KEGG   DRUG: D00059Help
Entry
D00059                      Drug                                   
Name
Levodopa (JP16/USP/INN);
Dopar (TN)
Formula
C9H11NO4
Exact mass
197.0688
Mol weight
197.1879
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antiparkinsonian [DS:H00057]
Remark
Same as: 
Therapeutic category: 
ATC code: 
Comment
dopamine precursor
Target
dopamine D1 receptor agonist [HSA:1812] [KO:K04144];
dopamine D2 receptor agonist [HSA:1813] [KO:K04145];
dopamine D3 receptor agonist [HSA:1814] [KO:K04146];
dopamine D4 receptor agonist [HSA:1815] [KO:K04147];
dopamine D5 receptor agonist [HSA:1816] [KO:K05840]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04728  Dopaminergic synapse  
 
Interaction
Drug interaction
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   116  Antiparkinsonian agents
    1164  Levodopas
     D00059  Levodopa (JP16/USP/INN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N04 ANTI-PARKINSON DRUGS
   N04B DOPAMINERGIC AGENTS
    N04BA Dopa and dopa derivatives
     N04BA01 Levodopa
      D00059  Levodopa (JP16/USP/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    dopamine D1-receptor [HSA:1812] [KO:K04144]
     Levodopa [ATC:N04BA01]
      D00059  Levodopa (JP16/USP/INN)
    dopamine D2-receptor [HSA:1813] [KO:K04145]
     Levodopa [ATC:N04BA01]
      D00059  Levodopa (JP16/USP/INN)
    dopamine D3-receptor [HSA:1814] [KO:K04146]
     Levodopa [ATC:N04BA01]
      D00059  Levodopa (JP16/USP/INN)
    dopamine D4-receptor [HSA:1815] [KO:K04147]
     Levodopa [ATC:N04BA01]
      D00059  Levodopa (JP16/USP/INN)
    dopamine D5-receptor [HSA:1816] [KO:K05840]
     Levodopa [ATC:N04BA01]
      D00059  Levodopa (JP16/USP/INN)
BRITE hierarchy
Other DBs
CAS: 
59-92-7
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        14
            1   C8y C    22.9600  -19.2500
            2   C8y C    22.9600  -20.6500
            3   C8x C    24.1500  -18.5500
            4   O1a O    21.7000  -18.5500
            5   C8x C    24.1500  -21.3500
            6   O1a O    21.7000  -21.3500
            7   C8y C    25.3400  -19.2500
            8   C8x C    25.3400  -20.6500
            9   C1b C    26.6000  -18.6200
            10  C1c C    27.7900  -19.2500
            11  C6a C    28.9800  -18.6200
            12  N1a N    27.7900  -20.6500
            13  O6a O    30.2400  -19.2500
            14  O6a O    28.9800  -17.2200
BOND        14
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 1
            7     5   8 1
            8     7   9 1
            9     9  10 1
            10   10  11 1
            11   10  12 1 #Up
            12   11  13 1
            13   11  14 2
            14    7   8 2

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