Pseudomonas sp. Os17: POS17_2970 Help Entry POS17_2970        CDS       T04177                                  Symbol rzxB Name (GenBank) polyketide synthase   KO K15675   rhizoxin biosynthesis, polyketide synthase / nonribosomal peptide synthetase RhiB Organism psos  Pseudomonas sp. Os17 Brite KEGG Orthology (KO) [BR:psos00001]  09180 Brite Hierarchies   09181 Protein families: metabolism    01008 Polyketide biosynthesis proteins [BR:psos01008]     POS17_2970 (rzxB) Polyketide biosynthesis proteins [BR:psos01008]  Polyketide synthase (PKS)   Modular type I PKS    trans-AT PKS     Rhizoxin hybrid PKS-NRPS      POS17_2970 (rzxB) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  ketoacyl-synt Ketoacyl-synt_C KR AMP-binding PP-binding PS-DH PKS_DH_N KAsynt_C_assoc adh_short adh_short_C2 Thiolase_N Methyltransf_12 Methyltransf_23 AMP-binding_C Nitroreductase Methyltransf_11 Methyltransf_25 Epimerase Methyltransf_31 Beta-ketacyl_N ApbA DUF6446 Motif Other DBs NCBI-ProteinID:  BAQ74664 UniProt:  A0A0D6BIX4 LinkDB All DBs Position 3286543..3306552 Genome browser AA seq 6669 aa AA seqDB search MSDNNPTQAGPQSPSSAAPEADQARESATIAGWNDTRHEYPLDLCLQQLIEQQVERSPDA VALCFDEQRLSFSQLNRRANRLAHYLRELGVGPDSLVGVQMERSLELMIALLAILKAGGA YLPLDPGYPEERLALLIEDASVGVVLTQQRFAQRLAAYGIEVLCLDDPASEELHACEDNP APVNRPEDLAYVIYTSGSTGRPKGCMLPHKAICNRLLWMQRHYGVGPQDRILQKTPFTFD VSVWELFLPLLSGACLVMARPEGHKDAHYLVELIQARQITICHFVPSMLRFFLKHPTVGE CRSLDKVFVSGEALTHELLLQFRARLQARLHNLYGPTEAAVDVTWWPAEPRPDRRVPIGR PIDNIQIHILDAEANPLPIGQTGELCIGGVGLARGYLNRPQLTAEKFIRDPFCAAPDARL YRTGDEARFLDNGEIEVLGRFDSQVKLRGFRIELGEIESTLNSHPAISDAVVLVQDAAGE DPKLVAYVVADGLDKKAVRDFVKSRLPEYMTPNRVQFVEQIPVTAHGKADRQALLATDGP APDSRRAATLDPQALSAWLQAYFIEALGIDELAVDDDLFDQGATSFTLVQAVHSIHQQYQ VTLPVEIFLEQPSIAAVIAFILDNNAASVDRPGVATTCPTPPSDAPEPIQLQRVDFDPRA YQRLVQVAPPSLERLGGLLSLLREVTLAGQGKYLYSSAGGLNAIQCYLYVAPGQVEGLPS GTWYYQPRLNRLLPIRVPADPGSPALAEAGFALFLVAQMAAIEPLYNHAAPALLVLEAGY IEQLLLSHQAGFDLALVPSQDVDAASVAQLCKLEPSHRVLHCLIPGDSGGAASGRCGLRF DDFLAASNNGFDLPGKDALERLHQQQRQIRSDLPQHGAGGIDLPAAPISADALQLRAAKR QYGDQALSVAQLSRLLSLLRAGPDARHLYHADALQDLEIYLQLAAGSEQAQAQCPPPGLY RYHADSHSLSPLGEGDPLAFNRSYTPFNRKHAQQARLRIFLVSARSAGNDPERRYRHLLQ AGRIGQLLLEQQTEFGIGLCPIGSMYFDKVRSAFHLDEHQELLHSFVGGAVSQGLPPGWP RLELQPELGNEDEAWTAREPENAGALAIIGLSGRYPGAAAPRELWHNLCAGRSSIQTLSR QALLHDAPGAADSPQWAVGALADKQLFDPLLFKITPAEAKTLDPQERLFLQAVWHCLENS GYTAAGLQRRAERVGVFVGAMWGDYQHHRPGDQGERATSFHSAIANRVSFFNDFSGPSVV FDTSCSSAMTALHFACTSLRQGECQAAIVGGVNLISHPSHLELLSALQLLSAEGQAHPFG LHANGWVAGEGVGALLIRPLEDARRDGDRILGVIRATAISHSGKTFRYGMPNAEIQAASM RRALEQAGLSAEAIGYVEAAAPGASLADGAEFAALAKVFGHRQGDTPLPVGSIKANIGHL ESASALSQITKVLLQFEHRQIAPTLGCVPLSPLIGPEHKQLLIADTLSDWQGPRRALINA FGASGSAGHLILEAPPPEVAAPEQRGPWLFPFSAASAAQLEQLLGAFADDLQAGRLGDAR LGDISYTLCVGRVALGQRLALVADSESELLTLLKAASECSTRCGSDARAAPPLATEADLR GLDRAALSTIGQRWVAGDTDLSQIARHDWRRVALAAYPFAGLDCHIATGAAEDEAATPVT DPRLQTALEGYLTQHFSKVSAIPESSIDSLESFDRYGLTSLMITTLNQRLAQAFGDLPST LFFEHQSISALANWFAARHPSRSRQLLGVQAPAAAAAQAAPASRAAPRPDSERRHEHAEP IAIIGLAGRFPGAPDIDSFWDNLKNAVDSISEIPGERWQHQPYYSPDRSQKGKINTKWGG FIDAVDRFDPLFFNISPRDAERMDPQERIFLETAWHTLEDAGYDRAGLQRHYQGKMGVFV GVMHGEYLLYTRSAAADCTDDAVDSSFGSIANRVSYVFDCTGPSMAVDTICSSSLTALHL AVQSLQRGECRVALAGGVNLSLHPNKYFIQSQLTMSSSDGRCRSFGEGGDGFVPGEGAGA VLLKPLSQAQADGDNIYGVIRATSLNHNGKTHGYTVPSPNAQGAMIAESLEKAGMDPREL SYIEAHGTGTALGDPIEISGLQQGFARRSAALGREPAGAQQCALGSAKSNIGHLESAAGI AGVAKVLLQLKHRQLVASLHSSRLNPGIAFGQSPFHIPQQLQEWRQPRLNLDGQERDYPL AASVSSFGSGGSNGHVIIAQYLAPEREAPVAGPPAIIVLSARTPLQLQQQIERLQQCLLR REREGQLPRLADLALTLQQGREAMEYRLAFTAASISELQERLAQGLEQWLKAPEHFGCFD GVHLGRVQENKAAMAVLAHDEDMQATLAAWADKGKYAKLLELWVRGLTFDWALLGAPLGS ARRISLPGYPFARERIWVSGDLQLPPPVQGLGEARLHPLLQRNVSDLTQQKFTSVFSGQE FFLRDHRVHEHKVLPGVAYLEMAREAVSRSLGDQALAGAVSLCHLVWSQPLTLSEQDQAP VTLEVQINAVDAHRLTFAILQQQTQALCCQGEAQWQQEPMEPLASLASLQARINGPCLDA EALYRQFDSVGIHYGPSHRTVRELHSSGGQLLAQIQLPPSLKADHRQFVLHPSLMDGALQ CTLGLLVADPLAQGATVQRQQTRVPFALDRLEHSGAALGEQVWAWVRPVAQASAAGHWVF DIDIYNQQGEHCVALHGFALREMKAPSALEVMLDDRGQTDACLLEKWQRVEPQPLPSGAA RVLLIANDPQGLQQLTARYPQRASMLLDGSESIETLAARLREAGPLEHLLWLAPSAMAAH TSAEQLIHAQQSGVLSCFRLIKALLLLGLDQQPLAWTLITRATLTVFGAASPLQQATDEP VAPAHASLHGLMGVLAKEYSHWPVCVVDLPAGDSWPSLDPLSLPADPRGEPLACRDDVWY RPYLAPCLVPLERGGEGESLYRDAGVYLVVGGAGGIGRLWSEHLIRTRGAQVIWLGRRPQ DARIDAAISELARLGPAPRYISADAGNHAALQQAVTQVLAEHGRIHGVIHAAIQLEDQSL ARMQPQKFAAGLAAKVDVCARLAEVFEHQPLDFMLFFSSLQSYTKSAGQSNYAAGCTFKN AFAQALGQQRGYPVKVINWGYWGDVGSVASDDYRRRMAEVGLGSIDGKQAMRALDALLGA PDDGAPLSQLTFLRTCGRLSETFEHLGLARHPGGLFGEYGEVRAPAYPSLIGRLHGLRPD SRQVRGVVGQVQAQRAALDELQVRLLYAQLQQLGLFTQACESLARLQQHSPVLPLYRRWF AKSLEELAQRGYVQLEGDTCRVANPQPLDLEALWQEWARQQPAWLEHPSLKAEALLAEAT LRVLPQILDGRIAATDVLFPDASMSRVEGIYKHNPVSDFFNEVLLDAMLEFVRGRLEQDP RASIRILEIGAGTGGTSARAFEKLQPLQAQIAEYCYTDVSQAFLMHAQQAYGPHAPYLSY QLFDVDQPLAAQGIKAGAYDLVIATNVLHATPDLRRALKNAKAALKHNGLLLINEIARNG LFTHLTFGLLKGWWLFDDPQHRLPGGPALAPRQWKQVLESEGYRQVHFPALAEHDLGQQI VIAQSNGLVWQERPERAEAPRIAPVRRETVVAQAPLAPRAPQPGISPAALGEVSSSRLKA ETVRYLKQVIGGLFKIEPEQIDAREALETYGIDSILVVQLTNLLRDQLAGVSSTLFFEYQ TIEALAEHFLATQKDRLQQLLGLDPAPASGAPPARAPVEPLFTPVPSRFAKRPPEPPAAQ QRHSDVAIVGLSGRYAGSDNVRQLWQHLKAGEHCIAQVPAERWDWRRYFDRTPGTAGRIY TPWGGFIGQIDRFDPLFFHISPREALKMDPQERLFLEEAYHCISDAGYTPARLAERQRVG VFVGVMNGTYSHQSSYWSVANRVSYQFNFQGPSLAVDTACSSSITALHLALQSLERGDSD CALVGGVSLLVDPVHYMGLSEMQMLSPGPHCKAFGADADGFVAGEGVGALLLKPLAQAEA DGDRIYGVIKGSMINAGGKTNGYTVPNPLAQSRLVVDSLARAGVDARAVSYVEAHGTGTA LGDPIEIAGLARAFSSSGATPGTQYCAIGSIKSNIGHCESAAGIAGITKVLLQLQHRQLV PSLHADTANPHIDFANTPFAVQRTLAEWPRPQVLIDGVPQTFKRIATVSSFGAGGANAHV VIEEYEDLRVRPPRVVDEQRPVLILLSAKSAEQLLQQARLLLDELAQGPLVEADLPALAF TLQVAREAMEHRHGWWVSSLAQLKAGLEQLLSAGVTSGRGRQKPEAQAPDFDIGRVLDAG AQQRLLDAWLDGAVLDWQLMYPQGTPAPLSLPGYPFARERYWQTPLAAAGVPGAVEERLH PLLHRNVSDLRGLRYLSRFSGSESLLAEHQVNGQGVLPGAALVSLIQAALSNALGAPVPA GRALVIEDLAWRQPFSVDAANNGELFLELTMPAQGEYQVGIYSYDPDAQLQLHAQARARY AVVMAPGLEFNGVGARVVEVEACYQRFAAMGIEYGQGYRRLLSLERQDDQVLARIALQDP ALTDGFALHPALLDGAMQGVMALLLEELGDTPALLLPATLGQCVLFADCPAALQVQIRRS GSTTDGHLFDLALFDEHGQCCATLHQLAFRTLSDHHQGASTALLCHKQWDDALPATALAT PGVAHRVLSLGHHRAFADLAQGLQARGIDHCALPAADYPQAALALAEQLQALLGAAQPCL IQLLVPADDAQGYRGLGGLLSSVSREQPALIGQLIEVAPALEAPQLLSALAAEAAAPNEC VLRYLAQAGTLRRQQLSWQPQPLYAAPAPWRPDGVYLISGGLGGVGAVMAQALLAAAPQA RVVLCGRTPAGDPAVQAKLVQLGEAVDYRAVDLANAAQVERLISDLVADYGALHGILHCA GITRDALLADKPKADFAAVFAAKVDGVQHLDRSSAGLALDFFVLYSSIASVLGNAGQTDY AAANGYLDAFASLRNRQVAAGTRHGRTLAINWPLWLEGGLHMSDTARRLLAQRSGIEAMA SATGVQAFYHALQRDDDQLMVLAGHREKLLALLRPPAPVAVEQAPLEGEALLPWLRQLLA RTLKIRPERLDNEVPFEQYGIDSLMIMEMTAVLEKRFGALSRTLFFQYPSLQALVEHLAT RPMSRAPQTSTSAQLRTLLASALHTPPEQIDEQRCFEDFGIDSVQVLELTRRLEGHFGAL PPGLLFEYSSLHALAGYLAPTAAQAPGEPLPSAPALQRRLFDKPWSPQPSSAASRDDIAI IGIAGRYPGAPTLEAFWENLSQGRNSIGEVPPERWDWRDYYSSDRGQSGVHNSKWGGFID GIDQFDPLFFNISPLEAELIDPQERLFLQTAWAAMEDAGYSRQLGAGAPEPMLQVGVYAG VMYSEYQLLGAEASLRGERMGFAGSSASIANRVSFCLNLQGPSLSLDSMCSSSLTALHLA CQDLHSGRTAMAIAGGVNLTLHPNKYLMLSSGQFISNQGQCASFGEGGDGYVPGEGVGVV VLKRLADAERDGDQIHGLIKGSYLNHGGKSTGYSVPDPRAQQAAISGALKDANVDPAAIS YIEAHGTGTRLGDPIEIAGLANALGPRAAGQTCWIGSVKSNIGHCEAAAGIAGLTKVLLQ LKHGKIAPSLHSRTLNPFIDFAATPFEVNQHLRDWPQPSHEGRLRPRIAGLSSFGAGGSN AHLIVAQYAGTRPQPEPDGRPQMILLSAREPGQLRQIASRLLEHLQQAPQRLDAIAWTLQ VGREAMEHRAALIATDAQQLLDALRGLAGGDDRGWICGDTQTGSAALEPFKNRSRTLQHE HLAQLYANGELQALLALWSAGLRIDWNALRAPDRQRPQRISLPTYPFATERYWAPTAAKG LPAATRVHPWLHSHTATGDGHQFTCLCNGEEPWLLDHVVNASKTLPGAACLEIIRAAVSQ ARGDGQARAMVIEQLNWLAPLTVGSAPRCLRVNLQALDGHWVVTLLSDDDAGAQPVLHCQ ARVTGEAAPAAERLDLAHWRERPWQRSLDSDEVYRLFEAMGLAYGASHRGIRQLLIAQQG SRREVLAQLDLEGIQAVGDCWLEPGMTDSALQAAIGMLLPLDAGPAAPLSLLMPFALQRL EILAPCTRQMWALLRGDRHDSAGRIDIELCDQQGQLCARLEGFCARSLGPLLQQPPATPV QQLLAPVWSVVEAQQQPRPDGQGAMLIFGVSPSRHQALAGLYPRARLVPGGPDSAATELL ADAEWAEVMWLAPAVEADADPVAAQQQGVLALFRLIKALLNQGYGRRPLRLSLITDRAVS TGPGDPCQAVHAAVHGLAGSLAKEYPHWTVHLADLADEQLDRLATAPFAALASGELLALR HGQWRQRQLARVQAASVPARLPVYRDGGVYLVIGGAGGIGAVWSQHLIRQHRARVVWIGR RALDAQIAAKLDELTAISLMHAGPAPVYLQADATDHLQLAAARQQIIERFGPINGVVHSA IVLKDHSLANMDESTFSQVLEAKVATSVALARAFGDSAAQLDFVLFFSSMMSFTTAAGQG NYAAGCTFADAFADQLRARWSCPVKVINWGYWGGVGSVSDARYRERMKALGLGSIEPEEG LRALEQLLAGGLDQLALLALLPGSDIDAIDSLAGLLGHEQIRLSSHRSGAMAALQERLEQ RLAALVAIT NT seq 20010 nt NT seq  +upstreamnt  +downstreamnt gtgtctgataacaacccaacccaagcgggtccacagagcccttcgtccgcagccccggag gctgatcaagcccgggaaagtgcgacgattgccggctggaacgacacccgccacgagtat ccgctggacctgtgcctgcagcagttgatcgagcaacaggtggagcgcagccccgatgcc gtggccctgtgcttcgacgagcagcgcctgagtttcagccagttgaatcgtcgggccaat cggttggcgcactacctgcgcgagctcggcgtcgggcccgacagcctggtgggcgtgcag atggagcgttcactggagctgatgatcgccttgctggcgatcctcaaggcggggggcgcc tacctgccgctggacccgggctaccccgaagagcgcctggccctgcttatcgaagacgcc tcggtcggcgtggtactgacacaacaacgctttgcccagcggctcgctgcctatggcatt gaagtgctctgtctggatgaccccgccagtgaggagctgcacgcctgcgaggataatccc gcgccggtcaaccgccctgaagatctggcctatgtgatctacacctcgggctccaccggg cgccccaaaggctgcatgttgccgcacaaggccatctgcaaccggctgctgtggatgcag cgtcactatggggtggggccacaggaccggatcctgcagaagacgcccttcaccttcgat gtctcggtctgggagctgtttttgccgttgctcagcggcgcctgtctggtcatggccagg cccgaaggccataaggacgcccactacctggtggagctcatccaggcgcggcagatcacc atctgccatttcgtgccgtccatgctgcgcttcttcctcaagcacccgacggtcggcgag tgtcgctctttggacaaggtcttcgtcagcggcgaggccctgacccacgagctgctgctg cagtttcgtgcgcggctgcaggcccgtctgcacaacctgtacggcccgaccgaggcggcg gtggacgtcacctggtggcctgccgaaccgcgcccggaccggcgcgtgcccattggccgg cccatcgacaatatccagatccacatcctcgatgccgaggccaatccgctgcccatcggc cagaccggcgagctgtgcattggcggtgtcggcctggcccggggctatctcaaccggccg caactgacggcggagaagttcattcgcgacccgttctgcgcagcacccgacgcccggctg tatcgcaccggtgacgaggcgcgcttcctcgacaacggcgagatcgaagtgctggggcgt ttcgattcccaggtcaagctgcgtgggtttcgcatcgaactgggcgaaattgaaagcacc ctcaacagccatccggccatcagcgacgcggtggtgctggtccaggatgccgccggcgaa gacccgaagctggtggcctatgtggttgccgacgggctggacaagaaggcagtgcgcgat ttcgtcaagtcgcgcctgccggagtacatgacgcccaatcgggtgcagttcgtcgaacag attccggtcacggcccacggcaaggccgatcgccaggcgctgctggccaccgacggcccg gcgcccgacagccgccgggccgcgaccctggatccccaggcactgagcgcctggctgcag gcgtacttcatcgaggcgctggggattgatgaactggcggtcgacgacgatctgttcgat cagggcgccacctcattcaccctggtgcaagcggtgcacagcattcatcagcagtaccag gtcacgctgccggtggagatatttctcgaacagccgagcatcgctgccgtcatcgccttt atcctcgacaacaacgctgcgagcgtcgaccggcccggcgtggcaacgacctgcccgacg ccgccaagcgacgccccggagccgatccagctgcagagggtggactttgatcctcgcgcc tatcaacgcctcgtccaggttgcgccgcccagccttgaacggctggggggcctgctctcg ctgttgcgtgaggtgacgctggcaggccagggcaagtacctctattcctcggccggcggc ctcaacgccatccagtgctacctgtatgtggccccggggcaggtcgagggcttgccctca ggcacctggtactaccagccgcggctcaatcgcctgttgccgatccgcgtgccggccgat ccgggctcgccagccctggccgaggccggctttgcactgtttctggtggcccagatggcc gccatcgagccgctctacaatcacgccgccccggcgctgctggtgctggaggcgggctat atcgaacagttgctgctgtcgcaccaggccggcttcgacctggccctggtcccgagccaa gacgtggacgcggcatcggttgcccagctgtgcaagctggagcccagccaccgggtgctg cattgcctgattcccggcgattcgggtggcgctgcaagtgggcgctgcggcctgcgcttc gacgacttcctggccgccagcaacaatggtttcgacctgccgggcaaggacgcgctggag cgcttgcaccagcaacagcggcagattcgcagtgacctgccgcagcacggggcagggggc atcgatctgcccgctgcaccgatcagcgccgacgccctgcaactgcgcgccgccaagcgc caatacggcgaccaggccttgagcgtggcgcagttgagccgattgttgagcctgttgcgg gccgggccggatgcccgtcacctgtaccacgccgacgcgctgcaggacctggagatctac ctgcaactggccgccggcagcgaacaggcccaggcgcagtgcccgccgcccggcctctat cgctaccacgccgacagccacagcctgagccccttgggcgaaggcgacccgctggcgttc aaccgcagctacacgccgttcaatcgcaagcacgcgcaacaggcgcgcttacggatattc ctggtgtccgctcgctcggcaggcaacgaccccgagcggcgttatcgccacctgctccag gccggacgcatcggccagttgctgctggaacaacagaccgagttcggcatcgggctgtgc cccatcggttcgatgtatttcgacaaggttcgcagcgccttccacctggatgaacaccag gagctgttgcacagctttgtcggcggcgccgtcagccagggattgccgccgggctggcca cggctggagctgcagcctgagcttgggaatgaggacgaagcctggaccgcccgcgagccc gagaacgcgggggcgctggcgatcatcggcctcagcggccgctaccccggcgccgccgcc ccccgggagctgtggcacaacctttgcgccggacgttcgtcgatccagacactcagccgc caagcgctgctgcatgacgcgccaggcgccgcggattcgccgcaatgggcagtgggcgcc ctggccgacaagcagttgtttgatccgctgttgttcaagatcacccccgccgaggcgaaa accctggacccccaggagcgattgttcctgcaagcggtctggcattgcctggaaaacagc ggctataccgccgccggtctgcagcgtcgggccgagcgggtgggggtgtttgtcggcgcg atgtggggcgactaccagcaccatcggcccggcgaccagggcgagcgcgccacctcgttc cattcggccatcgccaaccgggtgtcgttcttcaatgacttcagcggccccagcgtggtg ttcgacacctcgtgttcctcggcaatgaccgccctgcattttgcctgcaccagccttcgc cagggcgagtgccaggcggcgatcgtcggtggcgtcaacctgatcagccatccgtcgcac ctggagctgctgagcgccttgcagctgttgtccgcagagggccaggcgcatccgttcggt ctccacgccaacggttgggtggcaggcgagggcgtgggtgcgctgttgatccgccccctg gaggacgcccgccgcgacggtgaccggatccttggcgtgatccgcgccacggcgatcagc cacagcggcaagacctttcgctacggcatgccgaacgccgagattcaggccgcctcgatg cgccgggccctggagcaggcggggttgtccgccgaggcgattggctacgtggaggctgcc gcgcccggcgccagcctggcggacggcgccgaattcgcggcgctggccaaggtcttcggc caccgccagggcgatacgccactgccagtcggctcgatcaaggccaacatcggccacctt gaatcggcctcggcgctgtcgcagatcaccaaggtcctgctgcagttcgagcaccgccag atcgccccgaccctgggctgcgtgcccttgagcccactgatcggcccggagcacaaacag ctgctcattgccgacaccttgagtgactggcaaggccctcgacgggccttgatcaatgcc ttcggagccagtggttccgccggccacctgatcctcgaagcgccgccgcctgaggtcgcc gcgcccgagcagcgcgggccctggctgtttcccttttccgccgccagcgccgcgcagctc gagcaattgctcggggcgttcgccgacgaccttcaagccggtcgcctgggcgacgcgcgc cttggagacatcagctacaccctgtgcgtcggcagggttgcactgggccagcggctggcg ctggtggccgacagcgagtccgaactgctgaccttgctcaaggccgcgtcggagtgctcg acccgctgtggcagcgatgccagagcggcgccaccgctggccaccgaagcggacctgcgc ggcctcgatcgggctgccctgagcaccatcggccagcgttgggtggccggtgacaccgac ctgtcgcagattgcccgccatgactggcggcgcgtggccttggcggcgtacccctttgcc ggcctcgattgccatatcgccaccggcgccgccgaggacgaggcggcgacgccggtgacg gacccgcgcctgcaaacggcgctggagggctacctcacgcagcacttctcgaaagtctcg gccatacccgagagcagcatcgacagcctggaaagcttcgaccgctacggcctgacctcg ctgatgatcaccaccctcaaccagcgactggcccaagccttcggggacttgccaagcacg ctgttcttcgagcaccagagcatcagcgcactggccaactggttcgctgcccggcacccg tcgcgcagtcgccagttgctcggggttcaagcgcccgcggccgcggcggcacaggcggcc ccggccagccgtgcggcaccgcgtcccgacagcgagcgacgccacgagcacgccgagcca attgcaatcatcggcctggccggacgctttcccggtgccccggacatcgacagcttctgg gacaacctgaagaacgcagtcgacagcatcagcgaaatccccggcgagcgctggcagcac cagccttactacagccccgaccgcagccaaaaaggcaagatcaacaccaagtggggcgga ttcatcgacgctgtcgaccgcttcgacccgctgttcttcaatatttcaccgcgcgacgcc gagcgcatggaccctcaggaacggatcttcctcgaaaccgcctggcacaccctggaagac gcgggctacgaccgggccggcctgcaacgccattaccaggggaaaatgggcgtgtttgtc ggggtgatgcacggcgagtacctgctctatacccgttctgccgccgccgactgcaccgat gacgcggtggattcctccttcggctcgattgccaaccgggtgtcctacgtcttcgactgc accggcccgagcatggcggtcgacaccatctgttcctcctcgctgaccgcgctgcacctg gcggtgcagagcctgcaacggggcgagtgccgggtggcgctggccggcggcgtcaacctg tcgctgcacccgaacaagtacttcatccagtcgcagttgaccatgtcctccagcgatggc cgctgccgcagtttcggtgaaggcggcgacggtttcgtccccggcgaaggcgccggcgcg gtgttgctcaagcccctgtcacaggcacaggccgatggcgacaacatctacggggtgatc cgcgcaacgtcgctcaaccataacggcaagacccatggctacaccgtgcccagccccaat gcccagggggcaatgatcgccgagtcactggaaaaggccggcatggacccccgcgagctg agttacatcgaggcccacggcaccggcaccgcactcggcgatccaatcgaaatcagcggc ctgcaacagggctttgcccggcgcagtgcggcccttggcagggaaccggcgggggcacag cagtgcgcgctgggctcggccaaatcgaatatcggccatctggaatcggccgccgggatc gccggggtggccaaggtgctgctgcaactcaagcaccgccaactggtggcgtcgctgcat tcgagccgactcaacccgggcatcgcctttggccaatcgccgttccatatcccgcagcaa ctgcaagagtggcgtcaaccgcggctcaatctggatggccaggagcgcgactacccgctg gccgcgtccgtgtcgtcctttggttccggcggctccaatggccatgtgatcatcgcccag tacctggcgccggagcgggaagcgccggtggccgggccaccggcgatcatcgtgctgtcg gcccgcaccccgttgcagctgcaacagcaaatcgaacgtttgcagcagtgcctgttgcgg cgcgagcgcgaaggccagctgccgcgtctggcggacctggccctgaccctgcagcagggc cgggaggccatggaatatcgcctggcgttcaccgcagcgtccatcagcgagctgcaggag cgcctggcccagggcctggagcaatggctcaaggcgcctgagcacttcggctgcttcgac ggcgtgcatctggggcgggtacaggagaacaaggccgcgatggccgtgctggcccacgat gaggacatgcaagcgaccctggcggcctgggccgacaaaggcaaatacgcaaaactgctg gaattgtgggtcagggggctgacgttcgattgggcgctgctgggggcgcccctgggcagt gcccggcgcatcagcctgccggggtatccctttgcccgcgagcggatctgggtgtccggc gacctccagttgccgccgccggtccaggggctcggcgaagcccggctgcaccccttgctg caacgcaatgtctccgacctgacgcagcagaaattcacctcggtattcagcggtcaagag ttcttcctgcgcgatcatcgggtgcacgagcacaaagtcctgcctggcgtggcctacctg gaaatggcccgcgaggcggtcagtcgctccctgggggatcaggcactcgccggagcggtg agcctgtgccacctggtgtggtcgcaaccgctgacgctcagcgagcaggatcaggcgccc gttacgcttgaggtgcagatcaatgccgtggacgcccatcgcctgactttcgcgattctc caacagcagacccaggccctgtgctgccagggcgaggcgcaatggcagcaggaacccatg gaacccctggcgtcactggcatcgctgcaggccaggatcaacggcccgtgcctggacgcc gaggcgctgtaccgccagttcgacagcgtcggcatccactacggccccagccaccggacg gtccgcgaactgcacagcagcggcggacagttgctggcgcagatccagttgccgccatca ctgaaggccgatcaccggcaatttgtcctgcacccaagcctgatggacggcgccttgcaa tgcaccctgggcctgctggtcgccgacccgcttgcgcaaggcgcaacggtgcaacggcag cagacccgggtgccctttgccctggaccggctagagcacagcggtgcggccctgggggag caggtctgggcctgggtgcggcctgtggcgcaggccagcgcggccgggcattgggttttc gatatcgatatctacaaccagcagggcgagcattgcgttgcgctgcacggctttgccctg cgggagatgaaagcgccgtcggcgctggaggtgatgctcgacgaccgcgggcagacggac gcttgcctgctggagaaatggcagcgggtcgagcctcagcccttgccgtccggcgccgcc cgggtgctgttgatcgccaatgacccgcaaggcctgcaacagttgacggcgcgctatccg cagcgggcgtcgatgttgctggacggcagcgaatccatcgaaacgctcgccgcgcggctg cgcgaggccggcccgctggagcacctgctgtggctggcacccagcgccatggcggcgcac accagcgccgagcaactgatccacgcgcagcagtccggggtgttgagctgttttcgcttg atcaaggcgttgctgctcctgggcctggaccagcagccgctggcctggacgctcatcacc cgcgccaccctgacggtgttcggcgcggcgagcccgctgcaacaggccaccgatgaaccc gtggcgcccgctcacgccagccttcacgggctgatgggggtcctggccaaggagtacagc cattggccggtgtgcgtggtggacctgccggccggcgacagctggccgagcctggacccc ctgtcactgcccgccgatccccggggcgagcccctggcctgtcgcgacgatgtctggtat cgcccgtatcttgcgccctgcctggtgccgctggagcggggcggcgagggcgaaagcctg tatcgcgacgccggggtgtacctggtcgtcggcggtgccggcggcattggccggttgtgg agcgaacacctgatccgcacccgtggcgcccaggtcatctggctcgggcgccgcccgcag gatgcgcggattgacgccgccatcagtgaactggcccggttgggcccggcgccacgctat atcagcgccgatgccggcaaccacgccgcgctgcagcaggcagtgacccaggtgctggcc gagcatgggcggattcatggggtgatccacgccgcgatccagctggaggatcaaagcctg gcacgcatgcagccgcagaaattcgccgcggggctggccgccaaggtcgatgtctgtgcc cgtctggccgaggtgttcgagcaccagcccctggacttcatgctgtttttctcctcgttg cagagctataccaagtcggcgggccagagcaattacgcggccggttgtaccttcaagaac gccttcgcgcaggccctggggcaacaacgcggctacccggtgaaagtcatcaactggggc tactggggtgacgtcggctcggtggccagcgacgactaccggcgccgcatggccgaggtt ggcctgggctccatcgacggcaaacaggcgatgcgtgccctggacgcgctgctcggtgcc ccggacgacggcgcgccgctgagccagttgaccttcctgcgcacctgcgggcgcttgagc gaaaccttcgagcacctggggctggcccgtcatcctggcgggctgttcggcgaatatggc gaggttcgggcgccggcctatccatcgttgatcgggcgcctgcacggcctgcggccggac agtcggcaggtgcgcggcgttgtcgggcaggtgcaggcccaacgggcggcgctggatgag ctgcaggttcgcctgctctatgcccagttgcagcaactgggcctgttcacccaggcgtgc gaatcccttgcccggttgcagcagcacagccctgtgttgccgctgtaccgacgctggttc gccaagagccttgaggaactggcgcagcgcggctatgtgcagctggaaggcgatacctgc cgggtcgccaatccgcagcccctggacctggaggcgctgtggcaggaatgggcgcggcag cagccggcctggctcgagcaccccagcctcaaggccgaggccctgctggccgaagcgacc ctgcgggtcttgccgcagatcctcgacgggcggatcgcggccaccgacgtgctgttcccc gacgcctcgatgtccagggtcgagggcatctacaaacacaacccggtgtcggacttcttc aacgaagtgctgctcgacgccatgctcgaatttgtccgcggccgcctggagcaggatccc cgggcctcgatccggatcctggaaatcggcgccggcaccggcggcaccagtgcccgcgcc tttgaaaaactgcagcccctgcaagcgcagatcgccgagtactgctacaccgacgtctcc caggcgttcctgatgcacgcgcagcaggcctatggcccgcatgccccgtacctcagctac caactgttcgacgtcgaccagccgctggccgcccagggcatcaaggccggcgcctatgac ctggtgatcgccaccaacgttctgcacgccacgccggacctgcgccgcgccctgaaaaat gccaaggccgcgctcaagcacaacggcctgctgctgatcaacgagattgcccgcaatggc ctgttcactcacctgaccttcggcctgctcaagggctggtggctgttcgacgacccgcag catcgcctgccgggcggcccggcactggccccccggcagtggaagcaggtgctggaaagc gaaggctatcggcaggtgcatttcccggcgctggccgagcacgacctggggcagcagatc gtcatcgcccagagcaacggcctggtctggcaggagcgccccgagcgcgccgaagcgccc cgtattgcgccggtgcggcgtgaaacggtggtggcccaggcgcccctggcaccccgggcg ccgcaaccgggcatcagccccgcggcgctgggcgaggtgagcagcagccggctcaaagcc gagacggtgcgctacctcaagcaggtgattggcgggctgttcaagatcgagcccgagcag atcgacgcccgcgaggcgctggaaacctatggcatcgattcgatcctggtggtgcaactg accaacctgctgcgggaccagttggctggggtcagcagtacgctgttcttcgaataccag accatcgaggcattggcggagcattttctcgccacccagaaagaccggctgcaacagctg ctgggactggatccggcgccggccagcggcgcgccaccggccagggcgccggtcgagccc ttgttcacgccggtcccgtcgcgctttgccaagcgtcctcccgagccgccagcggcgcag cagcgccacagcgacgtcgccatcgtcgggctgtcagggcgctacgccgggtccgacaac gttcgccagctgtggcaacacctcaaggccggggagcactgcattgcccaagtgccggcc gaacgctgggactggcgccggtactttgaccggaccccgggaacggcaggtcgcatctat acgccatggggcggtttcattggccagatcgatcggttcgatccgctgttctttcacatt tcgccccgcgaagccctgaaaatggacccccaggagcggctgttcctggaagaggcctat cactgcatcagcgatgccggctataccccggcacgcctggccgagcggcagcgggtcggg gtgtttgtcggcgtgatgaacggtacctacagccaccagtccagttactggtcggtggcc aaccgagtgtcataccagttcaacttccagggcccgagcctggcggtggacaccgcctgt tcctcgtcgatcaccgcactgcatctggcgctgcaaagcctggagcgcggcgacagcgac tgcgccctggtgggtggggtcagcctgctggtggacccggtgcactacatgggcctgagc gaaatgcagatgttgtccccaggcccgcactgcaaggctttcggtgccgatgccgatggt tttgtcgccggtgaaggcgtgggcgcactgctgctcaagccgctggcgcaggccgaggcc gatggcgaccggatctacggcgtgatcaagggcagcatgatcaatgccgggggcaagacc aacggctacaccgtgcccaatcccctggcccagagccggctggtggtggattcgctggcc cgggccggggtcgacgccagggccgtgagctatgtcgaggcccatggcaccggcaccgcg ctgggcgatccgatcgagatcgccggcctggcccgggccttcagcagcagcggggcaacg cccgggacgcagtactgcgccatcggctcgatcaagagcaatatcggccattgcgaaagc gcagcgggtatcgccggtatcaccaaggtgctgttgcaactgcagcaccgccagctggtg ccatcgctgcacgccgataccgccaacccgcacatcgatttcgccaacactccgtttgcc gtgcagcgcacgctggccgagtggccgcggccgcaggtgctgatcgacggggtgccgcag acattcaagcgcatcgccacggtgtcctccttcggtgccggaggcgccaatgcccatgtg gtgatcgaagaatacgaagacctgcgggtacggccaccgagggtggtcgacgagcaacgc ccggtgctgatcctgttgtcggccaagagcgccgagcagctgctgcagcaagcccggctg ttgctcgacgaattggcccaggggccactggtcgaggccgatctgccggcactggccttc accctgcaagtggcgcgcgaggcgatggagcatcgccatggctggtgggtgagttccctg gcccagttgaaggccggcctggagcagttgctcagcgccggcgtcacgtcgggccgtggc cggcagaagcccgaggctcaggcgccggacttcgacatcggccgggtactcgacgccggg gcacagcaacgcctgctcgacgcctggctcgacggcgccgtgctggactggcaactgatg tacccccagggcacgcccgcgccattgagcctgccgggctatccctttgcccgcgagcgc tactggcagacgccgctggccgcggctggggtgcccggcgccgtcgaggaacgcctgcat ccactgctgcatcgcaacgtgtcggacctgcgcggcttgcgttacctgagccggttcagc ggcagcgaaagcctgttggccgagcaccaggtcaatggccagggcgtgctcccgggcgcg gcgctggtcagcctgatccaggcggcgctgagcaacgccctgggcgctccggtgccggcg ggcagggcgctggtgatagaggatctggcctggcgccagccgttcagcgtcgacgcggcc aacaacggcgagctgttcctggaactgaccatgccggcgcagggcgagtaccaggtcggg atctactcctacgaccctgacgcccagttgcaactgcatgcccaggcccgggcccgctat gccgtggtcatggcccccgggcttgaattcaacggcgtcggtgcccgggtggtggaggtc gaggcctgctaccagcgctttgccgccatgggcatcgagtatggccaggggtaccggcgg ctgctgtcgctggagcgccaggacgatcaggtactggcgcggatcgctctgcaggacccg gcgctgactgacggttttgccctgcatccggccttgctggatggcgccatgcaaggcgtg atggccttgctgctggaagagctgggggacacgccggccttgctgctgccggcgaccctg ggccagtgcgtgctgttcgccgactgcccggccgccctgcaggtgcagatacgccgcagc ggcagcaccacggacggccatctgttcgacctggcactgttcgacgagcatggccagtgc tgtgcaaccctccatcaactggcgttcaggaccctgagcgatcaccaccagggtgccagc accgcgctgctgtgccacaagcaatgggacgacgcgctgccggccacggcgctagccacg ccgggggtggcgcaccgggtgctgagcctgggccatcatcgcgcctttgccgacctggcc cagggcctgcaggcgcggggcatcgaccattgcgccttgcctgcggctgactacccacaa gccgcgctggcgctcgccgagcagctgcaagccttgctcggcgctgcgcagccctgcctg attcaactgctggtcccggcggacgatgcccagggctatcgtggcctgggcggcctgttg tccagcgtcagccgtgaacagccggcgttgatcgggcaattgatcgaagtggcaccggcg ctcgaggccccgcaactgctcagcgcattggccgccgaggccgccgcccccaacgagtgc gtcctgcgttatctggcgcaggcgggcaccctgcgccgtcagcagctgagctggcaaccc caacccctgtacgcggcccccgcgccttggcggccagacggggtgtacctgatcagcggt ggcttgggcggggtcggcgcagtcatggcgcaggcgctgctggccgcggcgccccaggcc cgggtggtgctctgcggccgcacgccagctggcgatcccgccgtgcaggccaagctggtg cagctgggggaggctgtcgactaccgcgccgtggacctggccaacgccgctcaggttgaa cgcttgatcagcgacctggtcgctgactacggcgccttgcacggcatcctgcattgcgcg ggcatcacccgtgacgccttgctggcggacaagcccaaggcagattttgccgcggtgttc gcggccaaggtcgacggcgtgcagcacctggatcgcagcagcgccgggctggccctggat ttcttcgtgttgtactcctcgatcgccagtgtgctgggcaacgcggggcagaccgactac gccgccgccaatggctatctggacgccttcgccagcctgcgcaaccggcaggtcgcggcc ggcacgcgacacggccgcaccctggcgatcaactggccgttatggctggaaggcggcttg cacatgagcgatacggcgcggcgcctgctggcgcagcgcagtggtattgaggccatggcc agcgccaccggcgtccaggccttctatcacgccctgcagcgcgatgatgaccaactgatg gtgctggccggccaccgggaaaagctccttgccttgctccggccgcccgcgccagtggcg gtggagcaagccccgctggagggagaggcactgctgccctggctgcgccagctgctggcc cggaccctgaagattcgcccggagcgactggacaacgaggtgccgttcgagcagtacggc atcgactcgctgatgatcatggagatgactgccgtcctggaaaaacgcttcggcgcgctg tccaggaccctgttcttccaataccccagcctgcaggcactggttgagcacctggccacg cggccgatgagccgcgcgccacagacctcgaccagcgcacaactgcgcaccttgctggcc agcgccttgcacacgccgccggagcagatcgacgagcagcgctgcttcgaggacttcggc atcgattcggtgcaggtacttgaactcacacgtcgcctggaagggcattttggcgcgttg ccgccggggctgctgttcgagtactccagcctgcatgccctggccggctacctggccccg actgcggcccaggcgcctggcgaaccgctgcccagcgccccggcgctgcaacgccggctg ttcgacaaaccgtggtcgccgcagccgtcgagcgccgcctcgcgggacgacatcgccatc atcggcattgccgggcgctaccccggcgccccgaccctcgaagccttctgggagaacctc agccagggcaggaacagcattggcgaagtgccgcccgagcgttgggactggcgcgactac tacagcagcgaccgcgggcagagcggggtgcacaacagcaagtggggcggctttatcgac ggcatcgatcagtttgatccgctgttcttcaatatctcgcccctggaagccgagctgatc gacccccaggagcggctgttcctgcaaaccgcctgggcggccatggaggacgccggctac agccgtcagctcggcgccggagcaccggagccgatgctgcaggtcggcgtctacgccggt gtgatgtacagcgagtatcaactgttgggcgccgaagccagcctgcgcggcgagcgcatg ggctttgccggttccagcgcgagcatcgccaaccgggtgtcgttctgcctcaacctgcaa ggcccgagcctgtcgctggactcgatgtgttccagctcgctgaccgcgctgcacctggcc tgccaggatctgcacagcggccgcacggccatggccattgccggtggcgtcaacctgacg ctgcaccccaacaagtacctgatgctcagcagcggccagttcatttccaaccagggccag tgcgccagcttcggcgagggcggtgacgggtatgtaccgggcgagggcgtgggcgtggtg gtgctcaagcgcctggcggacgccgagcgcgatggcgatcagatccacgggctgatcaag ggcagctacctcaaccacggcggcaagagcaccggctacagcgtgcccgatccacgggcg cagcaggccgccatcagcggcgcgctcaaggacgcgaatgtcgatccggcggccatcagc tacatcgaggcccatggcaccggcacccgtctgggcgacccgatcgaaatcgccggcctg gccaacgccctgggaccgcgggcagcggggcagacctgctggatcggctcggtgaaatcc aacatcggccactgcgaggccgccgccggtatcgccggcctgaccaaggtgctgttgcag ctcaagcacggaaaaatcgcgccgtcgctgcattcccggaccctcaacccctttatcgac tttgccgccacgccgttcgaggtcaaccagcacctgcgcgactggccacagccgtcccat gaggggcggctgcgaccgcggattgccgggctgtcctcgtttggcgcgggcggatccaac gcccacttgatcgtggcgcaatacgccggcacccggccgcagccggagcccgatggccgg ccgcagatgatcctgttgtcggcccgcgagcccggacagctgcgccagatcgccagccga ctgctagagcacttgcagcaggcgccgcagcgcctggacgcgattgcctggaccttgcag gtcgggcgcgaggccatggagcatcgcgccgcgttgatcgcgaccgacgcccaacagctg ctcgacgccttgcgcggtctggccggcggcgacgaccgtggctggatctgcggtgacacc cagaccggcagcgccgccctcgaacccttcaagaaccgttcgcgcaccctgcaacatgag catctggcccagctctacgccaatggcgaactgcaagccctgctggcgttgtggagcgcc ggcctgcgcatcgactggaacgcattgcgcgcgccggaccgccagcggccgcaacgcatc agcctgccgacctatcccttcgccaccgagcggtattgggcgcccacggcggccaagggc ttgccggcggcgaccagggtccatccctggctgcacagccacactgccaccggcgacggg caccagttcacctgcctctgcaacggcgaggagccgtggttgcttgaccatgtggtgaac gcgagcaaaaccctgcccggagcggcctgcctggaaatcatccgcgccgcggtgagccag gctcggggggacggccaggcacgggccatggtcatcgaacagctcaactggctggcgccc ttgaccgtcgggtccgcgccgcggtgcctgcgggtcaacctgcaagcgctggacggccac tgggtggtaacccttctcagcgacgatgacgcgggggcgcaaccggtgctgcattgtcag gcccgggtgacgggcgaggccgcgcctgcggccgagcgcctggatctggcgcactggcgc gagcgcccctggcagcgcagcctcgacagcgacgaggtctatcggctgttcgaggccatg ggcctggcctacggtgccagccatcgcggcatccgccagttgctgatcgcgcagcagggc agccggcgcgaggtgctggcacagctggaccttgagggtatccaggccgttggcgactgc tggctggagcccggcatgaccgacagcgcgctgcaggccgccatcggcatgctgctgcct ctggacgccgggccggcggcgccgttgtcgctgctgatgccctttgccttgcagcgcctg gaaatccttgcgccttgcacgcggcagatgtgggccctgttgcgtggcgaccggcacgac agcgcgggccggatcgacatcgagctctgtgaccagcaggggcaattgtgcgcccggctg gaagggttctgtgcccgatccctcggcccgttgctgcagcaaccaccggcaacgccggtc cagcagttgctggcaccggtctggtcggtggtcgaggcccaacagcagccgcggccggac gggcagggcgcgatgctgatcttcggcgtgagcccctcgcgtcatcaggcgctggccggg ctctatccccgggcgcgcctggtgccaggcggaccggacagcgccgcgaccgaactgctg gccgacgctgaatgggccgaggtgatgtggctggcgcctgcggtggaggccgacgcggat ccggtcgccgcgcaacagcagggcgtgctggcgctgttccggctgatcaaggcactgctg aaccagggctacggtcggcggccgctgcgcctgagcctgatcaccgaccgcgcggtgagc accggcccgggcgacccctgccaggcggtgcatgcggcggtgcatgggctggccggctcg ctggccaaggagtacccgcactggacagtgcacctggcggacctcgcggacgagcagttg gaccgcctggcgacagcgccgtttgccgccctggcgagcggcgagctgctggccctgcgt cacggccaatggcggcagcgccagctggcacgggtgcaggcggcctccgtgccggcccgg ttgccggtctatcgggacggcggggtgtacctggtgattggtggtgccggcgggattggc gcggtctggagccagcacctgattcgccagcatcgcgcccgggtggtgtggatcggccgg cgcgcgctggatgcgcagatcgccgccaagctcgatgagctgacggccatcagcctgatg cacgcagggcccgcgccggtctacctgcaggccgatgccacggaccacctgcagttggcc gcggcccggcagcagatcatcgagcgcttcggccccatcaatggcgtggtgcactcggcc atcgtgctcaaggatcacagcctggccaacatggacgagtcgaccttcagccaggtcctg gaggccaaggtcgccaccagcgtggccctggcccgggcctttggtgacagcgccgcgcag ctggacttcgtgctgttcttctcctcgatgatgtccttcaccacggccgccggccaaggc aactacgcggccggctgcaccttcgccgatgcctttgccgaccagcttcgggcgcgctgg tcgtgcccggtcaaggtgatcaactggggctactggggcggcgtgggctcggtgagcgac gcccgctaccgggaacgcatgaaggccctgggcctgggctccatcgagcccgaggaaggc ctgcgcgccctcgaacagttgctggcgggcggactggaccaactggcgctgctcgcgctg ctgccgggctccgacatcgacgccatcgacagcctggcaggactgctgggccacgagcag atccggctgtccagccaccgctccggggccatggcggcgctgcaggaacggctggagcaa cggctggcggcgctggtcgcgatcacctga

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