KEGG   DRUG: CarbamazepineHelp
Entry
D00252                      Drug                                   

Name
Carbamazepine (JP17/USP/INN);
Equetro (TN);
Tegretol (TN)
Product
  Generic
CARBAMAZEPINE (A-S Medication Solutions LLC), CARBAMAZEPINE (Actavis Elizabeth LLC), CARBAMAZEPINE (Aidarex Pharmaceuticals LLC), CARBAMAZEPINE (American Health Packaging), CARBAMAZEPINE (American Health Packaging), CARBAMAZEPINE (Aphena Pharma Solutions - Tennessee), CARBAMAZEPINE (Apotex Corp.), CARBAMAZEPINE (Apotex Corp.), CARBAMAZEPINE (Atlantic Biologicals Corps), CARBAMAZEPINE (Avera McKennan Hospital), CARBAMAZEPINE (Avera McKennan Hospital), CARBAMAZEPINE (Bryant Ranch Prepack), CARBAMAZEPINE (Cardinal Health), CARBAMAZEPINE (Cardinal Health), CARBAMAZEPINE (Cardinal Health), CARBAMAZEPINE (Cardinal Health), CARBAMAZEPINE (Clinical Solutions Wholesale), CARBAMAZEPINE (Contract Pharmacy Services-PA), CARBAMAZEPINE (Golden State Medical Supply), CARBAMAZEPINE (Golden State Medical Supply), CARBAMAZEPINE (Golden State Medical Supply), CARBAMAZEPINE (Major Pharmaceuticals), CARBAMAZEPINE (McKesson Contract Packaging), CARBAMAZEPINE (McKesson Contract Packaging), CARBAMAZEPINE (Morton Grove Pharmaceuticals), CARBAMAZEPINE (Mylan Institutional), CARBAMAZEPINE (NCS HealthCare of KY), CARBAMAZEPINE (NCS HealthCare of KY), CARBAMAZEPINE (Northwind Pharmaceuticals), CARBAMAZEPINE (Nostrum Laboratories), CARBAMAZEPINE (Nostrum Laboratories), CARBAMAZEPINE (PD-Rx Pharmaceuticals), CARBAMAZEPINE (Physicians Total Care), CARBAMAZEPINE (Prasco Laboratories), CARBAMAZEPINE (Precision Dose), CARBAMAZEPINE (Preferred Pharmaceuticals), CARBAMAZEPINE (Preferred Pharmaceuticals), CARBAMAZEPINE (REMEDYREPACK), CARBAMAZEPINE (REMEDYREPACK), CARBAMAZEPINE (REMEDYREPACK), CARBAMAZEPINEER (REMEDYREPACK), CARBAMAZEPINE (REMEDYREPACK), CARBAMAZEPINE (REMEDYREPACK), CARBAMAZEPINE (REMEDYREPACK), CARBAMAZEPINE (REMEDYREPACK), CARBAMAZEPINE (REMEDYREPACK), CARBAMAZEPINE (REMEDYREPACK), CARBAMAZEPINE (REMEDYREPACK), CARBAMAZEPINE (REMEDYREPACK), CARBAMAZEPINE (Rebel Distributors Corp), CARBAMAZEPINE (STAT RX USA LLC), CARBAMAZEPINE (Sandoz), CARBAMAZEPINE (State of Florida DOH Central Pharmacy), CARBAMAZEPINE (State of Florida DOH Central Pharmacy), CARBAMAZEPINE (State of Florida DOH Central Pharmacy), CARBAMAZEPINE (TYA Pharmaceuticals), CARBAMAZEPINE (Taro Pharmaceuticals U.S.A.), CARBAMAZEPINE (Taro Pharmaceuticals U.S.A.), EPITOL (Teva Pharmaceuticals USA), CARBAMAZEPINE (Teva Pharmaceuticals USA), CARBAMAZEPINE (Teva Pharmaceuticals USA), CARBAMAZEPINE (Torrent Pharmaceuticals Limited), CARBAMAZEPINE (Unit Dose Services), CARBAMAZEPINE (Upsher-Smith Laboratories)
Formula
C15H12N2O
Exact mass
236.095
Mol weight
236.2686
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cyp substrate
 DG01633  CYP3A4 substrate
Cyp inhibitor
 DG01915  CYP3A5 inhibitor
Cyp inducer
 DG01635  CYP3A4 inducer
 DG01897  CYP3A5 inducer
Transporter inducer
 DG01893  P-glycoprotein inducer
Remark
Same as: 
Therapeutic category: 
ATC code: 
Activity
Analgesic, Antiepileptic
Comment
Carboxamide derivative
Target
SCN1A [HSA:6323] [KO:K04833];
SCN2A [HSA:6326] [KO:K04834];
SCN3A [HSA:6328] [KO:K04836];
SCN4A [HSA:6329] [KO:K04837];
SCN5A [HSA:6331] [KO:K04838];
SCN8A [HSA:6334] [KO:K04840];
SCN9A [HSA:6335] [KO:K04841]
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP2C8 [HSA:1558], CYP2B6 [HSA:1555]
Interaction
Genomic biomarker: HLA-B [HSA:3106], HLA-A [HSA:3105]
CYP induction: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551], CYP2C19 [HSA:1557]
Transporter induction: ABCB1 [HSA:5243]
Drug interaction
Structure map
Anticonvulsants
Sodium channel blocking drugs
Other map
Drug metabolism - cytochrome P450
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AF Carboxamide derivatives
     N03AF01 Carbamazepine
      D00252  Carbamazepine (JP17/USP/INN)
USP drug classification [BR:br08302]
 Anticonvulsants
  Sodium Channel Agents
   Carbamazepine
    D00252  Carbamazepine (JP17/USP/INN)
 Bipolar Agents
  Mood Stabilizers
   Carbamazepine
    D00252  Carbamazepine (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   113  Antiepileptics
    1139  Others
     D00252  Carbamazepine (JP17/USP/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A)
     Carbamazepine
      D00252  Carbamazepine (JP17/USP/INN)
    voltage-gated sodium channel (SCN2A)
     Carbamazepine
      D00252  Carbamazepine (JP17/USP/INN)
    voltage-gated sodium channel (SCN3A)
     Carbamazepine
      D00252  Carbamazepine (JP17/USP/INN)
    voltage-gated sodium channel (SCN4A)
     Carbamazepine
      D00252  Carbamazepine (JP17/USP/INN)
    voltage-gated sodium channel (SCN5A)
     Carbamazepine
      D00252  Carbamazepine (JP17/USP/INN)
    voltage-gated sodium channel (SCN8A)
     Carbamazepine
      D00252  Carbamazepine (JP17/USP/INN)
    voltage-gated sodium channel (SCN9A)
     Carbamazepine
      D00252  Carbamazepine (JP17/USP/INN)
Cytochrome P450 interactions [BR:br08309]
 CYP inhbitors
  CYP2C19
   Carbamazepine
    D00252  Carbamazepine (JP17/USP/INN)
 CYP inducers
  CYP2C9
   Carbamazepine
    D00252  Carbamazepine (JP17/USP/INN)
  CYP2C19
   Carbamazepine
    D00252  Carbamazepine (JP17/USP/INN)
  CYP3A4
   Carbamazepine
    D00252  Carbamazepine (JP17/USP/INN)
  CYP3A5
   Carbamazepine
    D00252  Carbamazepine (JP17/USP/INN)
  CYP3A7
   Carbamazepine
    D00252  Carbamazepine (JP17/USP/INN)
  CYP3A
   Carbamazepine
    D00252  Carbamazepine (JP17/USP/INN)
 CYP substrates
  CYP2B6
   Carbamazepine
    D00252  Carbamazepine (JP17/USP/INN)
  CYP2C8
   Carbamazepine
    D00252  Carbamazepine (JP17/USP/INN)
  CYP3A4
   Carbamazepine
    D00252  Carbamazepine (JP17/USP/INN)
 Transporter inducers
  ABCB1
   Carbamazepine
    D00252  Carbamazepine (JP17/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00252  Carbamazepine
Neurological agents [br08367.html]
 Antiepileptic agents
  D00252
Pharmacogenomic biomarkers in FDA drug labels [br08341.html]
 Polymorphisms and germline mutations
  D00252
BRITE hierarchy
Other DBs
CAS: 
298-46-4
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        18
            1   C8y C    25.8138  -16.0918
            2   N1y N    27.0678  -15.4768
            3   C8y C    28.3384  -16.0677
            4   C8y C    28.6645  -17.4200
            5   C8y C    25.5184  -17.4703
            6   C2x C    27.8109  -18.5337
            7   C2x C    26.4089  -18.5521
            8   C8x C    24.7745  -15.1529
            9   C8x C    23.4416  -15.5834
            10  C8x C    23.1462  -16.9619
            11  C8x C    24.1856  -17.9009
            12  C8x C    30.0176  -17.7825
            13  C8x C    31.0080  -16.7920
            14  C8x C    30.6455  -15.4389
            15  C8x C    29.2925  -15.0764
            16  C5a C    27.1234  -14.0772
            17  O5a O    25.8856  -13.3793
            18  N1a N    28.3126  -13.3740
BOND        20
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 2
            8     1   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    5  11 2
            13    4  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17   15   3 2
            18    2  16 1
            19   16  17 2
            20   16  18 1

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