Entry |
|
Gene name |
PML, MYL, PP8675, RNF71, TRIM19
|
Definition |
(RefSeq) promyelocytic leukemia
|
KO |
| probable transcription factor PML |
|
Organism |
|
Pathway |
| Ubiquitin mediated proteolysis | | Endocytosis | | Influenza A | | Herpes simplex infection | | Pathways in cancer | | Transcriptional misregulation in cancer | | Acute myeloid leukemia |
|
Network |
| PML-RARA fusion to transcriptional activtion | | PML-RARA fusion to transcriptional repression |
|
Disease |
| Acute myeloid leukemia (AML) |
|
Drug target |
|
Brite |
KEGG Orthology (KO) [BR:hsa00001]
Genetic Information Processing
Folding, sorting and degradation
04120 Ubiquitin mediated proteolysis
5371 (PML)
Cellular Processes
Transport and catabolism
04144 Endocytosis
5371 (PML)
Human Diseases
Cancers
05200 Pathways in cancer
5371 (PML)
05202 Transcriptional misregulation in cancers
5371 (PML)
05221 Acute myeloid leukemia
5371 (PML)
Infectious diseases
05164 Influenza A
5371 (PML)
05168 Herpes simplex infection
5371 (PML)
Ubiquitin system [BR:hsa04121]
Ubiquitin ligases (E3)
Single Ring-finger type E3
TRIM/RBCC proteins
5371 (PML)
 |
SSDB |
   |
Motif |
 |
Other DBs |
NCBI-GeneID: NCBI-ProteinID: OMIM: HGNC: Ensembl: Vega: Pharos: UniProt: |
LinkDB |
 |
Structure |
PDB: |
Position |
15q24.1
|
AA seq |
882 aa  
MEPAPARSPRPQQDPARPQEPTMPPPETPSEGRQPSPSPSPTERAPASEEEFQFLRCQQC
QAEAKCPKLLPCLHTLCSGCLEASGMQCPICQAPWPLGADTPALDNVFFESLQRRLSVYR
QIVDAQAVCTRCKESADFWCFECEQLLCAKCFEAHQWFLKHEARPLAELRNQSVREFLDG
TRKTNNIFCSNPNHRTPTLTSIYCRGCSKPLCCSCALLDSSHSELKCDISAEIQQRQEEL
DAMTQALQEQDSAFGAVHAQMHAAVGQLGRARAETEELIRERVRQVVAHVRAQERELLEA
VDARYQRDYEEMASRLGRLDAVLQRIRTGSALVQRMKCYASDQEVLDMHGFLRQALCRLR
QEEPQSLQAAVRTDGFDEFKVRLQDLSSCITQGKDAAVSKKASPEAASTPRDPIDVDLPE
EAERVKAQVQALGLAEAQPMAVVQSVPGAHPVPVYAFSIKGPSYGEDVSNTTTAQKRKCS
QTQCPRKVIKMESEEGKEARLARSSPEQPRPSTSKAVSPPHLDGPPSPRSPVIGSEVFLP
NSNHVASGAGEAEERVVVISSSEDSDAENSSSRELDDSSSESSDLQLEGPSTLRVLDENL
ADPQAEDRPLVFFDLKIDNETQKISQLAAVNRESKFRVVIQPEAFFSIYSKAVSLEVGLQ
HFLSFLSSMRRPILACYKLWGPGLPNFFRALEDINRLWEFQEAISGFLAALPLIRERVPG
ASSFKLKNLAQTYLARNMSERSAMAAVLAMRDLCRLLEVSPGPQLAQHVYPFSSLQCFAS
LQPLVQAAVLPRAEARLLALHNVSFMELLSAHRRDRQGGLKKYSRYLSLQTTTLPPAQPA
FNLQALGTYFEGLLEGPALARAEGVSTPLAGRGLAERASQQS |
NT seq |
2649 nt  +upstreamnt +downstreamnt
atggagcctgcacccgcccgatctccgaggccccagcaggaccccgcccggccccaggag
cccaccatgcctccccccgagaccccctctgaaggccgccagcccagccccagccccagc
cctacagagcgagcccccgcttcggaggaggagttccagtttctgcgctgccagcaatgc
caggcggaagccaagtgcccgaagctgctgccttgtctgcacacgctgtgctcaggatgc
ctggaggcgtcgggcatgcagtgccccatctgccaggcgccctggcccctaggtgcagac
acacccgccctggataacgtctttttcgagagtctgcagcggcgcctgtcggtgtaccgg
cagattgtggatgcgcaggctgtgtgcacccgctgcaaagagtcggccgacttctggtgc
tttgagtgcgagcagctcctctgcgccaagtgcttcgaggcacaccagtggttcctcaag
cacgaggcccggcccctagcagagctgcgcaaccagtcggtgcgtgagttcctggacggc
acccgcaagaccaacaacatcttctgctccaaccccaaccaccgcacccctacgctgacc
agcatctactgccgaggatgttccaagccgctgtgctgctcgtgcgcgctccttgacagc
agccacagtgagctcaagtgcgacatcagcgcagagatccagcagcgacaggaggagctg
gacgccatgacgcaggcgctgcaggagcaggatagtgcctttggcgcggttcacgcgcag
atgcacgcggccgtcggccagctgggccgcgcgcgtgccgagaccgaggagctgatccgc
gagcgcgtgcgccaggtggtagctcacgtgcgggctcaggagcgcgagctgctggaggct
gtggacgcgcggtaccagcgcgactacgaggagatggccagtcggctgggccgcctggat
gctgtgctgcagcgcatccgcacgggcagcgcgctggtgcagaggatgaagtgctacgcc
tcggaccaggaggtgctggacatgcacggtttcctgcgccaggcgctctgccgcctgcgc
caggaggagccccagagcctgcaagctgccgtgcgcaccgatggcttcgacgagttcaag
gtgcgcctgcaggacctcagctcttgcatcacccaggggaaagatgcagctgtatccaag
aaagccagcccagaggctgccagcactcccagggaccctattgacgttgacctgcccgag
gaggcagagagagtgaaggcccaggttcaggccctggggctggctgaagcccagcctatg
gctgtggtacagtcagtgcccggggcacaccccgtgccagtgtacgccttctccatcaaa
ggcccttcctatggagaggatgtctccaatacaacgacagcccagaagaggaagtgcagc
cagacccagtgccccaggaaggtcatcaagatggagtctgaggaggggaaggaggcaagg
ttggctcggagctccccggagcagcccaggcccagcacctccaaggcagtctcaccaccc
cacctggatggaccgcctagccccaggagccccgtcataggaagtgaggtcttcctgccc
aacagcaaccacgtggccagtggcgccggggaggcagaggaacgcgttgtggtgatcagc
agctcggaagactcagatgccgaaaactcgtcctcccgagagctggatgacagcagcagt
gagtccagtgacctccagctggaaggccccagcaccctcagggtcctggacgagaacctt
gctgacccccaagcagaagacagacctctggttttctttgacctcaagattgacaatgaa
acccagaagattagccagctggctgcggtgaaccgggaaagcaagttccgcgtggtcatc
cagcctgaagccttcttcagcatctactccaaggccgtgtccctggaggtggggctgcag
cacttcctcagctttctgagctccatgcgccgccctatcttggcctgctacaagctgtgg
gggcctggcctcccaaacttcttccgggccctggaggacattaacaggctgtgggaattc
caggaggccatctcgggcttcctggctgccctgcctctcatccgggagcgtgtgcccggg
gccagcagcttcaaactcaagaacctggcccagacctacctggcgagaaacatgagcgag
cgcagcgccatggctgccgtgctggccatgcgtgacctgtgccgcctcctcgaggtctcc
ccgggcccccagctggcccagcatgtctaccccttcagtagcctgcagtgctttgcctcc
ctgcagcccctggtgcaggcagctgtgctgccccgggctgaggcccgcctcctggcccta
cacaacgtgagcttcatggagctgctgagtgcacaccgccgtgaccggcaggggggcctg
aagaagtacagccgctatctaagcctgcagaccaccacgttgccccctgcccagcctgct
ttcaacctgcaggctctgggcacctactttgaaggcctgttggagggtccggcgctggca
cgggcagaaggagtctccaccccacttgctggccgtggcttggcagagagggcctcccag
cagagctga |