Homo sapiens (human): 5141 Entry 5141              CDS       T01001                                  Gene name PDE4A, DPDE2, PDE4, PDE46 Definition (RefSeq) phosphodiesterase 4A   KO K13293   cAMP-specific phosphodiesterase 4 [EC:3.1.4.53] Organism hsa  Homo sapiens (human) Pathway hsa00230   Purine metabolism hsa04024   cAMP signaling pathway hsa05032   Morphine addiction Drug target Aminophylline (DG01062):  D00227 D05429 Apremilast:  D08860 Arofylline:  D02985 Bucladesine (DG00230):  D01238 D07546 Caffeine (DG00974):  D00528 D01453 D07603 Catramilast:  D06575 Choline theophyllinate:  D02017 Cilomilast:  D01704 Cipamfylline:  D03516 Diprophylline:  D00691 Doxofylline:  D03898 Drotaverine (DG00044):  D07088 D07879 Filaminast:  D04185 Flavoxate (DG00477):  D00718 D07961 Ibudilast:  D01385 Moxaverine (DG00045):  D07089 D08238 Papaverine (DG00043):  D02218 D07425 D07439 Piclamilast:  D05474 Propentofylline:  D01630 Proxyphylline:  D01771 Roflumilast:  D05744 Rolipram:  D01783 Theophylline (DG01061):  D00371 D01712 D06103 D06104 Tibenelast sodium:  D06132 Tofimilast:  D09020 Trapidil:  D01220 Brite KEGG Orthology (KO) [BR:hsa00001]  Metabolism   Nucleotide metabolism    00230 Purine metabolism     5141 (PDE4A)  Environmental Information Processing   Signal transduction    04024 cAMP signaling pathway     5141 (PDE4A)  Human Diseases   Substance dependence    05032 Morphine addiction     5141 (PDE4A) Enzymes [BR:hsa01000]  3. Hydrolases   3.1  Acting on ester bonds    3.1.4  Phosphoric-diester hydrolases     3.1.4.53  3',5'-cyclic-AMP phosphodiesterase      5141 (PDE4A) SSDB Motif Pfam:  PDEase_I NadA DUF5405 Other DBs NCBI-GeneID:  5141 NCBI-ProteinID:  NP_001104777 OMIM:  600126 HGNC:  8780 Ensembl:  ENSG00000065989 Vega:  OTTHUMG00000180411 Pharos:  P27815(Tclin) UniProt:  P27815 LinkDB Structure PDB:  2QYK 3I8V 3TVX Position 19p13.2 AA seq 886 aa MEPPTVPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQQRGYSDSAERAERERQ PHRPIERADAMDTSDRPGLRTTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGR SPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTP FAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDW CLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEI PSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTD QEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYML TLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGV SNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDM VLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLE LYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADL VHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEE ISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLT QQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLP STAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT NT seq 2661 nt   +upstreamnt  +downstreamnt atggaacccccgaccgtcccctcggaaaggagcctgtctctgtcactgcccgggccccgg gagggccaggccaccctgaagcctcccccgcagcacctgtggcggcagcctcggaccccc atccgtatccagcagcgcggctactccgacagcgcggagcgcgccgagcgggagcggcag ccgcaccggcccatagagcgcgccgatgccatggacaccagcgaccggcccggcctgcgc acgacccgcatgtcctggccctcgtccttccatggcactggcaccggcagcggcggcgcg ggcggaggcagcagcaggcgcttcgaggcagagaatgggccgacaccatctcctggccgc agccccctggactcgcaggcgagcccaggactcgtgctgcacgccggggcggccaccagc cagcgccgggagtccttcctgtaccgctcagacagcgactatgacatgtcacccaagacc atgtcccggaactcatcggtcaccagcgaggcgcacgctgaagacctcatcgtaacacca tttgctcaggtgctggccagcctccggagcgtccgtagcaacttctcactcctgaccaat gtgcccgttcccagtaacaagcggtccccgctgggcggccccacccctgtctgcaaggcc acgctgtcagaagaaacgtgtcagcagttggcccgggagactctggaggagctggactgg tgtctggagcagctggagaccatgcagacctatcgctctgtcagcgagatggcctcgcac aagttcaaaaggatgttgaaccgtgagctcacacacctgtcagaaatgagcaggtccgga aaccaggtctcagagtacatttccacaacattcctggacaaacagaatgaagtggagatc ccatcacccacgatgaaggaacgagaaaaacagcaagcgccgcgaccaagaccctcccag ccgcccccgccccctgtaccacacttacagcccatgtcccaaatcacagggttgaaaaag ttgatgcatagtaacagcctgaacaactctaacattccccgatttggggtgaagaccgat caagaagagctcctggcccaagaactggagaacctgaacaagtggggcctgaacatcttt tgcgtgtcggattacgctggaggccgctcactcacctgcatcatgtacatgatattccag gagcgggacctgctgaagaaattccgcatccctgtggacacgatggtgacatacatgctg acgctggaggatcactaccacgctgacgtggcctaccataacagcctgcacgcagctgac gtgctgcagtccacccacgtactgctggccacgcctgcactagatgcagtgttcacggac ctggagattctcgccgccctcttcgcggctgccatccacgatgtggatcaccctggggtc tccaaccagttcctcatcaacaccaattcggagctggcgctcatgtacaacgatgagtcg gtgctcgagaatcaccacctggccgtgggcttcaagctgctgcaggaggacaactgcgac atcttccagaacctcagcaagcgccagcggcagagcctacgcaagatggtcatcgacatg gtgctggccacggacatgtccaagcacatgaccctcctggctgacctgaagaccatggtg gagaccaagaaagtgaccagctcaggggtcctcctgctagataactactccgaccgcatc caggtcctccggaacatggtgcactgtgccgacctcagcaaccccaccaagccgctggag ctgtaccgccagtggacagaccgcatcatggccgagttcttccagcagggtgaccgagag cgcgagcgtggcatggaaatcagccccatgtgtgacaagcacactgcctccgtggagaag tctcaggtgggttttattgactacattgtgcacccattgtgggagacctgggcggacctt gtccacccagatgcccaggagatcttggacactttggaggacaaccgggactggtactac agcgccatccggcagagcccatctccgccacccgaggaggagtcaagggggccaggccac ccacccctgcctgacaagttccagtttgagctgacgctggaggaggaagaggaggaagaa atatcaatggcccagataccgtgcacagcccaagaggcattgactgcgcagggattgtca ggagtcgaggaagctctggatgcaaccatagcctgggaggcatccccggcccaggagtcg ttggaagttatggcacaggaagcatccctggaggccgagctggaggcagtgtatttgaca cagcaggcacagtccacaggcagtgcacctgtggctccggatgagttctcgtcccgggag gaattcgtggttgctgtaagccacagcagcccctctgccctggctcttcaaagccccctt ctccctgcttggaggaccctgtctgtttcagagcatgccccgggcctcccgggcctcccc tccacggcggccgaggtggaggcccaacgagagcaccaggctgccaagagggcttgcagt gcctgcgcagggacatttggggaggacacatccgcactcccagctcctggtggcgggggg tcaggtggagaccctacctga

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