KEGG   DRUG: RanitidineHelp
Entry
D00422                      Drug                                   

Name
Ranitidine (USAN/INN);
Ranitidine (TN)
Formula
C13H22N4O3S
Exact mass
314.1413
Mol weight
314.4038
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Anti-allergic agent
 DG01557  Histamine receptor antagonist
  DG01481  Histamine receptor H2 antagonist
Cyp inhibitor
 DG01645  CYP2D6 inhibitor
 DG01522  CYP3A4 inhibitor
Remark
ATC code: 
Chemical group: 
Activity
Antagonist [to histamine H2 receptors]
Target
H2-receptor [HSA:3274] [KO:K04150]
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gastric acid secretion
Metabolism
Transporter: SLC22A2 [HSA:6582]
Interaction
CYP inhibition: CYP2D6 [HSA:1565], CYP3A [HSA:1576 1577 1551]
Transporter inhibition: SLC22A2 [HSA:6582]
Drug interaction
Structure map
Antiulcer drugs
Histamine H2/H3 receptor agonists/antagonists
Other map
Bile secretion
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A02 DRUGS FOR ACID RELATED DISORDERS
   A02B DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
    A02BA H2-receptor antagonists
     A02BA02 Ranitidine
      D00422  Ranitidine (USAN/INN)
USP drug classification [BR:br08302]
 Gastrointestinal Agents
  Histamine2 (H2) receptor Antagonists
   Ranitidine
    D00422  Ranitidine (USAN/INN)
Risk category of Japanese OTC drugs [BR:br08312]
 First-class OTC drugs
  Inorganic and organic chemicals
   Ranitidine
    D00422  Ranitidine (USAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    H2-receptor
     Ranitidine
      D00422  Ranitidine (USAN/INN)
Cytochrome P450 interactions [BR:br08309]
 CYP inhbitors
  CYP2D6
   Ranitidine
    D00422  Ranitidine (USAN/INN)
  CYP3A
   Ranitidine
    D00422  Ranitidine (USAN/INN)
 Transporter inhibitors
  SLC22A2
   Ranitidine
    D00422  Ranitidine (USAN/INN)
 Transporter substrates
  SLC22A2
   Ranitidine
    D00422  Ranitidine (USAN/INN)
   Ranitidine
    D00422  Ranitidine (USAN/INN)
Rx-to-OTC switch list in the USA [br08315.html]
 D00422
BRITE hierarchy
Other DBs
CAS: 
66357-35-5
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        21
            1   C8y C    19.0765  -23.1392
            2   O2x O    20.1949  -23.9781
            3   C8x C    19.4959  -21.8111
            4   C1b C    17.8182  -23.8382
            5   C8y C    21.3133  -23.1392
            6   C8x C    20.8939  -21.8111
            7   N1c N    16.6298  -23.1392
            8   C1b C    22.5017  -23.8382
            9   C1a C    15.4415  -23.8382
            10  C1a C    16.6298  -21.7412
            11  S2a S    23.6900  -23.1392
            12  C1b C    24.9482  -23.8382
            13  C1b C    26.1366  -23.1392
            14  N1b N    27.3249  -23.8382
            15  C2c C    28.5831  -23.1392
            16  C2b C    29.7715  -23.8382
            17  N1b N    28.5831  -21.7412
            18  N2b N    30.9599  -23.1392 #+
            19  C1a C    27.3249  -21.0422
            20  O3a O    30.9599  -21.7412 #-
            21  O3a O    32.2181  -23.8382
BOND        21
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     4   7 1
            7     5   8 1
            8     7   9 1
            9     7  10 1
            10    8  11 1
            11   11  12 1
            12   12  13 1
            13   13  14 1
            14   14  15 1
            15   15  16 2
            16   15  17 1
            17   16  18 1
            18   17  19 1
            19   18  20 1
            20   18  21 2
            21    5   6 2

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