KEGG   REACTION: R05466
Entry
R05466                      Reaction                               
Name
deoxyamidinoproclavaminate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)
Definition
Deoxyguanidinoproclavaminic acid + 2-Oxoglutarate + Oxygen <=> Guanidinoproclavaminic acid + Succinate + CO2
Equation
C06656 + C00026 + C00007 <=> C06657 + C00042 + C00011
Comment

see R05468, R05469
Reaction class
RC00773  C06656_C06657
Enzyme
1.14.11.21
Pathway
rn00331  Clavulanic acid biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Module
M00674  Clavaminate biosynthesis, arginine + glyceraldehyde-3P => clavaminate
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.11  With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
    1.14.11.21
     R05466  Deoxyguanidinoproclavaminic acid + 2-Oxoglutarate + Oxygen <=> Guanidinoproclavaminic acid + Succinate + CO2
Orthology
K12675  clavaminate synthase [EC:1.14.11.21]
Reference
1  [PMID:9614345]
  Authors
McGowan SJ, Bycroft BW, Salmond GP.
  Title
Bacterial production of carbapenems and clavams: evolution of beta-lactam antibiotic pathways.
  Journal
Trends Microbiol 6:203-8 (1998)
DOI:10.1016/S0966-842X(98)01251-7
Other DBs
RHEA: 20024
LinkDB

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