KEGG   Homo sapiens (human): 5604Help
Entry
5604              CDS       T01001                                 

Gene name
MAP2K1, CFC3, MAPKK1, MEK1, MKK1, PRKMK1
Definition
(RefSeq) mitogen-activated protein kinase kinase 1
  KO
K04368  
mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
Organism
hsa  Homo sapiens (human)
Pathway
EGFR tyrosine kinase inhibitor resistance
Endocrine resistance
MAPK signaling pathway
ErbB signaling pathway
Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
Sphingolipid signaling pathway
Phospholipase D signaling pathway
Oocyte meiosis
Autophagy - animal
mTOR signaling pathway
PI3K-Akt signaling pathway
Apoptosis
Cellular senescence
Vascular smooth muscle contraction
VEGF signaling pathway
Apelin signaling pathway
Osteoclast differentiation
Focal adhesion
Gap junction
Signaling pathways regulating pluripotency of stem cells
Toll-like receptor signaling pathway
Natural killer cell mediated cytotoxicity
T cell receptor signaling pathway
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
TNF signaling pathway
Long-term potentiation
Neurotrophin signaling pathway
Cholinergic synapse
Serotonergic synapse
Long-term depression
Regulation of actin cytoskeleton
Insulin signaling pathway
GnRH signaling pathway
Progesterone-mediated oocyte maturation
Estrogen signaling pathway
Melanogenesis
Prolactin signaling pathway
Thyroid hormone signaling pathway
Oxytocin signaling pathway
Relaxin signaling pathway
Prion diseases
Alcoholism
Hepatitis B
Influenza A
Human papillomavirus infection
Kaposi's sarcoma-associated herpesvirus infection
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Thyroid cancer
Melanoma
Bladder cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
Breast cancer
Hepatocellular carcinoma
Gastric cancer
Central carbon metabolism in cancer
Choline metabolism in cancer
Module
MAPK (ERK1/2) signaling
Network
N00001  
EGF-EGFR-RAS-ERK signaling pathway
N00002  
BCR-ABL fusion kinase to RAS-ERK signaling pathway
N00003  
Mutation-activated KIT to RAS-ERK signaling pathway
N00004  
Duplication-activated FLT3 to RAS-ERK signaling pathway
N00005  
Mutation-activated MET to RAS-ERK signaling pathway
N00006  
Amplified EGFR to RAS-ERK signaling pathway
N00007  
EML4-ALK fusion kinase to RAS-ERK signaling pathway
N00008  
RET-PTC fusion kinase to RAS-ERK signaling pathway
N00009  
TRK fusion kinase to RAS-ERK signaling pathway
N00011  
Mutation-activated FGFR3 to RAS-ERK signaling pathway
N00012  
Mutation-activated KRAS/NRAS to ERK signaling pathway
N00013  
Mutation-activated BRAF to ERK signaling pathway
N00014  
Mutation-activated EGFR to RAS-ERK signaling pathway
N00015  
PDGF-PDGFR-RAS-ERK signaling pathway
N00016  
PDGF-overexpression to RAS-ERK signaling pathway
N00018  
Amplified PDGFR to RAS-ERK signaling pathway
N00019  
FGF-FGFR-RAS-ERK signaling pathway
N00020  
Amplified FGFR to RAS-ERK signaling pathway
N00021  
EGF-ERBB2-RAS-ERK signaling pathway
N00022  
ERBB2-overexpression to RAS-ERK signaling pathway
N00023  
EGF-EGFR-PLCG-ERK signaling pathway
N00024  
Mutation-activated EGFR to PLCG-ERK signaling pathway
N00025  
EML4-ALK fusion kinase to PLCG-ERK signaling pathway
N00041  
EGFR-overexpression to RAS-ERK signaling pathway
N00077  
HRAS-overexpression to RAS-ERK signaling pathway
N00078  
Mutation-activated HRAS to RAS-ERK signaling pathway
N00152  
CXCR-GNB/G-ERK signaling pathway
N00157  
KSHV vGPCR to GNB/G-ERK signaling pathway
N00160  
KSHV K1 to RAS-ERK signaling pathway
N00215  
KITLG-KIT-RAS-ERK signaling pathway
N00216  
HGF-MET-RAS-ERK signaling pathway
N00217  
FLT3LG-FLT3-RAS-ERK signaling pathway
N00229  
TGFA-EGFR-RAS-ERK signaling pathway
N00230  
TGFA-overexpression to RAS-ERK signaling pathway
N00233  
IGF2-IGF1R-RAS-ERK signaling pathway
N00235  
IGF2-overexpression to RAS-ERK signaling pathway
N00237  
IGF1R-overexpression to RAS-ERK signaling pathway
N00246  
HGF-overexpression to RAS-ERK signaling pathway
N00248  
MET-overexpression to RAS-ERK signaling pathway
N00252  
Amplified ERBB2 to RAS-ERK signaling pathway
N00259  
Amplified MET to RAS-ERK signaling pathway
Disease
H00523  
Noonan syndrome and related disorders
H01512  
Langerhans cell histiocytosis
Drug target
Binimetinib: 
Cobimetinib (DG01825): 
Pimasertib (DG01410): 
Selumetinib (DG01414): 
Trametinib (DG00723): 
Brite
KEGG Orthology (KO) [BR:hsa00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    5604 (MAP2K1)
   04015 Rap1 signaling pathway
    5604 (MAP2K1)
   04010 MAPK signaling pathway
    5604 (MAP2K1)
   04012 ErbB signaling pathway
    5604 (MAP2K1)
   04370 VEGF signaling pathway
    5604 (MAP2K1)
   04371 Apelin signaling pathway
    5604 (MAP2K1)
   04668 TNF signaling pathway
    5604 (MAP2K1)
   04066 HIF-1 signaling pathway
    5604 (MAP2K1)
   04068 FoxO signaling pathway
    5604 (MAP2K1)
   04072 Phospholipase D signaling pathway
    5604 (MAP2K1)
   04071 Sphingolipid signaling pathway
    5604 (MAP2K1)
   04024 cAMP signaling pathway
    5604 (MAP2K1)
   04022 cGMP - PKG signaling pathway
    5604 (MAP2K1)
   04151 PI3K-Akt signaling pathway
    5604 (MAP2K1)
   04150 mTOR signaling pathway
    5604 (MAP2K1)
 Cellular Processes
  Transport and catabolism
   04140 Autophagy - animal
    5604 (MAP2K1)
  Cell growth and death
   04114 Oocyte meiosis
    5604 (MAP2K1)
   04210 Apoptosis
    5604 (MAP2K1)
   04218 Cellular senescence
    5604 (MAP2K1)
  Cellular community - eukaryotes
   04510 Focal adhesion
    5604 (MAP2K1)
   04540 Gap junction
    5604 (MAP2K1)
   04550 Signaling pathways regulating pluripotency of stem cells
    5604 (MAP2K1)
  Cell motility
   04810 Regulation of actin cytoskeleton
    5604 (MAP2K1)
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    5604 (MAP2K1)
   04650 Natural killer cell mediated cytotoxicity
    5604 (MAP2K1)
   04660 T cell receptor signaling pathway
    5604 (MAP2K1)
   04662 B cell receptor signaling pathway
    5604 (MAP2K1)
   04664 Fc epsilon RI signaling pathway
    5604 (MAP2K1)
   04666 Fc gamma R-mediated phagocytosis
    5604 (MAP2K1)
   04062 Chemokine signaling pathway
    5604 (MAP2K1)
  Endocrine system
   04910 Insulin signaling pathway
    5604 (MAP2K1)
   04912 GnRH signaling pathway
    5604 (MAP2K1)
   04915 Estrogen signaling pathway
    5604 (MAP2K1)
   04914 Progesterone-mediated oocyte maturation
    5604 (MAP2K1)
   04917 Prolactin signaling pathway
    5604 (MAP2K1)
   04921 Oxytocin signaling pathway
    5604 (MAP2K1)
   04926 Relaxin signaling pathway
    5604 (MAP2K1)
   04919 Thyroid hormone signaling pathway
    5604 (MAP2K1)
   04916 Melanogenesis
    5604 (MAP2K1)
  Circulatory system
   04270 Vascular smooth muscle contraction
    5604 (MAP2K1)
  Nervous system
   04725 Cholinergic synapse
    5604 (MAP2K1)
   04726 Serotonergic synapse
    5604 (MAP2K1)
   04720 Long-term potentiation
    5604 (MAP2K1)
   04730 Long-term depression
    5604 (MAP2K1)
   04722 Neurotrophin signaling pathway
    5604 (MAP2K1)
  Development
   04380 Osteoclast differentiation
    5604 (MAP2K1)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    5604 (MAP2K1)
   05230 Central carbon metabolism in cancer
    5604 (MAP2K1)
   05231 Choline metabolism in cancer
    5604 (MAP2K1)
   05206 MicroRNAs in cancer
    5604 (MAP2K1)
   05205 Proteoglycans in cancer
    5604 (MAP2K1)
   05210 Colorectal cancer
    5604 (MAP2K1)
   05212 Pancreatic cancer
    5604 (MAP2K1)
   05225 Hepatocellular carcinoma
    5604 (MAP2K1)
   05226 Gastric cancer
    5604 (MAP2K1)
   05214 Glioma
    5604 (MAP2K1)
   05216 Thyroid cancer
    5604 (MAP2K1)
   05221 Acute myeloid leukemia
    5604 (MAP2K1)
   05220 Chronic myeloid leukemia
    5604 (MAP2K1)
   05218 Melanoma
    5604 (MAP2K1)
   05211 Renal cell carcinoma
    5604 (MAP2K1)
   05219 Bladder cancer
    5604 (MAP2K1)
   05215 Prostate cancer
    5604 (MAP2K1)
   05213 Endometrial cancer
    5604 (MAP2K1)
   05224 Breast cancer
    5604 (MAP2K1)
   05223 Non-small cell lung cancer
    5604 (MAP2K1)
  Neurodegenerative diseases
   05020 Prion diseases
    5604 (MAP2K1)
  Substance dependence
   05034 Alcoholism
    5604 (MAP2K1)
  Infectious diseases
   05164 Influenza A
    5604 (MAP2K1)
   05161 Hepatitis B
    5604 (MAP2K1)
   05167 Kaposi's sarcoma-associated herpesvirus infection
    5604 (MAP2K1)
   05165 Human papillomavirus infection
    5604 (MAP2K1)
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    5604 (MAP2K1)
   01522 Endocrine resistance
    5604 (MAP2K1)
Enzymes [BR:hsa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.12  Dual-specificity kinases (those acting on Ser/Thr and Tyr residues)
    2.7.12.2  mitogen-activated protein kinase kinase
     5604 (MAP2K1)
Protein kinases [BR:hsa01001]
 Serine/threonine protein kinases: STE group
  STE7 family
   5604 (MAP2K1)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GeneID: 
NCBI-ProteinID: 
OMIM: 
HGNC: 
Ensembl: 
Vega: 
Pharos: 
Q02750(Tclin)
UniProt: 
LinkDB All DBs
Structure
PDB: 

Jmol
Position
15q22.31
AA seq 393 aa AA seqDB search
MPKKKPTPIQLNPAPDGSAVNGTSSAETNLEALQKKLEELELDEQQRKRLEAFLTQKQKV
GELKDDDFEKISELGAGNGGVVFKVSHKPSGLVMARKLIHLEIKPAIRNQIIRELQVLHE
CNSPYIVGFYGAFYSDGEISICMEHMDGGSLDQVLKKAGRIPEQILGKVSIAVIKGLTYL
REKHKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQGTHY
SVQSDIWSMGLSLVEMAVGRYPIPPPDAKELELMFGCQVEGDAAETPPRPRTPGRPLSSY
GMDSRPPMAIFELLDYIVNEPPPKLPSGVFSLEFQDFVNKCLIKNPAERADLKQLMVHAF
IKRSDAEEVDFAGWLCSTIGLNQPSTPTHAAGV
NT seq 1182 nt NT seq  +upstreamnt  +downstreamnt
atgcccaagaagaagccgacgcccatccagctgaacccggcccccgacggctctgcagtt
aacgggaccagctctgcggagaccaacttggaggccttgcagaagaagctggaggagcta
gagcttgatgagcagcagcgaaagcgccttgaggcctttcttacccagaagcagaaggtg
ggagaactgaaggatgacgactttgagaagatcagtgagctgggggctggcaatggcggt
gtggtgttcaaggtctcccacaagccttctggcctggtcatggccagaaagctaattcat
ctggagatcaaacccgcaatccggaaccagatcataagggagctgcaggttctgcatgag
tgcaactctccgtacatcgtgggcttctatggtgcgttctacagcgatggcgagatcagt
atctgcatggagcacatggatggaggttctctggatcaagtcctgaagaaagctggaaga
attcctgaacaaattttaggaaaagttagcattgctgtaataaaaggcctgacatatctg
agggagaagcacaagatcatgcacagagatgtcaagccctccaacatcctagtcaactcc
cgtggggagatcaagctctgtgactttggggtcagcgggcagctcatcgactccatggcc
aactccttcgtgggcacaaggtcctacatgtcgccagaaagactccaggggactcattac
tctgtgcagtcagacatctggagcatgggactgtctctggtagagatggcggttgggagg
tatcccatccctcctccagatgccaaggagctggagctgatgtttgggtgccaggtggaa
ggagatgcggctgagaccccacccaggccaaggacccccgggaggccccttagctcatac
ggaatggacagccgacctcccatggcaatttttgagttgttggattacatagtcaacgag
cctcctccaaaactgcccagtggagtgttcagtctggaatttcaagattttgtgaataaa
tgcttaataaaaaaccccgcagagagagcagatttgaagcaactcatggttcatgctttt
atcaagagatctgatgctgaggaagtggattttgcaggttggctctgctccaccatcggc
cttaaccagcccagcacaccaacccatgctgctggcgtctaa

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