KEGG   Homo sapiens (human): 5604Help
Entry
5604              CDS       T01001                                 

Gene name
MAP2K1, CFC3, MAPKK1, MEK1, MKK1, PRKMK1
Definition
mitogen-activated protein kinase kinase 1 (EC:2.7.12.2)
Orthology
K04368  
mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
hsa  Homo sapiens (human)
Pathway
MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Oocyte meiosis
PI3K-Akt signaling pathway
Vascular smooth muscle contraction
Dorso-ventral axis formation
VEGF signaling pathway
Osteoclast differentiation
Focal adhesion
Gap junction
Signaling pathways regulating pluripotency of stem cells
Toll-like receptor signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Long-term potentiation
Neurotrophin signaling pathway
Cholinergic synapse
Serotonergic synapse
Long-term depression
Regulation of actin cytoskeleton
Insulin signaling pathway
GnRH signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Melanogenesis
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Prion diseases
Alcoholism
Hepatitis B
Influenza A
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Thyroid cancer
Melanoma
Bladder cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
Disease
H00523  
Noonan syndrome and related disorders
Drug target
Trametinib: 
Other: 
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    5604 (MAP2K1)
   04015 Rap1 signaling pathway
    5604 (MAP2K1)
   04010 MAPK signaling pathway
    5604 (MAP2K1)
   04012 ErbB signaling pathway
    5604 (MAP2K1)
   04370 VEGF signaling pathway
    5604 (MAP2K1)
   04668 TNF signaling pathway
    5604 (MAP2K1)
   04066 HIF-1 signaling pathway
    5604 (MAP2K1)
   04068 FoxO signaling pathway
    5604 (MAP2K1)
   04024 cAMP signaling pathway
    5604 (MAP2K1)
   04022 cGMP - PKG signaling pathway
    5604 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    5604 (MAP2K1)
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    5604 (MAP2K1)
  Cell growth and death
   04114 Oocyte meiosis
    5604 (MAP2K1)
  Cellular commiunity
   04510 Focal adhesion
    5604 (MAP2K1)
   04540 Gap junction
    5604 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    5604 (MAP2K1)
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    5604 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    5604 (MAP2K1)
   04660 T cell receptor signaling pathway
    5604 (MAP2K1)
   04662 B cell receptor signaling pathway
    5604 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    5604 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    5604 (MAP2K1)
   04062 Chemokine signaling pathway
    5604 (MAP2K1)
  Endocrine system
   04910 Insulin signaling pathway
    5604 (MAP2K1)
   04912 GnRH signaling pathway
    5604 (MAP2K1)
   04915 Estrogen signaling pathway
    5604 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    5604 (MAP2K1)
   04917 Prolactin signaling pathway
    5604 (MAP2K1)
   04921 Oxytocin signaling pathway
    5604 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    5604 (MAP2K1)
   04916 Melanogenesis
    5604 (MAP2K1)
  Circulatory system
   04270 Vascular smooth muscle contraction
    5604 (MAP2K1)
  Nervous system
   04725 Cholinergic synapse
    5604 (MAP2K1)
   04726 Serotonergic synapse
    5604 (MAP2K1)
   04720 Long-term potentiation
    5604 (MAP2K1)
   04730 Long-term depression
    5604 (MAP2K1)
   04722 Neurotrophin signaling pathway
    5604 (MAP2K1)
  Development
   04320 Dorso-ventral axis formation
    5604 (MAP2K1)
   04380 Osteoclast differentiation
    5604 (MAP2K1)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    5604 (MAP2K1)
   05206 MicroRNAs in cancer
    5604 (MAP2K1)
   05205 Proteoglycans in cancer
    5604 (MAP2K1)
   05210 Colorectal cancer
    5604 (MAP2K1)
   05212 Pancreatic cancer
    5604 (MAP2K1)
   05214 Glioma
    5604 (MAP2K1)
   05216 Thyroid cancer
    5604 (MAP2K1)
   05221 Acute myeloid leukemia
    5604 (MAP2K1)
   05220 Chronic myeloid leukemia
    5604 (MAP2K1)
   05218 Melanoma
    5604 (MAP2K1)
   05211 Renal cell carcinoma
    5604 (MAP2K1)
   05219 Bladder cancer
    5604 (MAP2K1)
   05215 Prostate cancer
    5604 (MAP2K1)
   05213 Endometrial cancer
    5604 (MAP2K1)
   05223 Non-small cell lung cancer
    5604 (MAP2K1)
  Neurodegenerative diseases
   05020 Prion diseases
    5604 (MAP2K1)
  Substance dependence
   05034 Alcoholism
    5604 (MAP2K1)
  Infectious diseases
   05164 Influenza A
    5604 (MAP2K1)
   05161 Hepatitis B
    5604 (MAP2K1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     5604 (MAP2K1)
Protein kinases [BR:hsa01001]
 Serine/threonine protein kinases: STE group
  STE7 family
   5604 (MAP2K1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GI: 
NCBI-GeneID: 
OMIM: 
HGNC: 
HPRD: 
UniProt: 
LinkDB All DBs
Structure
PDB: 

Jmol
Position
15q22.1-q22.33
AA seq 393 aa AA seqDB search
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
NT seq 1182 nt NT seq  +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagctgaacccggcccccgacggctctgcagtt
aacgggaccagctctgcggagaccaacttggaggccttgcagaagaagctggaggagcta
gagcttgatgagcagcagcgaaagcgccttgaggcctttcttacccagaagcagaaggtg
ggagaactgaaggatgacgactttgagaagatcagtgagctgggggctggcaatggcggt
gtggtgttcaaggtctcccacaagccttctggcctggtcatggccagaaagctaattcat
ctggagatcaaacccgcaatccggaaccagatcataagggagctgcaggttctgcatgag
tgcaactctccgtacatcgtgggcttctatggtgcgttctacagcgatggcgagatcagt
atctgcatggagcacatggatggaggttctctggatcaagtcctgaagaaagctggaaga
attcctgaacaaattttaggaaaagttagcattgctgtaataaaaggcctgacatatctg
agggagaagcacaagatcatgcacagagatgtcaagccctccaacatcctagtcaactcc
cgtggggagatcaagctctgtgactttggggtcagcgggcagctcatcgactccatggcc
aactccttcgtgggcacaaggtcctacatgtcgccagaaagactccaggggactcattac
tctgtgcagtcagacatctggagcatgggactgtctctggtagagatggcggttgggagg
tatcccatccctcctccagatgccaaggagctggagctgatgtttgggtgccaggtggaa
ggagatgcggctgagaccccacccaggccaaggacccccgggaggccccttagctcatac
ggaatggacagccgacctcccatggcaatttttgagttgttggattacatagtcaacgag
cctcctccaaaactgcccagtggagtgttcagtctggaatttcaagattttgtgaataaa
tgcttaataaaaaaccccgcagagagagcagatttgaagcaactcatggttcatgctttt
atcaagagatctgatgctgaggaagtggattttgcaggttggctctgctccaccatcggc
cttaaccagcccagcacaccaacccatgctgctggcgtctaa

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