Ursus maritimus (polar bear): 103660044
Help
Entry
103660044 CDS
T03271
Symbol
IGF1R
Name
(RefSeq) insulin-like growth factor 1 receptor
KO
K05087
insulin-like growth factor 1 receptor [EC:
2.7.10.1
]
Organism
umr
Ursus maritimus (polar bear)
Pathway
umr01521
EGFR tyrosine kinase inhibitor resistance
umr01522
Endocrine resistance
umr04010
MAPK signaling pathway
umr04014
Ras signaling pathway
umr04015
Rap1 signaling pathway
umr04066
HIF-1 signaling pathway
umr04068
FoxO signaling pathway
umr04114
Oocyte meiosis
umr04140
Autophagy - animal
umr04144
Endocytosis
umr04150
mTOR signaling pathway
umr04151
PI3K-Akt signaling pathway
umr04152
AMPK signaling pathway
umr04211
Longevity regulating pathway
umr04213
Longevity regulating pathway - multiple species
umr04510
Focal adhesion
umr04520
Adherens junction
umr04550
Signaling pathways regulating pluripotency of stem cells
umr04730
Long-term depression
umr04913
Ovarian steroidogenesis
umr04914
Progesterone-mediated oocyte maturation
umr05200
Pathways in cancer
umr05202
Transcriptional misregulation in cancer
umr05205
Proteoglycans in cancer
umr05214
Glioma
umr05215
Prostate cancer
umr05218
Melanoma
umr05224
Breast cancer
umr05225
Hepatocellular carcinoma
Brite
KEGG Orthology (KO) [BR:
umr00001
]
09130 Environmental Information Processing
09132 Signal transduction
04010 MAPK signaling pathway
103660044 (IGF1R)
04014 Ras signaling pathway
103660044 (IGF1R)
04015 Rap1 signaling pathway
103660044 (IGF1R)
04066 HIF-1 signaling pathway
103660044 (IGF1R)
04068 FoxO signaling pathway
103660044 (IGF1R)
04151 PI3K-Akt signaling pathway
103660044 (IGF1R)
04152 AMPK signaling pathway
103660044 (IGF1R)
04150 mTOR signaling pathway
103660044 (IGF1R)
09140 Cellular Processes
09141 Transport and catabolism
04144 Endocytosis
103660044 (IGF1R)
04140 Autophagy - animal
103660044 (IGF1R)
09143 Cell growth and death
04114 Oocyte meiosis
103660044 (IGF1R)
09144 Cellular community - eukaryotes
04510 Focal adhesion
103660044 (IGF1R)
04520 Adherens junction
103660044 (IGF1R)
04550 Signaling pathways regulating pluripotency of stem cells
103660044 (IGF1R)
09150 Organismal Systems
09152 Endocrine system
04913 Ovarian steroidogenesis
103660044 (IGF1R)
04914 Progesterone-mediated oocyte maturation
103660044 (IGF1R)
09156 Nervous system
04730 Long-term depression
103660044 (IGF1R)
09149 Aging
04211 Longevity regulating pathway
103660044 (IGF1R)
04213 Longevity regulating pathway - multiple species
103660044 (IGF1R)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
103660044 (IGF1R)
05202 Transcriptional misregulation in cancer
103660044 (IGF1R)
05205 Proteoglycans in cancer
103660044 (IGF1R)
09162 Cancer: specific types
05225 Hepatocellular carcinoma
103660044 (IGF1R)
05214 Glioma
103660044 (IGF1R)
05218 Melanoma
103660044 (IGF1R)
05215 Prostate cancer
103660044 (IGF1R)
05224 Breast cancer
103660044 (IGF1R)
09176 Drug resistance: antineoplastic
01521 EGFR tyrosine kinase inhibitor resistance
103660044 (IGF1R)
01522 Endocrine resistance
103660044 (IGF1R)
09180 Brite Hierarchies
09181 Protein families: metabolism
01001 Protein kinases [BR:
umr01001
]
103660044 (IGF1R)
09183 Protein families: signaling and cellular processes
04090 CD molecules [BR:
umr04090
]
103660044 (IGF1R)
Enzymes [BR:
umr01000
]
2. Transferases
2.7 Transferring phosphorus-containing groups
2.7.10 Protein-tyrosine kinases
2.7.10.1 receptor protein-tyrosine kinase
103660044 (IGF1R)
Protein kinases [BR:
umr01001
]
Receptor tyrosine kinases (RTK)
INSR family [OT]
103660044 (IGF1R)
CD molecules [BR:
umr04090
]
Proteins
103660044 (IGF1R)
BRITE hierarchy
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
PK_Tyr_Ser-Thr
Recep_L_domain
Pkinase
Furin-like
fn3
Kinase-like
DUF4476
Motif
Other DBs
NCBI-GeneID:
103660044
NCBI-ProteinID:
XP_040498652
UniProt:
A0A8M1GV33
LinkDB
All DBs
Position
Unknown
AA seq
1366 aa
AA seq
DB search
MKSGSGGGSPTSLWGLLFFSAALSLWPTSGEICGPGIDIRNDYQQLKRLENCTVIEGYLH
ILLISKAEDYRSYRFPKLTVITEYLLLFRVAGLESLGDLFPNLTVIRGWKLFYNYALVIF
EMTNLKDIGLYNLRNITRGAIRIEKNADLCYLSTVDWSLILDAVSNNYIVGNKPPKECGD
LCPGTMEEKPLCEKTTINNEYNYRCWTTNRCQKMCPSACGKRACTENNECCHPECLGSCS
APDNDTACVACRHYYYAGVCVPTCPPNTYRFEGWRCVDRDFCANIPSAESSDSEGFVIHD
GECMQECPSGFIRNGSQSMYCIPCEGPCPKVCEEEKKTKTIDSVTSAQMLQGCTIFKGNL
LINIRRGNNIASELENFMGLIEVVTGYVKIRHSHALVSLSFLKNLRQILGEEQLEGNYSF
YVLDNQNLQQLWDWDHRNLTIKAGKMYFAFNPKLCVSEIYRMEEVTGTKGRQSKGDINTR
NNGERASCESDVLHFTSTTTWKNHIIIRWHRYRPPDYRDLISFTVYYKEAPFKNVTEYDG
QDACGSNSWNMVDVDLPPNKDVDPGILLQGLKPWTQYAVYVKAVTLTMVNDHIRGAKSEI
LYIRTNASVPSIPLDVLSASNSSSQLIVKWNPPSLPNGNLSYYIVRWQRQPQDSYLYRHN
YCSKDKIPIRKYADGTIDVEEVTENPKTEVCGGEKGPCCACPKTEAEKQAEKEEAEYRKV
FENFLHNSIFVPRPERKRRDVTQITNTTMSSRGRNSTVADTYNITDPEELETEYPFFESR
VDNKERTVISNLRPFTLYRIDIHSCNHEAEKLGCSASNFVFARTMPAEGADDIPGPVTWE
SRPENSIFLKWPEPENPNGLILMYEIKYGSQIEDQRECVSRQEYRKYGGAKLNRLNPGNY
TARIQATSLSGNGSWTDPVFFYVPAKITYENFIHLIIALPVAVLLIVGGLVIMLYVFHRK
RNNSRLGNGVLYASVNPEYFSAADVYVPDEWEVAREKITMSRELGQGSFGMVYEGVAKGV
VKDEPETRVAIKTVNEAASMRERIEFLNEASVMKEFNCHHVVRLLGVVSQGQPTLVIMEL
MTRGDLKSYLRSLRPEIENNPVLAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNC
MVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTTHSDVWSFGVV
LWEIATLAEQPYQGLSNEQVLRFVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLE
IISSIKDEMEPGFREVSFYYSEENKPPEPEELDLEPENMESVPLDPSASSSSLPLPDRHS
GHKAENGPGPGVLVLRASFDERQPYAHMNGGRKNERALPLPQSSTC
NT seq
4101 nt
NT seq
+upstream
nt +downstream
nt
atgaagtctggctccggaggagggtccccgacctcgctgtgggggctcctgtttttctcc
gccgcgctctcgctctggccgacgagtggagaaatctgcgggccgggcatcgacatccgc
aacgactatcagcagctgaagcgtctggagaactgcacggtgatcgagggctacctccac
atcttgctcatctccaaggcagaggactaccgcagctaccgcttccccaagctcacggtc
atcaccgagtacctgctgctgttccgcgtggccggcctcgagagcctcggggacctcttc
ccgaacctcacggtcatccgcggctggaaactcttctacaattacgccctggtcatcttt
gagatgaccaatctcaaggatattgggctttacaatctgaggaacattactcggggggcc
atcaggattgagaaaaatgccgacctctgttacctctccacggtggactggtccctgatc
ctggacgcggtgtccaataactacatcgtggggaacaaacccccaaaggaatgcggggac
ctgtgtccggggacgatggaggagaagcccttgtgcgagaagacgaccatcaacaacgag
tacaactaccgctgctggactacaaaccgctgccagaaaatgtgcccgagcgcgtgcggg
aagcgagcgtgcaccgagaacaacgagtgctgtcaccccgagtgtctgggcagctgcagc
gcgccggacaacgacacggcctgcgtggcctgcaggcattactactacgccggcgtctgc
gtgcccacctgcccgcccaacacctaccgcttcgagggctggcgctgcgtggaccgcgac
ttctgcgccaacatccccagcgccgagagcagcgactccgaggggttcgtgatccacgac
ggcgagtgcatgcaggagtgcccctccgggttcatccggaatggcagtcagagtatgtac
tgcatcccttgcgaaggtccttgccccaaggtctgtgaggaagagaagaaaacaaagacc
attgattctgttacctctgctcaaatgctccaaggatgcaccatcttcaagggcaatttg
ctcattaacatccgccgaggcaataacattgcctcggaactggagaacttcatggggctc
atcgaggtggtgacaggctacgtgaagattcgccattcccacgccttggtctccttgtcc
ttcctaaaaaaccttcgccagatcttaggagaggagcagctggaggggaactactccttc
tacgtccttgacaaccagaacttgcagcagctgtgggactgggaccaccgcaacctgacc
atcaaagctgggaaaatgtactttgctttcaatcccaagttgtgcgtctccgagatttac
cgcatggaggaagtgacagggactaaggggcgccagagcaaaggggacataaacaccagg
aacaacggagagcgagcctcctgtgaaagcgacgtcctgcacttcacctctacgaccaca
tggaagaatcacatcatcataaggtggcaccgttaccggccccccgactacagggacctc
atcagcttcactgtctactacaaggaagcaccttttaaaaacgtcacggagtacgatggc
caggatgcctgtggctccaacagctggaacatggtggatgtggacctccctcccaacaag
gacgtcgatcctggcattttactgcagggactgaagccctggacgcagtatgccgtgtat
gtcaaggcggtgaccctcaccatggtgaacgaccacatccgtggggccaagagtgaaatc
ttgtacattcgtaccaatgcttcagttccttccattcccctggacgttctgtccgcgtcc
aactcgtcttctcagctcatcgtgaagtggaacccgccgtccctgcccaacgggaacctc
agttactacatcgtgaggtggcagcggcagcctcaggacagctacctgtaccggcacaat
tactgctccaaagacaaaatccccatcaggaagtatgccgacggcaccatcgacgtcgaa
gaggtgacggagaatcccaagaccgaggtgtgcggcggagagaaggggccttgctgcgcc
tgccccaaaaccgaggccgagaagcaggccgagaaggaggaggccgagtaccgcaaagtc
ttcgagaacttcctgcacaactccatctttgtgcccagaccggaaaggaagcggagagac
gtcacacaaatcaccaacaccaccatgtccagccgaggcaggaacagcacagtggcggac
acctataatatcacagacccagaagagctcgagacagaataccctttctttgagagcaga
gtagataacaaggagagaactgtcatctctaacctccggccttttactttgtaccgcatt
gacatccacagctgtaaccatgaggctgagaagctgggctgcagcgcctccaactttgtt
tttgcaagaaccatgcctgcagaaggagcagatgacattcctgggccggtgacctgggag
tcgaggcctgaaaactccatctttctaaagtggccagaacctgagaatcccaatggattg
attctaatgtatgaaataaaatacggatcacaaatcgaggatcagcgggaatgtgtatcc
agacaggagtacaggaaatatggaggcgccaagcttaaccggctcaacccggggaactat
acagcccggatccaggccacctctctctccgggaatgggtcgtggacggatcctgtgttc
ttctatgtcccagccaaaataacgtatgaaaacttcatccatctgatcatagctctgccc
gttgccgtcctgttgatagtgggagggctggttataatgttgtacgtcttccacaggaaa
agaaataacagcaggctggggaatggagtgctgtacgcgtccgtgaacccagagtacttc
agcgccgccgacgtgtacgtacctgacgagtgggaggttgctcgagagaagatcaccatg
agccgagagctgggccagggctcctttgggatggtatacgaaggagtcgccaaaggcgtg
gttaaagatgagcccgaaaccagggtggccattaaaacagtgaacgaggctgcgagcatg
cgcgaaaggattgaatttctcaatgaggcttcagtgatgaaggagttcaattgtcaccac
gtggtgcggttgctgggcgtggtgtcccagggccagccgacgctggtcatcatggaactg
atgacacggggggatctcaaaagctatctcaggtctctgaggccagaaatagagaataat
ccagtcctagcacctccaagcctgagcaagatgatccagatggctggggagattgcagat
ggcatggcatacctcaacgccaacaagtttgtccacagagaccttgctgcccggaactgc
atggtggccgaagatttcacggtcaaaatcggagatttcggtatgacaagagacatctat
gagacagactattacaggaaaggaggaaaggggctgctgcctgtgcgctggatgtccccc
gagtctctcaaggatggagtcttcaccactcactctgacgtctggtccttcggggtcgtg
ctctgggagattgccacgctggccgaacagccataccagggcttgtccaacgagcaggtc
cttcgcttcgtgatggagggcggccttctggacaagccggacaactgccccgacatgctg
tttgaactgatgcgcatgtgctggcagtacaaccccaagatgaggccttccttcctggag
atcatcagcagcatcaaggacgagatggagcccggcttccgggaggtctccttctactac
agcgaggagaacaagccgcccgagccggaggagctggacctggagcccgagaacatggag
agcgtccccctggacccctccgcctcctcgtcctccctgccgctgcccgacagacactca
ggacacaaggccgagaacggcccaggccccggcgtgctggtcctccgagccagcttcgat
gagagacagccttacgcgcacatgaacgggggacgcaagaacgagagggccttgcctctg
ccccagtcttcgacctgctga
DBGET
integrated database retrieval system
