KEGG   Homo sapiens (human): 478Help
Entry
478               CDS       T01001                                 

Gene name
ATP1A3, AHC2, ATP1A1, CAPOS, DYT12, RDP
Definition
(RefSeq) ATPase Na+/K+ transporting subunit alpha 3 (EC:3.6.3.9)
  KO
K01539  
sodium/potassium-transporting ATPase subunit alpha [EC:3.6.3.9]
Organism
hsa  Homo sapiens (human)
Pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Cardiac muscle contraction
Adrenergic signaling in cardiomyocytes
Insulin secretion
Thyroid hormone synthesis
Thyroid hormone signaling pathway
Aldosterone-regulated sodium reabsorption
Endocrine and other factor-regulated calcium reabsorption
Proximal tubule bicarbonate reclamation
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Carbohydrate digestion and absorption
Protein digestion and absorption
Bile secretion
Mineral absorption
Disease
H00831  
Primary dystonia
Drug target
Acetyldigitoxin: 
Acetyldigoxin: 
Digitoxin: 
Digoxin: 
Lanatoside C: 
Deslanoside: 
Metildigoxin [DG:DG00191]: 
Gitoformate: 
Proscillaridin: 
G-strophanthin: 
Other: 
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04024 cAMP signaling pathway
    478 (ATP1A3)
   04022 cGMP - PKG signaling pathway
    478 (ATP1A3)
 Organismal Systems
  Endocrine system
   04911 Insulin secretion
    478 (ATP1A3)
   04918 Thyroid hormone synthesis
    478 (ATP1A3)
   04919 Thyroid hormone signaling pathway
    478 (ATP1A3)
  Circulatory system
   04260 Cardiac muscle contraction
    478 (ATP1A3)
   04261 Adrenergic signaling in cardiomyocytes
    478 (ATP1A3)
  Digestive system
   04970 Salivary secretion
    478 (ATP1A3)
   04971 Gastric acid secretion
    478 (ATP1A3)
   04972 Pancreatic secretion
    478 (ATP1A3)
   04976 Bile secretion
    478 (ATP1A3)
   04973 Carbohydrate digestion and absorption
    478 (ATP1A3)
   04974 Protein digestion and absorption
    478 (ATP1A3)
   04978 Mineral absorption
    478 (ATP1A3)
  Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    478 (ATP1A3)
   04961 Endocrine and other factor-regulated calcium reabsorption
    478 (ATP1A3)
   04964 Proximal tubule bicarbonate reclamation
    478 (ATP1A3)
Enzymes [BR:hsa01000]
 3. Hydrolases
  3.6  Acting on acid anhydrides
   3.6.3  Acting on acid anhydrides to catalyse transmembrane movement of substances
    3.6.3.9  Na+/K+-exchanging ATPase
     478 (ATP1A3)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   478 (ATP1A3)
  Exosomal proteins of other body fluids (saliva and urine)
   478 (ATP1A3)
  Exosomal proteins of colorectal cancer cells
   478 (ATP1A3)
  Exosomal proteins of bladder cancer cells
   478 (ATP1A3)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-ProteinID: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
Ensembl: 
Vega: 
UniProt: 
LinkDB All DBs
Position
19q13.31
AA seq 1013 aa AA seqDB search
MGDKKDDKDSPKKNKGKERRDLDDLKKEVAMTEHKMSVEEVCRKYNTDCVQGLTHSKAQE
ILARDGPNALTPPPTTPEWVKFCRQLFGGFSILLWIGAILCFLAYGIQAGTEDDPSGDNL
YLGIVLAAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIREGEKMQVNAEEVVVGDL
VEIKGGDRVPADLRIISAHGCKVDNSSLTGESEPQTRSPDCTHDNPLETRNITFFSTNCV
EGTARGVVVATGDRTVMGRIATLASGLEVGKTPIAIEIEHFIQLITGVAVFLGVSFFILS
LILGYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKNLEAVETLGST
STICSDKTGTLTQNRMTVAHMWFDNQIHEADTTEDQSGTSFDKSSHTWVALSHIAGLCNR
AVFKGGQDNIPVLKRDVAGDASESALLKCIELSSGSVKLMRERNKKVAEIPFNSTNKYQL
SIHETEDPNDNRYLLVMKGAPERILDRCSTILLQGKEQPLDEEMKEAFQNAYLELGGLGE
RVLGFCHYYLPEEQFPKGFAFDCDDVNFTTDNLCFVGLMSMIDPPRAAVPDAVGKCRSAG
IKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDAKACVIHGTDL
KDFTSEQIDEILQNHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVNDSPALKKADI
GVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTLTSNIPEITPF
LLFIMANIPLPLGTITILCIDLGTDMVPAISLAYEAAESDIMKRQPRNPRTDKLVNERLI
SMAYGQIGMIQALGGFFSYFVILAENGFLPGNLVGIRLNWDDRTVNDLEDSYGQQWTYEQ
RKVVEFTCHTAFFVSIVVVQWADLIICKTRRNSVFQQGMKNKILIFGLFEETALAAFLSY
CPGMDVALRMYPLKPSWWFCAFPYSFLIFVYDEIRKLILRRNPGGWVEKETYY
NT seq 3042 nt NT seq  +upstreamnt  +downstreamnt
atgggggacaagaaagatgacaaggactcacccaagaagaacaagggcaaggagcgccgg
gacctggatgacctcaagaaggaggtggctatgacagagcacaagatgtcagtggaagag
gtctgccggaaatacaacacagactgtgtgcagggtttgacccacagcaaagcccaggag
atcctggcccgggatgggcctaacgcactcacgccaccgcctaccaccccagagtgggtc
aagttttgccggcagctcttcgggggcttctccatcctgctgtggatcggggctatcctc
tgcttcctggcctacggtatccaggcgggcaccgaggacgacccctctggtgacaacctg
tacctgggcatcgtgctggcggccgtggtgatcatcactggctgcttctcctactaccag
gaggccaagagctccaagatcatggagtccttcaagaacatggtgccccagcaagccctg
gtgatccgggaaggtgagaagatgcaggtgaacgctgaggaggtggtggtcggggacctg
gtggagatcaagggtggagaccgagtgccagctgacctgcggatcatctcagcccacggc
tgcaaggtggacaactcctccctgactggcgaatccgagccccagactcgctctcccgac
tgcactcacgacaaccccttggagactcggaacatcaccttcttttccaccaactgtgtg
gaaggcacggctcggggcgtggtggtggccacgggcgaccgcactgtcatgggccgtatc
gccaccctggcatcagggctggaggtgggcaagacgcccatcgccatcgagattgagcac
ttcatccagctcatcaccggcgtggctgtcttcctgggtgtctccttcttcatcctctcc
ctcattctcggatacacctggcttgaggctgtcatcttcctcatcggcatcatcgtggcc
aatgtcccagagggtctgctggccactgtcactgtgtgtctgacgctgaccgccaagcgc
atggcccggaagaactgcctggtgaagaacctggaggctgtagaaaccctgggctccacg
tccaccatctgctcagataagacagggaccctcactcagaaccgcatgacagtcgcccac
atgtggtttgacaaccagatccacgaggctgacaccactgaggaccagtcagggacctca
tttgacaagagttcgcacacctgggtggccctgtctcacatcgctgggctctgcaatcgc
gctgtcttcaagggtggtcaggacaacatccctgtgctcaagagggatgtggctggggat
gcgtctgagtctgccctgctcaagtgcatcgagctgtcctctggctccgtgaagctgatg
cgtgaacgcaacaagaaagtggctgagattcccttcaattccaccaacaaataccagctc
tccatccatgagaccgaggaccccaacgacaaccgatacctgctggtgatgaagggtgcc
cccgagcgcatcctggaccgctgctccaccatcctgctacagggcaaggagcagcctctg
gacgaggaaatgaaggaggccttccagaatgcctaccttgagctcggtggcctgggcgag
cgcgtgcttggtttctgccattattacctgcccgaggagcagttccccaagggctttgcc
ttcgactgtgatgacgtgaacttcaccacggacaacctctgctttgtgggcctcatgtcc
atgatcgacccaccccgggcagccgtccctgacgcggtgggcaagtgtcgcagcgcaggc
atcaaggtcatcatggtcaccggcgatcaccccatcacggccaaggccattgccaagggt
gtgggcatcatctctgagggcaacgagactgtggaggacatcgccgcccggctcaacatt
cccgtcagccaggttaacccccgggatgccaaggcctgcgtgatccacggcaccgacctc
aaggacttcacctccgagcaaatcgacgagatcctgcagaatcacaccgagatcgtcttc
gcccgcacatccccccagcagaagctcatcattgtggagggctgtcagagacagggtgca
attgtggctgtgaccggggatggtgtgaacgactcccccgctctgaagaaggccgacatt
ggggtggccatgggcatcgctggctctgacgtctccaagcaggcagctgacatgatcctg
ctggacgacaactttgcctccatcgtcacaggggtggaggagggccgcctgatcttcgac
aacctaaagaagtccattgcctacaccctgaccagcaatatcccggagatcacgcccttc
ctgctgttcatcatggccaacatcccgctgcccctgggcaccatcaccatcctctgcatc
gatctgggcactgacatggtccctgccatctcactggcgtacgaggctgccgaaagcgac
atcatgaagagacagcccaggaacccgcggacggacaaattggtcaatgagagactcatc
agcatggcctacgggcagattggaatgatccaggctctcggtggcttcttctcttacttt
gtgatcctggcagaaaatggcttcttgcccggcaacctggtgggcatccggctgaactgg
gatgaccgcaccgtcaatgacctggaagacagttacgggcagcagtggacatacgagcag
aggaaggtggtggagttcacctgccacacggccttctttgtgagcatcgttgtcgtccag
tgggccgatctgatcatctgcaagacccggaggaactcggtcttccagcagggcatgaag
aacaagatcctgatcttcgggctgtttgaggagacggccctggctgccttcctgtcctac
tgccccggcatggacgtggccctgcgcatgtaccctctcaagcccagctggtggttctgt
gccttcccctacagtttcctcatcttcgtctacgacgaaatccgcaaactcatcctgcgc
aggaacccagggggttgggtggagaaggaaacctactactga

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