KEGG   Homo sapiens (human): 6530Help
Entry
6530              CDS       T01001                                 

Gene name
SLC6A2, NAT1, NET, NET1, SLC6A5
Definition
(RefSeq) solute carrier family 6 member 2
  KO
K05035  solute carrier family 6 (neurotransmitter transporter, noradrenalin) member 2
Organism
hsa  Homo sapiens (human)
Disease
H01031  Orthostatic intolerance (OI)
Drug target
Amezinium metilsulfate: D01304
Amfepramone (DG00104): D03801 D07444
Amfetamine (DG00966): D02074 D07445
Amitifadine (DG01386): D10088 D10089
Amitriptyline (DG00934): D00809 D07448
Amitriptylinoxide: D07449
Amoxapine: D00228
Atomoxetine (DG00970): D02574 D07473
Bupropion (DG00957): D00817 D07591 D07938
Centanafadine (DG01858): D10697 D10698
Cidoxepin hydrochloride: D03491
Clomipramine (DG00929): D00811 D07727
Cocaine (DG00808): D00110 D02182
Dasotraline (DG01989): D10700 D10870
Desipramine (DG00927): D00812 D07791
Desvenlafaxine (DG00963): D02570 D07793
Dexamfetamine (DG00967): D02078 D03740
Dexmethylphenidate (DG00972): D03721 D07806
Dosulepin (DG00940): D01546 D07872
Doxepin (DG00937): D00814 D07875
Duloxetine (DG00962): D01179 D07880
Edivoxetine (DG01310): D09890 D09891
Esreboxetine (DG01309): D09340 D09341
Guanethidine (DG00258): D02237 D04382 D08030
Imipramine (DG00928): D00815 D08070 D08071
Imipraminoxide (DG01542): D07334 D08072
Levomilnacipran (DG01387): D10072 D10133
Liafensine: D10443
Lofepramine (DG00932): D01285 D08140
Maprotiline (DG00941): D00818 D02566
Mazindol: D00367
Metamfetamine (DG00968): D02242 D08187
Methylphenidate (DG00969): D01296 D04999
Milnacipran (DG00960): D01107 D08222
Nisoxetine: D05173
Nomifensine: D05200
Nortriptyline (DG00935): D00816 D08288
Phentermine (DG00102): D05458 D05459
Protriptyline (DG00936): D00484 D08447
Pyrovalerone hydrochloride: D05663
Reboxetine (DG00961): D02573 D08472
Sibutramine (DG00108): D02571 D08513
Talopram hydrochloride: D05997
Tapentadol (DG00826): D06007 D10199
Trimipramine (DG00931): D00394 D02408
Venlafaxine (DG00959): D00821 D08670
Viloxazine (DG00956): D02572 D08673
Brite
Transporters [BR:hsa02000]
 Solute Carrier Family (SLC)
  SLC6: Sodium- and chloride-dependent neurotransmitter transporter
   6530 (SLC6A2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif
Pfam: SNF
Motif
Other DBs
NCBI-GeneID: 6530
NCBI-ProteinID: NP_001034
OMIM: 163970
HGNC: 11048
Ensembl: ENSG00000103546
Vega: OTTHUMG00000133208
Pharos: P23975(Tclin)
UniProt: P23975 A0A024R6T9
LinkDB All DBs
Position
16q12.2
AA seq 617 aa AA seqDB search
MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWG
KKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYN
REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTW
NSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC
LMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY
RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFA
IFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSS
MGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTS
ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINF
KPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHL
VAQRDIRQFQLQHWLAI
NT seq 1854 nt NT seq  +upstreamnt  +downstreamnt
atgcttctggcgcggatgaacccgcaggtgcagcccgagaacaacggggcggacacgggt
ccagagcagccccttcgggcgcgcaaaactgcggagctgctggtggtgaaggagcgcaac
ggcgtccagtgcctgctggcgccccgcgacggcgacgcgcagccccgggagacctggggc
aagaagatcgacttcctgctgtccgtagtcggcttcgcagtggacctggccaacgtgtgg
cgcttcccctacctctgctacaagaacggcggcggtgccttcttgatcccgtacacactg
ttccttatcatcgcggggatgcccctgttctacatggagctggctctgggacagtacaac
cgggagggggctgccaccgtttggaaaatctgcccattcttcaaaggcgttggctatgct
gtcatcctgatcgccctgtacgttggcttctactacaacgtcatcatcgcctggtcactc
tactacctcttctcctccttcaccctcaacctgccctggaccgactgtggccacacctgg
aacagccccaactgtaccgaccccaagctcctcaatggctccgtgcttggcaaccacacc
aagtactccaagtacaagttcacgccggcagccgagttttatgagcgtggtgtcctgcac
cttcacgagagcagcgggattcatgacatcggcctgccccagtggcagctcttgctctgt
ctgatggtcgtcgtcatcgtcttgtattttagcctctggaaaggggtgaagacatcagga
aaggtggtgtggatcacagccacgctgccttacttcgtgctgttcgtgctcctggtccat
ggcgtcacgctgcccggagcctccaatggcatcaatgcctacctgcacatcgacttctac
cgcttgaaagaggccacggtatggattgatgccgcaactcagatatttttttccttgggg
gctggatttggagtattgattgcatttgccagttacaacaaatttgacaacaactgttac
agggatgccctgctgaccagcagcatcaactgtatcaccagcttcgtctctgggttcgcc
atcttctccatccttggttacatggcccatgaacacaaggtcaacattgaggatgtggcc
acagaaggagctggcctagtgttcatcctgtatccagaggccatttctaccctgtctgga
tctacattctgggctgttgtgtttttcgtcatgctcctggcgctgggccttgacagctca
atgggaggcatggaggctgtcatcacgggcctggcagatgacttccaggtcctgaagcga
caccggaaactcttcacatttggcgtcaccttcagcactttccttctcgccctgttctgc
ataaccaagggtggaatttacgtcttgaccctcctggacacctttgctgcgggcacctcc
atcctttttgctgtcctcatggaagccatcggagtttcctggttttatggagtggacagg
ttcagcaacgacatccagcagatgatggggttcaggccgggtctatactggagactgtgc
tggaagttcgtcagtcctgccttcctcctgttcgtggttgtggtcagcatcatcaacttc
aagccactcacctacgacgactacatcttcccgccctgggccaactgggtggggtggggc
atcgccctgtcctccatggtcctggtgcccatctacgtcatctataagttcctcagcacg
cagggctctctttgggagagactggcctatggcatcacgccagagaacgagcaccacctg
gtggctcagagggacatcagacagttccagttgcaacactggctggccatctga

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