Homo sapiens (human): 4988 Entry 4988              CDS       T01001                                  Gene name OPRM1, LMOR, M-OR-1, MOP, MOR, MOR1, OPRM Definition (RefSeq) opioid receptor mu 1   KO K04215   mu-type opioid receptor Organism hsa  Homo sapiens (human) Pathway hsa04080   Neuroactive ligand-receptor interaction hsa04915   Estrogen signaling pathway hsa05032   Morphine addiction Disease H01611   Alcohol dependence Drug target Acetyldihydrocodeine:  D07557 Alfentanil (DG00792):  D00835 D07122 Alvimopan:  D02878 Bevenopran:  D10349 Brifentanil hydrochloride:  D03156 Buprenorphine (DG00820):  D00836 D07132 Butorphanol (DG00821):  D00837 D03197 Carfentanil (DG01339):  D03405 D07620 Cebranopadol:  D10436 Codeine (DG01076):  D00195 D02101 D03579 D03580 D07740 Cyclazocine:  D03618 Dextropropoxyphene    Propoxyphene (DG00818):  D05632 Dextropropoxyphene (DG00818):  D00482 D07809 Dezocine:  D00838 Diamorphine (DG01003):  D07286 D07810 Difenoxin:  D03809 Dihydrocodeine (DG00814):  D01481 D03825 D07831 D07832 Diphenoxylate (DG00090):  D03860 D07861 Diprenorphine (DG01273):  D07863 D07864 Eluxadoline:  D10403 Eptazocine (DG01340):  D01879 D07904 Ethoheptazine citrate:  D01435 Ethylmorphine (DG01074):  D02205 D07929 Etorphine:  D07937 Hydrocodone (DG01075):  D03725 D04461 D08045 D08046 Hydromorphone (DG00811):  D00839 D08047 Levacetylmethadol (DG01000):  D00840 D04716 Levallorphan tartrate:  D02238 Levomethadone (DG01002):  D08121 D08122 Levorphanol (DG01341):  D00841 D08123 Lofentanil oxalate:  D04764 Loperamide (DG00092):  D00729 D08144 Loperamide oxide (DG00092):  D07113 Meptazinol (DG00825):  D04924 D08182 Methadone (DG00999):  D02102 D08195 Methadyl acetate:  D04973 Methylnaltrexone bromide:  D06618 Mirfentanil hydrochloride:  D05048 Morphine (DG00810):  D00842 D02271 D08233 D08234 Nalbuphine (DG00822):  D00843 D08246 Naldemedine (DG01342):  D10188 D10478 Nalorphine (DG01151):  D08247 D08248 Naloxone (DG01155):  D01340 D08249 Naltrexone (DG00997):  D02095 D05113 Ocfentanil hydrochloride:  D05217 Oxycodone (DG00813):  D00847 D02175 D03783 D05312 D05462 Oxymorphone (DG01343):  D00844 D08323 Pentazocine (DG00819):  D00498 D02111 D02227 Pethidine (DG00816):  D01383 D08343 Quadazocine mesylate:  D05667 Remifentanil (DG00795):  D01177 D08473 Samidorphan (DG01538):  D10162 D10163 Sufentanil (DG00793):  D00845 D05938 Tilidine (DG00823):  D06147 D08597 Tramadol (DG00824):  D01355 D08623 Trefentanil hydrochloride:  D06208 Trimebutine (DG00031):  D01500 D08639 Trimeperidine:  D06268 Brite KEGG Orthology (KO) [BR:hsa00001]  Environmental Information Processing   Signaling molecules and interaction    04080 Neuroactive ligand-receptor interaction     4988 (OPRM1)  Organismal Systems   Endocrine system    04915 Estrogen signaling pathway     4988 (OPRM1)  Human Diseases   Substance dependence    05032 Morphine addiction     4988 (OPRM1) G protein-coupled receptors [BR:hsa04030]  Class A. Rhodopsin family   Neuropeptide    Opioid     4988 (OPRM1) SSDB Motif Pfam:  7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srx 7tm_4 Other DBs NCBI-GeneID:  4988 NCBI-ProteinID:  NP_000905 OMIM:  600018 HGNC:  8156 Ensembl:  ENSG00000112038 Vega:  OTTHUMG00000015870 Pharos:  P35372(Tclin) UniProt:  P35372 G8XRH5 LinkDB Position 6q25.2 AA seq 400 aa MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCP PTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALAT STLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDF RTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFI FAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHI YVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNI EQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP NT seq 1203 nt   +upstreamnt  +downstreamnt atggacagcagcgctgcccccacgaacgccagcaattgcactgatgccttggcgtactca agttgctccccagcacccagccccggttcctgggtcaacttgtcccacttagatggcaac ctgtccgacccatgcggtccgaaccgcaccgacctgggcgggagagacagcctgtgccct ccgaccggcagtccctccatgatcacggccatcacgatcatggccctctactccatcgtg tgcgtggtggggctcttcggaaacttcctggtcatgtatgtgattgtcagatacaccaag atgaagactgccaccaacatctacattttcaaccttgctctggcagatgccttagccacc agtaccctgcccttccagagtgtgaattacctaatgggaacatggccatttggaaccatc ctttgcaagatagtgatctccatagattactataacatgttcaccagcatattcaccctc tgcaccatgagtgttgatcgatacattgcagtctgccaccctgtcaaggccttagatttc cgtactccccgaaatgccaaaattatcaatgtctgcaactggatcctctcttcagccatt ggtcttcctgtaatgttcatggctacaacaaaatacaggcaaggttccatagattgtaca ctaacattctctcatccaacctggtactgggaaaacctgctgaagatctgtgttttcatc ttcgccttcattatgccagtgctcatcattaccgtgtgctatggactgatgatcttgcgc ctcaagagtgtccgcatgctctctggctccaaagaaaaggacaggaatcttcgaaggatc accaggatggtgctggtggtggtggctgtgttcatcgtctgctggactcccattcacatt tacgtcatcattaaagccttggttacaatcccagaaactacgttccagactgtttcttgg cacttctgcattgctctaggttacacaaacagctgcctcaacccagtcctttatgcattt ctggatgaaaacttcaaacgatgcttcagagagttctgtatcccaacctcttccaacatt gagcaacaaaactccactcgaattcgtcagaacactagagaccacccctccacggccaat acagtggatagaactaatcatcagctagaaaatctggaagcagaaactgctccgttgccc taa

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