KEGG   Homo sapiens (human): 4088Help
Entry
4088              CDS       T01001                                 

Gene name
SMAD3, HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3
Definition
SMAD family member 3
Orthology
K04500  
mothers against decapentaplegic homolog 2/3
Organism
hsa  Homo sapiens (human)
Pathway
FoxO signaling pathway
Cell cycle
Endocytosis
Wnt signaling pathway
TGF-beta signaling pathway
Hippo signaling pathway
Adherens junction
Signaling pathways regulating pluripotency of stem cells
Chagas disease (American trypanosomiasis)
Hepatitis B
HTLV-I infection
Pathways in cancer
Colorectal cancer
Pancreatic cancer
Chronic myeloid leukemia
Inflammatory bowel disease (IBD)
Disease
H00800  
Loeys-Dietz syndrome (LDS)
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04310 Wnt signaling pathway
    4088 (SMAD3)
   04350 TGF-beta signaling pathway
    4088 (SMAD3)
   04390 Hippo signaling pathway
    4088 (SMAD3)
   04068 FoxO signaling pathway
    4088 (SMAD3)
 Cellular Processes
  Transport and catabolism
   04144 Endocytosis
    4088 (SMAD3)
  Cell growth and death
   04110 Cell cycle
    4088 (SMAD3)
  Cellular commiunity
   04520 Adherens junction
    4088 (SMAD3)
   04550 Signaling pathways regulating pluripotency of stem cells
    4088 (SMAD3)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    4088 (SMAD3)
   05210 Colorectal cancer
    4088 (SMAD3)
   05212 Pancreatic cancer
    4088 (SMAD3)
   05220 Chronic myeloid leukemia
    4088 (SMAD3)
  Immune diseases
   05321 Inflammatiory bowel disease (IBD)
    4088 (SMAD3)
  Infectious diseases
   05166 HTLV-I infection
    4088 (SMAD3)
   05161 Hepatitis B
    4088 (SMAD3)
   05142 Chagas disease (American trypanosomiasis)
    4088 (SMAD3)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 
Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
Ensembl: 
Vega: 
UniProt: 
LinkDB All DBs
Structure
PDB: 

Jmol
Position
15q22.33
AA seq 320 aa AA seqDB search
MELCEFAFNMKKDEVCVNPYHYQRVETPVLPPVLVPRHTEIPAEFPPLDDYSHSIPENTN
FPAGIEPQSNIPETPPPGYLSEDGETSDHQMNHSMDAGSPNLSPNPMSPAHNNLDLQPVT
YCEPAFWCSISYYELNQRVGETFHASQPSMTVDGFTDPSNSERFCLGLLSNVNRNAAVEL
TRRHIGRGVRLYYIGGEVFAECLSDSAIFVQSPNCNQRYGWHPATVCKIPPGCNLKIFNN
QEFAALLAQSVNQGFEAVYQLTRMCTIRMSFVKGWGAEYRRQTVTSTPCWIELHLNGPLQ
WLDKVLTQMGSPSIRCSSVS
NT seq 963 nt NT seq  +upstreamnt  +downstreamnt
atggagctgtgtgagttcgccttcaatatgaagaaggacgaggtctgcgtgaatccctac
cactaccagagagtagagacaccagttctacctcctgtgttggtgccacgccacacagag
atcccggccgagttccccccactggacgactacagccattccatccccgaaaacactaac
ttccccgcaggcatcgagccccagagcaatattccagagaccccaccccctggctacctg
agtgaagatggagaaaccagtgaccaccagatgaaccacagcatggacgcaggttctcca
aacctatccccgaatccgatgtccccagcacataataacttggacctgcagccagttacc
tactgcgagccggccttctggtgctccatctcctactacgagctgaaccagcgcgtcggg
gagacattccacgcctcgcagccatccatgactgtggatggcttcaccgacccctccaat
tcggagcgcttctgcctagggctgctctccaatgtcaacaggaatgcagcagtggagctg
acacggagacacatcggaagaggcgtgcggctctactacatcggaggggaggtcttcgca
gagtgcctcagtgacagcgctatttttgtccagtctcccaactgtaaccagcgctatggc
tggcacccggccaccgtctgcaagatcccaccaggatgcaacctgaagatcttcaacaac
caggagttcgctgccctcctggcccagtcggtcaaccagggctttgaggctgtctaccag
ttgacccgaatgtgcaccatccgcatgagcttcgtcaaaggctggggagcggagtacagg
agacagactgtgaccagtaccccctgctggattgagctgcacctgaatgggcctttgcag
tggcttgacaaggtcctcacccagatgggctccccaagcatccgctgttccagtgtgtct
tag

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