KEGG   PATHWAY: rno04020Help
Entry
rno04020                    Pathway                                

Name
Calcium signaling pathway - Rattus norvegicus (rat)
Description
Ca2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this external source of signal Ca2+ by activating various entry channels with widely different properties. The voltage-operated channels (VOCs) are found in excitable cells and generate the rapid Ca2+ fluxes that control fast cellular processes. There are many other Ca2+-entry channels, such as the receptor-operated channels (ROCs), for example the NMDA (N-methyl-D-aspartate) receptors (NMDARs) that respond to glutamate. There also are second-messenger-operated channels (SMOCs) and store-operated channels (SOCs).
The other principal source of Ca2+ for signalling is the internal stores that are located primarily in the endoplasmic/sarcoplasmic reticulum (ER/SR), in which inositol-1,4,5-trisphosphate receptors (IP3Rs) or ryanodine receptors (RYRs) regulate the release of Ca2+. The principal activator of these channels is Ca2+ itself and this process of Ca2+-induced Ca2+ release is central to the mechanism of Ca2+ signalling. Various second messengers or modulators also control the release of Ca2+. IP3, which is generated by pathways using different isoforms of phospholipase C (PLCbeta, delta, epsilon, gamma and zeta), regulates the IP3Rs. Cyclic ADP-ribose (cADPR) releases Ca2+ via RYRs. Nicotinic acid adenine dinucleotide phosphate (NAADP) may activate a distinct Ca2+ release mechanism on separate acidic Ca2+ stores. Ca2+ release via the NAADP-sensitive mechanism may also feedback onto either RYRs or IP3Rs. cADPR and NAADP are generated by CD38. This enzyme might be sensitive to the cellular metabolism, as ATP and NADH inhibit it.
The influx of Ca2+ from the environment or release from internal stores causes a very rapid and dramatic increase in cytoplasmic calcium concentration, which has been widely exploited for signal transduction. Some proteins, such as troponin C (TnC) involved in muscle contraction, directly bind to and sense Ca2+. However, in other cases Ca2+ is sensed through intermediate calcium sensors such as calmodulin (CALM).
Class
Environmental Information Processing; Signal transduction
BRITE hierarchy
Pathway map
Calcium signaling pathway
rno04020

All organismsOrtholog table
Other DBs
BSID: 
GO: 
Organism
Rattus norvegicus (rat) [GN:rno]
Gene
29715  
Slc8a1; solute carrier family 8 member A1 [KO:K05849]
140447  
Slc8a2; solute carrier family 8 member A2 [KO:K05849]
140448  
Slc8a3; solute carrier family 8 member A3 [KO:K05849]
29600  
Atp2b4; ATPase plasma membrane Ca2+ transporting 4 [KO:K05850] [EC:3.6.3.8]
29599  
Atp2b3; ATPase plasma membrane Ca2+ transporting 3 [KO:K05850] [EC:3.6.3.8]
24215  
Atp2b2; ATPase plasma membrane Ca2+ transporting 2 [KO:K05850] [EC:3.6.3.8]
29598  
Atp2b1; ATPase plasma membrane Ca2+ transporting 1 [KO:K05850] [EC:3.6.3.8]
25229  
Chrm1; cholinergic receptor, muscarinic 1 [KO:K04129]
24260  
Chrm3; cholinergic receptor, muscarinic 3 [KO:K04131]
53949  
Chrm5; cholinergic receptor, muscarinic 5 [KO:K04133]
25369  
Adora2a; adenosine A2a receptor [KO:K04266]
29316  
Adora2b; adenosine A2B receptor [KO:K04267]
24925  
Adrb1; adrenoceptor beta 1 [KO:K04141]
24176  
Adrb2; adrenoceptor beta 2 [KO:K04142]
25645  
Adrb3; adrenoceptor beta 3 [KO:K04143]
24316  
Drd1; dopamine receptor D1 [KO:K04144]
25195  
Drd5; dopamine receptor D5 [KO:K05840]
25461  
Hrh2; histamine receptor H 2 [KO:K04150]
25324  
Htr4; 5-hydroxytryptamine receptor 4 [KO:K04160]
25689  
Htr5a; 5-hydroxytryptamine receptor 5A [KO:K04161]
79247  
Htr5b; 5-hydroxytryptamine (serotonin) receptor 5B [KO:K04161]
64354  
Htr6; 5-hydroxytryptamine receptor 6 [KO:K04162]
65032  
Htr7; 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled [KO:K04163]
5-hydroxytryptamine receptor 7 [KO:K04163]
24896  
Gnas; GNAS complex locus [KO:K04632]
24611  
Gnal; G protein subunit alpha L [KO:K04633]
305509  
Adcy1; adenylate cyclase 1 [KO:K08041] [EC:4.6.1.1]
81636  
Adcy2; adenylate cyclase 2 [KO:K08042] [EC:4.6.1.1]
64508  
Adcy3; adenylate cyclase 3 [KO:K08043] [EC:4.6.1.1]
54223  
Adcy4; adenylate cyclase 4 [KO:K08044] [EC:4.6.1.1]
84420  
Adcy7; adenylate cyclase 7 [KO:K08047] [EC:4.6.1.1]
29241  
Adcy8; adenylate cyclase 8 [KO:K08048] [EC:4.6.1.1]
302950  
Adcy9; adenylate cyclase 9 [KO:K08049] [EC:4.6.1.1]
25636  
Prkaca; protein kinase cAMP-activated catalytic subunit alpha [KO:K04345] [EC:2.7.11.11]
293508  
Prkacb; protein kinase cAMP-activated catalytic subunit beta [KO:K04345] [EC:2.7.11.11]
64672  
Pln; phospholamban [KO:K05852]
116601  
Atp2a1; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1 [KO:K05853] [EC:3.6.3.8]
29693  
Atp2a2; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 [KO:K05853] [EC:3.6.3.8]
25391  
Atp2a3; ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 [KO:K05853] [EC:3.6.3.8]
361618  
Stim1; stromal interaction molecule 1 [KO:K16059]
117087  
Stim2; stromal interaction molecule 2 [KO:K18196]
304496  
Orai1; ORAI calcium release-activated calcium modulator 1 [KO:K16056]
304592  
Orai2; ORAI calcium release-activated calcium modulator 2 [KO:K16057]
309000  
Orai3; ORAI calcium release-activated calcium modulator 3 [KO:K16058]
24239  
Cacna1c; calcium voltage-gated channel subunit alpha1 C [KO:K04850]
29716  
Cacna1d; calcium voltage-gated channel subunit alpha1 D [KO:K04851]
114493  
Cacna1f; calcium voltage-gated channel subunit alpha1 F [KO:K04853]
682930  
Cacna1s; calcium voltage-gated channel subunit alpha1 S [KO:K04857]
25398  
Cacna1a; calcium voltage-gated channel subunit alpha1 A [KO:K04344]
257648  
Cacna1b; calcium voltage-gated channel subunit alpha1 B [KO:K04849]
54234  
Cacna1e; calcium voltage-gated channel subunit alpha1 E [KO:K04852]
29717  
Cacna1g; calcium voltage-gated channel subunit alpha1 G [KO:K04854]
114862  
Cacna1h; calcium voltage-gated channel subunit alpha1 H [KO:K04855]
56827  
Cacna1i; calcium voltage-gated channel subunit alpha1 I [KO:K04856]
25302  
Chrna7; cholinergic receptor nicotinic alpha 7 subunit [KO:K04809]
25505  
P2rx1; purinergic receptor P2X 1 [KO:K05215]
114115  
P2rx2; purinergic receptor P2X 2 [KO:K05216]
81739  
P2rx3; purinergic receptor P2X 3 [KO:K05217]
29659  
P2rx4; purinergic receptor P2X 4 [KO:K05218]
113995  
P2rx5; purinergic receptor P2X 5 [KO:K05219]
29665  
P2rx7; purinergic receptor P2X 7 [KO:K05220]
25041  
P2rx6; purinergic receptor P2X 6 [KO:K05221]
24408  
Grin1; glutamate ionotropic receptor NMDA type subunit 1 [KO:K05208]
24409  
Grin2a; glutamate ionotropic receptor NMDA type subunit 2A [KO:K05209]
24411  
Grin2c; glutamate ionotropic receptor NMDA type subunit 2C [KO:K05211]
24412  
Grin2d; glutamate ionotropic receptor NMDA type subunit 2D [KO:K05212]
114207  
Ryr1; ryanodine receptor 1 [KO:K04961]
689560  
Ryr2; ryanodine receptor 2 [KO:K04962]
170546  
Ryr3; ryanodine receptor 3 [KO:K04963]
114099  
Cysltr1; cysteinyl leukotriene receptor 1 [KO:K04322]
170926  
Cysltr2; cysteinyl leukotriene receptor 2 [KO:K04323]
81645  
Chrm2; cholinergic receptor, muscarinic 2 [KO:K04130]
29412  
Adra1a; adrenoceptor alpha 1A [KO:K04135]
24173  
Adra1b; adrenoceptor alpha 1B [KO:K04136]
29413  
Adra1d; adrenoceptor alpha 1D [KO:K04137]
24180  
Agtr1a; angiotensin II receptor, type 1a [KO:K04166]
81638  
Agtr1b; angiotensin II receptor, type 1b [KO:K04166]
24326  
Ednra; endothelin receptor type A [KO:K04197]
50672  
Ednrb; endothelin receptor type B [KO:K04198]
25439  
F2r; coagulation factor II (thrombin) receptor [KO:K03914]
24414  
Grm1; glutamate receptor, metabotropic 1 [KO:K04603]
24418  
Grm5; glutamate metabotropic receptor 5 [KO:K04604]
24938  
Grpr; gastrin releasing peptide receptor [KO:K04169]
24448  
Hrh1; histamine receptor H 1 [KO:K04149]
29595  
Htr2a; 5-hydroxytryptamine receptor 2A [KO:K04157]
29581  
Htr2b; 5-hydroxytryptamine receptor 2B [KO:K04157]
25187  
Htr2c; 5-hydroxytryptamine receptor 2C [KO:K04157]
25477  
Lhcgr; luteinizing hormone/choriogonadotropin receptor [KO:K04248]
366274  
Ntsr1; neurotensin receptor 1 [KO:K04211]
25342  
Oxtr; oxytocin receptor [KO:K04229]
25107  
Avpr1a; arginine vasopressin receptor 1A [KO:K04226]
29462  
Avpr1b; arginine vasopressin receptor 1B [KO:K04227]
vasopressin V1b receptor-like [KO:K04227]
114098  
Ltb4r2; leukotriene B4 receptor 2 [KO:K04297]
58949  
Ptafr; platelet-activating factor receptor [KO:K04279]
25637  
Ptger1; prostaglandin E receptor 1 [KO:K04258]
24929  
Ptger3; prostaglandin E receptor 3 [KO:K04260]
25652  
Ptgfr; prostaglandin F receptor [KO:K04262]
81509  
Bdkrb1; bradykinin receptor B1 [KO:K03915]
25245  
Bdkrb2; bradykinin receptor B2 [KO:K03916]
24807  
Tacr1; tachykinin receptor 1 [KO:K04222]
25007  
Tacr2; tachykinin receptor 2 [KO:K04223]
24808  
Tacr3; tachykinin receptor 3 [KO:K04224]
24816  
Tbxa2r; thromboxane A2 receptor [KO:K04264]
25570  
Trhr; thyrotropin releasing hormone receptor [KO:K04282]
252859  
Mlnr; motilin receptor [KO:K04282]
24889  
Cckar; cholecystokinin A receptor [KO:K04194]
25706  
Cckbr; cholecystokinin B receptor [KO:K04195]
24329  
Egfr; epidermal growth factor receptor [KO:K04361] [EC:2.7.10.1]
24337  
Erbb2; erb-b2 receptor tyrosine kinase 2 [KO:K05083] [EC:2.7.10.1]
29496  
Erbb3; erb-b2 receptor tyrosine kinase 3 [KO:K05084] [EC:2.7.10.1]
59323  
Erbb4; erb-b2 receptor tyrosine kinase 4 [KO:K05085] [EC:2.7.10.1]
25267  
Pdgfra; platelet derived growth factor receptor alpha [KO:K04363] [EC:2.7.10.1]
24629  
Pdgfrb; platelet derived growth factor receptor beta [KO:K05089] [EC:2.7.10.1]
81666  
Gnaq; G protein subunit alpha q [KO:K04634]
81662  
Gna11; guanine nucleotide binding protein, alpha 11 [KO:K04635]
309242  
Gna14; G protein subunit alpha 14 [KO:K04636]
89788  
Gna15; guanine nucleotide binding protein, alpha 15 [KO:K04637]
TRAV14S2; mCG140239-like [KO:K10784]
688340  
T-cell receptor alpha chain V region PHDS58-like [KO:K10784]
691714  
RGD1565478; similar to Immunoglobulin heavy chain (gamma polypeptide) [KO:K06856]
24655  
Plcd1; phospholipase C, delta 1 [KO:K05857] [EC:3.1.4.11]
287745  
Plcd3; phospholipase C, delta 3 [KO:K05857] [EC:3.1.4.11]
140693  
Plcd4; phospholipase C, delta 4 [KO:K05857] [EC:3.1.4.11]
24654  
Plcb1; phospholipase C beta 1 [KO:K05858] [EC:3.1.4.11]
29322  
Plcb3; phospholipase C beta 3 [KO:K05858] [EC:3.1.4.11]
85240  
Plcb2; phospholipase C, beta 2 [KO:K05858] [EC:3.1.4.11]
25031  
Plcb4; phospholipase C, beta 4 [KO:K05858] [EC:3.1.4.11]
25738  
Plcg1; phospholipase C, gamma 1 [KO:K01116] [EC:3.1.4.11]
29337  
Plcg2; phospholipase C, gamma 2 [KO:K05859] [EC:3.1.4.11]
114633  
Plce1; phospholipase C, epsilon 1 [KO:K05860] [EC:3.1.4.11]
497197  
Plcz1; phospholipase C, zeta 1 [KO:K05861] [EC:3.1.4.11]
25262  
Itpr1; inositol 1,4,5-trisphosphate receptor, type 1 [KO:K04958]
81678  
Itpr2; inositol 1,4,5-trisphosphate receptor, type 2 [KO:K04959]
25679  
Itpr3; inositol 1,4,5-trisphosphate receptor, type 3 [KO:K04960]
25668  
Cd38; CD38 molecule [KO:K01242] [EC:2.4.99.20 3.2.2.6]
308589  
Sphk2; sphingosine kinase 2 [KO:K04718] [EC:2.7.1.91]
170897  
Sphk1; sphingosine kinase 1 [KO:K04718] [EC:2.7.1.91]
294560  
Mcu; mitochondrial calcium uniporter [KO:K20858]
83529  
Vdac1; voltage-dependent anion channel 1 [KO:K05862]
83531  
Vdac2; voltage-dependent anion channel 2 [KO:K15040]
83532  
Vdac3; voltage-dependent anion channel 3 [KO:K15041]
25176  
Slc25a5; solute carrier family 25 member 5 [KO:K05863]
85333  
Slc25a4; solute carrier family 25 member 4 [KO:K05863]
689108  
Slc25a31; solute carrier family 25 member 31 [KO:K05863]
282819  
Ppif; peptidylprolyl isomerase F [KO:K09565] [EC:5.2.1.8]
290561  
Tnnc1; troponin C1, slow skeletal and cardiac type [KO:K05865]
296369  
Tnnc2; troponin C2, fast skeletal type [KO:K12042]
50663  
Calm2; calmodulin 2 [KO:K02183]
24242  
Calm1; calmodulin 1 [KO:K02183]
24244  
Calm3; calmodulin 3 [KO:K02183]
364774  
Calml5; calmodulin-like 5 [KO:K02183]
307100  
Calml3; calmodulin-like 3 [KO:K02183]
691455  
Calml4; calmodulin-like 4 [KO:K02183]
140671  
Phkg2; phosphorylase kinase catalytic subunit gamma 2 [KO:K00871] [EC:2.7.11.19]
29353  
Phkg1; phosphorylase kinase, gamma 1 [KO:K00871] [EC:2.7.11.19]
64561  
Phka1; phosphorylase kinase, alpha 1 [KO:K07190]
361377  
Phkb; phosphorylase kinase regulatory subunit beta [KO:K07190]
678739  
Phka2; phosphorylase kinase, alpha 2 [KO:K07190]
288057  
Mylk; myosin light chain kinase [KO:K00907] [EC:2.7.11.18]
117558  
Mylk2; myosin light chain kinase 2 [KO:K00907] [EC:2.7.11.18]
291926  
Mylk3; myosin light chain kinase 3 [KO:K00907] [EC:2.7.11.18]
myosin light chain kinase family member 4 [KO:K00907] [EC:2.7.11.18]
Mylk4; myosin light chain kinase family, member 4 [KO:K00907] [EC:2.7.11.18]
25400  
Camk2a; calcium/calmodulin-dependent protein kinase II alpha [KO:K04515] [EC:2.7.11.17]
24246  
Camk2d; calcium/calmodulin-dependent protein kinase II delta [KO:K04515] [EC:2.7.11.17]
24245  
Camk2b; calcium/calmodulin-dependent protein kinase II beta [KO:K04515] [EC:2.7.11.17]
171140  
Camk2g; calcium/calmodulin-dependent protein kinase II gamma [KO:K04515] [EC:2.7.11.17]
NEWGENE_621802; calcium/calmodulin-dependent protein kinase II gamma [KO:K04515] [EC:2.7.11.17]
25050  
Camk4; calcium/calmodulin-dependent protein kinase IV [KO:K05869] [EC:2.7.11.17]
24674  
Ppp3ca; protein phosphatase 3 catalytic subunit alpha [KO:K04348] [EC:3.1.3.16]
24675  
Ppp3cb; protein phosphatase 3 catalytic subunit beta [KO:K04348] [EC:3.1.3.16]
171378  
Ppp3cc; protein phosphatase 3 catalytic subunit gamma [KO:K04348] [EC:3.1.3.16]
29748  
Ppp3r1; protein phosphatase 3, regulatory subunit B, alpha [KO:K06268]
29749  
Ppp3r2; protein phosphatase 3, regulatory subunit B, beta [KO:K06268]
24598  
Nos1; nitric oxide synthase 1 [KO:K13240] [EC:1.14.13.39]
24599  
Nos2; nitric oxide synthase 2 [KO:K13241] [EC:1.14.13.39]
497963  
similar to Nitric oxide synthase, inducible (NOS type II) (Inducible NO synthase) (Inducible NOS) (iNOS) [KO:K13241] [EC:1.14.13.39]
24600  
Nos3; nitric oxide synthase 3 [KO:K13242] [EC:1.14.13.39]
81529  
Pde1a; phosphodiesterase 1A [KO:K13755] [EC:3.1.4.17]
29691  
Pde1b; phosphodiesterase 1B [KO:K13755] [EC:3.1.4.17]
81742  
Pde1c; phosphodiesterase 1C [KO:K13755] [EC:3.1.4.17]
50646  
Ptk2b; protein tyrosine kinase 2 beta [KO:K05871] [EC:2.7.10.2]
81677  
Itpka; inositol-trisphosphate 3-kinase A [KO:K00911] [EC:2.7.1.127]
54260  
Itpkb; inositol-trisphosphate 3-kinase B [KO:K00911] [EC:2.7.1.127]
308451  
Itpkc; inositol-trisphosphate 3-kinase C [KO:K00911] [EC:2.7.1.127]
24680  
Prkca; protein kinase C, alpha [KO:K02677] [EC:2.7.11.13]
25023  
Prkcb; protein kinase C, beta [KO:K19662] [EC:2.7.11.13]
24681  
Prkcg; protein kinase C, gamma [KO:K19663] [EC:2.7.11.13]
Compound
C00002  
ATP
C00004  
NADH
C00076  
Calcium cation
C00165  
Diacylglycerol
C00575  
3',5'-Cyclic AMP
C01245  
D-myo-Inositol 1,4,5-trisphosphate
C01330  
Sodium cation
C06124  
Sphingosine 1-phosphate
C13050  
Cyclic ADP-ribose
C13051  
Nicotinic acid adenine dinucleotide phosphate
Reference
  Authors
Berridge MJ, Bootman MD, Roderick HL.
  Title
Calcium signalling: dynamics, homeostasis and remodelling.
  Journal
Nat Rev Mol Cell Biol 4:517-29 (2003)
DOI:10.1038/nrm1155
Reference
  Authors
Berridge MJ, Lipp P, Bootman MD.
  Title
The versatility and universality of calcium signalling.
  Journal
Nat Rev Mol Cell Biol 1:11-21 (2000)
DOI:10.1038/35036035
Reference
  Authors
Wang MC, Dolphin A, Kitmitto A.
  Title
L-type voltage-gated calcium channels: understanding function through structure.
  Journal
FEBS Lett 564:245-50 (2004)
DOI:10.1016/S0014-5793(04)00253-4
Reference
  Authors
Ferrier GR, Howlett SE.
  Title
Cardiac excitation-contraction coupling: role of membrane potential in regulation of contraction.
  Journal
Am J Physiol Heart Circ Physiol 280:H1928-44 (2001)
Reference
  Authors
Keef KD, Hume JR, Zhong J.
  Title
Regulation of cardiac and smooth muscle Ca(2+) channels (Ca(V)1.2a,b) by protein kinases.
  Journal
Am J Physiol Cell Physiol 281:C1743-56 (2001)
Reference
PMID:8125957
  Authors
Hell JW, Appleyard SM, Yokoyama CT, Warner C, Catterall WA.
  Title
Differential phosphorylation of two size forms of the N-type calcium channel alpha 1 subunit which have different COOH termini.
  Journal
J Biol Chem 269:7390-6 (1994)
Reference
  Authors
Yunker AM.
  Title
Modulation and pharmacology of low voltage-activated ("T-Type") calcium channels.
  Journal
J Bioenerg Biomembr 35:577-98 (2003)
DOI:10.1023/B:JOBB.0000008025.65675.37
Reference
PMID:9149541
  Authors
Yakel JL.
  Title
Calcineurin regulation of synaptic function: from ion channels to transmitter release and gene transcription.
  Journal
Trends Pharmacol Sci 18:124-34 (1997)
DOI:10.1016/S0165-6147(97)01046-8
Reference
  Authors
Fukunaga K, Miyamoto E.
  Title
A working model of CaM kinase II activity in hippocampal long-term potentiation and memory.
  Journal
Neurosci Res 38:3-17 (2000)
DOI:10.1016/S0168-0102(00)00139-5
Reference
PMID:9235901
  Authors
Della Rocca GJ, van Biesen T, Daaka Y, Luttrell DK, Luttrell LM, Lefkowitz RJ.
  Title
Ras-dependent mitogen-activated protein kinase activation by G protein-coupled receptors. Convergence of Gi- and Gq-mediated pathways on calcium/calmodulin, Pyk2, and Src kinase.
  Journal
J Biol Chem 272:19125-32 (1997)
DOI:10.1074/jbc.272.31.19125
Reference
PMID:7861177
  Authors
Furuichi T, Mikoshiba K.
  Title
Inositol 1, 4, 5-trisphosphate receptor-mediated Ca2+ signaling in the brain.
  Journal
J Neurochem 64:953-60 (1995)
DOI:10.1046/j.1471-4159.1995.64030953.x
Reference
  Authors
Bruce JI, Straub SV, Yule DI.
  Title
Crosstalk between cAMP and Ca2+ signaling in non-excitable cells.
  Journal
Cell Calcium 34:431-44 (2003)
DOI:10.1016/S0143-4160(03)00150-7
Reference
  Authors
Lee HC, Munshi C, Graeff R.
  Title
Structures and activities of cyclic ADP-ribose, NAADP and their metabolic enzymes.
  Journal
Mol Cell Biochem 193:89-98 (1999)
Reference
  Authors
Crompton M.
  Title
Mitochondrial intermembrane junctional complexes and their role in cell death.
  Journal
J Physiol 529 Pt 1:11-21 (2000)
DOI:10.1111/j.1469-7793.2000.00011.x
Reference
  Authors
Grewal SS, York RD, Stork PJ.
  Title
Extracellular-signal-regulated kinase signalling in neurons.
  Journal
Curr Opin Neurobiol 9:544-53 (1999)
DOI:10.1016/S0959-4388(99)00010-0
Reference
  Authors
Trushin SA, Pennington KN, Carmona EM, Asin S, Savoy DN, Billadeau DD, Paya CV.
  Title
Protein kinase Calpha (PKCalpha) acts upstream of PKCtheta to activate IkappaB kinase and NF-kappaB in T lymphocytes.
  Journal
Mol Cell Biol 23:7068-81 (2003)
DOI:10.1128/MCB.23.19.7068-7081.2003
Reference
  Authors
Hutchins JR, Dikovskaya D, Clarke PR.
  Title
Regulation of Cdc2/cyclin B activation in Xenopus egg extracts via inhibitory phosphorylation of Cdc25C phosphatase by Ca(2+)/calmodulin-dependent protein [corrected] kinase II.
  Journal
Mol Biol Cell 14:4003-14 (2003)
DOI:10.1091/mbc.E03-02-0061
Reference
  Authors
Tornquist K
  Title
Sphingosine 1-phosphate, sphingosine kinase and autocrine calcium signalling in thyroid cells.
  Journal
Acta Physiol (Oxf) 204:151-7 (2012)
DOI:10.1111/j.1748-1716.2011.02265.x
Reference
  Authors
Feske S
  Title
Immunodeficiency due to defects in store-operated calcium entry.
  Journal
Ann N Y Acad Sci 1238:74-90 (2011)
DOI:10.1111/j.1749-6632.2011.06240.x
Reference
  Authors
Giachini FR, Lima VV, Hannan JL, Carneiro FS, Webb RC, Tostes RC
  Title
STIM1/Orai1-mediated store-operated Ca2+ entry: the tip of the iceberg.
  Journal
Braz J Med Biol Res 44:1080-7 (2011)
DOI:10.1590/S0100-879X2011007500133
Reference
  Authors
Baba Y, Kurosaki T
  Title
[Regulation of store-operated calcium entry by STIM1].
  Journal
Seikagaku 80:1123-8 (2008)
KO pathway
 
LinkDB All DBs

DBGET integrated database retrieval system