KEGG   DRUG: PrimidoneHelp
Entry
D00474                      Drug                                   

Name
Primidone (JP17/USP/INN);
Mysoline (TN)
Product
  Generic
Formula
C12H14N2O2
Exact mass
218.1055
Mol weight
218.2518
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Neuropsychiatric agent
 DG01904  Barbiturate antiepileptics
Cyp substrate
 DG01639  CYP2C19 substrate
Remark
Same as: 
Therapeutic category: 
ATC code: 
Activity
Antiepileptic
Comment
Barubiturate derivative
Active form of prodrug: Phenobarbital [DR:D00506] (major product), Phenylethylmalonamide [CPD:C07499] (byproduct)
Metabolism
Enzyme: CYP2C19 [HSA:1557]
Interaction
Drug interaction
Structure map
Anticonvulsants
GABA-A receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AA Barbiturates and derivatives
     N03AA03 Primidone
      D00474  Primidone (JP17/USP/INN)
USP drug classification [BR:br08302]
 Anticonvulsants
  Gamma-aminobutyric Acid (GABA) Augmenting Agents
   Primidone
    D00474  Primidone (JP17/USP/INN)
   Primidone
    D00474  Primidone (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   113  Antiepileptics
    1135  Primidones
     D00474  Primidone (JP17/USP/INN)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP2C19
   Primidone
    D00474  Primidone (JP17/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00474  Primidone
Neurological agents [br08367.html]
 Antiepileptic agents
  D00474
BRITE hierarchy
Other DBs
CAS: 
125-33-7
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        16
            1   C1z C    22.4914  -18.6613
            2   C8y C    23.6964  -17.9536
            3   C5x C    21.2571  -17.9768
            4   C5x C    22.4914  -20.0653
            5   C1b C    23.6964  -19.3574
            6   C8x C    24.9073  -18.6379
            7   C8x C    23.7489  -16.5496
            8   N1x N    20.0522  -18.6613
            9   O5x O    21.2571  -16.5554
            10  N1x N    21.2571  -20.7673
            11  O5x O    23.6847  -20.7673
            12  C1a C    25.0946  -19.3574
            13  C8x C    26.1124  -17.9302
            14  C8x C    24.8839  -15.8417
            15  C1x C    20.0522  -20.0653
            16  C8x C    26.1007  -16.5320
BOND        17
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 1
            5     2   6 2
            6     2   7 1
            7     3   8 1
            8     3   9 2
            9     4  10 1
            10    4  11 2
            11    5  12 1
            12    6  13 1
            13    7  14 2
            14    8  15 1
            15   13  16 2
            16   10  15 1
            17   14  16 1

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