KEGG   DRUG: D00355Help
Entry
D00355                      Drug                                   

Name
Lansoprazole (JAN/USP/INN);
Prevacid (TN)
Product
  Generic
LANSOPRAZOLE (Actavis), LANSOPRAZOLE (Aidarex Pharmaceuticals LLC), LANSOPRAZOLE (American Health Packaging), LANSOPRAZOLE (AvKARE), LANSOPRAZOLE (BluePoint Laboratoires), LANSOPRAZOLE (Breckenridge Pharmaceutical), LANSOPRAZOLE (Bryant Ranch Prepack), LANSOPRAZOLE (Bryant Ranch Prepack), LANSOPRAZOLE (Cadila Healthcare Limited), LANSOPRAZOLE (Dr.Reddy's Laboratories), LANSOPRAZOLE (McKesson Packaging Services a business unit of McKesson Corporation), LANSOPRAZOLE (Mylan Institutional), LANSOPRAZOLE (Mylan Pharmaceuticals), LANSOPRAZOLE (Physicians Total Care), LANSOPRAZOLE (Physicians Total Care), LANSOPRAZOLE (Preferred Pharmaceuticals), LANSOPRAZOLE (Preferred Pharmaceuticals), LANSOPRAZOLE (Preferred Pharmaceuticals), LANSOPRAZOLE (Proficient Rx LP), LANSOPRAZOLE (REMEDYREPACK), LANSOPRAZOLE (REMEDYREPACK), LANSOPRAZOLE (Rebel Distributors Corp), LANSOPRAZOLE (Rebel Distributors Corp), LANSOPRAZOLE (STAT Rx USA LLC), LANSOPRAZOLE (Sandoz), LANSOPRAZOLE (Sun Pharma Global FZE), LANSOPRAZOLE (Teva Pharmaceuticals USA), LANSOPRAZOLE (Unit Dose Services), LANSOPRAZOLE (Wockhardt Limited), LANSOPRAZOLE (Wockhardt USA LLC.), LANSOPRAZOLE (Zydus Pharmaceuticals (USA))
Formula
C16H14F3N3O2S
Exact mass
369.0759
Mol weight
369.3615
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anti-ulcerative [DS:H00045]
Remark
Therapeutic category: 
ATC code: 
Comment
See [DR:D08903]
proton pump inhibitor
Target
H+/K+ exchanging, alpha polypeptide inhibitor [HSA:495] [KO:K01542];
H+/K+ exchanging, beta polypeptide inhibitor [HSA:496] [KO:K01543]
  Pathway
hsa00190  Oxidative phosphorylation
hsa04966  Collecting duct acid secretion
hsa04971  Gastric acid secretion  
 
Metabolism
Enzyme: CYP2C19 [HSA:1557], CYP3A4 [HSA:1576]
Interaction
Genomic biomarker: CYP2C19 [HSA:1557]
CYP inhibition: CYP2C19 [HSA:1557]
Transporter inhibition: ABCC2 [HSA:1244]
Drug interaction
Structure map
Antiulcer drugs
Ion transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A02 DRUGS FOR ACID RELATED DISORDERS
   A02B DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
    A02BC Proton pump inhibitors
     A02BC03 Lansoprazole
      D00355  Lansoprazole (JAN/USP/INN)
USP drug classification [BR:br08302]
 Gastrointestinal Agents
  Proton Pump Inhibitors
   Lansoprazole
    D00355  Lansoprazole (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  23  Digestive organ agents
   232  Peptic ulcer agents
    2329  Others
     D00355  Lansoprazole (JAN/USP/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases
   H+/K+ exchanging, polypeptide
    Lansoprazole
     D00355  Lansoprazole (JAN/USP/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2C19
   Lansoprazole
    D00355  Lansoprazole (JAN/USP/INN)
  CYP3A4
   Lansoprazole
    D00355  Lansoprazole (JAN/USP/INN)
 Inhbitors
  CYP2C19
   Lansoprazole
    D00355  Lansoprazole (JAN/USP/INN)
 Inducers
  CYP1A2
   Lansoprazole
    D00355  Lansoprazole (JAN/USP/INN)
BRITE hierarchy
Other DBs
CAS: 
103577-45-3
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        25
            1   C8x C    14.2800  -19.3900
            2   C8x C    14.2800  -20.7900
            3   C8x C    15.4924  -21.4900
            4   C8y C    16.7049  -20.7900
            5   C8y C    16.7049  -19.3900
            6   C8x C    15.4924  -18.6900
            7   N5x N    18.0364  -21.2226
            8   C8y C    18.8593  -20.0900
            9   N4x N    18.0364  -18.9574
            10  S4a S    20.2300  -20.0900
            11  C1b C    20.9300  -21.3024
            12  O3c O    20.9300  -18.8776
            13  C8y C    22.3298  -21.3024
            14  C8y C    23.0203  -22.4980
            15  C8y C    24.4203  -22.4978
            16  C8x C    25.1201  -21.2853
            17  C8x C    24.4297  -20.0898
            18  N5x N    23.0297  -20.0899
            19  C1a C    22.3349  -23.6852
            20  O2a O    25.1110  -23.6932
            21  C1b C    26.5296  -23.6932
            22  C1d C    27.2156  -24.8806
            23  X   F    28.4280  -24.1806
            24  X   F    26.0032  -25.5806
            25  X   F    27.9156  -26.0931
BOND        27
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    5   9 1
            11    8  10 1
            12   10  11 1
            13   10  12 2
            14   11  13 1
            15   13  14 2
            16   14  15 1
            17   15  16 2
            18   16  17 1
            19   17  18 2
            20   13  18 1
            21   14  19 1
            22   15  20 1
            23   20  21 1
            24   21  22 1
            25   22  23 1
            26   22  24 1
            27   22  25 1

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