KEGG   DRUG: D00335Help
Entry
D00335                      Drug                                   

Name
Glipizide (USP/INN);
Glucotrol (TN)
Product
  Generic
GLIPIZIDE (Accord Healthcare), GLIPIZIDE (Actavis Elizabeth LLC), GLIPIZIDEER (Aidarex Pharmaceuticals LLC), GLIPIZIDE (Aidarex Pharmaceuticals LLC), GLIPIZIDE (American Health Packaging), GLIPIZIDE (Aphena Pharma Solutions - Tennessee), GLIPIZIDE (Apotex Corp.), GLIPIZIDE (Blenheim Pharmacal), GLIPIZIDE (Bryant Ranch Prepack), GLIPIZIDE (Bryant Ranch Prepack), GLIPIZIDE (Bryant Ranch Prepack), GLIPIZIDE (Bryant Ranch Prepack), GLIPIZIDEER (Bryant Ranch Prepack), GLIPIZIDE (Caraco Pharmaceutical Laboratories), GLIPIZIDE (Cardinal Health), GLIPIZIDE (Carilion Materials Management), GLIPIZIDE (Clinical Solutions Wholesale), GLIPIZIDE (Clinical Solutions Wholesale), GLIPIZIDE (Contract Pharmacy Services-PA), GLIPIZIDE (DIRECT RX), GLIPIZIDE (Dispensing Solutions), GLIPIZIDE (Golden State Medical Supply), GLIPIZIDE (Greenstone LLC), GLIPIZIDE (H.J. Harkins Company), GLIPIZIDE (IVAX Pharmaceuticals), GLIPIZIDE (Lake Erie Medical DBA Quality Care Products LLC), GLIPIZIDE (Lake Erie Medical DBA Quality Care Products LLC), GLIPIZIDE (Lake Erie Medical DBA Quality Care Products LLC), GLIPIZIDE (Lake Erie Medical DBA Quality Care Products LLC), GLIPIZIDE (Lake Erie Medical DBA Quality Care Products LLC), GLIPIZIDE (Lake Erie Medical DBA Quality Care Products LLC), GLIPIZIDE (Legacy Pharmaceutical Packaging), GLIPIZIDE (Major Pharmaceuticals), GLIPIZIDE (McKesson Contract Packaging), GLIPIZIDE (MedVantx), GLIPIZIDE (Mylan Institutional), GLIPIZIDE (Mylan Pharmaceuticals), GLIPIZIDE (NCS HealthCare of KY), GLIPIZIDE (NCS HealthCare of KY), GLIPIZIDE (PD-Rx Pharmaceuticals), GLIPIZIDEER (PD-Rx Pharmaceuticals), GLIPIZIDE (PD-Rx Pharmaceuticals), GLIPIZIDE (PD-Rx Pharmaceuticals), GLIPIZIDE (Par Pharmaceutical), GLIPIZIDE (Physicians Total Care), GLIPIZIDE (Physicians Total Care), GLIPIZIDE (Preferred Pharmaceuticals), GLIPIZIDE (Preferred Pharmaceuticals), GLIPIZIDE (Preferred Pharmaceuticals), GLIPIZIDE (Proficient Rx LP), GLIPIZIDE (Proficient Rx LP), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDEER (REMEDYREPACK), GLIPIZIDEER (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (REMEDYREPACK), GLIPIZIDE (Rebel Distributors Corp), GLIPIZIDE (Rebel Distributors Corp), GLIPIZIDE (STAT Rx USA LLC), GLIPIZIDE (Sandoz), GLIPIZIDE (St Marys Medical Park Pharmacy), GLIPIZIDE XL (St Marys Medical Park Pharmacy), GLIPIZIDE (State of Florida DOH Central Pharmacy), GLIPIZIDE (State of Florida DOH Central Pharmacy), GLIPIZIDE (State of Florida DOH Central Pharmacy), GLIPIZIDE (State of Florida DOH Central Pharmacy), GLIPIZIDE (State of Florida DOH Central Pharmacy), GLIPIZIDE (State of Florida DOH Central Pharmacy), GLIPIZIDE (State of Florida DOH Central Pharmacy), GLIPIZIDE (State of Florida DOH Central Pharmacy), GLIPIZIDE (TYA Pharmaceuticals), GLIPIZIDE (Unit Dose Services), GLIPIZIDE (Unit Dose Services), GLIPIZIDE (Unit Dose Services), GLIPIZIDE (Watson Laboratories), GLIPIZIDE (Watson Laboratories)
Formula
C21H27N5O4S
Exact mass
445.1784
Mol weight
445.5352
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antidiabetic [DS:H00409]
Remark
ATC code: 
Drug group: 
Comment
The effects of the sulfonylureas are initiated by binding to and blocking an ATP-sensitive K+ channel, which has been cloned.
Target
sulfonylurea receptor 1 agonist [HSA:6833] [KO:K05032]
  Pathway
hsa02010  ABC transporters
hsa04911  Insulin secretion
hsa04930  Type II diabetes mellitus  
 
Metabolism
Enzyme: CYP2C9 [HSA:1559]
Interaction
Genomic biomarker: G6PD [HSA:2539]
Drug interaction
Structure map
Sulfonamide derivatives - hypoglycemic agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BB Sulfonamides, urea derivatives
     A10BB07 Glipizide
      D00335  Glipizide (USP/INN)
USP drug classification [BR:br08302]
 Blood Glucose Regulators
  Antidiabetic Agents
   Glipizide
    D00335  Glipizide (USP/INN)
Target-based classification of drugs [BR:br08310]
 Transporters
  ABC transporters
   ABCC (CFTR/MRP) subfamily
    ABCC8 (sulfonylurea receptor 1)
     Glipizide
      D00335  Glipizide (USP/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2C9
   Glipizide
    D00335  Glipizide (USP/INN)
BRITE hierarchy
Other DBs
CAS: 
29094-61-9
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        31
            1   C8y C    19.7695  -15.5924
            2   C8x C    20.9709  -16.2923
            3   C8x C    19.7636  -14.1985
            4   S4a S    18.5623  -16.2863
            5   C8x C    22.1840  -15.5924
            6   C8x C    20.9768  -13.4986
            7   N1b N    17.3551  -15.5924
            8   O3c O    18.5623  -17.6860
            9   O3c O    18.5797  -14.7351
            10  C8y C    22.1840  -14.1985
            11  C5a C    16.1419  -16.2863
            12  C1b C    23.3912  -13.4986
            13  N1b N    14.9349  -15.5865
            14  O5a O    16.1419  -17.6803
            15  C1b C    24.5985  -14.1985
            16  C1y C    13.7276  -16.2863
            17  N1b N    25.8055  -13.5045
            18  C1x C    13.7276  -17.6803
            19  C1x C    12.5204  -15.5865
            20  C5a C    27.0128  -14.1985
            21  C1x C    12.5204  -18.3800
            22  C1x C    11.3131  -16.2863
            23  C8y C    28.2259  -13.5045
            24  O5a O    27.0128  -15.5982
            25  C1x C    11.3131  -17.6803
            26  C8x C    28.2259  -12.1107
            27  N5x N    29.4272  -14.2044
            28  N5x N    29.4332  -11.4109
            29  C8x C    30.6404  -13.5045
            30  C8y C    30.6404  -12.1107
            31  C1a C    31.8476  -11.4109
BOND        33
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     3   6 2
            6     4   7 1
            7     4   8 2
            8     4   9 2
            9     5  10 2
            10    7  11 1
            11   10  12 1
            12   11  13 1
            13   11  14 2
            14   12  15 1
            15   13  16 1
            16   15  17 1
            17   16  18 1
            18   16  19 1
            19   17  20 1
            20   18  21 1
            21   19  22 1
            22   20  23 1
            23   20  24 2
            24   21  25 1
            25   23  26 1
            26   23  27 2
            27   26  28 2
            28   27  29 1
            29   28  30 1
            30   30  31 1
            31    6  10 1
            32   22  25 1
            33   29  30 2

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