KEGG   ORTHOLOGY: K13376Help
Entry
K13376                      KO                                     
Name
TGFB2
Definition
transforming growth factor beta-2
Pathway
MAPK signaling pathway
Cytokine-cytokine receptor interaction
Cell cycle
Endocytosis
TGF-beta signaling pathway
Osteoclast differentiation
Hippo signaling pathway
Leishmaniasis
Chagas disease (American trypanosomiasis)
Malaria
Toxoplasmosis
Amoebiasis
Tuberculosis
Hepatitis B
HTLV-I infection
Pathways in cancer
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Chronic myeloid leukemia
Rheumatoid arthritis
Hypertrophic cardiomyopathy (HCM)
Dilated cardiomyopathy
Disease
H00083  
Allograft rejection
H00084  
Graft-versus-host disease
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04010 MAPK signaling pathway
    K13376  TGFB2; transforming growth factor beta-2
   04350 TGF-beta signaling pathway
    K13376  TGFB2; transforming growth factor beta-2
   04390 Hippo signaling pathway
    K13376  TGFB2; transforming growth factor beta-2
  Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K13376  TGFB2; transforming growth factor beta-2
 Cellular Processes
  Transport and catabolism
   04144 Endocytosis
    K13376  TGFB2; transforming growth factor beta-2
  Cell growth and death
   04110 Cell cycle
    K13376  TGFB2; transforming growth factor beta-2
 Organismal Systems
  Development
   04380 Osteoclast differentiation
    K13376  TGFB2; transforming growth factor beta-2
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K13376  TGFB2; transforming growth factor beta-2
   05205 Proteoglycans in cancer
    K13376  TGFB2; transforming growth factor beta-2
   05210 Colorectal cancer
    K13376  TGFB2; transforming growth factor beta-2
   05212 Pancreatic cancer
    K13376  TGFB2; transforming growth factor beta-2
   05220 Chronic myeloid leukemia
    K13376  TGFB2; transforming growth factor beta-2
   05211 Renal cell carcinoma
    K13376  TGFB2; transforming growth factor beta-2
  Immune diseases
   05323 Rheumatoid arthritis
    K13376  TGFB2; transforming growth factor beta-2
  Cardiovascular diseases
   05410 Hypertrophic cardiomyopathy (HCM)
    K13376  TGFB2; transforming growth factor beta-2
   05414 Dilated cardiomyopathy (DCM)
    K13376  TGFB2; transforming growth factor beta-2
  Infectious diseases
   05152 Tuberculosis
    K13376  TGFB2; transforming growth factor beta-2
   05166 HTLV-I infection
    K13376  TGFB2; transforming growth factor beta-2
   05161 Hepatitis B
    K13376  TGFB2; transforming growth factor beta-2
   05146 Amoebiasis
    K13376  TGFB2; transforming growth factor beta-2
   05144 Malaria
    K13376  TGFB2; transforming growth factor beta-2
   05145 Toxoplasmosis
    K13376  TGFB2; transforming growth factor beta-2
   05140 Leishmaniasis
    K13376  TGFB2; transforming growth factor beta-2
   05142 Chagas disease (American trypanosomiasis)
    K13376  TGFB2; transforming growth factor beta-2
Cytokines [BR:ko04052]
 TGF-beta family
  TGF-beta subfamily
   K13376  TGFB2; transforming growth factor beta-2
Cell adhesion molecules and their ligands [BR:ko04516]
 2. Integrin Family
  Beta1 integrins
   VLA-8
    ITGB1; integrin beta 1
     K13376 TGFB2; transforming growth factor beta-2
   alpha V beta 1
    ITGB1; integrin beta 1
     K13376 TGFB2; transforming growth factor beta-2
  Beta5 integrins
   alpha V beta 5
    ITGB5; integrin beta 5
     K13376 TGFB2; transforming growth factor beta-2
  Beta6 integrins
   alpha V beta 6
    ITGB6; integrin beta 6
     K13376  TGFB2; transforming growth factor beta-2
  Beta8 integrins
   alpha V beta 8
    ITGB8; integrin beta 8
     K13376 TGFB2; transforming growth factor beta-2
Heparan sulfate/heparin binding proteins [BR:ko00536]
 Growth factors/receptors
  K13376  TGFB2; transforming growth factor beta-2
BRITE hierarchy
Genes
HSA: 
7042(TGFB2)
PTR: 
457742(TGFB2)
PPS: 
100985755(TGFB2)
GGO: 
101125504(TGFB2)
PON: 
100461291(TGFB2)
MCC: 
707540(TGFB2)
MMU: 
21808(Tgfb2)
RNO: 
81809(Tgfb2)
CFA: 
488596(TGFB2)
AML: 
FCA: 
101093414(TGFB2)
BTA: 
534069(TGFB2)
SSC: 
397084(TGFB2)
ECB: 
100050377
MDO: 
100017548
SHR: 
100914910(TGFB2)
OAA: 
100080176
GGA: 
421352(TGFB2)
MGP: 
100549559
TGU: 
100231617(TGFB2)
ACS: 
100568228
XLA: 
373801(tgfb2)
XTR: 
100489680
DRE: 
369194(tgfb2)
TRU: 
101066787
OLA: 
101155037
CIN: 
778780(tgfbeta2)
SPU: 
588471
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Schmierer B, Hill CS
  Title
TGFbeta-SMAD signal transduction: molecular specificity and functional flexibility.
  Journal
Nat Rev Mol Cell Biol 8:970-82 (2007)
Reference
PMID:9759503
  Authors
Massague J.
  Title
TGF-beta signal transduction.
  Journal
Annu Rev Biochem 67:753-91 (1998)
Reference
  Authors
Chen YG
  Title
Endocytic regulation of TGF-beta signaling.
  Journal
Cell Res 19:58-70 (2009)
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