KEGG   ORTHOLOGY: K21163
Entry
K21163                      KO                                     
Symbol
sgcE5, ncsE5, kedE5
Name
enediyne biosynthesis protein E5
Pathway
map01059  Biosynthesis of enediyne antibiotics
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00824  9-membered enediyne core biosynthesis, malonyl-CoA => 3-hydroxyhexadeca-4,6,8,10,12,14-hexaenoyl-ACP => 9-membered enediyne core
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01059 Biosynthesis of enediyne antibiotics
    K21163  sgcE5, ncsE5, kedE5; enediyne biosynthesis protein E5
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K21163  sgcE5, ncsE5, kedE5; enediyne biosynthesis protein E5
Polyketide biosynthesis proteins [BR:ko01008]
 Polyketide tailoring proteins
  Others
   K21163  sgcE5, ncsE5, kedE5; enediyne biosynthesis protein E5
Genes
LANH: KR767_19065
MAH: MEALZ_1606(unbU)
MBUR: EQU24_12385
MEIN: methR_P2298
TIG: THII_0011
DAR: Daro_4058
EAA: I862_02175
BBT: BBta_7863
AOL: S58_72740
BRO: BRAD285_7692
HOH: Hoch_0694
BPUM: BW16_02230
BMEG: BG04_2489
PSAB: PSAB_23820
SGR: SGR_608(unbU)
SGB: WQO_33995
STRM: M444_38010
AMD: AMED_6870
AMN: RAM_35250
AMM: AMES_6765
AMZ: B737_6765
AOI: AORI_1835
AMYY: YIM_41010
AORI: SD37_32035
SESP: BN6_39240
ACTI: UA75_19090
ACAD: UA74_18600
ALO: CRK57503
MIL: ML5_5850
ACTN: L083_3234
CAI: Caci_6359
MAR: MAE_12850
MPK: VL20_1919
PLS: VT03_11610(rsxD)
LRS: PX52LOC_00384(rsxD)
FTJ: FTUN_8499
ULI: ETAA1_04370(rsxD)
ABAS: ACPOL_5989
GBA: J421_4030
CPRV: CYPRO_2339
AG: AAM78013(ncsE5) AFV52140(kedE5)
 » show all
Reference
PMID:12183628 (sgcE5)
  Authors
Liu W, Christenson SD, Standage S, Shen B
  Title
Biosynthesis of the enediyne antitumor antibiotic C-1027.
  Journal
Science 297:1170-3 (2002)
DOI:10.1126/science.1072110
  Sequence
[sgb:WQO_33995]
Reference
PMID:15797213 (ncsE5)
  Authors
Liu W, Nonaka K, Nie L, Zhang J, Christenson SD, Bae J, Van Lanen SG, Zazopoulos E, Farnet CM, Yang CF, Shen B
  Title
The neocarzinostatin biosynthetic gene cluster from Streptomyces carzinostaticus ATCC 15944 involving two iterative type I polyketide synthases.
  Journal
Chem Biol 12:293-302 (2005)
DOI:10.1016/j.chembiol.2004.12.013
  Sequence
Reference
PMID:23360970 (kedE5)
  Authors
Lohman JR, Huang SX, Horsman GP, Dilfer PE, Huang T, Chen Y, Wendt-Pienkowski E, Shen B
  Title
Cloning and sequencing of the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650 revealing new insights into biosynthesis of the enediyne family of antitumor antibiotics.
  Journal
Mol Biosyst 9:478-91 (2013)
DOI:10.1039/c3mb25523a
  Sequence
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