KEGG   DRUG: D00271Help
Entry
D00271                      Drug                                   

Name
Chlorpropamide (JP16/USP/INN);
Diabinese (TN)
Product
  Generic
Formula
C10H13ClN2O3S
Exact mass
276.0335
Mol weight
276.7398
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antidiabetic [DS:H00409]
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Comment
The effects of the sulfonylureas are initiated by binding to and blocking an ATP-sensitive K+ channel, which has been cloned.
Target
sulfonylurea receptor 1 agonist [HSA:6833] [KO:K05032]
  Pathway
hsa02010  ABC transporters
hsa04911  Insulin secretion
hsa04930  Type II diabetes mellitus  
 
Interaction
Genomic biomarker: G6PD [HSA:2539]
Drug interaction
Structure map
Sulfonamide derivatives - hypoglycemic agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BB Sulfonamides, urea derivatives
     A10BB02 Chlorpropamide
      D00271  Chlorpropamide (JP16/USP/INN)
USP drug classification [BR:br08302]
 Blood Glucose Regulators
  Antidiabetic Agents
   Chlorpropamide
    D00271  Chlorpropamide (JP16/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   396  Antidiabetic agents
    3961  Sulfonylureas
     D00271  Chlorpropamide (JP16/USP/INN)
Target-based classification of drugs [BR:br08310]
 Transporters
  ABC transporters
   ABCC (CFTR/MRP) subfamily
    ABCC8 (sulfonylurea receptor 1)
     Chlorpropamide
      D00271  Chlorpropamide (JP16/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00271  Chlorpropamide
  D00271  Chlorpropamide tablets
BRITE hierarchy
Other DBs
CAS: 
94-20-2
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        17
            1   C8x C    20.7200   -8.4700
            2   C8y C    20.7200   -9.8700
            3   C8x C    21.9324  -10.5700
            4   C8x C    23.1449   -9.8700
            5   C8y C    23.1449   -8.4700
            6   C8x C    21.9324   -7.7700
            7   X   Cl   19.5076  -10.5700
            8   S4a S    24.3824   -7.7700
            9   N1b N    25.5949   -8.4700
            10  C5a C    26.8073   -7.7700
            11  N1b N    28.0197   -8.4700
            12  C1b C    29.2322   -7.7700
            13  C1b C    30.4446   -8.4700
            14  C1a C    31.6570   -7.7700
            15  O5a O    26.8073   -6.3700
            16  O3c O    23.3925   -6.7801
            17  O3c O    25.3724   -6.7801
BOND        17
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     2   7 1
            8     5   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14   13  14 1
            15   10  15 2
            16    8  16 2
            17    8  17 2

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