KEGG   Homo sapiens (human): 3845Help
Entry
3845              CDS       T01001                                 

Gene name
KRAS, C-K-RAS, CFC2, K-RAS2A, K-RAS2B, K-RAS4A, K-RAS4B, KI-RAS, KRAS1, KRAS2, NS, NS3, RASK2
Definition
Kirsten rat sarcoma viral oncogene homolog
Orthology
K07827  
GTPase KRas
Organism
hsa  Homo sapiens (human)
Pathway
MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Chemokine signaling pathway
FoxO signaling pathway
PI3K-Akt signaling pathway
Dorso-ventral axis formation
Axon guidance
VEGF signaling pathway
Tight junction
Gap junction
Signaling pathways regulating pluripotency of stem cells
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Long-term potentiation
Neurotrophin signaling pathway
Cholinergic synapse
Serotonergic synapse
Long-term depression
Regulation of actin cytoskeleton
Insulin signaling pathway
GnRH signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Melanogenesis
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Aldosterone-regulated sodium reabsorption
Alcoholism
Hepatitis C
Hepatitis B
HTLV-I infection
Pathways in cancer
Viral carcinogenesis
Proteoglycans in cancer
MicroRNAs in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Thyroid cancer
Melanoma
Bladder cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
Central carbon metabolism in cancer
Disease
H00003  
Acute myeloid leukemia (AML)
H00010  
Multiple myeloma
H00014  
Non-small cell lung cancer
H00016  
Oral cancer
H00018  
Gastric cancer
H00019  
Pancreatic cancer
H00020  
Colorectal cancer
H00026  
Endometrial Cancer
H00027  
Ovarian cancer
H00030  
Cervical cancer
H00032  
Thyroid cancer
H00040  
Squamous cell carcinoma
H00041  
Kaposi's sarcoma
H00046  
Cholangiocarcinoma
H00047  
Gallbladder cancer
H00048  
Hepatocellular carcinoma
H00458  
Craniosynostosis
H00523  
Noonan syndrome and related disorders
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    3845 (KRAS)
   04015 Rap1 signaling pathway
    3845 (KRAS)
   04010 MAPK signaling pathway
    3845 (KRAS)
   04012 ErbB signaling pathway
    3845 (KRAS)
   04370 VEGF signaling pathway
    3845 (KRAS)
   04068 FoxO signaling pathway
    3845 (KRAS)
   04151 PI3K-Akt signaling pathway
    3845 (KRAS)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    3845 (KRAS)
  Cellular commiunity
   04530 Tight junction
    3845 (KRAS)
   04540 Gap junction
    3845 (KRAS)
   04550 Signaling pathways regulating pluripotency of stem cells
    3845 (KRAS)
 Organismal Systems
  Immune system
   04650 Natural killer cell mediated cytotoxicity
    3845 (KRAS)
   04660 T cell receptor signaling pathway
    3845 (KRAS)
   04662 B cell receptor signaling pathway
    3845 (KRAS)
   04664 Fc epsilon RI signaling pathway
    3845 (KRAS)
   04062 Chemokine signaling pathway
    3845 (KRAS)
  Endocrine system
   04910 Insulin signaling pathway
    3845 (KRAS)
   04912 GnRH signaling pathway
    3845 (KRAS)
   04915 Estrogen signaling pathway
    3845 (KRAS)
   04914 Progesterone-mediated oocyte maturation
    3845 (KRAS)
   04917 Prolactin signaling pathway
    3845 (KRAS)
   04921 Oxytocin signaling pathway
    3845 (KRAS)
   04919 Thyroid hormone signaling pathway
    3845 (KRAS)
   04916 Melanogenesis
    3845 (KRAS)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    3845 (KRAS)
  Nervous system
   04725 Cholinergic synapse
    3845 (KRAS)
   04726 Serotonergic synapse
    3845 (KRAS)
   04720 Long-term potentiation
    3845 (KRAS)
   04730 Long-term depression
    3845 (KRAS)
   04722 Neurotrophin signaling pathway
    3845 (KRAS)
  Development
   04320 Dorso-ventral axis formation
    3845 (KRAS)
   04360 Axon guidance
    3845 (KRAS)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    3845 (KRAS)
   05230 Central carbon metabolism in cancer
    3845 (KRAS)
   05206 MicroRNAs in cancer
    3845 (KRAS)
   05205 Proteoglycans in cancer
    3845 (KRAS)
   05203 Viral carcinogenesis
    3845 (KRAS)
   05210 Colorectal cancer
    3845 (KRAS)
   05212 Pancreatic cancer
    3845 (KRAS)
   05214 Glioma
    3845 (KRAS)
   05216 Thyroid cancer
    3845 (KRAS)
   05221 Acute myeloid leukemia
    3845 (KRAS)
   05220 Chronic myeloid leukemia
    3845 (KRAS)
   05218 Melanoma
    3845 (KRAS)
   05211 Renal cell carcinoma
    3845 (KRAS)
   05219 Bladder cancer
    3845 (KRAS)
   05215 Prostate cancer
    3845 (KRAS)
   05213 Endometrial cancer
    3845 (KRAS)
   05223 Non-small cell lung cancer
    3845 (KRAS)
  Substance dependence
   05034 Alcoholism
    3845 (KRAS)
  Infectious diseases
   05166 HTLV-I infection
    3845 (KRAS)
   05161 Hepatitis B
    3845 (KRAS)
   05160 Hepatitis C
    3845 (KRAS)
GTP-binding proteins [BR:hsa04031]
 Small (Monomeric) G-proteins
  Ras Family
   Ras [OT]
    3845 (KRAS)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
Ensembl: 
Vega: 
UniProt: 
LinkDB All DBs
Structure
PDB: 

Jmol
Position
12p12.1
AA seq 188 aa AA seqDB search
MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIEDSYRKQVVIDGETCLLDILDTAG
QEEYSAMRDQYMRTGEGFLCVFAINNTKSFEDIHHYREQIKRVKDSEDVPMVLVGNKCDL
PSRTVDTKQAQDLARSYGIPFIETSAKTRQGVDDAFYTLVREIRKHKEKMSKDGKKKKKK
SKTKCVIM
NT seq 567 nt NT seq  +upstreamnt  +downstreamnt
atgactgaatataaacttgtggtagttggagctggtggcgtaggcaagagtgccttgacg
atacagctaattcagaatcattttgtggacgaatatgatccaacaatagaggattcctac
aggaagcaagtagtaattgatggagaaacctgtctcttggatattctcgacacagcaggt
caagaggagtacagtgcaatgagggaccagtacatgaggactggggagggctttctttgt
gtatttgccataaataatactaaatcatttgaagatattcaccattatagagaacaaatt
aaaagagttaaggactctgaagatgtacctatggtcctagtaggaaataaatgtgatttg
ccttctagaacagtagacacaaaacaggctcaggacttagcaagaagttatggaattcct
tttattgaaacatcagcaaagacaagacagggtgttgatgatgccttctatacattagtt
cgagaaattcgaaaacataaagaaaagatgagcaaagatggtaaaaagaagaaaaagaag
tcaaagacaaagtgtgtaattatgtaa

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