| Entry |
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| Gene name |
SMAD4, DPC4, JIP, MADH4, MYHRS
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| Definition |
SMAD family member 4
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| Orthology |
| mothers against decapentaplegic homolog 4 |
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| Organism |
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| Pathway |
| FoxO signaling pathway | | Cell cycle | | Wnt signaling pathway | | TGF-beta signaling pathway | | Hippo signaling pathway | | Adherens junction | | Hepatitis B | | HTLV-I infection | | Pathways in cancer | | Colorectal cancer | | Pancreatic cancer | | Chronic myeloid leukemia |
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| Disease |
| Pancreatic cancer | | Colorectal cancer | | Hereditary hemorrhagic telangiectasia (HHT) | | Juvenile polyposis syndrome | | Primary pulmonary hypertension (PPH) |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
Environmental Information Processing
Signal transduction
04310 Wnt signaling pathway
4089 (SMAD4)
04350 TGF-beta signaling pathway
4089 (SMAD4)
04390 Hippo signaling pathway
4089 (SMAD4)
04068 FoxO signaling pathway
4089 (SMAD4)
Cellular Processes
Cell growth and death
04110 Cell cycle
4089 (SMAD4)
Cell communication
04520 Adherens junction
4089 (SMAD4)
Human Diseases
Cancers
05200 Pathways in cancer
4089 (SMAD4)
05210 Colorectal cancer
4089 (SMAD4)
05212 Pancreatic cancer
4089 (SMAD4)
05220 Chronic myeloid leukemia
4089 (SMAD4)
Infectious diseases
05166 HTLV-I infection
4089 (SMAD4)
05161 Hepatitis B
4089 (SMAD4)
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| SSDB |
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| Motif |
 |
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| Other DBs |
NCBI-GI: NCBI-GeneID: OMIM: HGNC: HPRD: Ensembl: Vega: UniProt: |
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| LinkDB |
 |
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| Structure |
PDB: |
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| Position |
18q21.1
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| AA seq |
552 aa  
MDNMSITNTPTSNDACLSIVHSLMCHRQGGESETFAKRAIESLVKKLKEKKDELDSLITA
ITTNGAHPSKCVTIQRTLDGRLQVAGRKGFPHVIYARLWRWPDLHKNELKHVKYCQYAFD
LKCDSVCVNPYHYERVVSPGIDLSGLTLQSNAPSSMMVKDEYVHDFEGQPSLSTEGHSIQ
TIQHPPSNRASTETYSTPALLAPSESNATSTANFPNIPVASTSQPASILGGSHSEGLLQI
ASGPQPGQQQNGFTGQPATYHHNSTTTWTGSRTAPYTPNLPHHQNGHLQHHPPMPPHPGH
YWPVHNELAFQPPISNHPAPEYWCSIAYFEMDVQVGETFKVPSSCPIVTVDGYVDPSGGD
RFCLGQLSNVHRTEAIERARLHIGKGVQLECKGEGDVWVRCLSDHAVFVQSYYLDREAGR
APGDAVHKIYPSAYIKVFDLRQCHRQMQQQAATAQAAAAAQAAAVAGNIPGPGSVGGIAP
AISLSAAAGIGVDDLRRLCILRMSFVKGWGPDYPRQSIKETPCWIEIHLHRALQLLDEVL
HTMPIADPQPLD |
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| NT seq |
1659 nt  +upstreamnt +downstreamnt
atggacaatatgtctattacgaatacaccaacaagtaatgatgcctgtctgagcattgtg
catagtttgatgtgccatagacaaggtggagagagtgaaacatttgcaaaaagagcaatt
gaaagtttggtaaagaagctgaaggagaaaaaagatgaattggattctttaataacagct
ataactacaaatggagctcatcctagtaaatgtgttaccatacagagaacattggatggg
aggcttcaggtggctggtcggaaaggatttcctcatgtgatctatgcccgtctctggagg
tggcctgatcttcacaaaaatgaactaaaacatgttaaatattgtcagtatgcgtttgac
ttaaaatgtgatagtgtctgtgtgaatccatatcactacgaacgagttgtatcacctgga
attgatctctcaggattaacactgcagagtaatgctccatcaagtatgatggtgaaggat
gaatatgtgcatgactttgagggacagccatcgttgtccactgaaggacattcaattcaa
accatccagcatccaccaagtaatcgtgcatcgacagagacatacagcaccccagctctg
ttagccccatctgagtctaatgctaccagcactgccaactttcccaacattcctgtggct
tccacaagtcagcctgccagtatactggggggcagccatagtgaaggactgttgcagata
gcatcagggcctcagccaggacagcagcagaatggatttactggtcagccagctacttac
catcataacagcactaccacctggactggaagtaggactgcaccatacacacctaatttg
cctcaccaccaaaacggccatcttcagcaccacccgcctatgccgccccatcccggacat
tactggcctgttcacaatgagcttgcattccagcctcccatttccaatcatcctgctcct
gagtattggtgttccattgcttactttgaaatggatgttcaggtaggagagacatttaag
gttccttcaagctgccctattgttactgttgatggatacgtggacccttctggaggagat
cgcttttgtttgggtcaactctccaatgtccacaggacagaagccattgagagagcaagg
ttgcacataggcaaaggtgtgcagttggaatgtaaaggtgaaggtgatgtttgggtcagg
tgccttagtgaccacgcggtctttgtacagagttactacttagacagagaagctgggcgt
gcacctggagatgctgttcataagatctacccaagtgcatatataaaggtctttgatttg
cgtcagtgtcatcgacagatgcagcagcaggcggctactgcacaagctgcagcagctgcc
caggcagcagccgtggcaggaaacatccctggcccaggatcagtaggtggaatagctcca
gctatcagtctgtcagctgctgctggaattggtgttgatgaccttcgtcgcttatgcata
ctcaggatgagttttgtgaaaggctggggaccggattacccaagacagagcatcaaagaa
acaccttgctggattgaaattcacttacaccgggccctccagctcctagacgaagtactt
cataccatgccgattgcagacccacaacctttagactga |
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