Homo sapiens (human): 5143 Entry 5143              CDS       T01001                                  Gene name PDE4C, DPDE1, PDE21 Definition (RefSeq) phosphodiesterase 4C   KO K13293   cAMP-specific phosphodiesterase 4 [EC:3.1.4.53] Organism hsa  Homo sapiens (human) Pathway hsa00230   Purine metabolism hsa04024   cAMP signaling pathway hsa05032   Morphine addiction Drug target Aminophylline (DG01062):  D00227 D05429 Apremilast:  D08860 Arofylline:  D02985 Bucladesine (DG00230):  D01238 D07546 Caffeine (DG00974):  D00528 D01453 D07603 Catramilast:  D06575 Choline theophyllinate:  D02017 Cilomilast:  D01704 Cipamfylline:  D03516 Diprophylline:  D00691 Doxofylline:  D03898 Drotaverine (DG00044):  D07088 D07879 Filaminast:  D04185 Flavoxate (DG00477):  D00718 D07961 Ibudilast:  D01385 Moxaverine (DG00045):  D07089 D08238 Papaverine (DG00043):  D02218 D07425 D07439 Piclamilast:  D05474 Propentofylline:  D01630 Proxyphylline:  D01771 Roflumilast:  D05744 Rolipram:  D01783 Theophylline (DG01061):  D00371 D01712 D06103 D06104 Tibenelast sodium:  D06132 Tofimilast:  D09020 Trapidil:  D01220 Brite KEGG Orthology (KO) [BR:hsa00001]  Metabolism   Nucleotide metabolism    00230 Purine metabolism     5143 (PDE4C)  Environmental Information Processing   Signal transduction    04024 cAMP signaling pathway     5143 (PDE4C)  Human Diseases   Substance dependence    05032 Morphine addiction     5143 (PDE4C) Enzymes [BR:hsa01000]  3. Hydrolases   3.1  Acting on ester bonds    3.1.4  Phosphoric-diester hydrolases     3.1.4.53  3',5'-cyclic-AMP phosphodiesterase      5143 (PDE4C) SSDB Motif Pfam:  PDEase_I Other DBs NCBI-GeneID:  5143 NCBI-ProteinID:  NP_000914 OMIM:  600128 HGNC:  8782 Ensembl:  ENSG00000105650 Vega:  OTTHUMG00000183353 Pharos:  Q08493(Tclin) UniProt:  Q08493 Q32MM7 O43849 LinkDB Structure PDB:  2QYM Position 19p13.11 AA seq 712 aa MENLGVGEGAEACSRLSRSRGRHSMTRAPKHLWRQPRRPIRIQQRFYSDPDKSAGCRERD LSPRPELRKSRLSWPVSSCRRFDLENGLSCGRRALDPQSSPGLGRIMQAPVPHSQRRESF LYRSDSDYELSPKAMSRNSSVASDLHGEDMIVTPFAQVLASLRTVRSNVAALARQQCLGA AKQGPVGNPSSSNQLPPAEDTGQKLALETLDELDWCLDQLETLQTRHSVGEMASNKFKRI LNRELTHLSETSRSGNQVSEYISRTFLDQQTEVELPKVTAEEAPQPMSRISGLHGLCHSA SLSSATVPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELSGNRPLTAIIFSIFQERDLL KTFQIPADTLATYLLMLEGHYHANVAYHNSLHAADVAQSTHVLLATPALEAVFTDLEILA ALFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQAENCDIFQNL SAKQRLSLRRMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQVLQN LVHCADLSNPTKPLPLYRQWTDRIMAEFFQQGDRERESGLDISPMCDKHTASVEKSQVGF IDYIAHPLWETWADLVHPDAQDLLDTLEDNREWYQSKIPRSPSDLTNPERDGPDRFQFEL TLEEAEEEDEEEEEEGEETALAKEALELPDTELLSPEAGPDPGDLPLDNQRT NT seq 2139 nt   +upstreamnt  +downstreamnt atggagaacctgggggtcggcgaaggggcagaggcttgcagcaggttgagtcgctctcgc ggccgccacagcatgaccagagccccgaagcacctgtggcggcaaccccggcgccccatc cgcatccaacagcgcttctattcggatccggacaagtccgcgggctgccgcgagagggac ctgagcccgcggccggagctcaggaagtcgcggctctcctggcccgtttcctcctgcagg cgctttgacctggaaaatgggctctcgtgtgggaggagggccctggaccctcagtccagc cctggcctgggccggattatgcaggctccagtcccgcacagccagcggcgcgagtccttc ctgtaccgctcagatagcgactatgaactctcgcccaaggccatgtctcggaactcctct gtggccagcgacctacatggagaggacatgattgtgacgccctttgcccaggtcctggcc agtctgcggaccgttcggagcaacgtggcggcccttgcccgccagcaatgcctaggagca gccaagcagggacccgtcggaaacccttcatccagcaatcagctccctcctgcagaggac acggggcagaagctggcattggagacgctagacgagctggactggtgcctggatcagttg gagacgctgcagacccggcactcggtgggggagatggcctccaacaagttcaagcggatc ctgaaccgggagttgacccacctgtccgaaaccagccgctccgggaaccaggtgtccgag tacatctcccggaccttcctggaccagcagaccgaggtggagctgcccaaggtgaccgct gaggaggccccacagcccatgtcccggatcagtggcctacatgggctctgccacagtgcc agcctctcctcagccactgtcccacgctttggggtccagactgaccaggaggagcaactg gccaaggagctagaagacaccaacaagtggggacttgatgtgttcaaggtggcggagcta agtgggaaccggcccctcacagctatcatattcagcatttttcaggagcgggacctgctg aagacattccagatcccagcagacacactggccacctacctgctgatgctggaaggtcac taccacgccaatgtggcctaccacaacagcctacatgccgccgacgtggcccagtccacg catgtgctgctggctacgcccgccctcgaggctgtgttcacagacttggaaatcctggct gccctctttgcaagcgccatccacgacgtggaccatcctggggtctccaaccagtttctg attaacaccaactcagagctggcgcttatgtacaacgacgcctcggtgctggagaaccat cacctggctgtgggcttcaagctgctgcaggcagagaactgcgatatcttccagaacctc agcgccaagcagcgactgagtctgcgcaggatggtcattgacatggtgctggccacagac atgtccaaacacatgaacctcctggccgacctcaagaccatggtggagaccaagaaggtg acaagcctcggtgtcctcctcctggacaactattccgaccgaatccaggtcttgcagaac ctggtgcactgtgctgatctgagcaaccccaccaagccgctgcccctgtaccgccagtgg acggaccgcatcatggccgagttcttccagcagggagaccgcgagcgtgagtcgggcctg gacatcagtcccatgtgtgacaagcatacggcctcagtggagaagtcccaggtgggtttc attgactacattgctcacccactgtgggagacttgggctgacctggtccacccagatgca caggacctgctggacacgctggaggacaatcgagagtggtaccagagcaagatcccccga agtccctcagacctcaccaaccccgagcgggacgggcctgacagattccagtttgaactg actctggaggaggcagaggaagaggatgaggaggaagaagaggagggggaagagacagct ttagccaaagaggccttggagttgcctgacactgaactcctgtcccctgaagccggccca gaccctggggacttacccctcgacaaccagaggacttag

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