KEGG   DRUG: D00330Help
Entry
D00330                      Drug                                   

Name
Flurbiprofen (JP16/USP/INN);
Ansaid (TN)
Product
  Generic
Formula
C15H13FO2
Exact mass
244.09
Mol weight
244.2609
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Analgesic;
Anti-inflammatory [DS:H00445 H00630]
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Target
cyclooxygenase-1 (COX-1) inhibitor [HSA:5742] [KO:K00509];
cyclooxygenase-2 (COX-2) inhibitor [HSA:5743] [KO:K11987]
  Pathway
hsa00590  Arachidonic acid metabolism
hsa04370  VEGF signaling pathway  
 
Metabolism
Enzyme: CYP2C9 [HSA:1559]
Interaction
Genomic biomarker: CYP2C9 [HSA:1559]
Drug interaction
Structure map
Cyclooxygenase inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 M MUSCULO-SKELETAL SYSTEM
  M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
   M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
    M01AE Propionic acid derivatives
     M01AE09 Flurbiprofen
      D00330  Flurbiprofen (JP16/USP/INN)
  M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
   M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
    M02AA Antiinflammatory preparations, non-steroids for topical use
     M02AA19 Flurbiprofen
      D00330  Flurbiprofen (JP16/USP/INN)
 R RESPIRATORY SYSTEM
  R02 THROAT PREPARATIONS
   R02A THROAT PREPARATIONS
    R02AX Other throat preparetions
     R02AX01 Flurbiprofen
      D00330  Flurbiprofen (JP16/USP/INN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01B ANTIINFLAMMATORY AGENTS
    S01BC Antiinflammatory agents, non-steroids
     S01BC04 Flurbiprofen
      D00330  Flurbiprofen (JP16/USP/INN)
USP drug classification [BR:br08302]
 Analgesics
  Nonsteroidal Anti-inflammatory Drugs
   Flurbiprofen
    D00330  Flurbiprofen (JP16/USP/INN)
 Anti-inflammatory Agents
  Nonsteroidal Anti-inflammatory Drugs
   Flurbiprofen
    D00330  Flurbiprofen (JP16/USP/INN)
 Ophthalmic Agents
  Ophthalmic Anti-inflammatories
   Flurbiprofen
    D00330  Flurbiprofen (JP16/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   114  Antipyretics and analgesics, anti-inflammatory agents
    1149  Others
     D00330  Flurbiprofen (JP16/USP/INN)
 2  Agents affecting individual organs
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2649  Others
     D00330  Flurbiprofen (JP16/USP/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Oxidoreductases
   cyclooxygenase-1 (COX-1)
    Flurbiprofen
     D00330  Flurbiprofen (JP16/USP/INN)
   cyclooxygenase-2 (COX-2)
    Flurbiprofen
     D00330  Flurbiprofen (JP16/USP/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2C9
   Flurbiprofen
    D00330  Flurbiprofen (JP16/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00330  Flurbiprofen
BRITE hierarchy
Other DBs
CAS: 
5104-49-4
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        18
            1   C8x C    28.9100  -18.0600
            2   C8y C    28.9100  -16.6600
            3   C8x C    27.6500  -15.9600
            4   C8x C    26.4600  -16.6600
            5   C8x C    26.4600  -18.0600
            6   C8x C    27.6500  -18.7600
            7   C8y C    30.1000  -15.9600
            8   C8y C    31.2900  -16.6600
            9   C8x C    32.5500  -15.9600
            10  C8y C    32.5500  -14.5600
            11  C8x C    31.2900  -13.8600
            12  C8x C    30.1000  -14.5600
            13  X   F    31.2900  -18.0600
            14  C1c C    33.7400  -13.8600
            15  C6a C    34.9300  -14.5600
            16  C1a C    33.7400  -12.4600
            17  O6a O    34.9300  -15.9600
            18  O6a O    36.1900  -13.8600
BOND        19
            1     4   5 2
            2     5   6 1
            3     7   8 2
            4     8   9 1
            5     9  10 2
            6    10  11 1
            7    11  12 2
            8    12   7 1
            9     6   1 2
            10    8  13 1
            11   10  14 1
            12    2   7 1
            13   14  15 1
            14    1   2 1
            15   14  16 1
            16    2   3 2
            17   15  17 2
            18    3   4 1
            19   15  18 1

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