| Entry |
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| Gene name |
HPSE2, HPA2, HPR2, UFS, UFS1
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| Definition |
(RefSeq) heparanase 2 (inactive)
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| KO |
| heparanase 2 [EC:3.2.1.-] |
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| Organism |
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| Pathway |
| Glycosaminoglycan degradation | | Metabolic pathways | | Proteoglycans in cancer |
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| Module |
| Heparan sulfate degradation |
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| Disease |
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| Brite |
KEGG Orthology (KO) [BR:hsa00001]
Metabolism
Glycan biosynthesis and metabolism
00531 Glycosaminoglycan degradation
60495 (HPSE2)
Human Diseases
Cancers
05205 Proteoglycans in cancer
60495 (HPSE2)
Enzymes [BR:hsa01000]
3. Hydrolases
3.2 Glycosylases
3.2.1 Glycosidases, i.e. enzymes that hydrolyse O- and S-glycosyl compounds
3.2.1.-
60495 (HPSE2)
Glycosaminoglycan binding proteins [BR:hsa00536]
Heparan sulfate/Haparin
Enzymes (General comment) Variety
60495 (HPSE2)
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| SSDB |
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| Motif |
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| Other DBs |
NCBI-GeneID: NCBI-ProteinID: OMIM: HGNC: Ensembl: Vega: Pharos: UniProt: |
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| LinkDB |
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| Position |
10q24.2
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| AA seq |
592 aa  
MRVLCAFPEAMPSSNSRPPACLAPGALYLALLLHLSLSSQAGDRRPLPVDRAAGLKEKTL
ILLDVSTKNPVRTVNENFLSLQLDPSIIHDGWLDFLSSKRLVTLARGLSPAFLRFGGKRT
DFLQFQNLRNPAKSRGGPGPDYYLKNYEDDIVRSDVALDKQKGCKIAQHPDVMLELQREK
AAQMHLVLLKEQFSNTYSNLILTARSLDKLYNFADCSGLHLIFALNALRRNPNNSWNSSS
ALSLLKYSASKKYNISWELGNEPNNYRTMHGRAVNGSQLGKDYIQLKSLLQPIRIYSRAS
LYGPNIGRPRKNVIALLDGFMKVAGSTVDAVTWQHCYIDGRVVKVMDFLKTRLLDTLSDQ
IRKIQKVVNTYTPGKKIWLEGVVTTSAGGTNNLSDSYAAGFLWLNTLGMLANQGIDVVIR
HSFFDHGYNHLVDQNFNPLPDYWLSLLYKRLIGPKVLAVHVAGLQRKPRPGRVIRDKLRI
YAHCTNHHNHNYVRGSITLFIINLHRSRKKIKLAGTLRDKLVHQYLLQPYGQEGLKSKSV
QLNGQPLVMVDDGTLPELKPRPLRAGRTLVIPPVTMGFYVVKNVNALACRYR |
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| NT seq |
1779 nt  +upstreamnt +downstreamnt
atgagggtgctttgtgccttccctgaagccatgccctccagcaactcccgcccccccgcg
tgcctagccccgggggctctctacttggctctgttgctccatctctccctttcctcccag
gctggagacaggagacccttgcctgtagacagagctgcaggtttgaaggaaaagaccctg
attctacttgatgtgagcaccaagaacccagtcaggacagtcaatgagaacttcctctct
ctgcagctggatccgtccatcattcatgatggctggctcgatttcctaagctccaagcgc
ttggtgaccctggcccggggactttcgcccgcctttctgcgcttcgggggcaaaaggacc
gacttcctgcagttccagaacctgaggaacccggcgaaaagccgcgggggcccgggcccg
gattactatctcaaaaactatgaggatgacattgttcgaagtgatgttgccttagataaa
cagaaaggctgcaagattgcccagcaccctgatgttatgctggagctccaaagggagaag
gcagctcagatgcatctggttcttctaaaggagcaattctccaatacttacagtaatctc
atattaacagccaggtctctagacaaactttataactttgctgattgctctggactccac
ctgatatttgctctaaatgcactgcgtcgtaatcccaataactcctggaacagttctagt
gccctgagtctgttgaagtacagcgccagcaaaaagtacaacatttcttgggaactgggt
aatgagccaaataactatcggaccatgcatggccgggcagtaaatggcagccagttggga
aaggattacatccagctgaagagcctgttgcagcccatccggatttattccagagccagc
ttatatggccctaatattgggcggccgaggaagaatgtcatcgccctcctagatggattc
atgaaggtggcaggaagtacagtagatgcagttacctggcaacattgctacattgatggc
cgggtggtcaaggtgatggacttcctgaaaactcgcctgttagacacactctctgaccag
attaggaaaattcagaaagtggttaatacatacactccaggaaagaagatttggcttgaa
ggtgtggtgaccacctcagctggaggcacaaacaatctatccgattcctatgctgcagga
ttcttatggttgaacactttaggaatgctggccaatcagggcattgatgtcgtgatacgg
cactcattttttgaccatggatacaatcacctcgtggaccagaattttaacccattacca
gactactggctctctctcctctacaagcgcctgatcggccccaaagtcttggctgtgcat
gtggctgggctccagcggaagccacggcctggccgagtgatccgggacaaactaaggatt
tatgctcactgcacaaaccaccacaaccacaactacgttcgtgggtccattacacttttt
atcatcaacttgcatcgatcaagaaagaaaatcaagctggctgggactctcagagacaag
ctggttcaccagtacctgctgcagccctatgggcaggagggcctaaagtccaagtcagtg
caactgaatggccagcccttagtgatggtggacgacgggaccctcccagaattgaagccc
cgcccccttcgggccggccggacattggtcatccctccagtcaccatgggcttttatgtg
gtcaagaatgtcaatgctttggcctgccgctaccgataa |
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