KEGG T01001: 5371

Homo sapiens (human): 5371

Entry

5371 CDS T01001

Gene name

PML, MYL, PP8675, RNF71, TRIM19

Definition

(RefSeq) promyelocytic leukemia

K10054

probable transcription factor PML

Organism

hsa Homo sapiens (human)

Pathway

hsa04120	Ubiquitin mediated proteolysis
hsa04144	Endocytosis
hsa05164	Influenza A
hsa05168	Herpes simplex infection
hsa05200	Pathways in cancer
hsa05202	Transcriptional misregulation in cancer
hsa05221	Acute myeloid leukemia

Network

N00109	PML-RARA fusion to transcriptional activtion
N00113	PML-RARA fusion to transcriptional repression

Disease

H00003

Acute myeloid leukemia (AML)

Drug target

Tretinoin (DG00433):

D00094

Brite

KEGG Orthology (KO) [BR:hsa00001]
Genetic Information Processing
  Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    5371 (PML)
Cellular Processes
  Transport and catabolism
   04144 Endocytosis
    5371 (PML)
Human Diseases
  Cancers
   05200 Pathways in cancer
    5371 (PML)
   05202 Transcriptional misregulation in cancers
    5371 (PML)
   05221 Acute myeloid leukemia
    5371 (PML)
  Infectious diseases
   05164 Influenza A
    5371 (PML)
   05168 Herpes simplex infection
    5371 (PML)
Ubiquitin system [BR:hsa04121]
Ubiquitin ligases (E3)
  Single Ring-finger type E3
   TRIM/RBCC proteins
    5371 (PML)

SSDB

Motif

Pfam:

DUF3583 zf-B_box zf-C3HC4_3 Prok-RING_4 zf-RING_5 Imm71 OmpH

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

Vega:

Pharos:

P29590(Tbio)

UniProt:

P29590

LinkDB

Structure

PDB:

4WJO 4WJN 5YUF 2MWX 2MVW 1BOR

Position

15q24.1

AA seq 882 aa
MEPAPARSPRPQQDPARPQEPTMPPPETPSEGRQPSPSPSPTERAPASEEEFQFLRCQQC
QAEAKCPKLLPCLHTLCSGCLEASGMQCPICQAPWPLGADTPALDNVFFESLQRRLSVYR
QIVDAQAVCTRCKESADFWCFECEQLLCAKCFEAHQWFLKHEARPLAELRNQSVREFLDG
TRKTNNIFCSNPNHRTPTLTSIYCRGCSKPLCCSCALLDSSHSELKCDISAEIQQRQEEL
DAMTQALQEQDSAFGAVHAQMHAAVGQLGRARAETEELIRERVRQVVAHVRAQERELLEA
VDARYQRDYEEMASRLGRLDAVLQRIRTGSALVQRMKCYASDQEVLDMHGFLRQALCRLR
QEEPQSLQAAVRTDGFDEFKVRLQDLSSCITQGKDAAVSKKASPEAASTPRDPIDVDLPE
EAERVKAQVQALGLAEAQPMAVVQSVPGAHPVPVYAFSIKGPSYGEDVSNTTTAQKRKCS
QTQCPRKVIKMESEEGKEARLARSSPEQPRPSTSKAVSPPHLDGPPSPRSPVIGSEVFLP
NSNHVASGAGEAEERVVVISSSEDSDAENSSSRELDDSSSESSDLQLEGPSTLRVLDENL
ADPQAEDRPLVFFDLKIDNETQKISQLAAVNRESKFRVVIQPEAFFSIYSKAVSLEVGLQ
HFLSFLSSMRRPILACYKLWGPGLPNFFRALEDINRLWEFQEAISGFLAALPLIRERVPG
ASSFKLKNLAQTYLARNMSERSAMAAVLAMRDLCRLLEVSPGPQLAQHVYPFSSLQCFAS
LQPLVQAAVLPRAEARLLALHNVSFMELLSAHRRDRQGGLKKYSRYLSLQTTTLPPAQPA
FNLQALGTYFEGLLEGPALARAEGVSTPLAGRGLAERASQQS

NT seq 2649 nt +upstreamnt +downstreamnt
atggagcctgcacccgcccgatctccgaggccccagcaggaccccgcccggccccaggag
cccaccatgcctccccccgagaccccctctgaaggccgccagcccagccccagccccagc
cctacagagcgagcccccgcttcggaggaggagttccagtttctgcgctgccagcaatgc
caggcggaagccaagtgcccgaagctgctgccttgtctgcacacgctgtgctcaggatgc
ctggaggcgtcgggcatgcagtgccccatctgccaggcgccctggcccctaggtgcagac
acacccgccctggataacgtctttttcgagagtctgcagcggcgcctgtcggtgtaccgg
cagattgtggatgcgcaggctgtgtgcacccgctgcaaagagtcggccgacttctggtgc
tttgagtgcgagcagctcctctgcgccaagtgcttcgaggcacaccagtggttcctcaag
cacgaggcccggcccctagcagagctgcgcaaccagtcggtgcgtgagttcctggacggc
acccgcaagaccaacaacatcttctgctccaaccccaaccaccgcacccctacgctgacc
agcatctactgccgaggatgttccaagccgctgtgctgctcgtgcgcgctccttgacagc
agccacagtgagctcaagtgcgacatcagcgcagagatccagcagcgacaggaggagctg
gacgccatgacgcaggcgctgcaggagcaggatagtgcctttggcgcggttcacgcgcag
atgcacgcggccgtcggccagctgggccgcgcgcgtgccgagaccgaggagctgatccgc
gagcgcgtgcgccaggtggtagctcacgtgcgggctcaggagcgcgagctgctggaggct
gtggacgcgcggtaccagcgcgactacgaggagatggccagtcggctgggccgcctggat
gctgtgctgcagcgcatccgcacgggcagcgcgctggtgcagaggatgaagtgctacgcc
tcggaccaggaggtgctggacatgcacggtttcctgcgccaggcgctctgccgcctgcgc
caggaggagccccagagcctgcaagctgccgtgcgcaccgatggcttcgacgagttcaag
gtgcgcctgcaggacctcagctcttgcatcacccaggggaaagatgcagctgtatccaag
aaagccagcccagaggctgccagcactcccagggaccctattgacgttgacctgcccgag
gaggcagagagagtgaaggcccaggttcaggccctggggctggctgaagcccagcctatg
gctgtggtacagtcagtgcccggggcacaccccgtgccagtgtacgccttctccatcaaa
ggcccttcctatggagaggatgtctccaatacaacgacagcccagaagaggaagtgcagc
cagacccagtgccccaggaaggtcatcaagatggagtctgaggaggggaaggaggcaagg
ttggctcggagctccccggagcagcccaggcccagcacctccaaggcagtctcaccaccc
cacctggatggaccgcctagccccaggagccccgtcataggaagtgaggtcttcctgccc
aacagcaaccacgtggccagtggcgccggggaggcagaggaacgcgttgtggtgatcagc
agctcggaagactcagatgccgaaaactcgtcctcccgagagctggatgacagcagcagt
gagtccagtgacctccagctggaaggccccagcaccctcagggtcctggacgagaacctt
gctgacccccaagcagaagacagacctctggttttctttgacctcaagattgacaatgaa
acccagaagattagccagctggctgcggtgaaccgggaaagcaagttccgcgtggtcatc
cagcctgaagccttcttcagcatctactccaaggccgtgtccctggaggtggggctgcag
cacttcctcagctttctgagctccatgcgccgccctatcttggcctgctacaagctgtgg
gggcctggcctcccaaacttcttccgggccctggaggacattaacaggctgtgggaattc
caggaggccatctcgggcttcctggctgccctgcctctcatccgggagcgtgtgcccggg
gccagcagcttcaaactcaagaacctggcccagacctacctggcgagaaacatgagcgag
cgcagcgccatggctgccgtgctggccatgcgtgacctgtgccgcctcctcgaggtctcc
ccgggcccccagctggcccagcatgtctaccccttcagtagcctgcagtgctttgcctcc
ctgcagcccctggtgcaggcagctgtgctgccccgggctgaggcccgcctcctggcccta
cacaacgtgagcttcatggagctgctgagtgcacaccgccgtgaccggcaggggggcctg
aagaagtacagccgctatctaagcctgcagaccaccacgttgccccctgcccagcctgct
ttcaacctgcaggctctgggcacctactttgaaggcctgttggagggtccggcgctggca
cgggcagaaggagtctccaccccacttgctggccgtggcttggcagagagggcctcccag
cagagctga

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