| Entry |
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| Gene name |
Fn1, E330027I09, Fn, Fn-1
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| Definition |
(RefSeq) fibronectin 1
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| KO |
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| Organism |
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| Pathway |
| PI3K-Akt signaling pathway | | Focal adhesion | | ECM-receptor interaction | | Regulation of actin cytoskeleton | | AGE-RAGE signaling pathway in diabetic complications | | Bacterial invasion of epithelial cells | | Amoebiasis | | Human papillomavirus infection | | Pathways in cancer | | Proteoglycans in cancer | | Small cell lung cancer |
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| Brite |
KEGG Orthology (KO) [BR:mmu00001]
Environmental Information Processing
Signal transduction
04151 PI3K-Akt signaling pathway
14268 (Fn1)
Signaling molecules and interaction
04512 ECM-receptor interaction
14268 (Fn1)
Cellular Processes
Cellular community - eukaryotes
04510 Focal adhesion
14268 (Fn1)
Cell motility
04810 Regulation of actin cytoskeleton
14268 (Fn1)
Human Diseases
Cancers
05200 Pathways in cancer
14268 (Fn1)
05205 Proteoglycans in cancer
14268 (Fn1)
05222 Small cell lung cancer
14268 (Fn1)
Endocrine and metabolic diseases
04933 AGE-RAGE signaling pathway in diabetic complications
14268 (Fn1)
Infectious diseases
05100 Bacterial invasion of epithelial cells
14268 (Fn1)
05165 Human papillomavirus infection
14268 (Fn1)
05146 Amoebiasis
14268 (Fn1)
Membrane trafficking [BR:mmu04131]
Endoplasmic reticulum (ER) - Golgi transport
Forward pathways
ER-Golgi intermediate compartment (ERGIC) proteins
14268 (Fn1)
Exosome [BR:mmu04147]
Exosomal proteins
Exosomal proteins of bladder cancer cells
14268 (Fn1)
Cell adhesion molecules and their ligands [BR:mmu04516]
1. Immunoglobulin Superfamily
Others
CXADR, CAR; coxsackievirus and adenovirus receptor [KO:K06788]
14268 (Fn1)
2. Integrin Family
Beta1 integrins
VLA-4
ITGB1; integrin beta 1 [KO:K05719]
14268 (Fn1)
VLA-5
14268 (Fn1)
VLA-8
14268 (Fn1)
alpha V beta 1
14268 (Fn1)
Beta3 integrins
alpha IIb beta 3
ITGB3; integrin beta 3 [KO:K06493]
14268 (Fn1)
VNR
14268 (Fn1)
Beta6 integrins
alpha V beta 6
ITGB6; integrin beta 6 [KO:K06589]
14268 (Fn1)
Beta7 integrins
alpha 4 beta 7
ITGB7; integrin beta 7 [KO:K06590]
14268 (Fn1)
Beta8 integrins
alpha V beta 8
ITGB8; integrin beta 8 [KO:K06591]
14268 (Fn1)
4. Link Protein Family
CD44; CD44 antigen [KO:K06256]
14268 (Fn1)
7. Others
SDC1; syndecan 1 [KO:K06257]
14268 (Fn1)
SDC4; syndecan 4 [KO:K16338]
14268 (Fn1)
Glycosaminoglycan binding proteins [BR:mmu00536]
Heparan sulfate/Haparin
Extracellular matrix molecules (General comment) Storage depot, cell adhesion and motility, ECM/barrier formation
14268 (Fn1)
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| SSDB |
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| Motif |
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| Other DBs |
NCBI-GeneID: NCBI-ProteinID: MGI: Ensembl: Vega: UniProt: |
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| LinkDB |
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| Structure |
PDB: |
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| Position |
1 C3; 1 36.05 cM
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| AA seq |
2477 aa  
MLRGPGPGRLLLLAVLCLGTSVRCTEAGKSKRQAQQIVQPQSPVAVSQSKPGCFDNGKHY
QINQQWERTYLGNALVCTCYGGSRGFNCESKPEPEETCFDKYTGNTYKVGDTYERPKDSM
IWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDKWRRPHETGGYMLECLCLGNGKGEWTC
KPIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGNGRITCTSRNRCNDQDTRTS
YRIGDTWSKKDNRGNLLQCVCTGNGRGEWKCERHALQSASAGSGSFTDVRTAIYQPQTHP
QPAPYGHCVTDSGVVYSVGMQWLKSQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPC
VLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHAVLVQTRGGNSNGALC
HFPFLYNNRNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAAHEEICTTNEGVMYRI
GDQWDKQHDLGHMMRCTCVGNGRGEWACIPYSQLRDQCIVDDITYNVNDTFHKRHEEGHM
LNCTCFGQGRGRWKCDPIDQCQDSETRTFYQIGDSWEKFVHGVRYQCYCYGRGIGEWHCQ
PLQTYPGTTGPVQVIITETPSQPNSHPIQWNAPEPSHITKYILRWRPKTSTGRWKEATIP
GHLNSYTIKGLTPGVIYEGQLISIQQYGHREVTRFDFTTSASTPVTSNTVTGETAPYSPV
VATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLL
PGRKYIVNVYQISEEGKQSLILSTSQTTAPDAPPDPTVDQVDDTSIVVRWSRPQAPITGY
RIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVFIQQETTGT
PRSDNVPPPTDLQFVELTDVKVTIMWTPPDSVVSGYRVEVLPVSLPGEHGQRLPVNRNTF
AEITGLSPGVTYLFKVFAVHQGRESNPLTAQQTTKLDAPTNLQFVNETDRTVLVTWTPPR
ARIAGYRLTAGLTRGGQPKQYNVGPLASKYPLRNLQPGSEYTVTLVAVKGNQQSPKATGV
FTTLQPLRSIPPYNTEVTETTIVITWTPAPRIGFKLGVRPSQGGEAPREVTSDSGSIVVS
GLTPGVEYTYTIQVLRDGQERDAPIVNRVVTPLSPPTNLHLEANPDTGVLTVSWERSTTP
DITGYRITTTPTNGQQGTSLEEVVHADQSSCTFENLNPGLEYNVSVYTVKDDKESAPISD
TVVPEVPQLTDLSFVDITDSSIGLRWTPLNSSTIIGYRITVVAAGEGIPIFEDFVDSSVG
YYTVTGLEPGIDYDISVITLINGGESAPTTLTQQTAVPPPTDLRFTNIGPDTMRVTWAPP
PSIELTNLLVRYSPVKNEEDVAELSISPSDNAVVLTNLLPGTEYLVSVSSVYEQHESIPL
RGRQKTGLDSPTGFDSSDITANSFTVHWVAPRAPITGYIIRHHAEHSVGRPRQDRVPPSR
NSITLTNLNPGTEYVVSIIAVNGREESPPLIGQQATVSDIPRDLEVIASTPTSLLISWEP
PAVSVRYYRITYGETGGNSPVQEFTVPGSKSTATINNIKPGADYTITLYAVTGRGDSPAS
SKPVSINYKTEIDKPSQMQVTDVQDNSISVRWLPSTSPVTGYRVTTTPKNGLGPSKTKTA
SPDQTEMTIEGLQPTVEYVVSVYAQNRNGESQPLVQTAVTNIDRPKGLAFTDVDVDSIKI
AWESPQGQVSRYRVTYSSPEDGIRELFPAPDGEDDTAELQGLRPGSEYTVSVVALHDDME
SQPLIGIQSTAIPAPTNLKFSQVTPTSFTAQWIAPSVQLTGYRVRVNPKEKTGPMKEINL
SPDSSSVIVSGLMVATKYEVSVYALKDTLTSRPAQGVITTLENVSPPRRARVTDATETTI
TISWRTKTETITGFQVDAIPANGQTPVQRSISPDVRSYTITGLQPGTDYKIHLYTLNDNA
RSSPVIIDASTAIDAPSNLRFLTTTPNSLLVSWQAPRARITGYIIKYEKPGSPPREVVPR
PRPGVTEATITGLEPGTEYTIYVIALKNNQKSEPLIGRKKTDELPQLVTLPHPNLHGPEI
LDVPSTVQKTPFITNPGYDTENGIQLPGTTHQQPSVGQQMIFEEHGFRRTTPPTAATPVR
LRPRPYLPNVDEEVQIGHVPRGDVDYHLYPHVPGLNPNASTGQEALSQTTISWTPFQESS
EYIISCQPVGTDEEPLQFQVPGTSTSATLTGLTRGVTYNIIVEALQNQRRHKVREEVVTV
GNAVSEGLNQPTDDSCFDPYTVSHYAIGEEWERLSDAGFKLTCQCLGFGSGHFRCDSSKW
CHDNGVNYKIGEKWDRQGENGQRMSCTCLGNGKGEFKCDPHEATCYDDGKTYHVGEQWQK
EYLGAICSCTCFGGQRGWRCDNCRRPGAAEPSPDGTTGHTYNQYTQRYNQRTNTNVNCPI
ECFMPLDVQADRDDSRE |
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| NT seq |
7434 nt  +upstreamnt +downstreamnt
atgctcaggggtccgggacccgggcggctgctgctgctggcagtcctgtgcctggggacc
tcggtgcgctgcaccgaagccgggaagagcaagaggcaggctcagcaaatcgtgcagcct
caatccccggtggctgtcagtcagagcaagcctggctgttttgacaatgggaagcactat
cagataaatcagcagtgggaacggacctacctaggcaacgccctggtttgtacctgctat
ggaggaagccggggttttaactgcgagagcaagcctgagcctgaagagacttgctttgac
aaatacactgggaacacttacaaagtgggtgacacttatgagcgccctaaagattccatg
atctgggactgtacctgcatcggggctgggagaggcaggatcagctgtaccattgcaaat
cgctgccatgaagggggtcagtcctacaagattggcgacaagtggaggaggccacatgag
actggtggctacatgttagagtgtctgtgtctgggaaatggaaaaggggaatggacctgc
aaacctatagctgagaagtgttttgatcatgctgctgggacgtcctacgtcgtgggggag
acctgggaaaagccctaccaaggctggatgatggtggactgtacttgtctaggcgaaggc
aatggacgcatcacctgtacctccagaaacagatgcaacgatcaggacacccggacatcc
tataggattggagacacgtggagcaagaaggacaaccgaggaaacctgcttcagtgtgtc
tgcacaggcaatggcagaggggagtggaagtgtgagcgacatgctctacaaagtgcttca
gccggatctggctccttcactgatgtccgaacagctatttaccaaccgcagactcacccc
cagcccgctccctacggccactgtgtcaccgacagtggtgtggtctactctgtgggaatg
cagtggctgaagtcgcaaggaaacaagcaaatgctgtgcacgtgcctgggcaatggcgtc
agctgccaggagacagccgtgacccagacttatggtggcaattcaaacggggagccctgt
gtcctcccgttcacctacaacggtaggaccttctattcctgcaccaccgaagggcggcaa
gacggacatctgtggtgtagcacaacttccaattacgaacaagaccagaagtattccttc
tgcacagaccatgcggttttggttcagactcgaggcggaaattccaatggtgctctgtgc
cacttccccttcctgtacaacaaccggaattacaccgactgtacttctgagggtcgcagg
gacaacatgaaatggtgcggcaccacccagaactacgatgccgatcagaagtttggattc
tgcccaatggctgcccacgaggagatctgcacaaccaatgaaggggtcatgtatcgcatt
ggggatcagtgggataagcagcatgacctgggccacatgatgaggtgcacgtgtgtgggg
aacggtcgtggagaatgggcctgcatcccctactcccagctccgagaccagtgcatcgtt
gatgacattacttacaatgtgaacgacacgttccacaagcgtcacgaggagggacatatg
ctgaactgtacctgctttggtcagggccggggcagatggaagtgtgaccccattgaccag
tgccaagattcagagacccggacattttaccagattggtgactcctgggagaagtttgtg
catggtgtccgataccagtgttactgctacggccgtggcatcggggagtggcactgtcaa
cctctgcagacctacccaggcacaactggacctgtccaagtaattatcacggagaccccc
agccagcccaattcccaccccatccagtggaatgccccggagccttcacacatcaccaag
tacattctcagatggagacctaaaacctctacgggtcgctggaaggaagctaccattcct
ggccaccttaactcctataccatcaaaggcctgaccccaggtgtgatctatgagggacag
ctcatcagcatccagcagtatggccacagagaagtgacacgcttcgacttcaccaccagc
gccagcacccctgtgaccagcaacacggtgaccggagagactgcgccctactctcctgtt
gtggccacttctgaatctgtaactgaaatcacagccagcagctttgtggtctcatgggtc
tcagcctccgacaccgtgtcaggcttccgggtggagtatgagctgagcgaggagggagat
gaaccacagtaccttgatctcccaagcacggccacttccgtgaacattcctgacctgctc
ccgggcagaaagtacattgtcaatgtctatcagatatctgaggagggaaaacagagcttg
atcctgtctacctcacagactacagcacctgacgctcctccagaccctaccgtggaccag
gttgatgatacttccattgttgttcggtggagtagaccccaggcacctatcacagggtat
agaattgtctattcaccttcagtagaaggcagtagcacagagctcaacctccctgaaacg
gccaactccgtcaccctcagcgacctgcagcccggtgttcagtacaacatcactatctat
gctgtggaggagaaccaggagagcacacccgttttcatccaacaagagaccactggcacc
ccaagatctgataacgtcccccctccgacggacctacagtttgtggaactgactgatgtg
aaagtcaccatcatgtggacccctcctgatagtgtggtgtctggataccgtgtggaggtc
ctgcctgtcagcctgcccggggaacatgggcagaggctgcctgtcaacagaaataccttt
gctgaaatcactgggctgtcccctggggtcacgtacctcttcaaagtctttgctgtgcac
cagggcagggaaagcaatcctctgacggcacaacagaccaccaaactcgacgctcccact
aacctccagtttgtcaatgaaactgacagaacagttctggtaacgtggactccacctcga
gcccgtatagcaggctaccgactgaccgcgggcctgacccgaggaggccagcccaagcag
tacaatgtgggacccttggcctccaagtatcccctgagaaatctgcagcctgggtctgag
tacaccgtgaccttggtggctgtgaaagggaaccagcagagtcccaaagccaccggagtc
tttactaccctgcagcctctgcgctccattccaccttacaacaccgaggtgacagagacc
acaattgtgatcacctggacccccgctccaaggattggcttcaagctgggtgtacgaccg
agccagggaggtgaggcaccccgagaagtgacttcagactctgggagcattgttgtgtct
ggcttgactccaggcgtggaatacacttacaccatccaagtcctgcgagatggccaggag
agagatgcaccgattgtcaacagagtagtgacaccgctgtctccaccgaccaacttgcat
ctggaggcaaaccctgacactggagtgcttactgtctcctgggagaggagcactacccca
gatatcactggctacagaataactactacccccacgaacgggcagcaggggacctctctg
gaagaagtggtccatgctgatcagagttcctgcacttttgagaacctgaatcctggcctg
gagtacaacgtcagtgtttacactgtcaaagatgacaaggaaagtgcccctatctctgat
accgttgtcccagaggtgccccagctcactgacctaagctttgttgatataactgattca
agcatcggcctgaggtggaccccgctaaactcttccaccattatcgggtaccgaatcaca
gtagttgcggcaggagaagggatccctatttttgaagattttgtggactcctcagtagga
tactacacagttacagggctggagcctggcattgactatgacatcagcgttatcactctc
attaatggcggagagagtgcccctactacactgacacagcaaacggctgtccctcctccc
acggatctgcgattcaccaatatcggtccagacacgatgcgggtcacttgggccccgcct
ccgtccatcgagctgaccaacctcttggtgcgctactcacccgtgaagaatgaagaggac
gttgcagagctatccatttcaccttcagacaatgccgtggtcctaacaaatctcctgcct
gggacagaatacttagtcagtgtctccagtgtctacgaacaacatgagagcatccctctc
cggggaaggcagaaaacaggtctcgattccccaactggttttgattcttctgatatcacc
gccaactcattcactgtccactgggtggctcctcgggcccccatcaccggctacatcatc
cgccatcacgccgagcattctgtcggaagacccaggcaggatcgagtgccgccctcgcgg
aattccatcaccctcaccaaccttaatccgggcaccgagtacgttgtcagcatcattgct
gttaatggcagagaggagagcccgccactgattggccagcaagccacagtttctgatatt
ccgagagatctggaggtcattgcctccacccccaccagcctgctcatcagttgggaaccc
cctgccgtctctgtgcgctattacagaatcacctacggagagacaggaggaaatagccct
gtccaggagttcactgtgcccggaagcaagtccacagccaccatcaacaacattaaacca
ggagcagactacaccatcaccctgtatgctgtcactggccgtggggacagtccagcaagc
agcaagccagtttccatcaattataaaacagaaattgacaagccgtcccagatgcaggtg
acagatgtccaggacaacagcatcagtgtcaggtggctgccttcaacttctcctgtgaca
ggctacagagtgaccaccactcccaaaaatggcctaggaccatcaaaaactaaaactgcc
agtccagatcaaacagaaatgaccattgaaggtttgcaacccactgtggagtacgtggtt
agtgtttatgctcagaaccggaacggagaaagccagcccctggttcaaactgcagtgacc
aacattgatcgccctaaaggactggcattcactgatgtggatgtcgattccatcaaaatt
gcttgggaaagcccacaggggcaagtttccaggtacagggtgacctactcgagccctgag
gatggaatccgggagcttttccctgcacctgatggtgaagacgacactgcagagctgcag
ggcctcaggccggggtctgagtacacagtcagtgtggttgccttgcacgatgatatggag
agccagcccctgattggaatccagtccacagccattcctgcgcccaccaatctgaagttc
agtcaggtgacacccaccagctttactgcccagtggatagcacccagtgttcagctcact
ggctaccgggtgcgggtgaacccgaaagagaagacaggaccaatgaaagaaatcaacctt
tctccagacagctcatcggtgattgtgtcaggactcatggtggccactaaatacgaagtc
agtgtctatgctctcaaggacacactgacaagcagaccagcccagggagtcatcactact
ctggagaatgttagccctccaagaagggcccgtgtgacggacgctacagagaccaccatc
actattagctggagaacaaagacagagacaatcactggcttccaagtcgatgccatccca
gccaatggccagaccccagttcagaggagcatcagcccggatgttagaagctacaccatt
acaggtttacagccaggcactgactacaagatccacctgtacactctgaacgacaatgcc
cggagctcgcccgtgatcatcgatgcctccaccgccatcgacgcaccatccaacctgcgg
ttcctgaccaccacacccaactccttgctggtgtcatggcaggcgccccgtgccaggatt
actggctacattatcaagtatgagaagcctggatcccctcccagagaagtggtccctcgg
ccccgccctggtgtcacggaggccaccattactggtctggagccaggaaccgagtacacc
atctacgtcattgccctgaagaacaatcagaagagtgagcccctgattgggaggaagaag
acagatgagcttccccaactggttacccttccacaccccaatcttcatggaccagagatc
ttggatgttccctccacagttcaaaagacccccttcatcaccaaccctgggtatgacacc
gaaaatggtattcagcttcctggcacaacccaccagcaacccagtgttgggcaacaaatg
atctttgaggaacatggctttaggcggacaacgccacccactgcggccacccccgtcagg
cttaggccaagaccatacctgccgaatgtagatgaggaggtccaaatcggtcatgttccc
aggggagacgtagactaccacctctatcctcatgttccgggcctcaatccaaatgcctct
acaggacaggaagctctctctcagacaaccatctcttggacgccgttccaggagagttct
gagtacatcatttcatgccaaccagttggcaccgacgaagagcccttacagttccaagtt
cctggaacttctaccagtgcgactctgactggccttaccagaggggtcacctacaacatc
atagtggaggcactgcagaaccagaggaggcacaaggttcgggaagaggttgtgactgtg
ggcaacgctgtcagcgaaggcctgaaccagcctacagatgactcatgctttgacccttac
acggtttcccattacgccattggagaggagtgggagcggttgtctgacgctggctttaag
ctcacatgccagtgcttgggctttggcagtggtcatttcagatgcgattcatctaaatgg
tgccatgacaacggtgtcaactacaagatcggagagaagtgggatcggcagggagaaaat
ggccagcggatgagctgcacatgcctcgggaatggaaagggagaattcaagtgtgatccc
catgaagcaacgtgctatgacgatgggaagacctaccatgtaggagaacagtggcagaaa
gaatatctcggagccatttgctcctgcacgtgtttcggaggccagcggggctggcgctgt
gacaactgccgtagacctggggctgctgaacccagtcccgatggcaccaccggccacacc
tacaaccagtatacacagagatacaatcagagaacaaacactaacgtaaattgccccatt
gagtgcttcatgccgctagatgtgcaagctgacagagacgattctcgagagtaa |
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