KEGG ENZYME: 1.13.11.26

ENZYME: 1.13.11.26

Entry

EC 1.13.11.26               Enzyme

Name

peptide-tryptophan 2,3-dioxygenase;
pyrrolooxygenase;
peptidyltryptophan 2,3-dioxygenase;
tryptophan pyrrolooxygenase;
[protein]-L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)

Class

Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen

Sysname

[protein]-L-tryptophan:oxygen 2,3-oxidoreductase (ring-opening)

Reaction(IUBMB)

[protein]-L-tryptophan + O2 = [protein]-N-formyl-L-kynurenine [RN:R04032]

Reaction(KEGG)

R04032

Substrate

[protein]-L-tryptophan;
O2 [CPD:C00007]

Product

[protein]-N-formyl-L-kynurenine

Comment

Also acts on tryptophan.

History

EC 1.13.11.26 created 1972, modified 2011

Reference

1 [PMID:4403729]

Authors

Frydman RB, Tomaro ML, Frydman B.

Title

Pyrrolooxygenase: its action on tryptophan-containing enzymes and peptides.

Journal

Biochim Biophys Acta 284:80-9 (1972)
DOI:10.1016/0005-2744(72)90047-2

Reference

2 [PMID:3699018]

Authors

Camoretti-Mercado B, Frydman RB

Title

Separation of tryptophan pyrrolooxygenase into three molecular forms. A study of their substrate specificities using tryptophyl-containing peptides and proteins.

Journal

Eur J Biochem 156:317-25 (1986)
DOI:10.1111/j.1432-1033.1986.tb09585.x

Other DBs

ExplorEnz - The Enzyme Database:

1.13.11.26

IUBMB Enzyme Nomenclature:

1.13.11.26

ExPASy - ENZYME nomenclature database:

1.13.11.26

BRENDA, the Enzyme Database:

1.13.11.26

CAS:	37256-64-7

LinkDB

DBGET integrated database retrieval system