KEGG   DRUG: ChlorpropamideHelp
Entry
D00271                      Drug                                   

Name
Chlorpropamide (JP17/USP/INN);
Diabinese (TN)
Product
  Generic
Formula
C10H13ClN2O3S
Exact mass
276.0335
Mol weight
276.7398
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Antidiabetic agent
 DG01790  Sulfonamide hypoglycemic
  DG01734  Sulfonamide type sulfonylurea receptor agonist
 DG01508  Sulfonylurea receptor agonist
Remark
Therapeutic category: 
ATC code: 
Activity
Antidiabetic
  Disease
Type 2 diabetes mellitus [DS:H00409]
Comment
The effects of the sulfonylureas are initiated by binding to and blocking an ATP-sensitive K+ channel, which has been cloned.
Target
sulfonylurea receptor 1 [HSA:6833] [KO:K05032]
  Pathway
ABC transporters
Insulin secretion
Type II diabetes mellitus
Interaction
Genomic biomarker: G6PD [HSA:2539]
Drug interaction
Structure map
Sulfonamide derivatives - hypoglycemic agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BB Sulfonylureas
     A10BB02 Chlorpropamide
      D00271  Chlorpropamide (JP17/USP/INN)
USP drug classification [BR:br08302]
 Blood Glucose Regulators
  Antidiabetic Agents
   Chlorpropamide
    D00271  Chlorpropamide (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   396  Antidiabetic agents
    3961  Sulfonylureas
     D00271  Chlorpropamide (JP17/USP/INN)
Target-based classification of drugs [BR:br08310]
 Transporters
  ABC transporters
   ABCC (CFTR/MRP) subfamily
    ABCC8 (sulfonylurea receptor 1)
     Chlorpropamide
      D00271  Chlorpropamide (JP17/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00271  Chlorpropamide
  D00271  Chlorpropamide tablets
Antidiabetics [br08361.html]
 D00271
Pharmacogenomic biomarkers in FDA drug labels [br08341.html]
 Polymorphisms and germline mutations
  D00271
BRITE hierarchy
Other DBs
CAS: 
94-20-2
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        17
            1   C8x C    20.7200   -8.4700
            2   C8y C    20.7200   -9.8700
            3   C8x C    21.9324  -10.5700
            4   C8x C    23.1449   -9.8700
            5   C8y C    23.1449   -8.4700
            6   C8x C    21.9324   -7.7700
            7   X   Cl   19.5076  -10.5700
            8   S4a S    24.3824   -7.7700
            9   N1b N    25.5949   -8.4700
            10  C5a C    26.8073   -7.7700
            11  N1b N    28.0197   -8.4700
            12  C1b C    29.2322   -7.7700
            13  C1b C    30.4446   -8.4700
            14  C1a C    31.6570   -7.7700
            15  O5a O    26.8073   -6.3700
            16  O3c O    23.3925   -6.7801
            17  O3c O    25.3724   -6.7801
BOND        17
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     2   7 1
            8     5   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14   13  14 1
            15   10  15 2
            16    8  16 2
            17    8  17 2

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