KEGG   REACTION: R07939
Entry
R07939                      Reaction                               
Name
caffeine:oxygen oxidoreductase (N3-demethylating)
Definition
Caffeine + NADPH + Oxygen + H+ <=> 1,7-Dimethylxanthine + NADP+ + Formaldehyde + H2O
Equation
C07481 + C00005 + C00007 + C00080 <=> C13747 + C00006 + C00067 + C00001
Comment
CYP1A2
Reaction class
RC00001  C00005_C00006
RC00334  C07481_C13747
RC01797  C00067_C07481
Enzyme
1.14.13.179     1.14.14.1
Pathway
rn00232  Caffeine metabolism
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
Module
M00915  Caffeine degradation, caffeine => xanthine
Brite
Enzymatic reactions [BR:br08201]
 1. Oxidoreductase reactions
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.179
     R07939  Caffeine + NADPH + Oxygen + H+ <=> 1,7-Dimethylxanthine + NADP+ + Formaldehyde + H2O
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1
     R07939  Caffeine + NADPH + Oxygen + H+ <=> 1,7-Dimethylxanthine + NADP+ + Formaldehyde + H2O
Orthology
K07409  cytochrome P450 family 1 subfamily A2 [EC:1.14.14.1]
K21723  methylxanthine N3-demethylase [EC:1.14.13.179]
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