Homo sapiens (human): 5347
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Entry
5347 CDS
T01001
Symbol
PLK1, PLK, STPK13
Name
(RefSeq) polo like kinase 1
KO
K06631
polo-like kinase 1 [EC:
2.7.11.21
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04068
FoxO signaling pathway
hsa04110
Cell cycle
hsa04114
Oocyte meiosis
hsa04914
Progesterone-mediated oocyte maturation
Network
nt06512
Chromosome cohesion and segregation
nt06515
Regulation of kinetochore-microtubule interactions
Element
N01485
Cohesin dissociation in prophase
N01499
Modifying of condensin II subunits
N01562
Microtubule depolymerization at the minus ends
Drug target
Onvansertib (
DG03017
):
D11458
D11459
Rigosertib (
DG01416
):
D10154
D10155
Volasertib (
DG01417
):
D10182
D10183
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04068 FoxO signaling pathway
5347 (PLK1)
09140 Cellular Processes
09143 Cell growth and death
04110 Cell cycle
5347 (PLK1)
04114 Oocyte meiosis
5347 (PLK1)
09150 Organismal Systems
09152 Endocrine system
04914 Progesterone-mediated oocyte maturation
5347 (PLK1)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
hsa01001
]
5347 (PLK1)
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
hsa03036
]
5347 (PLK1)
Enzymes [BR:
hsa01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.11 Protein-serine/threonine kinases
2.7.11.21 polo kinase
5347 (PLK1)
Protein kinases [BR:
hsa01001
]
Serine/threonine kinases: Other
PLK family [OT]
5347 (PLK1)
Chromosome and associated proteins [BR:
hsa03036
]
Eukaryotic type
Centromeric chromatin formation proteins
SAC (spindle assembly checkpoint) factors
Protein kinases
5347 (PLK1)
Centrosome formation proteins
Kinases and associated factors
5347 (PLK1)
Sister chromatid separation proteins
Polo kinases
5347 (PLK1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Pkinase
POLO_box
PK_Tyr_Ser-Thr
Kinase-like
Pkinase_fungal
ABC1
APH
Motif
Other DBs
NCBI-GeneID:
5347
NCBI-ProteinID:
NP_005021
OMIM:
602098
HGNC:
9077
Ensembl:
ENSG00000166851
UniProt:
P53350
Structure
PDB
LinkDB
All DBs
Position
16:23678889..23690367
Genome browser
AA seq
603 aa
AA seq
DB search
MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLG
KGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFF
EDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLG
NLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCI
MYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELL
NDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEE
PVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDK
YGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLK
YFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTK
LILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRL
KAS
NT seq
1812 nt
NT seq
+upstream
nt +downstream
nt
atgagtgctgcagtgactgcagggaagctggcacgggcaccggccgaccctgggaaagcc
ggggtccccggagttgcagctcccggagctccggcggcggctccaccggcgaaagagatc
ccggaggtcctagtggacccacgcagccggcggcgctatgtgcggggccgctttttgggc
aagggcggctttgccaagtgcttcgagatctcggacgcggacaccaaggaggtgttcgcg
ggcaagattgtgcctaagtctctgctgctcaagccgcaccagagggagaagatgtccatg
gaaatatccattcaccgcagcctcgcccaccagcacgtcgtaggattccacggctttttc
gaggacaacgacttcgtgttcgtggtgttggagctctgccgccggaggtctctcctggag
ctgcacaagaggaggaaagccctgactgagcctgaggcccgatactacctacggcaaatt
gtgcttggctgccagtacctgcaccgaaaccgagttattcatcgagacctcaagctgggc
aaccttttcctgaatgaagatctggaggtgaaaataggggattttggactggcaaccaaa
gtcgaatatgacggggagaggaagaagaccctgtgtgggactcctaattacatagctccc
gaggtgctgagcaagaaagggcacagtttcgaggtggatgtgtggtccattgggtgtatc
atgtataccttgttagtgggcaaaccaccttttgagacttcttgcctaaaagagacctac
ctccggatcaagaagaatgaatacagtattcccaagcacatcaaccccgtggccgcctcc
ctcatccagaagatgcttcagacagatcccactgcccgcccaaccattaacgagctgctt
aatgacgagttctttacttctggctatatccctgcccgtctccccatcacctgcctgacc
attccaccaaggttttcgattgctcccagcagcctggaccccagcaaccggaagcccctc
acagtcctcaataaaggcttggagaaccccctgcctgagcgtccccgggaaaaagaagaa
ccagtggttcgagagacaggtgaggtggtcgactgccacctcagtgacatgctgcagcag
ctgcacagtgtcaatgcctccaagccctcggagcgtgggctggtcaggcaagaggaggct
gaggatcctgcctgcatccccatcttctgggtcagcaagtgggtggactattcggacaag
tacggccttgggtatcagctctgtgataacagcgtgggggtgctcttcaatgactcaaca
cgcctcatcctctacaatgatggtgacagcctgcagtacatagagcgtgacggcactgag
tcctacctcaccgtgagttcccatcccaactccttgatgaagaagatcaccctccttaaa
tatttccgcaattacatgagcgagcacttgctgaaggcaggtgccaacatcacgccgcgc
gaaggtgatgagctcgcccggctgccctacctacggacctggttccgcacccgcagcgcc
atcatcctgcacctcagcaacggcagcgtgcagatcaacttcttccaggatcacaccaag
ctcatcttgtgcccactgatggcagccgtgacctacatcgacgagaagcgggacttccgc
acataccgcctgagtctcctggaggagtacggctgctgcaaggagctggccagccggctc
cgctacgcccgcactatggtggacaagctgctgagctcacgctcggccagcaaccgtctc
aaggcctcctaa
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