KEGG   DRUG: D00283Help
Entry
D00283                      Drug                                   

Name
Clozapine (JAN/USP/INN);
Clozaril (TN)
Product
  Generic
Formula
C18H19ClN4
Exact mass
326.1298
Mol weight
326.8233
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antipsychotic
Remark
Same as: 
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Multi-acting receptor targeted antipsychotic (MARTA)
Benzodiazepine derivative
Target
5-HT1A-receptor antagonist [HSA:3350] [KO:K04153];
5-HT2A-receptor antagonist [HSA:3356] [KO:K04157];
5-HT2C-receptor antagonist [HSA:3358] [KO:K04157];
5-HT7-receptor antagonist [HSA:3363] [KO:K04163];
alpha1-adrenergic receptor antagonist [HSA:146 147 148] [KO:K04137 K04136 K04135];
dopamine D2-receptor antagonist [HSA:1813] [KO:K04145];
dopamine D4-receptor antagonist [HSA:1815] [KO:K04147]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa04540  Gap junction
hsa04726  Serotonergic synapse
hsa04728  Dopaminergic synapse
hsa04970  Salivary secretion  
 
Metabolism
Enzyme: CYP1A2 [HSA:1544], CYP3A4 [HSA:1576]
Interaction
Genomic biomarker: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Benzodiazepine family
Serotonin receptor agonists/antagonists
Dopamine receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AH Diazepines, oxazepines and thiazepines
     N05AH02 Clozapine
      D00283  Clozapine (JAN/USP/INN)
USP drug classification [BR:br08302]
 Antipsychotics
  Treatment-Resistant
   Clozapine
    D00283  Clozapine (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D00283  Clozapine (JAN/USP/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    alpha1-adrenergic receptor
     Clozapine
      D00283  Clozapine (JAN/USP/INN)
   Dopamine
    dopamine D2-receptor
     Clozapine
      D00283  Clozapine (JAN/USP/INN)
    dopamine D4-receptor
     Clozapine
      D00283  Clozapine (JAN/USP/INN)
   Serotonin
    5-HT1A-receptor
     Clozapine
      D00283  Clozapine (JAN/USP/INN)
    5-HT2A-receptor
     Clozapine
      D00283  Clozapine (JAN/USP/INN)
    5-HT2C-receptor
     Clozapine
      D00283  Clozapine (JAN/USP/INN)
    5-HT7-receptor
     Clozapine
      D00283  Clozapine (JAN/USP/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP1A2
   Clozapine
    D00283  Clozapine (JAN/USP/INN)
  CYP3A4
   Clozapine
    D00283  Clozapine (JAN/USP/INN)
BRITE hierarchy
Other DBs
CAS: 
5786-21-0
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        23
            1   C2y C    17.6334  -14.2894
            2   C8y C    16.7913  -13.1798
            3   C8y C    17.1265  -11.8230
            4   N1x N    18.3875  -11.2449
            5   N2x N    19.0392  -14.3146
            6   C8y C    19.6411  -11.8672
            7   C8y C    19.9276  -13.2359
            8   C8x C    16.1194  -10.8546
            9   C8x C    14.7774  -11.2427
            10  C8x C    14.4422  -12.5995
            11  C8x C    15.4493  -13.5676
            12  C8x C    21.2588  -13.6730
            13  C8y C    22.3030  -12.7386
            14  C8x C    22.0166  -11.3699
            15  C8x C    20.6852  -10.9328
            16  N1y N    16.9989  -15.5391
            17  C1x C    15.5973  -15.5391
            18  C1x C    14.8965  -16.7529
            19  N1y N    15.5973  -17.9669
            20  C1x C    16.9989  -17.9669
            21  C1x C    17.6997  -16.7529
            22  X   Cl   23.6578  -13.1837
            23  C1a C    14.8903  -19.1909
BOND        26
            1     3   4 1
            2     1   5 2
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    7  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17    6  15 2
            18    1  16 1
            19   16  17 1
            20   17  18 1
            21   18  19 1
            22   19  20 1
            23   20  21 1
            24   16  21 1
            25   13  22 1
            26   19  23 1

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