KEGG   DRUG: LevodopaHelp
Entry
D00059                      Drug                                   

Name
Levodopa (JP17/USP/INN);
Dopar (TN)
Formula
C9H11NO4
Exact mass
197.0688
Mol weight
197.1879
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01592  COMT substrate
Neuropsychiatric agent
 DG01472  Dopamine agonist
  DG01467  Dopamine D1-receptor agonist
  DG01468  Dopamine D2-receptor agonist
  DG01469  Dopamine D3-receptor agonist
  DG01470  Dopamine D4-receptor agonist
  DG01471  Dopamine D5-receptor agonist
 DG01967  Antiparkinson agent
Remark
Same as: C00355
Therapeutic category: 1164
ATC code: N04BA01
Product: D00059<JP>
Product (mixture): D00253<JP/US> D02135<JP> D10293<JP/US>
Efficacy
Antiparkinsonian
  Disease
Parkinson's disease [DS:H00057]
Parkinsonism [DS:H01600]
Comment
Dopamine precursor
Active form of prodrug: Dopamine [DR:D07870]
Target
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04728  Dopaminergic synapse
hsa05012  Parkinson's disease
Interaction
Drug interaction
Structure map
map07057  Antiparkinsonian agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N04 ANTI-PARKINSON DRUGS
   N04B DOPAMINERGIC AGENTS
    N04BA Dopa and dopa derivatives
     N04BA01 Levodopa
      D00059  Levodopa (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   116  Antiparkinsonian agents
    1164  Levodopas
     D00059  Levodopa (JP17/USP/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    dopamine receptor
     Levodopa
      D00059  Levodopa (JP17/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00059  Levodopa
Drug classes of therapeutic agents [br08360.html]
 Neurological agents
  D00059
Prodrugs [br08324.html]
 D00059
BRITE hierarchy
Other DBs
CAS: 59-92-7
PubChem: 7847127
ChEBI: 15765
ChEMBL: CHEMBL1009
DrugBank: DB01235
PDB-CCD: DAH[PDBj]
LigandBox: D00059
NIKKAJI: J9.225H
LinkDB All DBs
KCF data Show

ATOM        14
            1   C8y C    22.9600  -19.2500
            2   C8y C    22.9600  -20.6500
            3   C8x C    24.1500  -18.5500
            4   O1a O    21.7000  -18.5500
            5   C8x C    24.1500  -21.3500
            6   O1a O    21.7000  -21.3500
            7   C8y C    25.3400  -19.2500
            8   C8x C    25.3400  -20.6500
            9   C1b C    26.6000  -18.6200
            10  C1c C    27.7900  -19.2500
            11  C6a C    28.9800  -18.6200
            12  N1a N    27.7900  -20.6500
            13  O6a O    30.2400  -19.2500
            14  O6a O    28.9800  -17.2200
BOND        14
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 1
            7     5   8 1
            8     7   9 1
            9     9  10 1
            10   10  11 1
            11   10  12 1 #Up
            12   11  13 1
            13   11  14 2
            14    7   8 2

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