KEGG   DRUG: GlipizideHelp
Entry
D00335                      Drug                                   

Name
Glipizide (USP/INN);
Glucotrol (TN)
Product
  Generic
GLIPIZIDE (A-S Medication Solutions), GLIPIZIDE (A-S Medication Solutions), GLIPIZIDE (A-S Medication Solutions), GLIPIZIDE (A-S Medication Solutions), GLIPIZIDE (A-S Medication Solutions), GLIPIZIDE (A-S Medication Solutions), GLIPIZIDE (A-S Medication Solutions), GLIPIZIDE (A-S Medication Solutions), GLIPIZIDE (A-S Medication Solutions), GLIPIZIDE (A-S Medication Solutions), GLIPIZIDE (Accord Healthcare), GLIPIZIDE (Actavis Elizabeth LLC), GLIPIZIDEER (Aidarex Pharmaceuticals LLC), GLIPIZIDE (Aidarex Pharmaceuticals LLC), GLIPIZIDE (American Health Packaging), GLIPIZIDE (Aphena Pharma Solutions - Tennessee), GLIPIZIDE (Apotex Corp.), GLIPIZIDE (Avera McKennan Hospital), GLIPIZIDE (Blenheim Pharmacal), GLIPIZIDE (Blenheim Pharmacal), GLIPIZIDE (Bryant Ranch Prepack), GLIPIZIDE (Bryant Ranch Prepack), GLIPIZIDE (Bryant Ranch Prepack), GLIPIZIDE (Bryant Ranch Prepack), GLIPIZIDEER (Bryant Ranch Prepack), GLIPIZIDE (Cardinal Health), GLIPIZIDE (Carilion Materials Management), GLIPIZIDE (Clinical Solutions Wholesale), GLIPIZIDE (Clinical Solutions Wholesale), GLIPIZIDE (Contract Pharmacy Services-PA), GLIPIZIDE (DIRECT RX), GLIPIZIDE (DIRECT RX), GLIPIZIDE (Dispensing Solutions), GLIPIZIDE (Golden State Medical Supply), GLIPIZIDE (Greenstone LLC), GLIPIZIDE (H.J. Harkins Company), GLIPIZIDE (Lake Erie Medical DBA Quality Care Products LLC), GLIPIZIDE (Lake Erie Medical DBA Quality Care Products LLC), GLIPIZIDE (Lake Erie Medical DBA Quality Care Products LLC), GLIPIZIDE (Lake Erie Medical DBA Quality Care Products LLC), GLIPIZIDE (Lake Erie Medical DBA Quality Care Products LLC), GLIPIZIDE (Lake Erie Medical DBA Quality Care Products LLC), GLIPIZIDE (Legacy Pharmaceutical Packaging), GLIPIZIDE (McKesson Contract Packaging), GLIPIZIDE (MedVantx), GLIPIZIDE (Mylan Institutional), GLIPIZIDE (Mylan Pharmaceuticals), GLIPIZIDE (Mylan Pharmaceuticals), GLIPIZIDE (NCS HealthCare of KY), GLIPIZIDE (NCS HealthCare of KY), GLIPIZIDE (NCS HealthCare of KY), GLIPIZIDE (Northwind Pharmaceuticals), GLIPIZIDE (Northwind Pharmaceuticals), GLIPIZIDE (Northwind Pharmaceuticals), GLIPIZIDE (NuCare Pharmaceuticals), GLIPIZIDE (NuCare Pharmaceuticals), GLIPIZIDE (PD-Rx Pharmaceuticals), GLIPIZIDEER (PD-Rx Pharmaceuticals), GLIPIZIDE (PD-Rx Pharmaceuticals), GLIPIZIDE (PD-Rx Pharmaceuticals), GLIPIZIDE (Par Pharmaceutical), GLIPIZIDE (Par Pharmaceuticals), GLIPIZIDE (Physicians Total Care), GLIPIZIDE (Physicians Total Care), GLIPIZIDE (Preferred Pharmaceuticals), GLIPIZIDE (Preferred Pharmaceuticals), GLIPIZIDE (Preferred Pharmaceuticals), GLIPIZIDE (Proficient Rx LP), GLIPIZIDE (Proficient Rx LP), GLIPIZIDE (Proficient Rx LP), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDEER (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDEER (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (Rebel Distributors Corp), GLIPIZIDE (Rebel Distributors Corp), GLIPIZIDE (STAT Rx USA LLC), GLIPIZIDE (Sandoz), GLIPIZIDE (St Marys Medical Park Pharmacy), GLIPIZIDE XL (St Marys Medical Park Pharmacy), GLIPIZIDE (State of Florida DOH Central Pharmacy), GLIPIZIDE (State of Florida DOH Central Pharmacy), GLIPIZIDE (State of Florida DOH Central Pharmacy), GLIPIZIDE (State of Florida DOH Central Pharmacy), GLIPIZIDE (State of Florida DOH Central Pharmacy), GLIPIZIDE (State of Florida DOH Central Pharmacy), GLIPIZIDE (State of Florida DOH Central Pharmacy), GLIPIZIDE (State of Florida DOH Central Pharmacy), GLIPIZIDE (Sun Pharmaceutical Industries), GLIPIZIDE (TYA Pharmaceuticals), GLIPIZIDE (Unit Dose Services), GLIPIZIDE (Unit Dose Services), GLIPIZIDE (Unit Dose Services), GLIPIZIDE (Unit Dose Services), GLIPIZIDE (Unit Dose Services), GLIPIZIDE (Upsher-Smith Laboratories), GLIPIZIDE (Watson Laboratories), GLIPIZIDE (Watson Laboratories), GLIPIZIDE ER (DirectRX)
Formula
C21H27N5O4S
Exact mass
445.1784
Mol weight
445.5352
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Antidiabetic agent
 DG01790  Sulfonamide hypoglycemic
  DG01734  Sulfonamide type sulfonylurea receptor agonist
 DG01508  Sulfonylurea receptor agonist
Remark
ATC code: 
Activity
Antidiabetic, Hypoglycemic, Sulfonylurea receptor agonist
Comment
The effects of the sulfonylureas are initiated by binding to and blocking an ATP-sensitive K+ channel, which has been cloned.
Target
ABCC8 (SUR1) [HSA:6833] [KO:K05032]
  Pathway
ABC transporters
Insulin secretion
Type II diabetes mellitus
Metabolism
Enzyme: CYP2C9 [HSA:1559]
Interaction
Genomic biomarker: G6PD [HSA:2539]
Drug interaction
Structure map
Sulfonamide derivatives - hypoglycemic agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BB Sulfonylureas
     A10BB07 Glipizide
      D00335  Glipizide (USP/INN)
USP drug classification [BR:br08302]
 Blood Glucose Regulators
  Antidiabetic Agents
   Glipizide
    D00335  Glipizide (USP/INN)
Target-based classification of drugs [BR:br08310]
 Transporters
  ABC transporters
   ABCC (CFTR/MRP) subfamily
    ABCC8 (sulfonylurea receptor 1)
     Glipizide
      D00335  Glipizide (USP/INN)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP2C9
   Glipizide
    D00335  Glipizide (USP/INN)
Antidiabetics [br08361.html]
 D00335
Pharmacogenomic biomarkers in FDA drug labels [br08341.html]
 Polymorphisms and germline mutations
  D00335
BRITE hierarchy
Other DBs
CAS: 
29094-61-9
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        31
            1   C8y C    19.1800  -20.9300
            2   C8x C    17.9200  -20.2300
            3   C8x C    19.1800  -22.3300
            4   S4a S    20.3700  -20.2300
            5   C8x C    16.7300  -20.9300
            6   C8x C    17.9200  -23.0300
            7   N1b N    21.5600  -20.9300
            8   C8y C    16.7300  -22.3300
            9   C5a C    22.7500  -20.2300
            10  C1b C    15.5400  -23.0300
            11  N1b N    24.0100  -20.9300
            12  O5a O    22.7500  -18.8300
            13  C1b C    14.3500  -22.3300
            14  C1y C    25.2000  -20.2300
            15  N1b N    13.0900  -23.0300
            16  C1x C    25.2000  -18.8300
            17  C1x C    26.3900  -20.9300
            18  C5a C    11.9000  -22.3300
            19  C1x C    26.3900  -18.1300
            20  C1x C    27.5800  -20.2300
            21  C8y C    10.7100  -23.0300
            22  O5a O    11.9000  -20.9300
            23  C1x C    27.5800  -18.8300
            24  C8x C    10.7100  -24.4300
            25  N5x N     9.5200  -22.3300
            26  N5x N     9.5200  -25.1300
            27  C8x C     8.3300  -23.0300
            28  C8y C     8.3300  -24.4300
            29  C1a C     7.1400  -25.1300
            30  O3c O    21.0700  -19.0176
            31  O3c O    19.6700  -19.0176
BOND        33
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     3   6 2
            6     4   7 1
            7     5   8 2
            8     7   9 1
            9     8  10 1
            10    9  11 1
            11    9  12 2
            12   10  13 1
            13   11  14 1
            14   13  15 1
            15   14  16 1
            16   14  17 1
            17   15  18 1
            18   16  19 1
            19   17  20 1
            20   18  21 1
            21   18  22 2
            22   19  23 1
            23   21  24 1
            24   21  25 2
            25   24  26 2
            26   25  27 1
            27   26  28 1
            28   28  29 1
            29    6   8 1
            30   20  23 1
            31   27  28 2
            32    4  30 2
            33    4  31 2

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