Homo sapiens (human): 5371 Entry 5371              CDS       T01001                                  Gene name PML, MYL, PP8675, RNF71, TRIM19 Definition (RefSeq) promyelocytic leukemia   KO K10054   probable transcription factor PML Organism hsa  Homo sapiens (human) Pathway hsa04120   Ubiquitin mediated proteolysis hsa04144   Endocytosis hsa05164   Influenza A hsa05168   Herpes simplex infection hsa05200   Pathways in cancer hsa05202   Transcriptional misregulation in cancer hsa05221   Acute myeloid leukemia Disease H00003   Acute myeloid leukemia (AML) Drug target Tretinoin (DG00433):  D00094 Brite KEGG Orthology (KO) [BR:hsa00001]  Genetic Information Processing   Folding, sorting and degradation    04120 Ubiquitin mediated proteolysis     5371 (PML)  Cellular Processes   Transport and catabolism    04144 Endocytosis     5371 (PML)  Human Diseases   Cancers    05200 Pathways in cancer     5371 (PML)    05202 Transcriptional misregulation in cancers     5371 (PML)    05221 Acute myeloid leukemia     5371 (PML)   Infectious diseases    05164 Influenza A     5371 (PML)    05168 Herpes simplex infection     5371 (PML) Ubiquitin system [BR:hsa04121]  Ubiquitin ligases (E3)   Single Ring-finger type E3    TRIM/RBCC proteins     5371 (PML) SSDB Motif Pfam:  DUF3583 zf-B_box zf-C3HC4_3 Prok-RING_4 zf-RING_5 Imm71 OmpH Other DBs NCBI-GeneID:  5371 NCBI-ProteinID:  NP_150241 OMIM:  102578 HGNC:  9113 Ensembl:  ENSG00000140464 Vega:  OTTHUMG00000137607 Pharos:  P29590(Tbio) UniProt:  P29590 LinkDB Structure PDB:  4WJO 4WJN 2MWX 2MVW 1BOR Position 15q24.1 AA seq 882 aa MEPAPARSPRPQQDPARPQEPTMPPPETPSEGRQPSPSPSPTERAPASEEEFQFLRCQQC QAEAKCPKLLPCLHTLCSGCLEASGMQCPICQAPWPLGADTPALDNVFFESLQRRLSVYR QIVDAQAVCTRCKESADFWCFECEQLLCAKCFEAHQWFLKHEARPLAELRNQSVREFLDG TRKTNNIFCSNPNHRTPTLTSIYCRGCSKPLCCSCALLDSSHSELKCDISAEIQQRQEEL DAMTQALQEQDSAFGAVHAQMHAAVGQLGRARAETEELIRERVRQVVAHVRAQERELLEA VDARYQRDYEEMASRLGRLDAVLQRIRTGSALVQRMKCYASDQEVLDMHGFLRQALCRLR QEEPQSLQAAVRTDGFDEFKVRLQDLSSCITQGKDAAVSKKASPEAASTPRDPIDVDLPE EAERVKAQVQALGLAEAQPMAVVQSVPGAHPVPVYAFSIKGPSYGEDVSNTTTAQKRKCS QTQCPRKVIKMESEEGKEARLARSSPEQPRPSTSKAVSPPHLDGPPSPRSPVIGSEVFLP NSNHVASGAGEAEERVVVISSSEDSDAENSSSRELDDSSSESSDLQLEGPSTLRVLDENL ADPQAEDRPLVFFDLKIDNETQKISQLAAVNRESKFRVVIQPEAFFSIYSKAVSLEVGLQ HFLSFLSSMRRPILACYKLWGPGLPNFFRALEDINRLWEFQEAISGFLAALPLIRERVPG ASSFKLKNLAQTYLARNMSERSAMAAVLAMRDLCRLLEVSPGPQLAQHVYPFSSLQCFAS LQPLVQAAVLPRAEARLLALHNVSFMELLSAHRRDRQGGLKKYSRYLSLQTTTLPPAQPA FNLQALGTYFEGLLEGPALARAEGVSTPLAGRGLAERASQQS NT seq 2649 nt   +upstreamnt  +downstreamnt atggagcctgcacccgcccgatctccgaggccccagcaggaccccgcccggccccaggag cccaccatgcctccccccgagaccccctctgaaggccgccagcccagccccagccccagc cctacagagcgagcccccgcttcggaggaggagttccagtttctgcgctgccagcaatgc caggcggaagccaagtgcccgaagctgctgccttgtctgcacacgctgtgctcaggatgc ctggaggcgtcgggcatgcagtgccccatctgccaggcgccctggcccctaggtgcagac acacccgccctggataacgtctttttcgagagtctgcagcggcgcctgtcggtgtaccgg cagattgtggatgcgcaggctgtgtgcacccgctgcaaagagtcggccgacttctggtgc tttgagtgcgagcagctcctctgcgccaagtgcttcgaggcacaccagtggttcctcaag cacgaggcccggcccctagcagagctgcgcaaccagtcggtgcgtgagttcctggacggc acccgcaagaccaacaacatcttctgctccaaccccaaccaccgcacccctacgctgacc agcatctactgccgaggatgttccaagccgctgtgctgctcgtgcgcgctccttgacagc agccacagtgagctcaagtgcgacatcagcgcagagatccagcagcgacaggaggagctg gacgccatgacgcaggcgctgcaggagcaggatagtgcctttggcgcggttcacgcgcag atgcacgcggccgtcggccagctgggccgcgcgcgtgccgagaccgaggagctgatccgc gagcgcgtgcgccaggtggtagctcacgtgcgggctcaggagcgcgagctgctggaggct gtggacgcgcggtaccagcgcgactacgaggagatggccagtcggctgggccgcctggat gctgtgctgcagcgcatccgcacgggcagcgcgctggtgcagaggatgaagtgctacgcc tcggaccaggaggtgctggacatgcacggtttcctgcgccaggcgctctgccgcctgcgc caggaggagccccagagcctgcaagctgccgtgcgcaccgatggcttcgacgagttcaag gtgcgcctgcaggacctcagctcttgcatcacccaggggaaagatgcagctgtatccaag aaagccagcccagaggctgccagcactcccagggaccctattgacgttgacctgcccgag gaggcagagagagtgaaggcccaggttcaggccctggggctggctgaagcccagcctatg gctgtggtacagtcagtgcccggggcacaccccgtgccagtgtacgccttctccatcaaa ggcccttcctatggagaggatgtctccaatacaacgacagcccagaagaggaagtgcagc cagacccagtgccccaggaaggtcatcaagatggagtctgaggaggggaaggaggcaagg ttggctcggagctccccggagcagcccaggcccagcacctccaaggcagtctcaccaccc cacctggatggaccgcctagccccaggagccccgtcataggaagtgaggtcttcctgccc aacagcaaccacgtggccagtggcgccggggaggcagaggaacgcgttgtggtgatcagc agctcggaagactcagatgccgaaaactcgtcctcccgagagctggatgacagcagcagt gagtccagtgacctccagctggaaggccccagcaccctcagggtcctggacgagaacctt gctgacccccaagcagaagacagacctctggttttctttgacctcaagattgacaatgaa acccagaagattagccagctggctgcggtgaaccgggaaagcaagttccgcgtggtcatc cagcctgaagccttcttcagcatctactccaaggccgtgtccctggaggtggggctgcag cacttcctcagctttctgagctccatgcgccgccctatcttggcctgctacaagctgtgg gggcctggcctcccaaacttcttccgggccctggaggacattaacaggctgtgggaattc caggaggccatctcgggcttcctggctgccctgcctctcatccgggagcgtgtgcccggg gccagcagcttcaaactcaagaacctggcccagacctacctggcgagaaacatgagcgag cgcagcgccatggctgccgtgctggccatgcgtgacctgtgccgcctcctcgaggtctcc ccgggcccccagctggcccagcatgtctaccccttcagtagcctgcagtgctttgcctcc ctgcagcccctggtgcaggcagctgtgctgccccgggctgaggcccgcctcctggcccta cacaacgtgagcttcatggagctgctgagtgcacaccgccgtgaccggcaggggggcctg aagaagtacagccgctatctaagcctgcagaccaccacgttgccccctgcccagcctgct ttcaacctgcaggctctgggcacctactttgaaggcctgttggagggtccggcgctggca cgggcagaaggagtctccaccccacttgctggccgtggcttggcagagagggcctcccag cagagctga

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