KEGG   PATHWAY: mmu04662Help
Entry
mmu04662                    Pathway                                

Name
B cell receptor signaling pathway - Mus musculus (mouse)
Description
B cells are an important component of adaptive immunity. They produce and secrete millions of different antibody molecules, each of which recognizes a different (foreign) antigen. The B cell receptor (BCR) is an integral membrane protein complex that is composed of two immunoglobulin (Ig) heavy chains, two Ig light chains and two heterodimers of Ig-alpha and Ig-beta. After BCR ligation by antigen, three main protein tyrosine kinases (PTKs) -the SRC-family kinase LYN, SYK and the TEC-family kinase BTK- are activated. Phosphatidylinositol 3-kinase (PI3K) and phospholipase C-gamma 2 (PLC-gamma 2) are important downstream effectors of BCR signalling. This signalling ultimately results in the expression of immediate early genes that further activate the expression of other genes involved in B cell proliferation, differentiation and Ig production as well as other processes.
Class
Organismal Systems; Immune system
BRITE hierarchy
Pathway map
B cell receptor signaling pathway
mmu04662

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BSID: 
GO: 
Organism
Mus musculus (mouse) [GN:mmu]
Gene
641025  
CRP55H; Ig heavy chain Mem5-like [KO:K06856]
12518  
Cd79a; CD79A antigen (immunoglobulin-associated alpha) [KO:K06506]
15985  
Cd79b; CD79B antigen [KO:K06507]
17096  
Lyn; LYN proto-oncogene, Src family tyrosine kinase [KO:K05854] [EC:2.7.10.2]
666513  
Gm11787; predicted gene 11787 [KO:K05854] [EC:2.7.10.2]
20963  
Syk; spleen tyrosine kinase [KO:K05855] [EC:2.7.10.2]
12229  
Btk; Bruton agammaglobulinemia tyrosine kinase [KO:K07370] [EC:2.7.10.2]
26377  
Dapp1; dual adaptor for phosphotyrosine and 3-phosphoinositides 1 [KO:K12229]
17060  
Blnk; B cell linker [KO:K07371]
22324  
Vav1; vav 1 oncogene [KO:K05730]
22325  
Vav2; vav 2 oncogene [KO:K05730]
57257  
Vav3; vav 3 oncogene [KO:K05730]
19353  
Rac1; RAS-related C3 botulinum substrate 1 [KO:K04392]
19354  
Rac2; RAS-related C3 botulinum substrate 2 [KO:K07860]
170758  
Rac3; RAS-related C3 botulinum substrate 3 [KO:K07861]
234779  
Plcg2; phospholipase C, gamma 2 [KO:K05859] [EC:3.1.4.11]
19057  
Ppp3cc; protein phosphatase 3, catalytic subunit, gamma isoform [KO:K04348] [EC:3.1.3.16]
19055  
Ppp3ca; protein phosphatase 3, catalytic subunit, alpha isoform [KO:K04348] [EC:3.1.3.16]
19056  
Ppp3cb; protein phosphatase 3, catalytic subunit, beta isoform [KO:K04348] [EC:3.1.3.16]
19058  
Ppp3r1; protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type I) [KO:K06268]
19059  
Ppp3r2; protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type II) [KO:K06268]
18018  
Nfatc1; nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1 [KO:K04446]
18019  
Nfatc2; nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 [KO:K17332]
18021  
Nfatc3; nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 3 [KO:K17333]
14784  
Grb2; growth factor receptor bound protein 2 [KO:K04364]
20662  
Sos1; son of sevenless homolog 1 (Drosophila) [KO:K03099]
20663  
Sos2; son of sevenless homolog 2 (Drosophila) [KO:K03099]
240168  
Rasgrp3; RAS, guanyl releasing protein 3 [KO:K12362]
15461  
Hras; Harvey rat sarcoma virus oncogene [KO:K02833]
16653  
Kras; Kirsten rat sarcoma viral oncogene homolog [KO:K07827]
18176  
Nras; neuroblastoma ras oncogene [KO:K07828]
110157  
Raf1; v-raf-leukemia viral oncogene 1 [KO:K04366] [EC:2.7.11.1]
26395  
Map2k1; mitogen-activated protein kinase kinase 1 [KO:K04368] [EC:2.7.12.2]
26396  
Map2k2; mitogen-activated protein kinase kinase 2 [KO:K04369] [EC:2.7.12.2]
26413  
Mapk1; mitogen-activated protein kinase 1 [KO:K04371] [EC:2.7.11.24]
26417  
Mapk3; mitogen-activated protein kinase 3 [KO:K04371] [EC:2.7.11.24]
14281  
Fos; FBJ osteosarcoma oncogene [KO:K04379]
16476  
Jun; jun proto-oncogene [KO:K04448]
18751  
Prkcb; protein kinase C, beta [KO:K19662] [EC:2.7.11.13]
108723  
Card11; caspase recruitment domain family, member 11 [KO:K07367]
12042  
Bcl10; B cell leukemia/lymphoma 10 [KO:K07368]
240354  
Malt1; MALT1 paracaspase [KO:K07369] [EC:3.4.22.-]
12675  
Chuk; conserved helix-loop-helix ubiquitous kinase [KO:K04467] [EC:2.7.11.10]
16150  
Ikbkb; inhibitor of kappaB kinase beta [KO:K07209] [EC:2.7.11.10]
16151  
Ikbkg; inhibitor of kappaB kinase gamma [KO:K07210]
18033  
Nfkb1; nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 [KO:K02580]
19697  
Rela; v-rel reticuloendotheliosis viral oncogene homolog A (avian) [KO:K04735]
18035  
Nfkbia; nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha [KO:K04734]
18036  
Nfkbib; nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta [KO:K02581]
18037  
Nfkbie; nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, epsilon [KO:K05872]
68713  
Ifitm1; interferon induced transmembrane protein 1 [KO:K19831]
12520  
Cd81; CD81 antigen [KO:K06508]
12478  
Cd19; CD19 antigen [KO:K06465]
12902  
Cr2; complement receptor 2 [KO:K04012]
18709  
Pik3r2; phosphoinositide-3-kinase regulatory subunit 2 [KO:K02649]
18708  
Pik3r1; phosphoinositide-3-kinase regulatory subunit 1 [KO:K02649]
18710  
Pik3r3; phosphoinositide-3-kinase regulatory subunit 3 [KO:K02649]
18706  
Pik3ca; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha [KO:K00922] [EC:2.7.1.153]
18707  
Pik3cd; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta [KO:K00922] [EC:2.7.1.153]
74769  
Pik3cb; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta [KO:K00922] [EC:2.7.1.153]
11651  
Akt1; thymoma viral proto-oncogene 1 [KO:K04456] [EC:2.7.11.1]
11652  
Akt2; thymoma viral proto-oncogene 2 [KO:K04456] [EC:2.7.11.1]
23797  
Akt3; thymoma viral proto-oncogene 3 [KO:K04456] [EC:2.7.11.1]
56637  
Gsk3b; glycogen synthase kinase 3 beta [KO:K03083] [EC:2.7.11.26]
14130  
Fcgr2b; Fc receptor, IgG, low affinity IIb [KO:K12560]
16331  
Inpp5d; inositol polyphosphate-5-phosphatase D [KO:K03084] [EC:3.1.3.86]
16332  
Inppl1; inositol polyphosphate phosphatase-like 1 [KO:K15909] [EC:3.1.3.86]
12483  
Cd22; CD22 antigen [KO:K06467]
12517  
Cd72; CD72 antigen [KO:K06504]
15170  
Ptpn6; protein tyrosine phosphatase, non-receptor type 6 [KO:K05697] [EC:3.1.3.48]
83490  
Pik3ap1; phosphoinositide-3-kinase adaptor protein 1 [KO:K12230]
18733  
Pirb; paired Ig-like receptor B [KO:K06512]
Compound
C00076  
Calcium cation
C00165  
Diacylglycerol
C01245  
D-myo-Inositol 1,4,5-trisphosphate
C05981  
Phosphatidylinositol-3,4,5-trisphosphate
Reference
  Authors
Niiro H, Clark EA.
  Title
Regulation of B-cell fate by antigen-receptor signals.
  Journal
Nat Rev Immunol 2:945-56 (2002)
DOI:10.1038/nri955
Reference
  Authors
Kurosaki T.
  Title
Genetic analysis of B cell antigen receptor signaling.
  Journal
Annu Rev Immunol 17:555-92 (1999)
DOI:10.1146/annurev.immunol.17.1.555
Reference
  Authors
Nitschke L.
  Title
The role of CD22 and other inhibitory co-receptors in B-cell activation.
  Journal
Curr Opin Immunol 17:290-7 (2005)
DOI:10.1016/j.coi.2005.03.005
Reference
  Authors
Morgan BP, Marchbank KJ, Longhi MP, Harris CL, Gallimore AM.
  Title
Complement: central to innate immunity and bridging to adaptive responses.
  Journal
Immunol Lett 97:171-9 (2005)
DOI:10.1016/j.imlet.2004.11.010
Reference
  Authors
Kurosaki T.
  Title
Regulation of B-cell signal transduction by adaptor proteins.
  Journal
Nat Rev Immunol 2:354-63 (2002)
DOI:10.1038/nri801
Reference
  Authors
Nitschke L, Tsubata T.
  Title
Molecular interactions regulate BCR signal inhibition by CD22 and CD72.
  Journal
Trends Immunol 25:543-50 (2004)
DOI:10.1016/j.it.2004.08.002
Reference
  Authors
Jumaa H, Hendriks RW, Reth M.
  Title
B cell signaling and tumorigenesis.
  Journal
Annu Rev Immunol 23:415-45 (2005)
DOI:10.1146/annurev.immunol.23.021704.115606
Reference
  Authors
Rickert RC.
  Title
Regulation of B lymphocyte activation by complement C3 and the B cell coreceptor complex.
  Journal
Curr Opin Immunol 17:237-43 (2005)
DOI:10.1016/j.coi.2005.03.001
Reference
  Authors
Zouali M, Sarmay G
  Title
B lymphocyte signaling pathways in systemic autoimmunity: implications for pathogenesis and treatment.
  Journal
Arthritis Rheum 50:2730-41 (2004)
DOI:10.1002/art.20487
Reference
  Authors
Chiles TC.
  Title
Regulation and function of cyclin D2 in B lymphocyte subsets.
  Journal
J Immunol 173:2901-7 (2004)
DOI:10.4049/jimmunol.173.5.2901
Reference
  Authors
Allam A, Marshall AJ
  Title
Role of the adaptor proteins Bam32, TAPP1 and TAPP2 in lymphocyte activation.
  Journal
Immunol Lett 97:7-17 (2005)
DOI:10.1016/j.imlet.2004.09.019
Reference
  Authors
Gold MR
  Title
To make antibodies or not: signaling by the B-cell antigen receptor.
  Journal
Trends Pharmacol Sci 23:316-24 (2002)
DOI:10.1016/S0165-6147(02)02045-X
Reference
PMID:9697839
  Authors
Fu C, Turck CW, Kurosaki T, Chan AC
  Title
BLNK: a central linker protein in B cell activation.
  Journal
Immunity 9:93-103 (1998)
DOI:10.1016/S1074-7613(00)80591-9
Reference
  Authors
Okada T, Maeda A, Iwamatsu A, Gotoh K, Kurosaki T
  Title
BCAP: the tyrosine kinase substrate that connects B cell receptor to phosphoinositide 3-kinase activation.
  Journal
Immunity 13:817-27 (2000)
DOI:10.1016/S1074-7613(00)00079-0
Reference
  Authors
Shinohara H, Maeda S, Watarai H, Kurosaki T
  Title
IkappaB kinase beta-induced phosphorylation of CARMA1 contributes to CARMA1 Bcl10 MALT1 complex formation in B cells.
  Journal
J Exp Med 204:3285-93 (2007)
DOI:10.1084/jem.20070379
KO pathway
 
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