KEGG   DRUG: Valproic acidHelp
Entry
D00399                      Drug                                   

Name
Valproic acid (USP);
Depakene (TN)
Product
  Generic
VALPROIC (Actavis Pharma), VALPROIC ACID (Aphena Pharma Solutions - Tennessee), VALPROIC ACID (Aphena Pharma Solutions - Tennessee), VALPROIC ACID (Aphena Pharma Solutions - Tennessee), VALPROIC (Aphena Pharma Solutions - Tennessee), VALPROIC ACID (Atlantic Biologicals Corps), VALPROIC ACID (Avera McKennan Hospital), VALPROIC ACID (Banner Life Sciences LLC.), VALPROIC ACID (Bionpharma), VALPROIC ACID (Caraco Pharmaceutical Laboratories), VALPROIC ACID (Cardinal Health), VALPROIC ACID (Cardinal Health), VALPROIC ACID (Cardinal Health), VALPROIC (Clinical Solutions Wholesale), VALPROIC ACID (Contract Pharmacy Services-PA), VALPROIC ACID (Contract Pharmacy Services-PA), VALPROIC (Contract Pharmacy Services-PA), VALPROIC (Contract Pharmacy Services-PA), VALPROIC ACID (Golden State Medical Supply), VALPROIC ACID (Hi-Tech Pharmacal), VALPROIC ACID (Morton Grove Pharmaceuticals), VALPROIC ACID (NCS HealthCare of KY), VALPROIC (NCS HealthCare of KY), VALPROIC ACID (Par Pharmaceutical), VALPROIC ACID (Pharmaceutical Associates), VALPROIC (Physicians Total Care), VALPROIC ACID (Precision Dose), VALPROIC ACID (REMEDYREPACK), VALPROIC (REMEDYREPACK), VALPROIC ACID (REMEDYREPACK), VALPROIC ACID (REMEDYREPACK), VALPROIC ACID (Rebel Distributors Corp), VALPROIC ACID (Upsher-Smith Laboratories)
Formula
C8H16O2
Exact mass
144.115
Mol weight
144.2114
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG02035  Fatty acid antiepileptics
Other
 DG01575  Calcium channel blocker
  DG01573  Calcium channel T type blocker
Cyp substrate
 DG01633  CYP3A substrate
Remark
Same as: C07185
ATC code: N03AG01
Chemical structure group: DG00849
Product (DG00849): D00399<US> D00304<US> D00710<JP/US>
Efficacy
Anticonvulsant
Comment
Fatty acid derivative
Valproic acid is contraindicated in patients with known urea cycle disorders [DS:H00164 H00185 H00186 H00187 H01028 H01032]
Target
ABAT [HSA:18] [KO:K13524]
SSADH [HSA:7915] [KO:K00139]
GAD [HSA:2571 2572] [KO:K01580]
CACNA1-T [HSA:8911 8912 8913] [KO:K04856 K04855 K04854]
  Pathway
hsa04020  Calcium signaling pathway
hsa04727  GABAergic synapse
Interaction
Drug interaction
Structure map
map07033  Anticonvulsants
map07036  Calcium channel blocking drugs
map07048  Antimigraines
Other map
map00982  Drug metabolism - cytochrome P450
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AG Fatty acid derivatives
     N03AG01 Valproic acid
      D00399  Valproic acid (USP)
USP drug classification [BR:br08302]
 Anticonvulsants
  Gamma-aminobutyric Acid (GABA) Augmenting Agents
   Valproate
    D00399  Valproic acid (USP)
 Antimigraine Agents
  Prophylactic
   Valproate
    D00399  Valproic acid (USP)
 Bipolar Agents
  Mood Stabilizers
   Valproate
    D00399  Valproic acid (USP)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A)
     Valproic acid
      D00399  Valproic acid (USP)
    voltage-gated sodium channel (SCN2A)
     Valproic acid
      D00399  Valproic acid (USP)
    voltage-gated sodium channel (SCN3A)
     Valproic acid
      D00399  Valproic acid (USP)
    voltage-gated sodium channel (SCN4A)
     Valproic acid
      D00399  Valproic acid (USP)
    voltage-gated sodium channel (SCN5A)
     Valproic acid
      D00399  Valproic acid (USP)
    voltage-gated sodium channel (SCN8A)
     Valproic acid
      D00399  Valproic acid (USP)
    voltage-gated sodium channel (SCN9A)
     Valproic acid
      D00399  Valproic acid (USP)
    voltage-gated sodium channel (SCN10A)
     Valproic acid
      D00399  Valproic acid (USP)
    voltage-gated sodium channel (SCN11A)
     Valproic acid
      D00399  Valproic acid (USP)
   Ca2+ channel, CACN alpha-1, CaVx.x
    calcium channel T type
     Valproic acid
      D00399  Valproic acid (USP)
 Enzymes
  Oxidoreductases
   aldehyde dehydrogenase 5 family member A1
    Valproic acid
     D00399  Valproic acid (USP)
  Transferases
   GABA transaminase
    Valproic acid
     D00399  Valproic acid (USP)
  Hydrolases
   histone deacetylase
    Valproic acid
     D00399  Valproic acid (USP)
  Lyases
   glutamate decarboxylase
    Valproic acid
     D00399  Valproic acid (USP)
Drug classes of therapeutic agents [br08360.html]
 Neurological agents
  D00399
Pharmacogenomic biomarkers in FDA drug labels [br08341.html]
 Polymorphisms and germline mutations
  D00399
BRITE hierarchy
Other DBs
CAS: 99-66-1
PubChem: 7847465
ChEBI: 39867
ChEMBL: CHEMBL109
DrugBank: DB00313
PDB-CCD: 2PP[PDBj]
LigandBox: D00399
NIKKAJI: J4.972G
LinkDB All DBs
KCF data Show

ATOM        10
            1   C1c C    25.4573  -18.6784
            2   C1b C    25.4573  -17.3002
            3   C1b C    24.2485  -19.3967
            4   C6a C    26.6604  -19.3967
            5   C1b C    24.2427  -16.5935
            6   C1b C    23.0396  -18.6784
            7   O6a O    26.6604  -20.7925
            8   O6a O    27.8692  -18.6784
            9   C1a C    23.0339  -17.3002
            10  C1a C    21.8367  -19.3967
BOND        9
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     4   7 1
            7     4   8 2
            8     5   9 1
            9     6  10 1

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