KEGG   Homo sapiens (human): 5054Help
Entry
5054              CDS       T01001                                 

Gene name
SERPINE1, PAI, PAI-1, PAI1, PLANH1
Definition
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
Orthology
K03982  
plasminogen activator inhibitor-1
Organism
hsa  Homo sapiens (human)
Pathway
HIF-1 signaling pathway
p53 signaling pathway
Hippo signaling pathway
Complement and coagulation cascades
Chagas disease (American trypanosomiasis)
Disease
H00223  
Inherited thrombophilia
H01106  
Plasminogen activator inhibitor type 1 (PAI-1) deficiency
Drug target
Other: 
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04390 Hippo signaling pathway
    5054 (SERPINE1)
   04066 HIF-1 signaling pathway
    5054 (SERPINE1)
 Cellular Processes
  Cell growth and death
   04115 p53 signaling pathway
    5054 (SERPINE1)
 Organismal Systems
  Immune system
   04610 Complement and coagulation cascades
    5054 (SERPINE1)
 Human Diseases
  Infectious diseases
   05142 Chagas disease (American trypanosomiasis)
    5054 (SERPINE1)
Exosome [BR:hsa04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   5054 (SERPINE1)
Heparan sulfate/heparin binding proteins [BR:hsa00536]
 Coagulation and fibrinolysis (General comment) Coagulation, inflammation, complement control
  5054 (SERPINE1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 
Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
Ensembl: 
Vega: 
UniProt: 
LinkDB All DBs
Structure
PDB: 

Jmol
Position
7q22.1
AA seq 402 aa AA seqDB search
MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPY
GVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAI
FVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAV
DQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPD
GHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPK
FSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASS
STAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP
NT seq 1209 nt NT seq  +upstreamnt  +downstreamnt
atgcagatgtctccagccctcacctgcctagtcctgggcctggcccttgtctttggtgaa
gggtctgctgtgcaccatcccccatcctacgtggcccacctggcctcagacttcggggtg
agggtgtttcagcaggtggcgcaggcctccaaggaccgcaacgtggttttctcaccctat
ggggtggcctcggtgttggccatgctccagctgacaacaggaggagaaacccagcagcag
attcaagcagctatgggattcaagattgatgacaagggcatggcccccgccctccggcat
ctgtacaaggagctcatggggccatggaacaaggatgagatcagcaccacagacgcgatc
ttcgtccagcgggatctgaagctggtccagggcttcatgccccacttcttcaggctgttc
cggagcacggtcaagcaagtggacttttcagaggtggagagagccagattcatcatcaat
gactgggtgaagacacacacaaaaggtatgatcagcaacttgcttgggaaaggagccgtg
gaccagctgacacggctggtgctggtgaatgccctctacttcaacggccagtggaagact
cccttccccgactccagcacccaccgccgcctcttccacaaatcagacggcagcactgtc
tctgtgcccatgatggctcagaccaacaagttcaactatactgagttcaccacgcccgat
ggccattactacgacatcctggaactgccctaccacggggacaccctcagcatgttcatt
gctgccccttatgaaaaagaggtgcctctctctgccctcaccaacattctgagtgcccag
ctcatcagccactggaaaggcaacatgaccaggctgccccgcctcctggttctgcccaag
ttctccctggagactgaagtcgacctcaggaagcccctagagaacctgggaatgaccgac
atgttcagacagtttcaggctgacttcacgagtctttcagaccaagagcctctccacgtc
gcgcaggcgctgcagaaagtgaagatcgaggtgaacgagagtggcacggtggcctcctca
tccacagctgtcatagtctcagcccgcatggcccccgaggagatcatcatggacagaccc
ttcctctttgtggtccggcacaaccccacaggaacagtccttttcatgggccaagtgatg
gaaccctga

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