KEGG T01001: 4089

Homo sapiens (human): 4089

Entry

4089 CDS T01001

Gene name

SMAD4, DPC4, JIP, MADH4, MYHRS

Definition

(RefSeq) SMAD family member 4

K04501

mothers against decapentaplegic homolog 4

Organism

hsa Homo sapiens (human)

Pathway

hsa04068	FoxO signaling pathway
hsa04110	Cell cycle
hsa04310	Wnt signaling pathway
hsa04350	TGF-beta signaling pathway
hsa04371	Apelin signaling pathway
hsa04390	Hippo signaling pathway
hsa04520	Adherens junction
hsa04550	Signaling pathways regulating pluripotency of stem cells
hsa04659	Th17 cell differentiation
hsa04933	AGE-RAGE signaling pathway in diabetic complications
hsa05161	Hepatitis B
hsa05166	HTLV-I infection
hsa05200	Pathways in cancer
hsa05210	Colorectal cancer
hsa05212	Pancreatic cancer
hsa05220	Chronic myeloid leukemia
hsa05225	Hepatocellular carcinoma
hsa05226	Gastric cancer

Module

hsa_M00679	BMP signaling
hsa_M00680	TGF-beta signaling
hsa_M00681	Activin signaling

Network

N00063	TGF-beta signaling pathway
N00106	AML1-EVI1 fusion to TGF-beta signaling pathway
N00107	EVI-1 overexpression to TGF-beta signaling pathway

Disease

H00019	Pancreatic cancer
H00020	Colorectal cancer
H00533	Hereditary hemorrhagic telangiectasia (HHT)
H01023	Juvenile polyposis syndrome

Brite

KEGG Orthology (KO) [BR:hsa00001]
Environmental Information Processing
  Signal transduction
   04310 Wnt signaling pathway
    4089 (SMAD4)
   04350 TGF-beta signaling pathway
    4089 (SMAD4)
   04390 Hippo signaling pathway
    4089 (SMAD4)
   04371 Apelin signaling pathway
    4089 (SMAD4)
   04068 FoxO signaling pathway
    4089 (SMAD4)
Cellular Processes
  Cell growth and death
   04110 Cell cycle
    4089 (SMAD4)
  Cellular community - eukaryotes
   04520 Adherens junction
    4089 (SMAD4)
   04550 Signaling pathways regulating pluripotency of stem cells
    4089 (SMAD4)
Organismal Systems
  Immune system
   04659 Th17 cell differentiation
    4089 (SMAD4)
Human Diseases
  Cancers
   05200 Pathways in cancer
    4089 (SMAD4)
   05210 Colorectal cancer
    4089 (SMAD4)
   05212 Pancreatic cancer
    4089 (SMAD4)
   05225 Hepatocellular carcinoma
    4089 (SMAD4)
   05226 Gastric cancer
    4089 (SMAD4)
   05220 Chronic myeloid leukemia
    4089 (SMAD4)
  Endocrine and metabolic diseases
   04933 AGE-RAGE signaling pathway in diabetic complications
    4089 (SMAD4)
  Infectious diseases
   05166 HTLV-I infection
    4089 (SMAD4)
   05161 Hepatitis B
    4089 (SMAD4)

SSDB

Motif

Pfam:

MH2 MH1 IRF-3

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

Q13485(Tbio)

UniProt:

Q13485 A0A024R274

LinkDB

Structure

PDB:

5MEY 1YGS 5C4V 1U7F 1DD1 1U7V 1MR1 5MEZ 1G88 5MF0

Position

18q21.2

AA seq 552 aa
MDNMSITNTPTSNDACLSIVHSLMCHRQGGESETFAKRAIESLVKKLKEKKDELDSLITA
ITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKNELKHVKYCQYAFD
LKCDSVCVNPYHYERVVSPGIDLSGLTLQSNAPSSMMVKDEYVHDFEGQPSLSTEGHSIQ
TIQHPPSNRASTETYSTPALLAPSESNATSTANFPNIPVASTSQPASILGGSHSEGLLQI
ASGPQPGQQQNGFTGQPATYHHNSTTTWTGSRTAPYTPNLPHHQNGHLQHHPPMPPHPGH
YWPVHNELAFQPPISNHPAPEYWCSIAYFEMDVQVGETFKVPSSCPIVTVDGYVDPSGGD
RFCLGQLSNVHRTEAIERARLHIGKGVQLECKGEGDVWVRCLSDHAVFVQSYYLDREAGR
APGDAVHKIYPSAYIKVFDLRQCHRQMQQQAATAQAAAAAQAAAVAGNIPGPGSVGGIAP
AISLSAAAGIGVDDLRRLCILRMSFVKGWGPDYPRQSIKETPCWIEIHLHRALQLLDEVL
HTMPIADPQPLD

NT seq 1659 nt +upstreamnt +downstreamnt
atggacaatatgtctattacgaatacaccaacaagtaatgatgcctgtctgagcattgtg
catagtttgatgtgccatagacaaggtggagagagtgaaacatttgcaaaaagagcaatt
gaaagtttggtaaagaagctgaaggagaaaaaagatgaattggattctttaataacagct
ataactacaaatggagctcatcctagtaaatgtgttaccatacagagaacattggatggg
aggcttcaggtggctggtcggaaaggatttcctcatgtgatctatgcccgtctctggagg
tggcctgatcttcacaaaaatgaactaaaacatgttaaatattgtcagtatgcgtttgac
ttaaaatgtgatagtgtctgtgtgaatccatatcactacgaacgagttgtatcacctgga
attgatctctcaggattaacactgcagagtaatgctccatcaagtatgatggtgaaggat
gaatatgtgcatgactttgagggacagccatcgttgtccactgaaggacattcaattcaa
accatccagcatccaccaagtaatcgtgcatcgacagagacatacagcaccccagctctg
ttagccccatctgagtctaatgctaccagcactgccaactttcccaacattcctgtggct
tccacaagtcagcctgccagtatactggggggcagccatagtgaaggactgttgcagata
gcatcagggcctcagccaggacagcagcagaatggatttactggtcagccagctacttac
catcataacagcactaccacctggactggaagtaggactgcaccatacacacctaatttg
cctcaccaccaaaacggccatcttcagcaccacccgcctatgccgccccatcccggacat
tactggcctgttcacaatgagcttgcattccagcctcccatttccaatcatcctgctcct
gagtattggtgttccattgcttactttgaaatggatgttcaggtaggagagacatttaag
gttccttcaagctgccctattgttactgttgatggatacgtggacccttctggaggagat
cgcttttgtttgggtcaactctccaatgtccacaggacagaagccattgagagagcaagg
ttgcacataggcaaaggtgtgcagttggaatgtaaaggtgaaggtgatgtttgggtcagg
tgccttagtgaccacgcggtctttgtacagagttactacttagacagagaagctgggcgt
gcacctggagatgctgttcataagatctacccaagtgcatatataaaggtctttgatttg
cgtcagtgtcatcgacagatgcagcagcaggcggctactgcacaagctgcagcagctgcc
caggcagcagccgtggcaggaaacatccctggcccaggatcagtaggtggaatagctcca
gctatcagtctgtcagctgctgctggaattggtgttgatgaccttcgtcgcttatgcata
ctcaggatgagttttgtgaaaggctggggaccggattacccaagacagagcatcaaagaa
acaccttgctggattgaaattcacttacaccgggccctccagctcctagacgaagtactt
cataccatgccgattgcagacccacaacctttagactga

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