| Entry |
|
|---|
| Gene name |
HPSE2, HPA2, HPR2, UFS, UFS1
|
|---|
| Definition |
heparanase 2 (inactive)
|
|---|
| Orthology |
| heparanase 2 [EC:3.2.1.-] |
|
|---|
| Organism |
|
|---|
| Pathway |
| Glycosaminoglycan degradation | | Metabolic pathways | | Proteoglycans in cancer |
|
|---|
| Module |
| Heparan sulfate degradation |
|
|---|
| Disease |
|
|---|
| Brite |
KEGG Orthology (KO) [BR:hsa00001]
Metabolism
Glycan biosynthesis and metabolism
00531 Glycosaminoglycan degradation
60495 (HPSE2)
Human Diseases
Cancers
05205 Proteoglycans in cancer
60495 (HPSE2)
Enzymes [BR:hsa01000]
3. Hydrolases
3.2 Glycosylases
3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
3.2.1.-
60495 (HPSE2)
Glycosaminoglycan binding proteins [BR:hsa00536]
Heparan sulfate/Haparin
Enzymes (General comment) Variety
60495 (HPSE2)
 |
|---|
| SSDB |
   |
|---|
| Motif |
 |
|---|
| Other DBs |
NCBI-GI: NCBI-GeneID: OMIM: HGNC: HPRD: UniProt: |
|---|
| LinkDB |
 |
|---|
| Position |
10q23-q24
|
|---|
| AA seq |
534 aa  
MRVLCAFPEAMPSSNSRPPACLAPGALYLALLLHLSLSSQAGDRRPLPVDRAAGLKEKTL
ILLDVSTKNPVRTVNENFLSLQLDPSIIHDGWLDFLSSKRLVTLARGLSPAFLRFGGKRT
DFLQFQNLRNPAKSRGGPGPDYYLKNYEDDIVRSDVALDKQKGCKIAQHPDVMLELQREK
AAQMHLVLLKEQFSNTYSNLILTEPNNYRTMHGRAVNGSQLGKDYIQLKSLLQPIRIYSR
ASLYGPNIGRPRKNVIALLDGFMKVAGSTVDAVTWQHCYIDGRVVKVMDFLKTRLLDTLS
DQIRKIQKVVNTYTPGKKIWLEGVVTTSAGGTNNLSDSYAAGFLWLNTLGMLANQGIDVV
IRHSFFDHGYNHLVDQNFNPLPDYWLSLLYKRLIGPKVLAVHVAGLQRKPRPGRVIRDKL
RIYAHCTNHHNHNYVRGSITLFIINLHRSRKKIKLAGTLRDKLVHQYLLQPYGQEGLKSK
SVQLNGQPLVMVDDGTLPELKPRPLRAGRTLVIPPVTMGFYVVKNVNALACRYR |
|---|
| NT seq |
1605 nt  +upstreamnt +downstreamnt
atgagggtgctttgtgccttccctgaagccatgccctccagcaactcccgcccccccgcg
tgcctagccccgggggctctctacttggctctgttgctccatctctccctttcctcccag
gctggagacaggagacccttgcctgtagacagagctgcaggtttgaaggaaaagaccctg
attctacttgatgtgagcaccaagaacccagtcaggacagtcaatgagaacttcctctct
ctgcagctggatccgtccatcattcatgatggctggctcgatttcctaagctccaagcgc
ttggtgaccctggcccggggactttcgcccgcctttctgcgcttcgggggcaaaaggacc
gacttcctgcagttccagaacctgaggaacccggcgaaaagccgcgggggcccgggcccg
gattactatctcaaaaactatgaggatgacattgttcgaagtgatgttgccttagataaa
cagaaaggctgcaagattgcccagcaccctgatgttatgctggagctccaaagggagaag
gcagctcagatgcatctggttcttctaaaggagcaattctccaatacttacagtaatctc
atattaacagagccaaataactatcggaccatgcatggccgggcagtaaatggcagccag
ttgggaaaggattacatccagctgaagagcctgttgcagcccatccggatttattccaga
gccagcttatatggccctaatattgggcggccgaggaagaatgtcatcgccctcctagat
ggattcatgaaggtggcaggaagtacagtagatgcagttacctggcaacattgctacatt
gatggccgggtggtcaaggtgatggacttcctgaaaactcgcctgttagacacactctct
gaccagattaggaaaattcagaaagtggttaatacatacactccaggaaagaagatttgg
cttgaaggtgtggtgaccacctcagctggaggcacaaacaatctatccgattcctatgct
gcaggattcttatggttgaacactttaggaatgctggccaatcagggcattgatgtcgtg
atacggcactcattttttgaccatggatacaatcacctcgtggaccagaattttaaccca
ttaccagactactggctctctctcctctacaagcgcctgatcggccccaaagtcttggct
gtgcatgtggctgggctccagcggaagccacggcctggccgagtgatccgggacaaacta
aggatttatgctcactgcacaaaccaccacaaccacaactacgttcgtgggtccattaca
ctttttatcatcaacttgcatcgatcaagaaagaaaatcaagctggctgggactctcaga
gacaagctggttcaccagtacctgctgcagccctatgggcaggagggcctaaagtccaag
tcagtgcaactgaatggccagcccttagtgatggtggacgacgggaccctcccagaattg
aagccccgcccccttcgggccggccggacattggtcatccctccagtcaccatgggcttt
tatgtggtcaagaatgtcaatgctttggcctgccgctaccgataa |
|---|
