KEGG H.sapiens: 5468

Homo sapiens (human): 5468

Entry

5468 CDS H.sapiens

Gene name PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma

Definition peroxisome proliferator-activated receptor gamma

Orthology K08530 peroxisome proliferator-activated receptor gamma

Pathway hsa03320 PPAR signaling pathway
hsa05016 Huntington's disease
hsa05200 Pathways in cancer
hsa05216 Thyroid cancer

Disease H00032 Thyroid cancer
H00409 Type II diabetes mellitus
H00420 Familial partial lipodystrophy (FPL)

Class Organismal Systems; Endocrine System; PPAR signaling pathway
[PATH:hsa03320]
Human Diseases; Cancers; Pathways in cancer [PATH:hsa05200]
Human Diseases; Cancers; Thyroid cancer [PATH:hsa05216]
Human Diseases; Neurodegenerative Diseases; Huntington's disease
[PATH:hsa05016]

SSDB

Motif Pfam: zf-C4 Hormone_recep PPARgamma_N
PROSITE: NUCLEAR_REC_DBD_1 NUCLEAR_REC_DBD_2

Other DBs NCBI-GI: 116284368
NCBI-GeneID: 5468
OMIM: 601487
HGNC: 9236
HPRD: 03288
Ensembl: ENSG00000132170
UniProt: P37231

Structure

PDB: 1ZGY 3LMP 2ZVT 3ET3 2HWQ 2FVJ 2HFP 3FEJ
     2VSR 2Q5S 2F4B 3KMG 3HOD 3H0A 2I4J 2I4P
     2GTK 1FM6 1FM9 2Q61 2Q59 1PRG 2P4Y 2I4Z
     2ZK2 3BC5 2ATH 3GBK 3G9E 3FUR 3CS8 2Q8S
     2Q5P 2POB 2G0H 1K74 2PRG 3IA6 2HWR 2VV4
     2VST 1I7I 2ZK0 3ET0 3D6D 2ZNO 3CWD 2Q6S
     1RDT 2ZK6 2Q6R 2ZK5 1ZEO 1KNU 2G0G 3K8S
     2VV0 2ZK4 2ZK3 3HO0 3B3K 2ZK1 3CDS 1NYX
     2VV2 3CDP 2OM9 2VV3 1WM0 4PRG 3PRG 3DZY
     3E00 3DZU 2VV1 2QMV

Position 3p25

AA seq 477 aa
MTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDP
VVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASG
FHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAI
RFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGK
TTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYA
KSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPF
GDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQ
LKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY

NT seq 1434 nt +upstreamnt +downstreamnt
atgaccatggttgacacagagatgccattctggcccaccaactttgggatcagctccgtg
gatctctccgtaatggaagaccactcccactcctttgatatcaagcccttcactactgtt
gacttctccagcatttctactccacattacgaagacattccattcacaagaacagatcca
gtggttgcagattacaagtatgacctgaaacttcaagagtaccaaagtgcaatcaaagtg
gagcctgcatctccaccttattattctgagaagactcagctctacaataagcctcatgaa
gagccttccaactccctcatggcaattgaatgtcgtgtctgtggagataaagcttctgga
tttcactatggagttcatgcttgtgaaggatgcaagggtttcttccggagaacaatcaga
ttgaagcttatctatgacagatgtgatcttaactgtcggatccacaaaaaaagtagaaat
aaatgtcagtactgtcggtttcagaaatgccttgcagtggggatgtctcataatgccatc
aggtttgggcggatgccacaggccgagaaggagaagctgttggcggagatctccagtgat
atcgaccagctgaatccagagtccgctgacctccgggccctggcaaaacatttgtatgac
tcatacataaagtccttcccgctgaccaaagcaaaggcgagggcgatcttgacaggaaag
acaacagacaaatcaccattcgttatctatgacatgaattccttaatgatgggagaagat
aaaatcaagttcaaacacatcacccccctgcaggagcagagcaaagaggtggccatccgc
atctttcagggctgccagtttcgctccgtggaggctgtgcaggagatcacagagtatgcc
aaaagcattcctggttttgtaaatcttgacttgaacgaccaagtaactctcctcaaatat
ggagtccacgagatcatttacacaatgctggcctccttgatgaataaagatggggttctc
atatccgagggccaaggcttcatgacaagggagtttctaaagagcctgcgaaagcctttt
ggtgactttatggagcccaagtttgagtttgctgtgaagttcaatgcactggaattagat
gacagcgacttggcaatatttattgctgtcattattctcagtggagaccgcccaggtttg
ctgaatgtgaagcccattgaagacattcaagacaacctgctacaagccctggagctccag
ctgaagctgaaccaccctgagtcctcacagctgtttgccaagctgctccagaaaatgaca
gacctcagacagattgtcacggaacacgtgcagctactgcaggtgatcaagaagacggag
acagacatgagtcttcacccgctcctgcaggagatctacaaggacttgtactag

All links

Pathway (4)   
   KEGG PATHWAY (4)   
Disease (10)   
   KEGG DISEASE (3)   
   OMIM (7)   
Drug (11)   
   KEGG DRUG (11)   
Genome (1)   
   KEGG GENOME (1)   
Gene (13)   
   KEGG ORTHOLOGY (1)   
   NCBI-Gene (1)   
   NCBI-GI (7)   
   UniGene (1)   
   HGNC (1)   
   HPRD (1)   
   ENSEMBL-HSA (1)   
Protein sequence (17)   
   UniProt (1)   
   RefSeq(pep) (4)   
   IPI (12)   
DNA sequence (22)   
   RefSeq(nuc) (4)   
   GenBank (9)   
   EMBL (9)   
3D Structure (76)   
   PDB (76)   
Protein domain (5)   
   Pfam (3)   
   PROSITE (2)   
All databases (159)

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