KEGG   Homo sapiens (human): 5054Help
Entry
5054              CDS       T01001                                 

Gene name
SERPINE1, PAI, PAI-1, PAI1, PLANH1
Definition
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
Orthology
K03982  
plasminogen activator inhibitor-1
Organism
hsa  Homo sapiens (human)
Pathway
HIF-1 signaling pathway
p53 signaling pathway
Hippo signaling pathway
Complement and coagulation cascades
Chagas disease (American trypanosomiasis)
Disease
H00223  
Inherited thrombophilia
H01106  
Plasminogen activator inhibitor type 1 (PAI-1) deficiency
Drug target
Other: 
Class
Environmental Information Processing; Signal transduction; Hippo signaling pathway [PATH:hsa04390]
Environmental Information Processing; Signal transduction; HIF-1 signaling pathway [PATH:hsa04066]
Cellular Processes; Cell growth and death; p53 signaling pathway [PATH:hsa04115]
Organismal Systems; Immune system; Complement and coagulation cascades [PATH:hsa04610]
Human Diseases; Infectious diseases; Chagas disease (American trypanosomiasis) [PATH:hsa05142]
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: 
Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
Ensembl: 
Vega: 
UniProt: 
LinkDB All DBs
Structure
PDB: 

Jmol
Position
7q22.1
AA seq 402 aa AA seqDB search
MQMSPALTCLVLGLALVFGEGSAVHHPPSYVAHLASDFGVRVFQQVAQASKDRNVVFSPY
GVASVLAMLQLTTGGETQQQIQAAMGFKIDDKGMAPALRHLYKELMGPWNKDEISTTDAI
FVQRDLKLVQGFMPHFFRLFRSTVKQVDFSEVERARFIINDWVKTHTKGMISNLLGKGAV
DQLTRLVLVNALYFNGQWKTPFPDSSTHRRLFHKSDGSTVSVPMMAQTNKFNYTEFTTPD
GHYYDILELPYHGDTLSMFIAAPYEKEVPLSALTNILSAQLISHWKGNMTRLPRLLVLPK
FSLETEVDLRKPLENLGMTDMFRQFQADFTSLSDQEPLHVAQALQKVKIEVNESGTVASS
STAVIVSARMAPEEIIMDRPFLFVVRHNPTGTVLFMGQVMEP
NT seq 1209 nt NT seq  +upstreamnt  +downstreamnt
atgcagatgtctccagccctcacctgcctagtcctgggcctggcccttgtctttggtgaa
gggtctgctgtgcaccatcccccatcctacgtggcccacctggcctcagacttcggggtg
agggtgtttcagcaggtggcgcaggcctccaaggaccgcaacgtggttttctcaccctat
ggggtggcctcggtgttggccatgctccagctgacaacaggaggagaaacccagcagcag
attcaagcagctatgggattcaagattgatgacaagggcatggcccccgccctccggcat
ctgtacaaggagctcatggggccatggaacaaggatgagatcagcaccacagacgcgatc
ttcgtccagcgggatctgaagctggtccagggcttcatgccccacttcttcaggctgttc
cggagcacggtcaagcaagtggacttttcagaggtggagagagccagattcatcatcaat
gactgggtgaagacacacacaaaaggtatgatcagcaacttgcttgggaaaggagccgtg
gaccagctgacacggctggtgctggtgaatgccctctacttcaacggccagtggaagact
cccttccccgactccagcacccaccgccgcctcttccacaaatcagacggcagcactgtc
tctgtgcccatgatggctcagaccaacaagttcaactatactgagttcaccacgcccgat
ggccattactacgacatcctggaactgccctaccacggggacaccctcagcatgttcatt
gctgccccttatgaaaaagaggtgcctctctctgccctcaccaacattctgagtgcccag
ctcatcagccactggaaaggcaacatgaccaggctgccccgcctcctggttctgcccaag
ttctccctggagactgaagtcgacctcaggaagcccctagagaacctgggaatgaccgac
atgttcagacagtttcaggctgacttcacgagtctttcagaccaagagcctctccacgtc
gcgcaggcgctgcagaaagtgaagatcgaggtgaacgagagtggcacggtggcctcctca
tccacagctgtcatagtctcagcccgcatggcccccgaggagatcatcatggacagaccc
ttcctctttgtggtccggcacaaccccacaggaacagtccttttcatgggccaagtgatg
gaaccctga

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