KEGG ORTHOLOGY: K01253

ORTHOLOGY: K01253

Entry

K01253                      KO

Symbol

EPHX1

Name

microsomal epoxide hydrolase [EC:3.3.2.9]

Pathway

map00980

Metabolism of xenobiotics by cytochrome P450

map04976

Bile secretion

map05204

Chemical carcinogenesis - DNA adducts

map05207

Chemical carcinogenesis - receptor activation

map05208

Chemical carcinogenesis - reactive oxygen species

Reaction

R07013

(1R,2S)-naphthalene 1,2-oxide hydrolase

R07014

(1S,2R)-naphthalene 1,2-oxide hydrolase

R07027

1-nitronaphthalene-5,6-oxide hydrolase

R07071

bromobenzene-3,4-oxide hydrolase

R07072

bromobenzene-2,3-oxide hydrolase

R07082

benzo[a]pyrene-7,8-oxide hydrolase

R09410

epoxide hydrolase

R09417

microsomal epoxide hydrolase

R09443

microsomal epoxide hydrolase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K01253  EPHX1; microsomal epoxide hydrolase
09150 Organismal Systems
  09154 Digestive system
   04976 Bile secretion
    K01253  EPHX1; microsomal epoxide hydrolase
09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K01253  EPHX1; microsomal epoxide hydrolase
   05207 Chemical carcinogenesis - receptor activation
    K01253  EPHX1; microsomal epoxide hydrolase
   05208 Chemical carcinogenesis - reactive oxygen species
    K01253  EPHX1; microsomal epoxide hydrolase
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K01253  EPHX1; microsomal epoxide hydrolase
Enzymes [BR:ko01000]
3. Hydrolases
  3.3  Acting on ether bonds
   3.3.2  Ether hydrolases
    3.3.2.9  microsomal epoxide hydrolase
     K01253  EPHX1; microsomal epoxide hydrolase
Peptidases and inhibitors [BR:ko01002]
Serine peptidases
  Family S33
   K01253  EPHX1; microsomal epoxide hydrolase

Other DBs

COG:

COG0596

GO:

0004301

Genes

HSA:	2052(EPHX1)

PTR:	457777(EPHX1)

PPS:	100995858(EPHX1)

GGO:	101130068(EPHX1)

PON:	100173792(EPHX1) 100437687

NLE:	100592261(EPHX1)

HMH:	116457775(EPHX1)

MCC:	700180(EPHX1)

MCF:	101866419(EPHX1)

MTHB:

126937150

MNI:	105478502(EPHX1)

CSAB:

103230002(EPHX1)

CATY:

105576938(EPHX1)

PANU:

101012773(EPHX1)

TGE:	112623225(EPHX1)

MLEU:

105552348(EPHX1)

RRO:	104660094(EPHX1)

RBB:	108538734(EPHX1)

TFN:	117074936(EPHX1)

PTEH:

111537082(EPHX1)

CANG:

105516681(EPHX1)

CJC:	100409580(EPHX1)

SBQ:	101029266(EPHX1)

CIMI:

108302734(EPHX1)

CSYR:

103269955(EPHX1)

MMUR:

105863794(EPHX1)

LCAT:

123627522(EPHX1)

PCOQ:

105810378(EPHX1)

OGA:	100943654(EPHX1)

MMU:	13849(Ephx1)

MCAL:

110290857

MPAH:

110321688(Ephx1)

RNO:	25315(Ephx1)

MCOC:

116096986(Ephx1)

ANU:	117722048 117722080(Ephx1)

MUN:	110559921(Ephx1)

CGE:	100750792(Ephx1) 100758590

MAUA:

101835523 121137159

PROB:

127223704(Ephx1)

PLEU:

MORG:

MFOT:

AAMP:

NGI:	103725112 103725113

HGL:	101725522(Ephx1)

CPOC:

100721931(Ephx1)

CCAN:

109691482 109691483

DORD:

106001117

DSP:	122102745(Ephx1)

PLOP:

125359706(Ephx1)

NCAR:

124961084

MMMA:

107140500(Ephx1)

OCU:	100009104(EPHX1)

OPI:	101530165(EPHX1)

TUP:	102495357(EPHX1)

GVR:	103600115(EPHX1)

CFA:	480113(EPHX1)

CLUD:

112648822(EPHX1)

VVP:	112923564(EPHX1)

VLG:	121486260(EPHX1)

NPO:	129508629(EPHX1)

AML:	100477671(EPHX1)

UMR:	103669061(EPHX1)

UAH:	113262914(EPHX1)

UAR:	123791844(EPHX1)

ELK:

111150921

LLV:

125085943

MPUF:

106003316(EPHX1)

MNP:	132025517(EPHX1)

MLK:	131814562(EPHX1)

NVS:	122918688(EPHX1)

ORO:	101368385(EPHX1)

EJU:	114215601(EPHX1)

ZCA:	113933305(EPHX1)

MLX:	118013009(EPHX1)

NSU:	110571396(EPHX1) 123323815

LWW:	102745377(EPHX1)

FCA:	101085519(EPHX1)

PYU:	121015164(EPHX1)

PCOO:

112863168(EPHX1)

PBG:	122476210(EPHX1)

PVIV:

125159627(EPHX1)

LRUF:

124510305

PTG:	102949568(EPHX1)

PPAD:

109250808(EPHX1)

PUC:	125917789 125917793

AJU:

106968617

HHV:	120234147(EPHX1)

BTA:	535293(EPHX1)

BOM:	102267623(EPHX1)

BIU:	109570425(EPHX1)

BBUB:

102409402(EPHX1)

BBIS:

104997889(EPHX1)

CHX:	100860945(EPHX1)

OAS:	101111038(EPHX1)

BTAX:

128061886(EPHX1)

ODA:	120880347(EPHX1)

CCAD:

122451836(EPHX1)

MBEZ:

129551639(EPHX1)

SSC:	397639(EPHX1)

CFR:	102519415(EPHX1)

CBAI:

105083879(EPHX1)

CDK:	105099693(EPHX1)

VPC:	102527697(EPHX1)

BACU:

103003233(EPHX1)

BMUS:

118892445(EPHX1)

LVE:	103074317(EPHX1)

OOR:	101288139(EPHX1)

DLE:	111177519(EPHX1)

PCAD:

102984566(EPHX1)

PSIU:

116748723(EPHX1)

NASI:

112404976(EPHX1)

ECB:	100054269(EPHX1)

EPZ:	103543505(EPHX1)

EAI:	106844729(EPHX1)

MYB:	102263401(EPHX1)

MYD:	102767193(EPHX1)

MMYO:

118678977(EPHX1)

PKL:	118727632(EPHX1)

EFUS:

103293524(EPHX1)

MNA:	107543604(EPHX1)

DRO:	112318922(EPHX1)

SHON:

119003202(EPHX1)

AJM:	119044442(EPHX1)

PDIC:

114512342(EPHX1)

PHAS:

123832837(EPHX1)

MMF:	118640564(EPHX1)

PPAM:

129073004(EPHX1)

HAI:	109391461(EPHX1)

RFQ:	117018666(EPHX1)

PALE:

102883919(EPHX1)

PGIG:

120619125(EPHX1)

PVP:	105292584(EPHX1)

RAY:	107517097(EPHX1)

MJV:	108408993(EPHX1)

TOD:	119244568(EPHX1)

SARA:

101537100(EPHX1)

SETR:

126013425(EPHX1)

LAV:	100673770(EPHX1)

TMU:

101360751

ETF:	101652159(EPHX1)

DNM:	101418215(EPHX1)

MDO:	100025778(EPHX1)

GAS:	123245662(EPHX1)

SHR:	100925093(EPHX1)

AFZ:

127559537

PCW:	110205523(EPHX1)

OAA:	100081956(EPHX1)

GGA:	421321(EPHX1) 421447(EPHX1L)

PCOC:

116229249 116231009(EPHX1)

MGP:	100539493 100545721(EPHX1)

CJO:	107311037(EPHX1) 107311272

TPAI:

128086988(EPHX1) 128088795

LMUT:

125688586 125690026(EPHX1)

NMEL:

110395399(EPHX1) 110396838

APLA:

101790722 101801005(EPHX1)

ACYG:

106029739 106031535(EPHX1)

CATA:

118253352(EPHX1) 118254315

AFUL:

116487216(EPHX1) 116487912

TGU:	100222959(EPHX1) 100227392

LSR:	110477509(EPHX1) 110477916

SCAN:

103817382 103819288(EPHX1)

PMOA:

120505979(EPHX1) 120506812

OTC:	121335741 121346931(EPHX1)

PRUF:

121357056(EPHX1) 121358526

GFR:	102041759(EPHX1) 102042334

FAB:	101806940(EPHX1) 101814529

OMA:	130250644 130251392(EPHX1)

PHI:	102100615 102109472(EPHX1)

PMAJ:

107201686 107201817(EPHX1)

CCAE:

111926266(EPHX1) 111926954

CCW:	104684354 104685565(EPHX1)

CBRC:

103612689(EPHX1) 103624121

ETL:	114059335 114073697(EPHX1)

ZAB:	102060438 102070896(EPHX1)

ACHL:

103799966(EPHX1)

SVG:	106853010 106853915(EPHX1)

MMEA:

130575999 130578661(EPHX1)

HRT:	120750675 120750700(EPHX1)

FPG:	101912868 101914944(EPHX1)

FCH:	102050687 102059804(EPHX1)

CLV:	102085632(EPHX1) 102092641

EGZ:	104134609(EPHX1)

NNI:	104019274(EPHX1)

PCRI:

104024981 104031194(EPHX1)

PLET:

104618973(EPHX1) 104619723

EHS:	104512259 104514942

PCAO:

104043305(EPHX1) 104050640

ACUN:

113478105(EPHX1) 113478705

TALA:

104363663 104368663(EPHX1)

PADL:

103925015(EPHX1)

AFOR:

103898883(EPHX1) 103902677

ACHC:

115349892(EPHX1) 115350316

HALD:

104314305 104325460(EPHX1)

HLE:	104838144(EPHX1) 104840322

AGEN:

126051650 126052582

GCL:	127014846 127015250

CCRI:

104161930(EPHX1) 104164844

CSTI:

104553225(EPHX1) 104557585

CMAC:

104481879(EPHX1) 104486566

MUI:

104547407

BREG:

104637062 104637550(EPHX1)

FGA:	104070751 104073957(EPHX1)

GSTE:

104259295(EPHX1)

LDI:	104348936(EPHX1) 104350292

MNB:	103775848 103777511(EPHX1)

OHA:	104329296 104331963(EPHX1)

NNT:	104405042(EPHX1) 104406829

SHAB:

115613418 115613509(EPHX1)

DPUB:

104299949 104300896(EPHX1)

PGUU:

104458493(EPHX1) 104459025

ACAR:

104518807 104527715

CPEA:

104386207(EPHX1) 104396428

AVIT:

104267999(EPHX1) 104268224

CVF:	104282324 104294655(EPHX1)

RTD:	128906503(EPHX1) 128907507

CUCA:

104056265 104067037(EPHX1)

TEO:	104370184(EPHX1) 104373427

BRHI:

104491536(EPHX1)

AAM:	106482713(EPHX1) 106485556

AROW:

112963396(EPHX1) 112973398

NPD:	112942790(EPHX1) 112957521

TGT:	104578955(EPHX1)

DNE:	112980038(EPHX1) 112997146

SCAM:

104151569(EPHX1) 104151692

ASN:	102368835(EPHX1) 102386213

AMJ:	102571832 102577262(EPHX1)

CPOO:

109319775(EPHX1) 109319862

GGN:	109296897(EPHX1)

PSS:	102456152 102457257(EPHX1)

CMY:	102934448(EPHX1) 102942209

CCAY:

125633687(EPHX1) 125633785

DCC:	119852686(EPHX1) 119853587

CPIC:

101936865(EPHX1) 101949762

TST:	117874510(EPHX1) 117874592

CABI:

116819064 116823869(EPHX1)

MRV:	120400560(EPHX1) 120400786

ACS:	100554472 100555586(ephx1)

ASAO:

132761291 132761373(EPHX1)

PVT:	110075401(EPHX1)

SUND:

121915364(EPHX1) 121934079

PBI:	103058096(EPHX1)

PMUR:

107289275(EPHX1)

CTIG:

120307226(EPHX1) 120307716

TSR:	106541570 106542798(EPHX1)

PGUT:

117671761(EPHX1) 117671857

APRI:

131188013(EPHX1)

PTEX:

113433034(EPHX1) 113433158

NSS:	113420395(EPHX1) 113420917

VKO:	123025614(EPHX1) 123032030

PMUA:

114594523 114594618(EPHX1)

PRAF:

128410969 128411072(EPHX1)

ZVI:	118081778 118083220(EPHX1)

HCG:	128348556 128350086(EPHX1)

GJA:	107119060(EPHX1)

STOW:

125425855 125437417(EPHX1)

EMC:

129328324

XLA:	108716563 432100(ephx1.L)

XTR:	100158543(ephx1) 105946059

NPR:	108787057(EPHX1) 108802126

RTEM:

120937855(EPHX1) 120938076 120938077

BBUF:

120999601(EPHX1) 120999807 120999808 120999809

BGAR:

122931001 122931002 122931003 122934641(EPHX1)

MUO:	115465310(EPHX1) 115465422

GSH:	117357613(EPHX1) 117358061

DRE:	394043(ephx1)

SRX:

107732537

SANH:

107690044(ephx1)

SGH:	107553477 107601524

CCAR:

109080243

CAUA:

113062837 113063108 113120712

CGIB:

127938440 127983838

PTET:

122324509 122324778(ephx1)

LROH:

127182777(ephx1)

OMC:	131527413(ephx1)

PPRM:

120493268(ephx1)

RKG:	130103079(ephx1)

MAMB:

125278271(ephx1)

CIDE:

127501785

MASI:

127410303 127415710

TROS:

130565846(ephx1)

TDW:	130434266(ephx1)

MANU:

129429137 129429138

IPU:	108263372(ephx5)

PHYP:

113542048(ephx1)

SMEO:

124376972(ephx1)

TFD:	113647581(ephx1)

TVC:	132843536(ephx1)

AMEX:

103040834(ephx1)

CMAO:

118815250(ephx1)

EEE:	113587098(ephx1)

CHAR:

105900083(ephx1) 105909349

TRU:	101066103(ephx1)

TFS:	130534365(ephx5)

TNG:	GSTEN00030811G001

LCO:	104918259 104918311(ephx1)

NCC:	104963447(ephx1)

TBEN:

117489081(ephx1) 117499680(ephx5)

CGOB:

115003531(ephx1) 115020096

PGEO:

117439870(ephx1) 117459885(ephx5)

GACU:

117536607(ephx1) 117553133(ephx5)

EMAC:

134859195(ephx5) 134876952(ephx1)

ELY:	117248410(ephx5) 117271285(ephx1)

EFO:	125897156(ephx1) 125903794(ephx5)

PLEP:

121954425(ephx5) 121955668(ephx1) 121964048

SLUC:

116051469(ephx5) 116065557(ephx1)

ECRA:

117960017(ephx5) 117961646(ephx1)

ESP:	116705706 116705884(ephx1)

PFLV:

114571843 114573297(ephx1)

GAT:	120807746(ephx1) 120820603(ephx5)

PPUG:

119194870(ephx1) 119214299(ephx5)

AFB:	129092092(ephx5) 129107120(ephx1)

CLUM:

117727545(ephx1) 117743845(ephx5)

PSWI:

130202368 130203056 130207069(ephx5)

MSAM:

119909018(ephx1) 119916924(ephx5) 119918272

SCHU:

122863157(ephx1) 122884001(ephx5)

CUD:	121506648(ephx1) 121510636 121510637 121510638

ALAT:

119012274(ephx1) 119033157 119033158

MZE:	101463752 101487605(ephx1)

ONL:	100693015(ephx1) 100711364 100711636

OAU:	116314224(ephx1) 116318528

OLA:	101166982 101172051(ephx1)

OML:	112141000(ephx1) 112161741(ephx5)

CSAI:

133418422(ephx1) 133463478(ephx5)

XMA:	102229129 102230310(ephx1)

XCO:	114138263 114158698(ephx1)

XHE:	116713645 116734282(ephx1)

PRET:

103477226

PFOR:

103134161(ephx1)

PLAI:

106961696(ephx1)

PMEI:

106930043(ephx1)

GAF:	122824815(ephx1) 122842946(ephx5)

PPRL:

129359987(ephx5) 129369188(ephx1)

CVG:	107093270(ephx1)

CTUL:

119797626(ephx5) 119797636(ephx1)

GMU:	124859323(ephx5) 124881512(ephx1)

NFU:

107375461

KMR:	108233942(ephx5) 108246518(ephx1)

ALIM:

106515907 106532950(ephx1)

NWH:	119417756(ephx5) 119417998(ephx1)

AOCE:

111583489(ephx1) 111585235

MCEP:

124999376(ephx1) 125019156(ephx5)

CSEM:

103380678(ephx1)

POV:	109632306(ephx1)

SSEN:

122784166(ephx1)

HHIP:

117758195(ephx1)

HSP:	118099717(ephx1)

SMAU:

118290106(ephx1)

LCF:	108877099(ephx5) 108901766

SDU:	111220582 111239530(ephx1)

SLAL:

111661516(ephx1)

XGL:	120788741(ephx1) 120796290(ephx5)

HCQ:	109516170 109524815

SSCV:

125978755 125990183

SBIA:

133496267(ephx1) 133509465(ephx5)

PEE:	133409921(ephx5) 133416960(ephx1)

PTAO:

133468425(ephx1) 133485561(ephx5)

BPEC:

110154206(ephx1)

MALB:

109958771(ephx1)

BSPL:

114870553(ephx5)

SJO:	128372653(ephx5) 128377137(ephx1)

SASA:

106571450 106607860

STRU:

115174737 115192170 115201724

OTW:	112250359(ephx1) 112261919

OMY:	110499486(ephx5) 110499548 110522278 110529658

OGO:	123990800 123995128 124040433(ephx5)

ONE:	115107806 115118720 115139362 115144473

OKI:	109866501 109870261 109870264 109900267

OKE:	118357678 118386954 118397798 118402703(ephx5)

SALP:

111954385 111973113

SNH:	120019006 120024146 120029362 120029363 120029925 120029926

CCLU:

121547755(ephx5) 121548868 121552613

ELS:	105017773(ephx1)

SFM:	108925178(ephx1)

PKI:	111854029(ephx1)

AANG:

118217958(ephx5) 118230719(ephx1)

LOC:	102682886(ephx1) 102687913

PSPA:

121315717 121315718

ARUT:

117402351(ephx5) 117402598

PSEX:

120516512(ephx5)

LCM:	102353239(EPHX1)

CMK:

RTP:

CPLA:

HOC:

PMRN:

116947939(EPHX1)

LRJ:	133341224(EPHX1)

BFO:	118403733 118403746 118404497 118404498 118404531 118418327

BBEL:

109476326 109476397

CIN:

100176449

SCLV:

120335264

SPU:	105437391 588166

LPIC:

129268187

APLC:

110978249

AJC:	117103745 117114357 117116249

SKO:

RZE:

VPS:

ACOO:

HHAL:

SGRE:

DPX:	DAPPUDRAFT_301203

DMK:

116921463

DPZ:	124319336 124336222

PVM:	113814676 113815867

PJA:	122245739 122245740

PCHN:

125032423 125032480 125032492

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

MNZ:

HAZT:

EAF:	111705076 111705077

TCF:

DSV:

VDE:

VJA:

TUT:

DPTE:

DFR:	124490217 124493950

CSCU:

PTEP:

ABRU:

UDV:

SDM:

LPOL:

106458781 106473233 106477280

PMEO:

129585230 129589033 129591709 129591716

CEL:	CELE_W01A11.1(W01A11.1)

CBR:

CBG_18950

CRQ:	GCK72_017934

NAI:	NECAME_00373

LOA:	LOAG_01695

TSP:

LAK:

NVE:

EPA:

ADF:

AMIL:

PDAM:

SPIS:

XEN:

TAD:	TRIADDRAFT_63297

NCR:

NCU08783

NTE:	NEUTE1DRAFT122640(NEUTE1DRAFT_122640)

SMP:	SMAC_04550

PAN:	PODANSg1577 PODANSg2534

PBEL:

QC761_700510

PPSD:

QC762_001380 QC762_700510

PPSP:

QC763_001380 QC763_700510

PPSA:

QC764_001380 QC764_700510

MTM:	MYCTH_2120346

MGR:

PPEI:

PGRI:

SSCK:

FGR:	FGSG_01765

FPU:	FPSE_11393

FPOA:

FPOAC1_001873 FPOAC1_006228 FPOAC1_013440

FVN:	FVRRES_02107 FVRRES_06832

FVR:	FVEG_12319

FOX:	FOXG_13212

NHE:	NECHADRAFT_45915 NECHADRAFT_53192

FFC:	NCS54_00980200 NCS54_01394900

FKR:	NCS57_00503200 NCS57_01376900

FMU:	J7337_007667 J7337_013713

TRE:	TRIREDRAFT_64469

TRR:	M419DRAFT_36708

MAW:

MAJ:

PCHM:

CMT:

AMUS:

CFJ:	CFIO01_01286

CLUP:

CLUP02_04735 CLUP02_07353

CHIG:

CH63R_03746 CH63R_06191 CH63R_09604

ELA:	UCREL1_8323

PFY:	PFICI_13875

BFU:	BCIN_14g05560

MBE:

MBM_02500

PSCO:

LY89DRAFT_710694

GLZ:	GLAREA_08702 GLAREA_12516

ANI:	ANIA_03017

AFM:	AFUA_2G14860 AFUA_3G08960

ACT:	ACLA_036930

NFI:	NFIA_068170

AOR:	AO090005001384

ANG:	An12g08930 An16g02170(hyl1)

AFV:	AFLA_004204

ALUC:

AKAW2_61223A AKAW2_70182A

ACHE:

ACHE_40396A

APUU:

APUU_30512A APUU_60886A

PCS:	N7525_008829

PDP:	PDIP_08560

TMF:	EYB26_001367 EYB26_001374

TRG:	TRUGW13939_03191 TRUGW13939_06026

PBN:	PADG_00494

BGH:	BDBG_05030

PNO:	SNOG_02284

PTE:

PTT_15786

BZE:	COCCADRAFT_33094

BSC:	COCSADRAFT_185751

BOR:	COCMIDRAFT_107314

AALT:

CC77DRAFT_1022077 CC77DRAFT_801013

ARAB:

EKO05_0003744 EKO05_0007025

ZTR:	MYCGRDRAFT_71676

PFJ:	MYCFIDRAFT_52339

FFU:	CLAFUR5_02648 CLAFUR5_03954 CLAFUR5_04468 CLAFUR5_14183

CBET:

CB0940_02999 CB0940_03071 CB0940_11798 CB0940_12212

BCOM:

BAUCODRAFT_490072

NPA:	UCRNP2_8786

CNE:

CNN02220

CNB:

CNBN2260

CNG:	CNAG_06497

CGI:	CGB_N3310C

TMS:	TREMEDRAFT_45464

TASA:

A1Q1_01368

CCAC:

CcaHIS019_0301030(CcaverHIS019_0301030)

SGRA:

EX895_004028 EX895_004254

BUR:	Bcep18194_B1704

PUB:	SAR11_0803(ephX1)

BCL:

ABC1387

FRA:	Francci3_2199

FAL:	FRAAL2594 FRAAL3740

» show all

Reference

PMID:13679044

Authors

von Dippe P, Zhu QS, Levy D

Title

Cell surface expression and bile acid transport function of one topological form of m-epoxide hydrolase.

Journal

Biochem Biophys Res Commun 309:804-9 (2003)
DOI:10.1016/j.bbrc.2003.08.074

Reference

PMID:19340413

Authors

Decker M, Arand M, Cronin A

Title

Mammalian epoxide hydrolases in xenobiotic metabolism and signalling.

Journal

Arch Toxicol 83:297-318 (2009)
DOI:10.1007/s00204-009-0416-0

Reference

PMID:2891713

Authors

Skoda RC, Demierre A, McBride OW, Gonzalez FJ, Meyer UA

Title

Human microsomal xenobiotic epoxide hydrolase. Complementary DNA sequence, complementary DNA-directed expression in COS-1 cells, and chromosomal localization.

Journal

J Biol Chem 263:1549-54 (1988)

Sequence

[hsa:2052]

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