KEGG   DRUG: D00395Help
Entry
D00395                      Drug                                   

Name
Troglitazone (JAN/USAN/INN);
Rezulin (TN)
Formula
C24H27NO5S
Exact mass
441.161
Mol weight
441.5399
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antidiabetic [DS:H00409]
Remark
ATC code: 
Comment
hepatotoxicity
Target
peroxisome proliferator-activated receptor (PPAR) gamma agonist [HSA:5468] [KO:K08530]
  Pathway
hsa03320  PPAR signaling pathway  
 
Interaction
CYP induction: CYP3A4 [HSA:1576], CYP3A5 [HSA:1577], CYP3A7 [HSA:1551]
Drug interaction
Structure map
Antidiabetics
Peroxisome proliferator-activated receptor (PPAR) agonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BG Thiazolidinediones
     A10BG01 Troglitazone
      D00395  Troglitazone (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Thyroid hormone like receptors
   Peroxisome proliferator-activated receptor (PPAR)
    peroxisome proliferator-activated receptor (PPAR) gamma
     Troglitazone
      D00395  Troglitazone (JAN/USAN/INN)
Cytochrome P450 interactions [BR:br08309]
 Inducers
  CYP3A5
   Troglitazone
    D00395  Troglitazone (JAN/USAN/INN)
  CYP3A7
   Troglitazone
    D00395  Troglitazone (JAN/USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
97322-87-7
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        31
            1   C8y C    14.4237  -16.8030
            2   C8y C    14.4237  -18.2037
            3   C8y C    15.6367  -18.9040
            4   C8y C    16.8497  -18.2037
            5   C8y C    16.8497  -16.8030
            6   C8y C    15.6367  -16.1027
            7   C1x C    18.0627  -18.9040
            8   C1x C    19.2757  -18.2037
            9   C1z C    19.2757  -16.8030
            10  O2x O    18.0627  -16.1027
            11  O2a O    21.7017  -16.8030
            12  C1b C    20.4887  -16.1027
            13  C8y C    22.9147  -16.1027
            14  C8x C    22.9147  -14.7020
            15  C8x C    24.1277  -16.8030
            16  C8x C    25.3407  -16.1027
            17  C8y C    25.3407  -14.7020
            18  C8x C    24.1277  -14.0017
            19  O5x O    26.5538  -16.8030
            20  C5x C    27.7668  -16.1027
            21  C1y C    27.7668  -14.7020
            22  C1b C    26.5538  -14.0017
            23  N1x N    29.0989  -16.5355
            24  C5x C    29.9222  -15.4024
            25  S2x S    29.0989  -14.2692
            26  C1a C    15.6367  -14.7022
            27  C1a C    13.2107  -16.1027
            28  O1a O    13.2107  -18.9040
            29  C1a C    15.6367  -20.3045
            30  O5x O    31.3016  -15.4024
            31  C1a C    20.4881  -17.5030
BOND        34
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12   11  12 1
            13    9  12 1
            14   11  13 1
            15   13  14 2
            16   13  15 1
            17   15  16 2
            18   16  17 1
            19   17  18 2
            20   14  18 1
            21   19  20 2
            22   20  21 1
            23   21  22 1
            24   17  22 1
            25   20  23 1
            26   23  24 1
            27   24  25 1
            28   21  25 1
            29    6  26 1
            30    1  27 1
            31    2  28 1
            32    3  29 1
            33   24  30 2
            34    9  31 1

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