KEGG   DRUG: D00426Help
Entry
D00426                      Drug                                   

Name
Risperidone (JP16/USAN/INN);
Risperdal (TN)
Product
  Generic
RISPERIDONE (Aidarex Pharmaceuticals LLC), RISPERIDONE (Ajanta Pharma Limited), RISPERIDONE (American Health Packaging), RISPERIDONE (Amneal Pharmaceuticals of New York), RISPERIDONE (Aphena Pharma Solutions - Tennessee), RISPERIDONE (Apotex Corp), RISPERIDONE (Apotex Corp.), RISPERIDONE (Atlantic Biologicals Corps), RISPERIDONE (Aurobindo Pharma Limited), RISPERIDONE (Aurobindo Pharma Limited), RISPERIDONE (Aurolife Pharma LLC), RISPERIDONE (AvPAK), RISPERIDONE (Breckenridge Pharmaceutical), RISPERIDONE (Breckenridge Pharmaceutical), RISPERIDONE (Bryant Ranch Prepack), RISPERIDONE (Bryant Ranch Prepack), RISPERIDONE (Bryant Ranch Prepack), RISPERIDONE (Bryant Ranch Prepack), RISPERIDONE (Bryant Ranch Prepack), RISPERIDONE (Bryant Ranch Prepack), RISPERIDONE (Cadila Healthcare Limited), RISPERIDONE (Cadila Healthcare Limited), RISPERIDONE (Caraco Pharmaceutical Laboratories), RISPERIDONE (Cardinal Health), RISPERIDONE (Cardinal Health), RISPERIDONE (Cardinal Health), RISPERIDONE (Cardinal Health), RISPERIDONE (Cardinal Health), RISPERIDONE (Cardinal Health), RISPERIDONE (Clinical Solutions Wholesale), RISPERIDONE (Cobalt Laboratories), RISPERIDONE (Contract Pharmacy Services-PA), RISPERIDONE (Contract Pharmacy Services-PA), RISPERIDONE (Dr. Reddy's Laboratories Limited), RISPERIDONE (Dr. Reddy's Laboratories Limited), RISPERIDONE (Dr. Reddy's Laboratories Limited), RISPERIDONE (Gen-Source Rx), RISPERIDONE (H.J. Harkins Company), RISPERIDONE (Heritage Pharmaceuticals), RISPERIDONE (Hikma Pharmaceutical), RISPERIDONE (Jubilant Cadista Pharmaceuticals), RISPERIDONE (Lake Erie Medical DBA Quality Care Products LLC), RISPERIDONE (Major Pharmaceuticals), RISPERIDONE (Major Pharmaceuticals), RISPERIDONE (McKesson Contract Packaging), RISPERIDONE (McKesson Packaging Services a business unit of McKesson Corporation), RISPERIDONE (Mylan Institutional), RISPERIDONE (Mylan Institutional), RISPERIDONE (Mylan Pharmaceuticals), RISPERIDONE (Mylan Pharmaceuticals), RISPERIDONE (NCS HealthCare of KY), RISPERIDONE (PD-Rx Pharmaceuticals), RISPERIDONE (Par Pharmaceutical Companies), RISPERIDONE (Physicians Total Care), RISPERIDONE (Qualitest Pharmaceuticals), RISPERIDONE (Qualitest Pharmaceuticals), RISPERIDONE (REMEDYREPACK), RISPERIDONE (REMEDYREPACK), RISPERIDONE (REMEDYREPACK), RISPERIDONE (REMEDYREPACK), RISPERIDONE (REMEDYREPACK), RISPERIDONE (REMEDYREPACK), RISPERIDONE (REMEDYREPACK), RISPERIDONE (REMEDYREPACK), RISPERIDONE (REMEDYREPACK), RISPERIDONE (REMEDYREPACK), RISPERIDONE (REMEDYREPACK), RISPERIDONE (REMEDYREPACK), RISPERIDONE (REMEDYREPACK), RISPERIDONE (REMEDYREPACK), RISPERIDONE (REMEDYREPACK), RISPERIDONE (REMEDYREPACK), RISPERIDONE (REMEDYREPACK), RISPERIDONE (REMEDYREPACK), RISPERIDONE (REMEDYREPACK), RISPERIDONE (Ranbaxy Pharmaceuticals), RISPERIDONE (Ratiopharm), RISPERIDONE (Rebel Distributors Corp), RISPERIDONE (Roxane Laboratories), RISPERIDONE (STAT Rx USA LLC), RISPERIDONE (Sandoz), RISPERIDONE (State of Florida DOH Central Pharmacy), RISPERIDONE (State of Florida DOH Central Pharmacy), RISPERIDONE (State of Florida DOH Central Pharmacy), RISPERIDONE (State of Florida DOH Central Pharmacy), RISPERIDONE (State of Florida DOH Central Pharmacy), RISPERIDONE (Sun Pharmaceutical Industries Limited), RISPERIDONE (TYA Pharmaceuticals), RISPERIDONE (TYA Pharmaceuticals), RISPERIDONE (Taro Pharmaceuticals U.S.A.), RISPERIDONE (Teva Pharmaceuticals USA), RISPERIDONE (Torrent Pharmaceuticals Limited), RISPERIDONE (Tris Pharma), RISPERIDONE (Unit Dose Services), RISPERIDONE (WOCKHARDT LIMITED), RISPERIDONE (WOCKHARDT LIMITED), RISPERIDONE (WOCKHARDT USA LLC), RISPERIDONE (WOCKHARDT USA LLC.), RISPERIDONE (Zydus Pharmaceuticals (USA)), RISPERIDONE (Zydus Pharmaceuticals (USA))
Formula
C23H27FN4O2
Exact mass
410.2118
Mol weight
410.4845
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Neuroleptic, Antipsychotic
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Serotonin-dopamine antagonists (SDA)
prodrug, active substance: Paliperidone [DR:D05339]
Target
5-HT2A-receptor antagonist [HSA:3356] [KO:K04157];
dopamine D2-receptor antagonist [HSA:1813] [KO:K04145];
alpha1-adrenergic receptor antagonist [HSA:146 147 148] [KO:K04137 K04136 K04135]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa04540  Gap junction
hsa04970  Salivary secretion  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565], CYP3A4 [HSA:1576]
Interaction
Genomic biomarker: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Antipsychotics
Serotonin receptor agonists/antagonists
Dopamine receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AX Other antipsychotics
     N05AX08 Risperidone
      D00426  Risperidone (JP16/USAN/INN)
USP drug classification [BR:br08302]
 Antipsychotics
  2nd Generation/Atypical
   Risperidone
    D00426  Risperidone (JP16/USAN/INN)
 Bipolar Agents
  Bipolar Agents, Other
   Risperidone
    D00426  Risperidone (JP16/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D00426  Risperidone (JP16/USAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    alpha1-adrenergic receptor
     Risperidone
      D00426  Risperidone (JP16/USAN/INN)
   Dopamine
    dopamine D2-receptor
     Risperidone
      D00426  Risperidone (JP16/USAN/INN)
   Serotonin
    5-HT2A-receptor
     Risperidone
      D00426  Risperidone (JP16/USAN/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2D6
   Risperidone
    D00426  Risperidone (JP16/USAN/INN)
  CYP3A4
   Risperidone
    D00426  Risperidone (JP16/USAN/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00426  Risperidone
  D00426  Risperidone fine granules
  D00426  Risperidone tablets
  D00426  Risperidone solution
BRITE hierarchy
Other DBs
CAS: 
106266-06-2
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        30
            1   C1y C    22.2076  -18.2560
            2   C1x C    22.2076  -16.8437
            3   C1x C    23.4315  -18.9622
            4   C1x C    23.4315  -16.1376
            5   C1x C    24.6555  -18.2560
            6   N1y N    24.6555  -16.8437
            7   C1b C    25.8795  -16.1847
            8   C1b C    27.0564  -16.8437
            9   C8y C    28.2333  -16.1847
            10  C8y C    29.4572  -16.8437
            11  C8y C    28.2333  -14.7724
            12  N4y N    30.6813  -16.1847
            13  O5x O    29.4572  -18.2560
            14  N5x N    29.4572  -14.0663
            15  C1a C    27.0564  -14.0663
            16  C8y C    30.6813  -14.7253
            17  C1x C    31.9523  -16.8437
            18  C1x C    31.9523  -14.0663
            19  C1x C    33.1292  -16.1847
            20  C1x C    33.1292  -14.7724
            21  C8y C    20.9846  -18.9624
            22  N5x N    19.8537  -18.1619
            23  O2x O    18.7431  -18.9900
            24  C8y C    19.1873  -20.3023
            25  C8y C    20.5727  -20.2852
            26  C8x C    18.4886  -21.5043
            27  C8y C    19.1911  -22.7295
            28  C8x C    20.6034  -22.7337
            29  C8x C    21.3021  -21.5317
            30  X   F    18.4827  -23.9479
BOND        34
            1     1   2 1
            2     1   3 1
            3     2   4 1
            4     3   5 1
            5     4   6 1
            6     6   7 1
            7     7   8 1
            8     8   9 1
            9     9  10 1
            10    9  11 2
            11   10  12 1
            12   10  13 2
            13   11  14 1
            14   11  15 1
            15   12  16 1
            16   12  17 1
            17   16  18 1
            18   17  19 1
            19   18  20 1
            20    5   6 1
            21   14  16 2
            22   19  20 1
            23    1  21 1
            24   21  22 2
            25   22  23 1
            26   23  24 1
            27   24  25 2
            28   21  25 1
            29   24  26 1
            30   26  27 2
            31   27  28 1
            32   28  29 2
            33   29  25 1
            34   27  30 1

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