KEGG   ORTHOLOGY: K05083Help
Entry
K05083                      KO                                     

Name
ERBB2, HER2
Definition
receptor tyrosine-protein kinase erbB-2 [EC:2.7.10.1]
Pathway
ErbB signaling pathway
Calcium signaling pathway
HIF-1 signaling pathway
Focal adhesion
Adherens junction
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Pancreatic cancer
Endometrial cancer
Prostate cancer
Bladder cancer
Non-small cell lung cancer
Disease
H00018  
Gastric cancer
H00019  
Pancreatic cancer
H00022  
Bladder cancer
H00026  
Endometrial Cancer
H00027  
Ovarian cancer
H00028  
Choriocarcinoma
H00030  
Cervical cancer
H00031  
Breast cancer
H00046  
Cholangiocarcinoma
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04012 ErbB signaling pathway
    K05083  ERBB2, HER2; receptor tyrosine-protein kinase erbB-2
   04066 HIF-1 signaling pathway
    K05083  ERBB2, HER2; receptor tyrosine-protein kinase erbB-2
   04020 Calcium signaling pathway
    K05083  ERBB2, HER2; receptor tyrosine-protein kinase erbB-2
 Cellular Processes
  Cellular commiunity
   04510 Focal adhesion
    K05083  ERBB2, HER2; receptor tyrosine-protein kinase erbB-2
   04520 Adherens junction
    K05083  ERBB2, HER2; receptor tyrosine-protein kinase erbB-2
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K05083  ERBB2, HER2; receptor tyrosine-protein kinase erbB-2
   05206 MicroRNAs in cancer
    K05083  ERBB2, HER2; receptor tyrosine-protein kinase erbB-2
   05205 Proteoglycans in cancer
    K05083  ERBB2, HER2; receptor tyrosine-protein kinase erbB-2
   05212 Pancreatic cancer
    K05083  ERBB2, HER2; receptor tyrosine-protein kinase erbB-2
   05219 Bladder cancer
    K05083  ERBB2, HER2; receptor tyrosine-protein kinase erbB-2
   05215 Prostate cancer
    K05083  ERBB2, HER2; receptor tyrosine-protein kinase erbB-2
   05213 Endometrial cancer
    K05083  ERBB2, HER2; receptor tyrosine-protein kinase erbB-2
   05223 Non-small cell lung cancer
    K05083  ERBB2, HER2; receptor tyrosine-protein kinase erbB-2
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     K05083  ERBB2, HER2; receptor tyrosine-protein kinase erbB-2
Protein kinases [BR:ko01001]
 Tyrosine protein kinases
  EGFR family [OT]
   K05083  ERBB2, HER2; receptor tyrosine-protein kinase erbB-2
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of breast cancer cells
   K05083  ERBB2, HER2; receptor tyrosine-protein kinase erbB-2
Enzyme-linked receptors [BR:ko01020]
 Receptor tyrosine kinases
  RTK class I (EGF receptor family)
   K05083  ERBB2, HER2; receptor tyrosine-protein kinase erbB-2
Cytokine receptors [BR:ko04050]
 Receptor tyrosine kinase
  RTK class I (EGF receptor family)
   K05083  ERBB2, HER2; receptor tyrosine-protein kinase erbB-2
Cellular antigens [BR:ko04090]
 Proteins
  K05083  CD340, ERBB2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2
BRITE hierarchy
Genes
HSA: 
2064(ERBB2)
PTR: 
454636(ERBB2)
PPS: 
100977227(ERBB2)
GGO: 
101140885(ERBB2)
PON: 
100450307(ERBB2)
MCC: 
697573(ERBB2)
MCF: 
102146608(ERBB2)
MMU: 
13866(Erbb2)
RNO: 
24337(Erbb2)
CGE: 
100759983(Erbb2)
HGL: 
101705227(Erbb2)
TUP: 
102487164(ERBB2)
CFA: 
403883(ERBB2)
AML: 
FCA: 
751824(ERBB2)
PTG: 
102961961(ERBB2)
BTA: 
505709(ERBB2)
BOM: 
102267975(ERBB2)
PHD: 
102319937(ERBB2)
CHX: 
102181989(ERBB2)
OAS: 
780519(ERBB2)
SSC: 
100516641(ERBB2)
CFR: 
102519604(ERBB2)
BACU: 
103002640(ERBB2)
LVE: 
103075672(ERBB2)
ECB: 
100054739(ERBB2)
MYB: 
102243033(ERBB2)
MYD: 
102771013(ERBB2)
PALE: 
102885300(ERBB2)
MDO: 
100017172(ERBB2)
SHR: 
100914727(ERBB2)
GGA: 
426130(ERBB2)
FAB: 
101818019(ERBB2)
PHI: 
102108835(ERBB2)
FPG: 
101914383(ERBB2)
FCH: 
102057575(ERBB2)
CLV: 
102094013(ERBB2)
ASN: 
102369818(ERBB2)
AMJ: 
102561352(ERBB2)
CMY: 
102946701(ERBB2)
ACS: 
100565910(erbb2)
PBI: 
XLA: 
724075(erbb2)
XTR: 
100492078(erbb2)
DRE: 
386966(erbb2)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102348821(ERBB2)
CMK: 
103183785(erbb2)
CIN: 
778955(egfr1)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Holbro T, Hynes NE.
  Title
ErbB receptors: directing key signaling networks throughout life.
  Journal
Annu Rev Pharmacol Toxicol 44:195-217 (2004)
Reference
  Authors
Citri A, Yarden Y.
  Title
EGF-ERBB signalling: towards the systems level.
  Journal
Nat Rev Mol Cell Biol 7:505-16 (2006)
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