KEGG   DRUG: Valproic acidHelp
Entry
D00399                      Drug                                   

Name
Valproic acid (USP);
Depakene (TN)
Product
  Generic
VALPROIC (Actavis Pharma), VALPROIC ACID (Aphena Pharma Solutions - Tennessee), VALPROIC ACID (Aphena Pharma Solutions - Tennessee), VALPROIC (Aphena Pharma Solutions - Tennessee), VALPROIC ACID (Atlantic Biologicals Corps), VALPROIC ACID (Avera McKennan Hospital), VALPROIC ACID (Banner Life Sciences LLC.), VALPROIC ACID (Bionpharma), VALPROIC ACID (Caraco Pharmaceutical Laboratories), VALPROIC ACID (Cardinal Health), VALPROIC ACID (Cardinal Health), VALPROIC ACID (Cardinal Health), VALPROIC ACID (Cardinal Health), VALPROIC (Clinical Solutions Wholesale), VALPROIC (Contract Pharmacy Services-PA), VALPROIC (Contract Pharmacy Services-PA), VALPROIC ACID (Golden State Medical Supply), VALPROIC ACID (Hi-Tech Pharmacal), VALPROIC ACID (McKesson Packaging Services Business Unit of McKesson Corporation), VALPROIC ACID (Morton Grove Pharmaceuticals), VALPROIC ACID (NCS HealthCare of KY), VALPROIC (NCS HealthCare of KY), VALPROIC ACID (Pharmaceutical Associates), VALPROIC (Physicians Total Care), VALPROIC ACID (Pliva), VALPROIC ACID (Precision Dose), VALPROIC ACID (Qualitest Pharmaceuticals), VALPROIC ACID (REMEDYREPACK), VALPROIC ACID (Rebel Distributors Corp), VALPROIC ACID (Sun Pharmaceutical Industries Limited), VALPROIC ACID (Upsher-Smith Laboratories), VALPROIC ACID (Upsher-Smith Laboratories), VALPROIC ACID (Upsher-Smith Laboratories), VALPROIC ACID (Watson Laboratories)
Formula
C8H16O2
Exact mass
144.115
Mol weight
144.2114
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Other
 DG01575  Calcium channel blocker
  DG01573  Calcium channel T type blocker
Cyp substrate
 DG01633  CYP3A4 substrate
Remark
Same as: 
ATC code: 
Chemical group: 
Activity
Anticonvulsant
Comment
Fatty acid derivative
Valproic acid is contraindicated in patients with known urea cycle disorders [DS:H00164 H00185 H00186 H00187 H01028 H01032]
Target
  Pathway
Alanine, aspartate and glutamate metabolism
Valine, leucine and isoleucine degradation
beta-Alanine metabolism
Propanoate metabolism
Butanoate metabolism
MAPK signaling pathway
Calcium signaling pathway
GABAergic synapse
Metabolism
Enzyme: CYP2C9 [HSA:1559], CYP3A4 [HSA:1576]
Interaction
Genomic biomarker: (1) NAGS [HSA:162417], CPS [HSA:1373], ASS [HSA:445], OTC [HSA:5009], ASL [HSA:435], ARG [HSA:383 384], (2) POLG [HSA:5428]
Drug interaction
Structure map
Anticonvulsants
Calcium channel blocking drugs
Antimigraines
Other map
Drug metabolism - cytochrome P450
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AG Fatty acid derivatives
     N03AG01 Valproic acid
      D00399  Valproic acid (USP)
USP drug classification [BR:br08302]
 Anticonvulsants
  Gamma-aminobutyric Acid (GABA) Augmenting Agents
   Valproate
    D00399  Valproic acid (USP)
 Antimigraine Agents
  Prophylactic
   Valproate
    D00399  Valproic acid (USP)
 Bipolar Agents
  Mood Stabilizers
   Valproate
    D00399  Valproic acid (USP)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Ca2+ channel, CACN alpha-1, CaVx.x
    calcium channel T type
     Valproic acid
      D00399  Valproic acid (USP)
 Enzymes
  Transferases
   histone acetyltransferase
    Valproic acid
     D00399  Valproic acid (USP)
   GABA transaminase
    Valproic acid
     D00399  Valproic acid (USP)
  Hydrolases
   histone deacetylase
    Valproic acid
     D00399  Valproic acid (USP)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP2C9
   Valproic acid
    D00399  Valproic acid (USP)
  CYP3A4
   Valproic acid
    D00399  Valproic acid (USP)
Neurological agents [br08367.html]
 Antiepileptic agents
  D00399
Pharmacogenomic biomarkers in FDA drug labels [br08341.html]
 Polymorphisms and germline mutations
  D00399
BRITE hierarchy
Other DBs
CAS: 
99-66-1
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        10
            1   C1c C    25.4573  -18.6784
            2   C1b C    25.4573  -17.3002
            3   C1b C    24.2485  -19.3967
            4   C6a C    26.6604  -19.3967
            5   C1b C    24.2427  -16.5935
            6   C1b C    23.0396  -18.6784
            7   O6a O    26.6604  -20.7925
            8   O6a O    27.8692  -18.6784
            9   C1a C    23.0339  -17.3002
            10  C1a C    21.8367  -19.3967
BOND        9
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     4   7 1
            7     4   8 2
            8     5   9 1
            9     6  10 1

» Japanese version   » Back

DBGET integrated database retrieval system