KEGG   DRUG: AzathioprineHelp
Entry
D00238                      Drug                                   

Name
Azathioprine (JP17/USP/INN);
Azasan (TN);
Imuran (TN)
Product
  Generic
AZATHIOPRINE (Aidarex Pharmaceuticals LLC), AZATHIOPRINE (American Health Packaging), AZATHIOPRINE (Amneal Pharmaceuticals LLC), AZATHIOPRINE (Amneal Pharmaceuticals of New York), AZATHIOPRINE (Aphena Pharma Solutions - Tennessee), AZATHIOPRINE (Aphena Pharma Solutions - Tennessee), AZATHIOPRINE (Avera McKennan Hospital), AZATHIOPRINE (Cadila Healthcare Limited), AZATHIOPRINE (Cadila Healthcare Limited), AZATHIOPRINE (Cardinal Health), AZATHIOPRINE (Glenmark Pharmaceuticals), AZATHIOPRINE (Glenmark Pharmaceuticals), AZATHIOPRINE (Mylan Institutional), AZATHIOPRINE (Mylan Pharmaceuticals), AZATHIOPRINE (NCS HealthCare of KY), AZATHIOPRINE (Physicians Total Care), AZATHIOPRINE (Rebel Distributors Corp..), AZASAN (Salix Pharmaceuticals), AZATHIOPRINE (Zydus Pharmaceuticals (USA)), AZATHIOPRINE (Zydus Pharmaceuticals (USA))
Formula
C9H7N7O2S
Exact mass
277.0382
Mol weight
277.2626
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Anti-inflammatory
 DG01985  Disease modifying anti-rheumatic drugs (DMARDs)
Remark
Same as: C06837
Therapeutic category: 3999
ATC code: L04AX01
Chemical structure group: DG00743
Product (DG00743): D00238<JP/US> D03033<US>
Efficacy
Immunosuppressant, Nucleic acid biosynthesis inhibitor
  Disease
Prevention of rejection in renal homotransplantation [DS:H00083]
Rheumatoid arthritis [DS:H00630]
Comment
Azathioprine is metabolized to 6-mercaptopurine (6-MP) [DR:D04931]
Interaction
Drug interaction
Structure map
map07046  Immunosuppressive agents
map07050  Antirheumatics - DMARDs and biological agents
Other map
map00983  Drug metabolism - other enzymes
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L04 IMMUNOSUPPRESSANTS
   L04A IMMUNOSUPPRESSANTS
    L04AX Other immunosuppressants
     L04AX01 Azathioprine
      D00238  Azathioprine (JP17/USP/INN)
USP drug classification [BR:br08302]
 Immunological Agents
  Immune Suppressants
   Azathioprine
    D00238  Azathioprine (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   399  Miscellaneous
    3999  Others
     D00238  Azathioprine (JP17/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00238  Azathioprine
  D00238  Azathioprine tablets
Drug classes of therapeutic agents [br08360.html]
 Antirheumatic and antigout agents
  D00238
Pharmacogenomic biomarkers in FDA drug labels [br08341.html]
 Polymorphisms and germline mutations
  D00238
BRITE hierarchy
Other DBs
CAS: 446-86-6
PubChem: 7847305
ChEBI: 2948
ChEMBL: CHEMBL1542
DrugBank: DB00993
LigandBox: D00238
NIKKAJI: J2.047H
LinkDB All DBs
KCF data Show

ATOM        19
            1   C8y C    22.2600  -23.0300
            2   C8y C    21.0700  -23.7300
            3   S2a S    22.2600  -21.6300
            4   N5x N    23.4500  -23.7300
            5   C8y C    21.0700  -25.1300
            6   N4x N    19.7400  -23.2400
            7   C8y C    21.0700  -20.9300
            8   C8x C    23.4500  -25.1300
            9   N5x N    19.7400  -25.5500
            10  N5x N    22.2600  -25.8300
            11  C8x C    18.9000  -24.4300
            12  C8y C    21.0700  -19.5300
            13  O3a O    23.5200  -19.5300 #-
            14  N2b N    22.2600  -18.8300 #+
            15  N5x N    19.7400  -19.1100
            16  C8x C    18.9000  -20.2300
            17  N4y N    19.7400  -21.3500
            18  O3a O    22.2600  -17.4300
            19  C1a C    18.5276  -22.0500
BOND        21
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 2
            5     2   6 1
            6     3   7 1
            7     4   8 1
            8     5   9 1
            9     5  10 1
            10    6  11 1
            11    8  10 2
            12    9  11 2
            13    7  12 2
            14   13  14 1
            15   12  14 1
            16   12  15 1
            17   15  16 2
            18   16  17 1
            19    7  17 1
            20   14  18 2
            21   17  19 1

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