KEGG   Klebsiella pneumoniae subsp. pneumoniae MGH 78578 (serotype K52): KPN_04234
Entry
KPN_04234         CDS       T00566                                 
Symbol
metL
Name
(GenBank) bifunctional aspartate kinase II/homoserine dehydrogenase II
  KO
K12525  bifunctional aspartokinase / homoserine dehydrogenase 2 [EC:2.7.2.4 1.1.1.3]
Organism
kpn  Klebsiella pneumoniae subsp. pneumoniae MGH 78578 (serotype K52)
Pathway
kpn00260  Glycine, serine and threonine metabolism
kpn00261  Monobactam biosynthesis
kpn00270  Cysteine and methionine metabolism
kpn00300  Lysine biosynthesis
kpn01100  Metabolic pathways
kpn01110  Biosynthesis of secondary metabolites
kpn01120  Microbial metabolism in diverse environments
kpn01230  Biosynthesis of amino acids
Module
kpn_M00016  Lysine biosynthesis, succinyl-DAP pathway, aspartate => lysine
kpn_M00017  Methionine biosynthesis, aspartate => homoserine => methionine
kpn_M00018  Threonine biosynthesis, aspartate => homoserine => threonine
Brite
KEGG Orthology (KO) [BR:kpn00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00260 Glycine, serine and threonine metabolism
    KPN_04234 (metL)
   00270 Cysteine and methionine metabolism
    KPN_04234 (metL)
   00300 Lysine biosynthesis
    KPN_04234 (metL)
  09110 Biosynthesis of other secondary metabolites
   00261 Monobactam biosynthesis
    KPN_04234 (metL)
Enzymes [BR:kpn01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.3  homoserine dehydrogenase
     KPN_04234 (metL)
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.2  Phosphotransferases with a carboxy group as acceptor
    2.7.2.4  aspartate kinase
     KPN_04234 (metL)
SSDB
Motif
Pfam: AA_kinase Homoserine_dh NAD_binding_3
Other DBs
NCBI-ProteinID: ABR79613
UniProt: A6TGC9
LinkDB
Position
4635009..4637441
AA seq 810 aa
MSVIAQAGAKGRQLHKFGGSSLADAKCYLRVAGIMKEYSQAGDMMVVSAAGSTTNQLISW
LKLSQSDRLAAHQVQQSLRRYHTELIGGLLEPAAADTLIAAFIHDLERLAGLLDGGVSEA
VYAEVVGHGEVWSARLMAAVLNQLGMEAAWLDARAFLRAERAAQPQVDEGLSYPLLQQLM
AQHPNKRLVVTGFISRNQAGETVLLGRNGSDYSATQIGALAGASRVTIWSDVAGVYSADP
RKVKDACLLPLLRLDEASELARLAAPVLHARTLQPVSASDIDLQLRCSYTPEQGSTRIER
VLASGTGARIVTSHDDVCLVEFQVPAGHDFKLAHKELDALLKRAQLRPLAVGVHADRKLL
QFCYTSEVADSALKLLDEAGLPGELRLRQKLALVAMVGAGVTRNPLHCHRFWQQLKGQPV
EFTWQSEEGISLVAVLRAGPTESLIQGLHQSLFRAEKRIGLMLFGKGNIGSRWLELFARE
QTTLSARTGFEFILAGVVDSKRSLLNYDGLDASRALAFFNDEAVEQDEESLFLWMRAHPY
DDLVVLDVTASEQLADQYLDFASHGFHVISANKLAGASSSDKYRQIHDAFEKTGRHWLYN
ATVGAGLPVNHTVRDLIDSGDTILGLSGIFSGTLSWLFLQFDGTVPFTDLVDQAWQQGLT
EPDPRVDLSGKDVMRKLVILAREAGYDIEPDQVRVESLVPAHCEEGSVDHFFENGEELNE
QMLQRLEAAREMGLVLRYVARFDANGKARVGVEAVREEHPLAALLPCDNVFAIESRWYRD
NPLVIRGPGAGRDVTAGAIQSDINRLAQLL
NT seq 2433 nt   +upstreamnt  +downstreamnt
atgagtgtgattgcgcaggcaggggcgaagggtcgtcagctgcacaaatttggtgggagt
agtttagcggatgcgaaatgttacctgcgcgtcgcggggatcatgaaggagtattcgcag
gcgggggatatgatggtcgtctccgccgctggcagcaccaccaaccagctgatcagctgg
cttaagcttagccagagcgatcgccttgctgcgcatcaggttcagcagtcgcttcgccgc
tatcacaccgagctgattggcggtctgctggagcctgcggcggcggatacgttgatagcc
gcctttatccacgaccttgagcgtctggctggtctgctggacggcggggtttccgaagcg
gtctatgcggaagtggtcggccatggggaagtgtggtccgcgcgcctgatggcggcggtt
ctcaaccagctgggtatggaagccgcctggctggacgcgcgcgcgttcctgcgcgcggaa
cgcgccgcgcagccgcaggtggatgagggattatcttacccactgctgcagcagctgatg
gcgcagcatcctaacaaacgtctggtggtgaccggctttatctcccgcaaccaggccggc
gaaaccgtcctgctgggccgtaacgggtctgactactctgccacccagatcggcgcgctg
gcgggcgcctcccgggtcactatctggagcgacgttgccggggtgtacagcgcggatccg
cgcaaggtgaaagacgcctgcctgctgccgctgctgcgtctggacgaagccagcgagctg
gcgcgcctggccgcgccggtgctccatgcccgcacgctacagccggtttccgccagtgat
atcgatctgcagttacgctgcagctacacgccggaacagggttccacgcgcattgagcgc
gtgctggcctccggtaccggcgcacggattgtcaccagccatgacgacgtctgcctggtg
gagttccaggtgccggccggtcacgatttcaaactggcgcataaagagctggacgctctg
ctcaaacgcgcccagctgcgcccgttagccgttggcgtccatgccgaccgtaagctgctg
cagttctgctatacctccgaggtggccgacagcgcgctgaaattgctcgatgaagccggt
ctgccgggcgagctgcgtctgcgtcagaagctggcgctggtggcgatggtgggcgcggga
gtcacccgtaacccgctgcactgccaccgtttctggcagcagctcaaagggcagccggtg
gagttcacctggcagtctgaagaggggatcagcctggtggcggtgctacgcgccgggccg
acggaaagcctgatccaggggctgcatcagtccttgtttcgcgccgaaaagcgtattggc
ctgatgctgttcggcaaagggaatattggttcccgctggctggagcttttcgcccgtgaa
caaactacgctctcggcgcgtaccggtttcgagtttattctcgccggcgtagtcgacagt
aaacgcagcctgctgaattacgacgggctggatgccagccgggcgctggctttcttcaac
gatgaagcggtggagcaggatgaagagtcgctgttcctgtggatgcgcgcgcacccgtat
gatgatttagtggtgctggacgtcaccgccagcgaacagctggccgaccagtatcttgat
ttcgccagccatggcttccacgtcattagcgccaacaagctggcgggcgccagcagcagt
gataaatatcgtcagatccacgacgcgtttgagaagacggggcgccactggttgtataac
gccaccgtgggcgccggcttgccggtgaaccatacggtgcgcgacctgatcgacagcggc
gatactattctcggcctgagcggtatcttctcgggaacgctctcctggctgttcctgcag
tttgatggcaccgtgccgttcaccgacctggtggatcaggcgtggcagcaggggctgacc
gagccggatccgcgcgtcgatctgtccggtaaggatgtgatgcgtaagctggtgatcctc
gcgcgggaagcgggctatgacatcgaaccggatcaggtgcgtgtggaatcactggtgccg
gcgcactgtgaagaggggtcggtcgatcacttctttgagaatggcgaagagctgaacgag
cagatgctgcagcgtctggaagcggcccgcgagatggggctggtgctccgctacgtggcg
cgctttgatgccaacggcaaagcacgcgtcggtgtggaagcggtacgcgaagagcacccg
ctggcggcgctgctgccgtgcgataacgtgtttgccatcgaaagccgctggtatcgcgat
aacccgctggtgatccgcgggcccggcgccgggcgcgatgtgaccgccggggcgatccag
tcggatattaaccgcctggcgcagctgctgtaa

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