KEGG   ORTHOLOGY: K05083Help
Entry
K05083                      KO                                     

Name
ERBB2, HER2, CD340
Definition
receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1]
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko01522  Endocrine resistance
ko01524  Platinum drug resistance
ko04010  MAPK signaling pathway
ko04012  ErbB signaling pathway
ko04020  Calcium signaling pathway
ko04066  HIF-1 signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
ko04520  Adherens junction
ko04530  Tight junction
ko05200  Pathways in cancer
ko05205  Proteoglycans in cancer
ko05206  MicroRNAs in cancer
ko05212  Pancreatic cancer
ko05213  Endometrial cancer
ko05215  Prostate cancer
ko05219  Bladder cancer
ko05223  Non-small cell lung cancer
ko05224  Breast cancer
ko05226  Gastric cancer
ko05230  Central carbon metabolism in cancer
Disease
H00018  Gastric cancer
H00019  Pancreatic cancer
H00022  Bladder cancer
H00026  Endometrial cancer
H00027  Ovarian cancer
H00028  Choriocarcinoma
H00030  Cervical cancer
H00031  Breast cancer
H00046  Cholangiocarcinoma
H01508  Salivary gland cancer
H01554  Fallopian tube cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   04012 ErbB signaling pathway
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   04066 HIF-1 signaling pathway
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   04020 Calcium signaling pathway
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   04151 PI3K-Akt signaling pathway
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   04520 Adherens junction
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   04530 Tight junction
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   05230 Central carbon metabolism in cancer
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   05206 MicroRNAs in cancer
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   05205 Proteoglycans in cancer
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   05212 Pancreatic cancer
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   05226 Gastric cancer
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   05219 Bladder cancer
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   05215 Prostate cancer
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   05213 Endometrial cancer
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   05224 Breast cancer
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   05223 Non-small cell lung cancer
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   01524 Platinum drug resistance
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
   01522 Endocrine resistance
    K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
Protein kinases [BR:ko01001]
 Receptor tyrosine kinases (RTK)
  EGFR family [OT]
   K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of breast cancer cells
   K05083  ERBB2, HER2, CD340; receptor tyrosine-protein kinase erbB-2
CD molecules [BR:ko04090]
 Proteins
  K05083  CD340, ERBB2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2
BRITE hierarchy
Genes
HSA: 2064(ERBB2)
PTR: 454636(ERBB2)
PPS: 100977227(ERBB2)
GGO: 101140885(ERBB2)
PON: 100450307(ERBB2)
NLE: 100601700(ERBB2)
MCC: 697573(ERBB2)
MCF: 102146608(ERBB2)
CSAB: 103243533(ERBB2)
RRO: 104674848(ERBB2)
RBB: 108527784(ERBB2)
CJC: 100391332(ERBB2)
SBQ: 101043415(ERBB2)
MMU: 13866(Erbb2)
RNO: 24337(Erbb2)
CGE: 100759983(Erbb2)
NGI: 103743825(Erbb2)
HGL: 101705227(Erbb2)
CCAN: 109693877(Erbb2)
OCU: 100009554(ERBB2)
TUP: 102487164(ERBB2)
CFA: 403883(ERBB2)
AML: 100480029(ERBB2)
UMR: 103661560(ERBB2)
ORO: 101364161(ERBB2)
FCA: 751824(ERBB2)
PTG: 102961961(ERBB2)
AJU: 106980462(ERBB2)
BTA: 505709(ERBB2)
BOM: 102267975(ERBB2)
BIU: 109573971(ERBB2)
PHD: 102319937(ERBB2)
CHX: 102181989(ERBB2)
OAS: 780519(ERBB2)
SSC: 100516641(ERBB2)
CFR: 102519604(ERBB2)
CDK: 105099069(ERBB2)
BACU: 103002640(ERBB2)
LVE: 103075672(ERBB2)
OOR: 101283619(ERBB2)
ECB: 100054739(ERBB2)
EPZ: 103550160(ERBB2)
EAI: 106826341(ERBB2)
MYB: 102243033(ERBB2)
MYD: 102771013(ERBB2)
HAI: 109380800(ERBB2)
RSS: 109455834(ERBB2)
PALE: 102885300(ERBB2)
LAV: 100662583(ERBB2)
TMU: 101354844
MDO: 100017172(ERBB2)
SHR: 100914727(ERBB2)
GGA: 426130(ERBB2)
MGP: 100550880(ERBB2)
CJO: 107325215(ERBB2)
GFR: 102032307(ERBB2)
FAB: 101818019(ERBB2)
PHI: 102108835(ERBB2)
PMAJ: 107215327(ERBB2)
CCW: 104697788(ERBB2)
FPG: 101914383(ERBB2)
FCH: 102057575(ERBB2)
CLV: 102094013(ERBB2)
EGZ: 104129607(ERBB2)
AAM: 106486153(ERBB2)
ASN: 102369818(ERBB2)
AMJ: 102561352(ERBB2)
PSS: 102457099(ERBB2)
CMY: 102946701(ERBB2)
CPIC: 101931763(ERBB2)
ACS: 100565910(erbb2)
PVT: 110082059(ERBB2)
PBI: 103065858(ERBB2)
GJA: 107114744(ERBB2)
XLA: 108700774(erbb2.L) 108702492 724075(erbb2.S)
XTR: 100492078(erbb2)
NPR: 108792756(ERBB2)
DRE: 386966(erbb2)
IPU: 108273851(ERBB2)
AMEX: 103042851(erbb2)
TRU: 101074842(erbb2)
LCO: 104926899(erbb2)
NCC: 104946774(erbb2)
MZE: 101482712(erbb2)
OLA: 101174230
XMA: 102234046(erbb2)
PRET: 103481805
NFU: 107387934
CSEM: 103381605(erbb2)
LCF: 108890417(erbb2)
HCQ: 109523903(erbb2)
BPEC: 110171045(erbb2)
SASA: 106579080(erbb2)
ELS: 105030222(erbb2)
LCM: 102348821(ERBB2)
CMK: 103183785(erbb2)
CIN: 778955(egfr1)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:3003577
  Authors
Yamamoto T, Ikawa S, Akiyama T, Semba K, Nomura N, Miyajima N, Saito T, Toyoshima K
  Title
Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor.
  Journal
Nature 319:230-4 (1986)
DOI:10.1038/319230a0
  Sequence
[hsa:2064]
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