KEGG   PATHWAY: hsa03320Help
Entry
hsa03320                    Pathway                                
Name
PPAR signaling pathway - Homo sapiens (human)
Description
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake.
Class
Organismal Systems; Endocrine System
BRITE hierarchy
Pathway map
hsa03320  PPAR signaling pathway
hsa03320

All organismsOrtholog table
Disease H00151  Cerebrotendinous xanthomatosis
H00154  Hyperlipoproteinemia, type I
H00157  Hyperlipoproteinemia, type V
H00407  Peroxisomal beta-oxidation enzyme deficiency
H00420  Familial partial lipodystrophy (FPL)
Drug D00279  Clofibrate (JP15/USP/INN)
D00334  Gemfibrozil (JAN/USP/INN)
D00395  Troglitazone (JAN/USAN/INN)
D00565  Fenofibrate (JAN/INN)
D00596  Rosiglitazone maleate (JAN/USAN)
D00945  Pioglitazone hydrochloride (JAN/USP)
D01208  Aluminum clofibrate (JAN/INN)
D01366  Bezafibrate (JP15/USAN/INN)
D02815  Alitretinoin (USAN)
D03106  Bexarotene (USAN/INN)
D03493  Ciglitazone (USAN/INN)
D03521  Ciprofibrate (USAN/INN)
D03653  Darglitazone sodium (USAN)
D03747  Ibrolipim (USAN/INN)
D05030  Mifobate (USAN/INN)
D05091  Muraglitazar (USAN/INN)
D05150  Netoglitazone (USAN/INN)
D05292  Oxfenicine (USAN/INN)
D05739  Rivoglitazone (USAN/INN)
D06102  Theofibrate (USAN)
D07187  Etofibrate (INN)
D07724  Magnesium clofibrate (INN)
D08378  pioglitazone (INN)
D08491  Rosiglitazone (INN)
D08890  Choline fenofibrate (INN/USAN)
Organism
Homo sapiens (human) [GN:hsa]
Gene
948  CD36, CHDS7, FAT, GP3B, GP4, GPIV, PASIV, SCARB3 [KO:K06259]
10999  SLC27A4, ACSVL4, FATP4, IPS [KO:K08745] [EC:6.2.1.-]
376497  SLC27A1, ACSVL5, FATP, FATP1, FLJ00336, MGC71751 [KO:K08745] [EC:6.2.1.-]
11001  SLC27A2, ACSVL1, FACVL1, FATP2, HsT17226, VLACS, VLCS, hFACVL1 [KO:K08746] [EC:6.2.1.3 6.2.1.-]
10998  SLC27A5, ACSB, ACSVL6, FACVL3, FATP5, FLJ22987, VLACSR, VLCS-H2, VLCSH2 [KO:K08748] [EC:6.2.1.7]
28965  SLC27A6, ACSVL2, DKFZp779M0564, FACVL2, FATP6, VLCS-H1 [KO:K08749]
2168  FABP1, FABPL, L-FABP [KO:K08750]
2169  FABP2, FABPI, I-FABP, MGC133132 [KO:K08751]
2170  FABP3, FABP11, H-FABP, MDGI, O-FABP [KO:K08752]
2167  FABP4, A-FABP, aP2 [KO:K08753]
2171  FABP5, E-FABP, EFABP, PA-FABP, PAFABP [KO:K08754]
2172  FABP6, I-15P, I-BABP, I-BALB, I-BAP, ILBP, ILBP3, ILLBP [KO:K08755]
2173  FABP7, B-FABP, BLBP, DKFZp547J2313, FABPB, MRG [KO:K08756]
5465  PPARA, MGC2237, MGC2452, NR1C1, PPAR, PPARalpha, hPPAR [KO:K07294]
6256  RXRA, FLJ00280, FLJ00318, FLJ16020, FLJ16733, MGC102720, NR2B1 [KO:K08524]
6257  RXRB, DAUDI6, H-2RIIBP, MGC1831, NR2B2, RCoR-1 [KO:K08525]
6258  RXRG, NR2B3, RXRC [KO:K08526]
5467  PPARD, FAAR, MGC3931, NR1C2, NUC1, NUCI, NUCII, PPARB [KO:K04504]
5468  PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma [KO:K08530]
335  APOA1, MGC117399 [KO:K08757]
336  APOA2, Apo-AII, ApoA-II, apoAII [KO:K08758]
345  APOC3, APOCIII, MGC150353 [KO:K08759]
116519  APOA5, APOAV, FLJ97995, MGC126836, MGC126838, RAP3 [KO:K09025]
5360  PLTP, HDLCQ9 [KO:K08761]
9415  FADS2, D6D, DES6, FADSD6, LLCDL2, SLL0262, TU13 [KO:K10226] [EC:1.14.19.-]
6319  SCD, FADS5, MSTP008, SCD1, SCDOS [KO:K00507] [EC:1.14.19.1]
79966  SCD5, ACOD4, FADS4, FLJ21032, HSCD5, SCD2, SCD4 [KO:K00507] [EC:1.14.19.1]
1581  CYP7A1, CP7A, CYP7, CYPVII, MGC126826, MGC138389 [KO:K00489] [EC:1.14.13.17]
1582  CYP8B1, CP8B, CYP12, FLJ17826 [KO:K07431] [EC:1.14.13.95]
10062  NR1H3, LXR-a, LXRA, RLD-1 [KO:K08536]
1593  CYP27A1, CP27, CTX, CYP27 [KO:K00488] [EC:1.14.13.15]
1622  DBI, ACBD1, ACBP, CCK-RP, EP, MGC70414 [KO:K08762]
4023  LPL, HDLCQ11, LIPD [KO:K01059] [EC:3.1.1.34]
2180  ACSL1, ACS1, FACL1, FACL2, LACS, LACS1, LACS2 [KO:K01897] [EC:6.2.1.3]
2181  ACSL3, ACS3, FACL3, PRO2194 [KO:K01897] [EC:6.2.1.3]
2182  ACSL4, ACS4, FACL4, LACS4, MRX63, MRX68 [KO:K01897] [EC:6.2.1.3]
23305  ACSL6, ACS2, FACL6, FLJ16173, KIAA0837, LACS_6, LACS2, LACS5 [KO:K01897] [EC:6.2.1.3]
51703  ACSL5, ACS2, ACS5, FACL5 [KO:K01897] [EC:6.2.1.3]
4973  OLR1, CLEC8A, LOX1, LOXIN, SCARE1, SLOX1 [KO:K08763]
1962  EHHADH, ECHD, L-PBE, LBFP, LBP, MGC120586, PBFE [KO:K07514] [EC:5.3.3.8 1.1.1.35 4.2.1.17]
1579  CYP4A11, CP4Y, CYP4A2, CYP4AII [KO:K07425] [EC:1.14.15.3]
284541  CYP4A22 [KO:K07425] [EC:1.14.15.3]
30  ACAA1, ACAA, PTHIO, THIO [KO:K07513] [EC:2.3.1.16]
6342  SCP2, DKFZp686C12188, DKFZp686D11188, NLTP, NSL-TP, SCPX [KO:K08764] [EC:2.3.1.176]
51  ACOX1, ACOX, MGC1198, PALMCOX, SCOX [KO:K00232] [EC:1.3.3.6]
8310  ACOX3 [KO:K00232] [EC:1.3.3.6]
8309  ACOX2, BCOX, BRCACOX, BRCOX, THCCox [KO:K10214] [EC:1.17.99.3]
126129  CPT1C, CATL1, CPT1P, CPTIC, FLJ23809 [KO:K08765] [EC:2.3.1.21]
1374  CPT1A, CPT1, CPT1-L, L-CPT1 [KO:K08765] [EC:2.3.1.21]
1375  CPT1B, CPT1-M, CPT1M, CPTI, FLJ55729, FLJ58750, KIAA1670, M-CPT1, MCCPT1, MCPT1 [KO:K08765] [EC:2.3.1.21]
1376  CPT2, CPT1, CPTASE [KO:K08766] [EC:2.3.1.21]
33  ACADL, ACAD4, FLJ94052, LCAD [KO:K00255] [EC:1.3.99.13]
34  ACADM, ACAD1, FLJ18227, FLJ93013, FLJ99884, MCAD, MCADH [KO:K00249] [EC:1.3.99.3]
51129  ANGPTL4, ANGPTL2, ARP4, FIAF, HFARP, NL2, PGAR, pp1158 [KO:K08767]
10580  SORBS1, CAP, DKFZp451C066, DKFZp586P1422, FLAF2, FLJ12406, KIAA1296, R85FL, SH3D5, SH3P12, SORB1 [KO:K06086]
5346  PLIN1, PERI, PLIN [KO:K08768]
9370  ADIPOQ, ACDC, ACRP30, ADIPQTL1, ADPN, APM-1, APM1, GBP28, adiponectin [KO:K07296]
4312  MMP1, CLG, CLGN [KO:K01388] [EC:3.4.24.7]
7350  UCP1, SLC25A7, UCP [KO:K08769]
3611  ILK, DKFZp686F1765, ILK-2, P59 [KO:K06272] [EC:2.7.11.1]
5170  PDPK1, MGC20087, MGC35290, PDK1, PRO0461 [KO:K06276] [EC:2.7.11.1]
7316  UBC, HMG20 [KO:K08770]
5105  PCK1, MGC22652, PEPCK-C, PEPCK1, PEPCKC [KO:K01596] [EC:4.1.1.32]
5106  PCK2, PEPCK, PEPCK-M, PEPCK2 [KO:K01596] [EC:4.1.1.32]
2710  GK, GK1, GKD [KO:K00864] [EC:2.7.1.30]
2712  GK2, GKP2, GKTA [KO:K00864] [EC:2.7.1.30]
364  AQP7, AQP7L, AQP9, AQPap, MGC149555, MGC149556 [KO:K08771]
3158  HMGCS2 [KO:K01641] [EC:2.3.3.10]
4199  ME1, HUMNDME, MES [KO:K00029] [EC:1.1.1.40]
Compound
C02165  Leukotriene B4
C14762  13(S)-HODE
C14767  9(S)-HODE
C14776  8(S)-HETE
C15493  9-cis-Retinoic acid
Reference PMID:15828220
  Authors Takahashi N, Goto T, Kusudo T, Moriyama T, Kawada T.
  Title [The structures and functions of peroxisome proliferator-activated receptors (PPARs)]
  Journal Nippon Rinsho 63:557-64 (2005)
Reference PMID:15828221
  Authors Fujii H.
  Title [PPARs-mediated intracellular signal transduction]
  Journal Nippon Rinsho 63:565-71 (2005)
Reference PMID:15828222
  Authors Takada I, Kato S.
  Title [PPARs target genes]
  Journal Nippon Rinsho 63:573-7 (2005)
Reference PMID:15828223
  Authors Inoue H.
  Title [Endogenous ligands for PPARs]
  Journal Nippon Rinsho 63:578-83 (2005)
Reference PMID:16476485
  Authors Feige JN, Gelman L, Michalik L, Desvergne B, Wahli W.
  Title From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions.
  Journal Prog Lipid Res 45:120-59 (2006)
Reference PMID:16601267
  Authors Desvergne B, Michalik L, Wahli W.
  Title Transcriptional regulation of metabolism.
  Journal Physiol Rev 86:465-514 (2006)
Reference PMID:14999402
  Authors Mandard S, Muller M, Kersten S.
  Title Peroxisome proliferator-activated receptor alpha target genes.
  Journal Cell Mol Life Sci 61:393-416 (2004)
Reference PMID:10529898
  Authors Desvergne B, Wahli W.
  Title Peroxisome proliferator-activated receptors: nuclear control of metabolism.
  Journal Endocr Rev 20:649-88 (1999)
Reference PMID:15673477
  Authors Savage DB.
  Title PPARgamma as a metabolic regulator: insights from genomics and pharmacology.
  Journal Expert Rev Mol Med 2005:1-16 (2005)
Reference PMID:16511590
  Authors Semple RK, Chatterjee VK, O'Rahilly S.
  Title PPAR gamma and human metabolic disease.
  Journal J Clin Invest 116:581-9 (2006)
Reference PMID:16360030
  Authors Lehrke M, Lazar MA.
  Title The many faces of PPARgamma.
  Journal Cell 123:993-9 (2005)
Reference PMID:11921433
  Authors Hauner H.
  Title The mode of action of thiazolidinediones.
  Journal Diabetes Metab Res Rev 18 Suppl 2:S10-5 (2002)
Related
pathway
hsa00071  Fatty acid metabolism
hsa00072  Synthesis and degradation of ketone bodies
hsa00120  Primary bile acid biosynthesis
hsa00564  Glycerophospholipid metabolism
hsa04920  Adipocytokine signaling pathway
KO pathway ko03320
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