Long-term depression
Inflammatory mediator regulation of TRP channels
GnRH signaling pathway
Estrogen signaling pathway
Thyroid hormone synthesis
Oxytocin signaling pathway
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Alzheimer's disease
Huntington's disease
Proteoglycans in cancer
Disease
H00063  
Spinocerebellar ataxia (SCA)
Class
Environmental Information Processing; Signal transduction; Calcium signaling pathway [PATH:hsa04020]
Environmental Information Processing; Signal transduction; Phosphatidylinositol signaling system [PATH:hsa04070]
Cellular Processes; Cell growth and death; Oocyte meiosis [PATH:hsa04114]
Cellular Processes; Cell communication; Gap junction [PATH:hsa04540]
Organismal Systems; Endocrine system; GnRH signaling pathway [PATH:hsa04912]
Organismal Systems; Endocrine system; Estrogen signaling pathway [PATH:hsa04915]
Organismal Systems; Endocrine system; Oxytocin signaling pathway [PATH:hsa04921]
Organismal Systems; Endocrine system; Thyroid hormone synthesis [PATH:hsa04918]
Organismal Systems; Circulatory system; Vascular smooth muscle contraction [PATH:hsa04270]
Organismal Systems; Digestive system; Salivary secretion [PATH:hsa04970]
Organismal Systems; Digestive system; Gastric acid secretion [PATH:hsa04971]
Organismal Systems; Digestive system; Pancreatic secretion [PATH:hsa04972]
Organismal Systems; Nervous system; Glutamatergic synapse [PATH:hsa04724]
Organismal Systems; Nervous system; Cholinergic synapse [PATH:hsa04725]
Organismal Systems; Nervous system; Dopaminergic synapse [PATH:hsa04728]
Organismal Systems; Nervous system; Serotonergic synapse [PATH:hsa04726]
Organismal Systems; Nervous system; Long-term potentiation [PATH:hsa04720]
Organismal Systems; Nervous system; Long-term depression [PATH:hsa04730]
Organismal Systems; Nervous system; Retrograde endocannabinoid signaling [PATH:hsa04723]
Organismal Systems; Sensory system; Inflammatory mediator regulation of TRP channels [PATH:hsa04750]
Organismal Systems; Environmental adaptation; Circadian entrainment [PATH:hsa04713]
Human Diseases; Cancers; Proteoglycans in cancer [PATH:hsa05205]
Human Diseases; Neurodegenerative diseases; Alzheimer's disease [PATH:hsa05010]
Human Diseases; Neurodegenerative diseases; Huntington's disease [PATH:hsa05016]
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
Ensembl: 
Vega: 
UniProt: 
LinkDB All DBs
Position
3p26.1
AA seq 2710 aa AA seqDB search
MSDKMSSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPETGDLNNPPKKFRDCLFKL
CPMNRYSAQKQFWKAAKPGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNV
IQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIGDSVVIGD
KVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILKGGDVV
RLFHAEQEKFLTCDEHRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCRGGAGYWN
SLFRFKHLATGHYLAAEVDPDFEEECLEFQPSVDPDQDASRSRLRNAQEKMVYSLVSVPE
GNDISSIFELDPTTLRGGDSLVPRNSYVRLRHLCTNTWVHSTNIPIDKEEEKPVMLKIGT
SPVKEDKEAFAIVPVSPAEVRDLDFANDASKVLGSIAGKLEKGTITQNERRSVTKLLEDL
VYFVTGGTNSGQDVLEVVFSKPNRERQKLMREQNILKQIFKLLQAPFTDCGDGPMLRLEE
LGDQRHAPFRHICRLCYRVLRHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLH
NNRKLLEKHITAAEIDTFVSLVRKNREPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPT
NADILIETKLVLSRFEFEGVSSTGENALEAGEDEEEVWLFWRDSNKEIRSKSVRELAQDA
KEGQKEDRDVLSYYRYQLNLFARMCLDRQYLAINEISGQLDVDLILRCMSDENLPYDLRA
SFCRLMLHMHVDRDPQEQVTPVKYARLWSEIPSEIAIDDYDSSGASKDEIKERFAQTMEF
VEEYLRDVVCQRFPFSDKEKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLAILDCVH
VTTIFPISKMAKGEENKGSNVMRSIHGVGELMTQVVLRGGGFLPMTPMAAAPEGNVKQAE
PEKEDIMVMDTKLKIIEILQFILNVRLDYRISCLLCIFKREFDESNSQTSETSSGNSSQE
GPSNVPGALDFEHIEEQAEGIFGGSEENTPLDLDDHGGRTFLRVLLHLTMHDYPPLVSGA
LQLLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELWVYKGQGP
DETMDGASGENEHKKTEEGNNKPQKHESTSSYNYRVVKEILIRLSKLCVQESASVRKSRK
QQQRLLRNMGAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQNQALLHKHI
NLFLNPGILEAVTMQHIFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKFLQTIVKAE
GKFIKKCQDMVMAELVNSGEDVLVFYNDRASFQTLIQMMRSERDRMDENSPLMYHIHLVE
LLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAYINFLNHCYVDTEVEMKE
IYTSNHMWKLFENFLVDICRACNNTSDRKHADSILEKYVTEIVMSIVTTFFSSPFSDQST
TLQTRQPVFVQLLQGVFRVYHCNWLMPSQKASVESCIRVLSDVAKSRAIAIPVDLDSQVN
NLFLKSHSIVQKTAMNWRLSARNAARRDSVLAASRDYRNIIERLQDIVSALEDRLRPLVQ
AELSVLVDVLHRPELLFPENTDARRKCESGGFICKLIKHTKQLLEENEEKLCIKVLQTLR
EMMTKDRGYGEKGEALRQVLVNRYYGNVRPSGRRESLTSFGNGPLSAGGPGKPGGGGGGS
GSSSMSRGEMSLAEVQCHLDKEGASNLVIDLIMNASSDRVFHESILLAIALLEGGNTTIQ
HSFFCRLTEDKKSEKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEVDRDAPSRKK
AKEPTTQITEEVRDQLLEASAATRKAFTTFRREADPDDHYQPGEGTQATADKAKDDLEMS
AVITIMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDCICGSTTGGLGL
LGLYINEKNVALINQTLESLTEYCQGPCHENQNCIATHESNGIDIITALILNDINPLGKK
RMDLVLELKNNASKLLLAIMESRHDSENAERILYNMRPKELVEVIKKAYMQGEVEFEDGE
NGEDGAASPRNVGHNIYILAHQLARHNKELQSMLKPGGQVDGDEALEFYAKHTAQIEIVR
LDRTMEQIVFPVPSICEFLTKESKLRIYYTTERDEQGSKINDFFLRSEDLFNEMNWQKKL
RAQPVLYWCARNMSFWSSISFNLAVLMNLLVAFFYPFKGVRGGTLEPHWSGLLWTAMLIS
LAIVIALPKPHGIRALIASTILRLIFSVGLQPTLFLLGAFNVCNKIIFLMSFVGNCGTFT
RGYRAMVLDVEFLYHLLYLVICAMGLFVHEFFYSLLLFDLVYREETLLNVIKSVTRNGRS
IILTAVLALILVYLFSIVGYLFFKDDFILEVDRLPNETAVPETGESLASEFLFSDVCRVE
SGENCSSPAPREELVPAEETEQDKEHTCETLLMCIVTVLSHGLRSGGGVGDVLRKPSKEE
PLFAARVIYDLLFFFMVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDK
FDNKTVTFEEHIKEEHNMWHYLCFIVLVKVKDSTEYTGPESYVAEMIKERNLDWFPRMRA
MSLVSSDSEGEQNELRNLQEKLESTMKLVTNLSGQLSELKDQMTEQRKQKQRIGLLGHPP
HMNVNPQQPA
NT seq 8133 nt NT seq  +upstreamnt  +downstreamnt
atgtctgacaaaatgtctagcttcctacatattggagacatttgttctctgtacgcggag
ggatcgacaaatggatttattagcaccttgggcctggttgatgatcgttgtgttgtacag
ccagaaaccggggaccttaacaatccacctaagaaattcagagactgcctctttaagcta
tgtcccatgaaccgctactctgcccaaaagcagttctggaaagccgctaagcctggggcc
aacagcaccacagacgcagtgctactcaacaaactgcaccacgctgcagacttggaaaag
aagcagaatgagacagaaaacaggaaattgctggggaccgtaatccagtatggcaatgtg
atccagctcctgcatttgaaaagtaataaatacctaacagtgaataagaggcttcctgct
ctgttggagaagaatgccatgagagtcacattggacgaggctggaaatgaagggtcctgg
ttttatattcagccattctacaagctgcgatccattggagacagcgtggtcataggtgac
aaggtggttctgaaccccgtcaatgctggtcagcccctacatgctagcagccatcaactg
gtagataacccaggctgcaatgaggtcaattccgtcaactgcaatacaagctggaaaata
gtccttttcatgaaatggagtgataacaaagacgacatattaaaggggggtgacgtggtg
aggctgtttcatgctgagcaggagaagtttctcacctgtgacgaacacaggaagaagcag
cacgtcttcctgagaaccacgggccggcagtcggccacatctgccaccagttcaaaagcc
ctgtgggaggtggaggtggtccagcatgacccatgtcggggcggagcagggtattggaac
agccttttccgtttcaagcatctggccacggggcattacttggcagcagaggtagaccct
gactttgaggaagaatgcctggagtttcagccctcagtggaccctgatcaggacgcctct
cgaagtaggttgcggaatgcccaagaaaagatggtatactccctggtctctgtgcctgaa
ggcaatgacatctcctccattttcgagctagatcccaccactctgcgtggaggtgacagc
cttgtcccaaggaactcttatgttcggctcagacacctatgtactaatacctgggttcac
agcacaaatattcctattgacaaggaagaagaaaagcccgtgatgctgaaaattggcacc
tctcctgtgaaggaggataaggaagcatttgccatagttccggtttctcctgctgaagtt
cgggacctggactttgccaatgatgccagcaaggtgctgggctccattgctgggaagcta
gagaagggcaccatcacccagaatgaaaggaggtctgtaaccaagctgctagaagatttg
gtttacttcgtcactggtggaactaattctggtcaagatgttctcgaagttgtcttctcc
aagcccaacagagaacggcagaaactgatgagagaacagaatattctcaagcagatcttc
aagttgttacaagccccattcacagactgcggtgatggcccaatgcttcggctggaagag
ctcggggaccagcggcacgctcctttcagacacatctgccggctctgctacagggtgctg
agacactcgcagcaagactacaggaagaaccaggagtatatagccaagcagtttggcttc
atgcagaagcagattggctatgatgtgttggctgaagacactatcactgccctgctccac
aataatcggaaactcctggaaaaacacattaccgcggcagagattgacacatttgtcagc
ctggtgcgaaagaacagggagcccagattcttagattacctctccgacctctgtgtctcc
atgaacaaatcaattccagtgacccaggaactgatatgtaaagctgtgctgaaccccacc
aacgctgacatcctgattgagaccaagttggttctttctcgttttgaatttgaaggtgtc
tcttccactggagagaatgctctggaggcaggagaagacgaggaagaggtgtggctgttt
tggagggacagcaacaaagagattcgcagcaagagtgtgagggaattggctcaggatgct
aaagaagggcagaaggaggaccgagacgttctcagctactacagatatcagctgaacctc
tttgcgaggatgtgtctggaccgccaatacctggccatcaacgaaatctcaggccagctg
gatgtcgatctcattctccgctgcatgtctgacgagaacctgccctatgacctcagggcg
tccttctgccgcctcatgcttcacatgcatgtggaccgagatccccaggaacaagtcacc
cccgtgaaatatgcccgcctctggtcggagattccctcggagatcgccattgacgactat
gatagtagtggagcttccaaagatgaaattaaggagagatttgctcagaccatggagttt
gtggaggagtatttaagagatgtggtttgtcagaggttccctttctctgataaagagaag
aataagcttacgtttgaggttgtaaatttagctaggaatctcatatactttggtttctac
aacttctctgaccttctacgattaactaagatccttctggccatattggactgtgtacat
gtgacaacaatcttccccattagcaagatggcgaaaggagaagagaataaaggcagtaac
gtgatgagatctattcatggcgtgggagagctgatgacccaggtggtgctccggggagga
ggctttttgcccatgactcccatggctgctgcccctgaaggcaatgtgaagcaggcagag
cctgagaaggaggacatcatggtcatggacaccaagctgaagatcattgagatactccag
tttattttgaatgtgaggttggattataggatctcctgcctcctgtgtatatttaagcga
gagtttgatgaaagcaattcccagacttcagaaacatcctccggaaacagcagccaagaa
gggccaagtaatgtaccaggtgctcttgactttgaacacattgaagaacaagcagaaggc
atctttggaggaagtgaggagaacaccccactggacttggatgaccacggcggcagaacc
tttctccgtgtcctgctccacttgacgatgcatgactacccacccctggtgtcaggggcc
ctgcagctcctcttccggcacttcagccagaggcaggaggtgctccaggccttcaaacag
gttcaactgctggttaccagccaagatgtggacaactacaaacagatcaaacaagacttg
gatcaactgaggtccatcgtggaaaagtcagagctttgggtgtacaaagggcagggcccc
gatgagactatggatggtgcatctggagaaaatgaacataagaaaacggaggagggaaat
aacaagccacaaaagcatgaaagcaccagcagctacaactacagagtggtcaaagagatt
ttgattcggcttagcaaactctgtgttcaagagagtgcctcagtgagaaagagcaggaag
cagcaacagcgtctgctccggaacatgggcgcgcacgccgtggtgctggagctgctgcag
attccctatgagaaggccgaagataccaagatgcaagagataatgaggttggctcatgaa
tttttgcagaatttctgcgcaggcaaccagcagaatcaagctttgctacataaacacata
aacctgtttctcaacccagggatcctggaggcagtaaccatgcagcacatcttcatgaac
aatttccagctttgcagtgagatcaacgagagagttgttcagcacttcgttcactgcata
gagactcacggtcggaatgtccagtatataaagttcttacagacaattgtcaaggcagaa
gggaaatttattaaaaaatgccaagacatggttatggccgagctggtcaattcgggagag
gatgtcctcgtgttctacaacgacagagcctctttccagactctgatccagatgatgcgg
tcagaacgggatcggatggatgagaacagccctctcatgtaccacatccacttggtcgag
ctcctggctgtgtgcacggagggtaagaatgtctacacagagatcaagtgcaactccctg
ctcccgctggatgacatcgttcgcgtggtgacccacgaggactgcatccctgaggttaaa
attgcatacattaacttcctgaatcactgctatgtggatacagaggtggaaatgaaggag
atttataccagcaatcacatgtggaaattgtttgagaatttccttgtagacatctgcagg
gcctgtaacaacactagtgacaggaaacatgcagactcgattttggagaagtatgtcacc
gaaatcgtcatgagtattgttactactttcttcagctctcccttctcagaccagagtacg
actttgcagactcgccagcctgtctttgtgcaactgctgcaaggcgtgttcagggtttac
cactgcaactggttaatgccaagccaaaaagcctccgtggagagctgtattcgggtgctg
tctgatgtagccaagagccgggccattgccattcccgtggacctggacagccaagtcaac
aacctctttctcaagtcccacagcattgtgcagaaaacagccatgaactggcggctctca
gcccgcaatgccgcacgcagggactctgttctggcagcttccagagactaccggaatatc
attgagagattgcaggacatcgtctccgcgctggaggaccgtctcaggcccctggtgcag
gcagagttatctgtgctcgtggatgttctccacagacccgagctgcttttcccagagaac
acagacgccagaaggaaatgtgaaagtggcggtttcatttgcaagttaataaagcataca
aaacagctgctagaagaaaatgaagagaagctctgcattaaggtcctacagaccctgagg
gaaatgatgaccaaagatagaggctatggagaaaagggtgaggcgctcaggcaagttctg
gtcaaccgttactatggaaacgtcagaccttcgggacgaagagagagccttaccagcttt
ggcaatggcccactgtcagcaggaggacccggcaagcccgggggaggagggggaggttcc
ggatccagctctatgagcaggggtgagatgagtctggccgaggttcagtgtcaccttgac
aaggagggggcttccaatctagttatcgacctcatcatgaacgcatccagtgaccgagtg
ttccatgaaagcattctcctggccattgcccttctggaaggaggcaacaccaccatccag
cactcctttttctgtcgcttgacagaagataagaagtcagagaaattctttaaggtgttt
tatgaccggatgaaggtggcccagcaagaaatcaaagcaacagtgacagtgaacaccagt
gacttgggaaataaaaagaaagacgatgaggtagacagggatgccccatcacggaaaaaa
gctaaagagcccacaacacagataacagaagaggtccgggatcagctcctggaggcctcc
gctgccaccaggaaagccttcaccactttcaggagggaggctgatcccgacgaccactac
cagcctggagagggcacccaggccactgccgacaaggccaaggacgacctggagatgagc
gcggtcatcaccatcatgcagcccatcctccgcttccttcagctcctgtgtgaaaaccac
aaccgagacctgcagaacttcctccgttgccaaaataacaagaccaactacaatttggta
tgtgagaccctgcagtttctggactgtatttgtggaagcacaactggaggccttggtctt
ctgggcttgtatataaatgaaaagaacgtagcgcttatcaaccaaaccctggaaagtctg
accgaatactgtcaaggaccttgccatgagaaccagaactgcatagccacccatgaatcc
aatggcattgacatcatcacagccctgatcctcaatgatatcaatcctttgggaaagaag
aggatggaccttgtgttagaactgaagaacaatgcctcgaagttgctcctggccatcatg
gaaagcaggcacgacagtgaaaacgcagagaggatactttataacatgaggcccaaggaa
ctggtggaagtgatcaagaaagcctacatgcaaggtgaagtggaatttgaggatggagaa
aacggtgaggatggggcggcgtcccccaggaacgtggggcacaacatctacatattagcc
catcagttggctcggcataacaaagaacttcagagcatgctgaaacctggtggccaagtg
gacggagatgaagccctggagttttatgccaagcacacggcgcagatagagattgtcaga
ttagaccgaacaatggaacagatagtctttcccgtgcccagcatatgtgaattcctaacc
aaggagtcaaaactacgaatttactatactacagagagagacgaacaaggcagcaaaatc
aatgatttctttctgcggtctgaagacctcttcaatgaaatgaattggcagaagaaactg
agagcccagcccgtgttgtactggtgtgcccgcaacatgtctttctggagcagcatttcg
tttaacctggccgtcctgatgaacctgctggtggcgtttttctacccgtttaagggagtc
cgaggaggaaccctggagccccactggtcgggactcctgtggacagccatgctcatctct
ctggccatcgtcattgccctccccaagccccatggcatccgggccttaattgcctccaca
attctacgactgatattttcagtcgggttacaacccacgttgtttcttctgggcgctttc
aatgtatgcaataaaatcatctttctaatgagctttgtgggcaactgtgggacattcaca
agaggctaccgagccatggttctggatgttgagttcctctatcatttgttgtatctggtg
atctgtgccatggggctctttgtccatgaattcttctacagtctgctgctttttgattta
gtgtacagagaagagactttgcttaatgtcattaaaagtgtcactcgcaatggacggtcc
atcatcctgacagcagttctggctctgatcctcgtttacctgttctcaatagtgggctat
cttttcttcaaggatgactttatcttggaagtagataggctgcccaatgaaacagctgtt
ccagaaaccggcgagagtttggcaagcgagttcctgttctccgatgtgtgtagggtggag
agtggggagaactgctcctctcctgcacccagagaagagctggtccctgcagaagagacg
gaacaggataaagagcacacatgtgagacgctgctgatgtgcattgtcactgtgctgagt
cacgggctgcggagcgggggtggagtaggagatgtactcaggaagccgtccaaagaggaa
cccctgtttgctgctagagttatttatgacctcttgttcttcttcatggtcatcatcatt
gttcttaacctgatttttggggttatcattgacacttttgctgacctgaggagtgagaag
cagaagaaggaagagatcttgaagaccacgtgctttatctgtggcttggaaagagacaag
tttgacaacaagactgtcacctttgaagagcacatcaaggaagaacacaacatgtggcac
tatctgtgcttcatcgtcctggtgaaagtaaaggactccaccgaatatactgggcctgag
agttacgtggcagaaatgatcaaggaaagaaaccttgactggttccccaggatgagagcc
atgtcattggtcagcagtgattctgaaggagaacagaatgagctgagaaacctgcaggag
aagctggagtccaccatgaaacttgtcacgaacctttctggccagctgtcggaattaaag
gatcagatgacagaacaaaggaagcagaaacaaagaattggtcttctaggacatcctcct
cacatgaatgtcaacccacaacaaccagcataa

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