Entry |
|
Name |
Carbamazepine (JP17/USP/INN);
Equetro (TN);
Tegretol (TN)
|
Product |
|
Generic |
CARBAMAZEPINE (Aidarex Pharmaceuticals LLC), CARBAMAZEPINE (American Health Packaging), CARBAMAZEPINE (American Health Packaging), CARBAMAZEPINE (American Health Packaging), CARBAMAZEPINE (Aphena Pharma Solutions - Tennessee), CARBAMAZEPINE (Apotex Corp.), CARBAMAZEPINE (Apotex Corp.), CARBAMAZEPINE (Atlantic Biologicals Corps), CARBAMAZEPINE (Avera McKennan Hospital), CARBAMAZEPINE (Avera McKennan Hospital), CARBAMAZEPINE (Bryant Ranch Prepack), CARBAMAZEPINE (Bryant Ranch Prepack), CARBAMAZEPINE (Bryant Ranch Prepack), CARBAMAZEPINE (Cardinal Health), CARBAMAZEPINE (Clinical Solutions Wholesale), CARBAMAZEPINE (Contract Pharmacy Services-PA), CARBAMAZEPINE (Contract Pharmacy Services-PA), CARBAMAZEPINE (Contract Pharmacy Services-PA), CARBAMAZEPINE (Golden State Medical Supply), CARBAMAZEPINE (Golden State Medical Supply), CARBAMAZEPINE (Lake Erie Medical DBA Quality Care Products LLC), CARBAMAZEPINE (Major Pharmaceuticals), CARBAMAZEPINE (Morton Grove Pharmaceuticals), CARBAMAZEPINE (Mylan Institutional), CARBAMAZEPINE (NCS HealthCare of KY), CARBAMAZEPINE (NCS HealthCare of KY), CARBAMAZEPINE (Northwind Pharmaceuticals), CARBAMAZEPINE (Nostrum Laboratories), CARBAMAZEPINE (Nostrum Laboratories), CARBAMAZEPINE (NuCare Pharmaceuticals), CARBAMAZEPINE (NuCare Pharmaceuticals), CARBAMAZEPINE (NuCare Pharmaceuticals), CARBAMAZEPINE (PD-Rx Pharmaceuticals), CARBAMAZEPINE (Physicians Total Care), CARBAMAZEPINE (Prasco Laboratories), CARBAMAZEPINE (Precision Dose), CARBAMAZEPINE (Precision Dose), CARBAMAZEPINE (Preferred Pharmaceuticals), CARBAMAZEPINE (Preferred Pharmaceuticals), CARBAMAZEPINE (REMEDYREPACK), CARBAMAZEPINE (REMEDYREPACK), CARBAMAZEPINE (REMEDYREPACK), CARBAMAZEPINE (REMEDYREPACK), CARBAMAZEPINE (REMEDYREPACK), CARBAMAZEPINE (REMEDYREPACK), CARBAMAZEPINE (REMEDYREPACK), CARBAMAZEPINE (REMEDYREPACK), CARBAMAZEPINE (REMEDYREPACK), CARBAMAZEPINE (Rebel Distributors Corp), CARBAMAZEPINE (Sandoz), CARBAMAZEPINE (State of Florida DOH Central Pharmacy), CARBAMAZEPINE (State of Florida DOH Central Pharmacy), CARBAMAZEPINE (State of Florida DOH Central Pharmacy), CARBAMAZEPINE (TYA Pharmaceuticals), CARBAMAZEPINE (Taro Pharmaceuticals U.S.A.), CARBAMAZEPINE (Taro Pharmaceuticals U.S.A.), CARBAMAZEPINE (Teva Pharmaceuticals USA), CARBAMAZEPINE (Teva Pharmaceuticals USA), EPITOL (Teva Pharmaceuticals USA), CARBAMAZEPINE (Torrent Pharmaceuticals Limited), CARBAMAZEPINE (Unit Dose Services) |
Formula |
C15H12N2O
|
Exact mass |
236.095
|
Mol weight |
236.2686
|
Structure |

     |
Simcomp |
 |
Class |
Neuropsychiatric agent
DG02034 Carboxamide antiepileptics
Cyp substrate
DG01633 CYP3A substrate
Cyp inhibitor
DG01915 CYP3A5 inhibitor
Cyp inducer
DG01635 CYP3A4 inducer
DG01897 CYP3A5 inducer
Transporter inducer
DG01893 P-glycoprotein inducer
|
Remark |
Same as: Therapeutic category: ATC code: Product: |
Efficacy |
Analgesic, Antiepileptic |
Disease |
Trigeminal neuralgia [DS: H01638] |
Comment |
Carboxamide derivative
|
Target |
|
Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
Interaction |
CYP induction: CYP3A4 [HSA: 1576]
Transporter induction: ABCB1 [HSA: 5243]
 |
Structure map |
| Anticonvulsants | | Sodium channel blocking drugs |
|
Other map |
| Drug metabolism - cytochrome P450 |
|
Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N03 ANTIEPILEPTICS
N03A ANTIEPILEPTICS
N03AF Carboxamide derivatives
N03AF01 Carbamazepine
D00252 Carbamazepine (JP17/USP/INN)
USP drug classification [BR:br08302]
Anticonvulsants
Sodium Channel Agents
Carbamazepine
D00252 Carbamazepine (JP17/USP/INN)
Bipolar Agents
Mood Stabilizers
Carbamazepine
D00252 Carbamazepine (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
113 Antiepileptics
1139 Others
D00252 Carbamazepine (JP17/USP/INN)
117 Psychotropics
1179 Others
D00252 Carbamazepine (JP17/USP/INN)
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated cation channels
Na+ channel, SCN alpha, NaV1.x
voltage-gated sodium channel (SCN1A)
Carbamazepine
D00252 Carbamazepine (JP17/USP/INN)
voltage-gated sodium channel (SCN2A)
Carbamazepine
D00252 Carbamazepine (JP17/USP/INN)
voltage-gated sodium channel (SCN3A)
Carbamazepine
D00252 Carbamazepine (JP17/USP/INN)
voltage-gated sodium channel (SCN4A)
Carbamazepine
D00252 Carbamazepine (JP17/USP/INN)
voltage-gated sodium channel (SCN5A)
Carbamazepine
D00252 Carbamazepine (JP17/USP/INN)
voltage-gated sodium channel (SCN8A)
Carbamazepine
D00252 Carbamazepine (JP17/USP/INN)
voltage-gated sodium channel (SCN9A)
Carbamazepine
D00252 Carbamazepine (JP17/USP/INN)
voltage-gated sodium channel (SCN10A)
Carbamazepine
D00252 Carbamazepine (JP17/USP/INN)
Carbamazepine
D00252 Carbamazepine (JP17/USP/INN)
voltage-gated sodium channel (SCN11A)
Carbamazepine
D00252 Carbamazepine (JP17/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00252 Carbamazepine
Drug classes of therapeutic agents [br08360.html]
Neurological agents
D00252
Pharmacogenomic biomarkers in FDA drug labels [br08341.html]
Polymorphisms and germline mutations
D00252
 |
Other DBs |
CAS: 298-46-4 PubChem: ChEBI: ChEMBL: DrugBank: LigandBox: NIKKAJI: |
LinkDB |
 |
KCF data |
 ATOM 18
1 C8y C 25.8138 -16.0918
2 N1y N 27.0678 -15.4768
3 C8y C 28.3384 -16.0677
4 C8y C 28.6645 -17.4200
5 C8y C 25.5184 -17.4703
6 C2x C 27.8109 -18.5337
7 C2x C 26.4089 -18.5521
8 C8x C 24.7745 -15.1529
9 C8x C 23.4416 -15.5834
10 C8x C 23.1462 -16.9619
11 C8x C 24.1856 -17.9009
12 C8x C 30.0176 -17.7825
13 C8x C 31.0080 -16.7920
14 C8x C 30.6455 -15.4389
15 C8x C 29.2925 -15.0764
16 C5a C 27.1234 -14.0772
17 O5a O 25.8856 -13.3793
18 N1a N 28.3126 -13.3740
BOND 20
1 3 4 1
2 1 5 1
3 4 6 1
4 2 3 1
5 5 7 1
6 1 2 1
7 6 7 2
8 1 8 2
9 8 9 1
10 9 10 2
11 10 11 1
12 5 11 2
13 4 12 2
14 12 13 1
15 13 14 2
16 14 15 1
17 15 3 2
18 2 16 1
19 16 17 2
20 16 18 1
|
|