Homo sapiens (human): 5142 Entry 5142              CDS       T01001                                  Gene name PDE4B, DPDE4, PDEIVB Definition (RefSeq) phosphodiesterase 4B   KO K13293   cAMP-specific phosphodiesterase 4 [EC:3.1.4.53] Organism hsa  Homo sapiens (human) Pathway hsa00230   Purine metabolism hsa04024   cAMP signaling pathway hsa05032   Morphine addiction Drug target Aminophylline (DG01062):  D00227 D05429 Apremilast:  D08860 Arofylline:  D02985 Bucladesine (DG00230):  D01238 D07546 Caffeine (DG00974):  D00528 D01453 D07603 Catramilast:  D06575 Choline theophyllinate:  D02017 Cilomilast:  D01704 Cipamfylline:  D03516 Diprophylline:  D00691 Doxofylline:  D03898 Drotaverine (DG00044):  D07088 D07879 Filaminast:  D04185 Flavoxate (DG00477):  D00718 D07961 Ibudilast:  D01385 Moxaverine (DG00045):  D07089 D08238 Papaverine (DG00043):  D02218 D07425 D07439 Piclamilast:  D05474 Propentofylline:  D01630 Proxyphylline:  D01771 Roflumilast:  D05744 Rolipram:  D01783 Theophylline (DG01061):  D00371 D01712 D06103 D06104 Tibenelast sodium:  D06132 Tofimilast:  D09020 Trapidil:  D01220 Brite KEGG Orthology (KO) [BR:hsa00001]  Metabolism   Nucleotide metabolism    00230 Purine metabolism     5142 (PDE4B)  Environmental Information Processing   Signal transduction    04024 cAMP signaling pathway     5142 (PDE4B)  Human Diseases   Substance dependence    05032 Morphine addiction     5142 (PDE4B) Enzymes [BR:hsa01000]  3. Hydrolases   3.1  Acting on ester bonds    3.1.4  Phosphoric-diester hydrolases     3.1.4.53  3',5'-cyclic-AMP phosphodiesterase      5142 (PDE4B) SSDB Motif Pfam:  PDEase_I Other DBs NCBI-GeneID:  5142 NCBI-ProteinID:  NP_001032418 OMIM:  600127 HGNC:  8781 Ensembl:  ENSG00000184588 Vega:  OTTHUMG00000009088 Pharos:  Q07343(Tclin) UniProt:  Q07343 X5DNX5 LinkDB Structure PDB:  4KP6 3FRG 3GWT 3D3P 1F0J 5K6J 4MYQ 1XM6 3O0J 2QYL 3O57 1ROR 1RO6 1XLZ 1RO9 4NW7 1TB5 1XLX 3HMV 1XOS 3W5E 1XMU 1XN0 1XM4 1XOT 1Y2H 1XMY 3O56 3KKT 3WD9 1Y2J 4WZI 3LY2 3G45 4X0F Position 1p31.3 AA seq 736 aa MKKSRSVMTVMADDNVKDYFECSLSKSYSSSSNTLGIDLWRGRRCCSGNLQLPPLSQRQS ERARTPEGDGISRPTTLPLTTLPSIAITTVSQECFDVENGPSPGRSPLDPQASSSAGLVL HATFPGHSQRRESFLYRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVR NNFTILTNLHGTSNKRSPAASQPPVSRVNPQEESYQKLAMETLEELDWCLDQLETIQTYR SVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKK KQQLMTQISGVKKLMHSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSH NRPLTCIMYAIFQERDLLKTFRISSDTFITYMMTLEDHYHSDVAYHNSLHAADVAQSTHV LLSTPALDAVFTDLEILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHL AVGFKLLQEEHCDIFMNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTS SGVLLLDNYTDRIQVLRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEI SPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSP SPPLDEQNRDCQGLMEKFQFELTLDEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLG ETDIDIATEDKSPVDT NT seq 2211 nt   +upstreamnt  +downstreamnt atgaagaaaagcaggagtgtgatgacggtgatggctgatgataatgttaaagattatttt gaatgtagcttgagtaaatcctacagttcttccagtaacacacttgggatcgacctctgg agagggagaaggtgttgctcaggaaacttacagttaccaccactgtctcaaagacagagt gaaagggcaaggactcctgagggagatggtatttccaggccgaccacactgcctttgaca acgcttccaagcattgctattacaactgtaagccaggagtgctttgatgtggaaaatggc ccttccccaggtcggagtccactggatccccaggccagctcttccgctgggctggtactt cacgccacctttcctgggcacagccagcgcagagagtcatttctctacagatcagacagc gactatgacttgtcaccaaaggcgatgtcgagaaactcttctcttccaagcgagcaacac ggcgatgacttgattgtaactccttttgcccaggtccttgccagcttgcgaagtgtgaga aacaacttcactatactgacaaaccttcatggtacatctaacaagaggtccccagctgct agtcagcctcctgtctccagagtcaacccacaagaagaatcttatcaaaaattagcaatg gaaacgctggaggaattagactggtgtttagaccagctagagaccatacagacctaccgg tctgtcagtgagatggcttctaacaagttcaaaagaatgctgaaccgggagctgacacac ctctcagagatgagccgatcagggaaccaggtgtctgaatacatttcaaatactttctta gacaagcagaatgatgtggagatcccatctcctacccagaaagacagggagaaaaagaaa aagcagcagctcatgacccagataagtggagtgaagaaattaatgcatagttcaagccta aacaatacaagcatctcacgctttggagtcaacactgaaaatgaagatcacctggccaag gagctggaagacctgaacaaatggggtcttaacatctttaatgtggctggatattctcac aatagacccctaacatgcatcatgtatgctatattccaggaaagagacctcctaaagaca ttcagaatctcatctgacacatttataacctacatgatgactttagaagaccattaccat tctgacgtggcatatcacaacagcctgcacgctgctgatgtagcccagtcgacccatgtt ctcctttctacaccagcattagacgctgtcttcacagatttggagatcctggctgccatt tttgcagctgccatccatgacgttgatcatcctggagtctccaatcagtttctcatcaac acaaattcagaacttgctttgatgtataatgatgaatctgtgttggaaaatcatcacctt gctgtgggtttcaaactgctgcaagaagaacactgtgacatcttcatgaatctcaccaag aagcagcgtcagacactcaggaagatggttattgacatggtgttagcaactgatatgtct aaacatatgagcctgctggcagacctgaagacaatggtagaaacgaagaaagttacaagt tcaggcgttcttctcctagacaactataccgatcgcattcaggtccttcgcaacatggta cactgtgcagacctgagcaaccccaccaagtccttggaattgtatcggcaatggacagac cgcatcatggaggaatttttccagcagggagacaaagagcgggagaggggaatggaaatt agcccaatgtgtgataaacacacagcttctgtggaaaaatcccaggttggtttcatcgac tacattgtccatccattgtgggagacatgggcagatttggtacagcctgatgctcaggac attctcgataccttagaagataacaggaactggtatcagagcatgatacctcaaagtccc tcaccaccactggacgagcagaacagggactgccagggtctgatggagaagtttcagttt gaactgactctcgatgaggaagattctgaaggacctgagaaggagggagagggacacagc tatttcagcagcacaaagacgctttgtgtgattgatccagaaaacagagattccctggga gagactgacatagacattgcaacagaagacaagtcccccgtggatacataa

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